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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

Oncology Research 2025年第1期33卷 235-243页

作者： hassan m.otifi Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using mAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of mAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Pollen morphology of the family Cistaceae in Egypt and its systematic significance

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Journal of Systematics and Evolution 2011年第4期49卷 362-371页

作者： Nasr m.hassan Botany Department Faculty of ScienceAssiut University

The pollen morphology of 11 species (including two subspecies and two varieties) belonging to two genera (Helianthemum and Fumana) of the family Cistaceae in Egypt was studied using light and scanning electron *** grains of the studied taxa were found to be radially symmetrical and *** size,shape,apertures,and exine ornamentation characteristics were valuable parameters among the studied *** largest pollen size was recorded in *** and the smallest one observed in *** ***- *** shape in the Egyptian taxa varied from (sub-)prolate to prolate spheroidal,but *** is different in having sub-oblate *** pollen data confirm that *** and *** are very closely related *** sculpture was useful in distinguishing between *** *** and *** *** main pollen types of exine ornamentation were recognized: retipilate;reticulate to verrucate;and *** on palynological data,a key for the studied taxa is suggested.

关键词： Cistaceae exine sculpture palynology scanning electron microscopy.

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Study of magnetic and optical properties of Zn1-xTmxTe(Tm = mn,Fe,Co,Ni) diluted magnetic semiconductors：First principle approach

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Chinese Physics B 2017年第2期26卷 452-460页

作者： Q mahmood m hassan m A Faridi Department of Physics University of the Punjab Quaid-e-Azam Campus-54590 Lahore Pakistan Centre for High Energy Physics University of the Punjab Lahore Pakistan

We present structural,magnetic and optical characteristics of Zn_（1-x）Tm_xTe（Tm = mn,Fe,Co,Ni and x = 6.25%）,calculated through Wien2 k code,by using full potential linearized augmented plane wave（FP-LAPW） *** optimization of the crystal structures have been done to compare the ferromagnetic（Fm） and antiferromagnetic（AFm） ground state energies,to elucidate the ferromagnetic phase stability,which further has been verified through the formation and cohesive ***,the estimated Curie temperatures T_c have demonstrated above room temperature ferromagnetism（RTFm） in Zn_（1-x）Tm_xTe（Tm =mn,Fe,Co,Ni and x= 6.25%）.The calculated electronic properties have depicted that mn- and Co-doped ZnTe behave as ferromagnetic semiconductors,while half-metallic ferromagnetic behaviors are observed in Fe- and Ni-doped *** presence of ferromagnetism is also demonstrated to be due to both the p-d and s-d hybridizations between the host lattice cations and Tm *** calculated band gaps and static real dielectric constants have been observed to vary according to Penn＇s *** evaluated band gaps lie in near visible and ultraviolet regions,which make these materials suitable for various important device applications in optoelectronic and spintronic.

关键词： magnetic semiconductors density functional theory optical and dielectric properties electron density of states and band structure of crystalline solids

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New Exact Solutions of Two Nonlinear Physical models

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Communications in Theoretical Physics 2010年第4期53卷 596-604页

作者： m.m.hassan mathematics Department Faculty of Science Minia University

Abundant new exact solutions of the Schamel-Korteweg-de Vries （S-KdV） equation and modified Zakharov- Kuznetsov equation arising in plasma and dust plasma are presented by using the extended mapping method and the availability of symbolic computation. These solutions include the Jacobi elliptic function solutions, hyperbolic function solutions, rational solutions, and periodic wave solutions. In the limiting cases, the solitary wave solutions are obtained and some known solutions are also recovered.

关键词： modified Zakharov-Kuznetsov equation Schamel-Korteweg-de Vries equation traveling and periodic wave solutions extended mapping method

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Fe_(3)O_(4)-carbon spheres core–shell supported palladium nanoparticles:A robust and recyclable catalyst for suzuki coupling reaction

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Chinese Journal of Chemical Engineering 2022年第11期51卷 75-85页

作者： mohamed A.Almaradhi hassan m.A.hassan mosaed S.Alhumaimess Department of Chemistry College of ScienceJouf UniversityPO Box 2014SakakaSaudi Arabia

Suzuki-miyaura(S-m)is regarded the most powerful way for synthesis biaryls,triaryls,or incorporating of substituted aryl moieties in organic preparation by the cross-coupling of aryl boronic acid with aryl halides using the Pd *** work reports the combining of the hydrothermal and microwaveassisted protocol to convert the glucose to magnetic carbon spheres(Fe_(3)O_(4)-CSPs)decorated with Pd nanoparticles(NPs)as the catalyst for Suzuki-miyaura cross-coupling *** physicochemical properties in the produced composite were examined using FESEm,HRTEm,nitrogen isotherms,Raman spectroscopy,FTIR,XPS,and *** as-fabricated composite Pd/Fe_(3)O_(4)-CSPs is mostly spherical with a core–shell structure and possesses a great surface area of 253.2 m^(2).g^(-1).Its catalytic performance demonstrates that the composite has excellent stability and high tolerance Suzuki-miyaura crosscoupling reactions in 30 min at 80℃.Both activated and deactivated aryl halides provided excellent *** as-fabricated catalyst was recycled for up to four catalytic cycles without a substantial decline in ***,this research offers a facile roadmap for synthesizing Pd/Fe_(3)O_(4)-CSPs composites and promoting the practical implementation of Pd/Fe_(3)O_(4)-CSPs catalysts for organic transformation processes.

关键词： Heterogeneous catalysis Aryl halide Suzuki coupling Palladium nanoparticles Carbon spheres

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Statistical Inference of Chen Distribution Based on Two Progressive Type-II Censoring Schemes

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Computers, materials & Continua 2021年第3期66卷 2797-2814页

作者： hassan m.Aljohani Department of mathematics&Statistics Faculty of ScienceTaif UniversityTaif21944Saudi Arabia

An inverse problemin practical scientific investigations is the process of computing unknown parameters from a set of observations where the observations are only recorded indirectly,such as monitoring and controlling quality in industrial process *** regression can be thought of as linear inverse *** other words,the procedure of unknown estimation parameters can be expressed as an inverse ***,maximum likelihood provides an unstable solution,and the problembecomes more complicated if unknown parameters are estimated from different ***,researchers search for better *** study two joint censoring schemes for lifetime products in industrial process *** practice,this type of data can be collected in fields such as the medical industry and industrial *** this study,statistical inference for the Chen lifetime products is considered and analyzed to estimate underlying *** likelihood and Bayes’rule are both studied for model *** asymptotic distribution of maximumlikelihood estimators and the empirical distributions obtained withmarkov chainmonte Carlo algorithms are utilized to build the interval *** results using tables and figures are adopted through simulation studies and verified in an analysis of the lifetime *** briefly describe the performance of developed methods.

关键词： Chen distributions progressive type-II censoring maximum likelihood mean posterior Bayesian estimation mCmC

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InGaN/GaN laser diode characterization and quantum well number effect

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Chinese Optics Letters 2009年第3期7卷 226-230页

作者： S.m.Thahab H.Abu hassan Z.hassan Nano-Optoelectronics Research and Technology Laboratory School of PhysicsUniversiti Sains Malaysia

The effect of quantum well number on the quantum efficiency and temperature characteristics of In- GaN/GaN laser diodes （LDs） is determined and investigated. The 3-nm-thick In0.13Ca0.87N wells and two 6-am-thick GaN barriers are selected as an active region for Fabry-Perot （FP） cavity waveguide edge emitting LD. The internal quantum efficiency and internal optical loss coefficient are extracted through the simulation software for single, double, and triple InGaN/GaN quantum wells. The effects of device temperature on the laser threshold current, external differential quantum efficiency （DQE）, and output wavelength are also investigated. The external quantum efficiency and characteristic temperature are improved significantly when the quantum well number is two. It is indicated that the laser structures with many quantum wells will suffer from the inhomogeneity of the carrier density within the quantum well itself which affects the LD performance.

关键词： Computer software Efficiency Fabry Perot interferometers Quantum well lasers Semiconductor lasers Semiconductor quantum wells

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Theoretical investigation of optical properties and band gap engineering for Zn1-xTmxTe(Tm=Fe,Co)alloys by modified Becke-Johnson potential

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Chinese Physics B 2017年第8期26卷 491-498页

作者： Q mahmood m Yaseen m hassan Shahid m Ramay Asif mahmood materials Growth and Simulation Laboratory Department of PhysicsUniversity of the PunjabQuaid-i-Azam Campus54590LahorePakistan Department Of Physlcs University of Agriculture UniversityFaisalabad 38040Pakistan Physics and Astronomy Department College of ScienceKing Sand UniversityRiyadhSaudi Arabia Chemical Engineering Department College of EngineeringKing Saud UniversityRiyadhSaudi Arabia

The direct band gap ZnTe with transition metal （Tm） impurities plays a vital role in optoelectronic and spintronic applications. In the present study, we use the advanced modified Becke-Johnson （mBJ） functional for performing the structural computations and detailed investigations of the optical characters in Zn1_xTmxTe （Tm = Fe, Co） alloys with 0 ≤ x ≤1. By employing the FP-LAPW method, we determine various optical parameters for the ternary alloys and for the end binaries. The calculated static dielectric constants and optical band gaps for Zn1_xTmxTe （Tm = Fe, Co） have an inverse relation that verifies the Penn model. We find that the static dielectric constant is nearly equal to the square of the static refractive index, and both increase with Tm content. Furthermore, we also find a slight shift of peaks to a higher energy region with increasing Tm concentration. The decreasing band gap and high value of the absorption in the visible region of electromagnetic spectrum make these alloys suitable for photonic and solar cell applications.

关键词： amorphous semiconductors transition metal-doped ZnTe structural computation optical property

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