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A Hirshfeld Surface Analysis and Crystal Structure of 2’-[1-(2-Fluoro-phenyl)-1H-tetrazol-5-Yl]-4-Methoxy-biphenyl-2-Carbaldehyde

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Crystal Structure Theory and Applications 2013年第3期2卷 124-131页

作者： S. Madan Kumar b. C. Manjunath G. S. Lingaraju M. M. M. Abdoh M. p. Sadashiva N. K. Lokanath Department of physics Faculty of Science An Najah National University Nabtus West Bank Palestinian Territories Department of Studies in Chemistry University of Mysore Mysore India Department of Studies in physics University of Mysore Mysore India

The title compound, C21H15FN4O2 is synthesized and characterized by 1H NMR, LC-MS and finally confirmed by single crystal X-ray diffraction method. This molecule crystallizes in the monoclinic crystal system and space group p21/c, with crystal parameters a = 9.4386(5) A, b = 20.8082(1) A, c = 9.4338(6) A, β = 99.566(2)0, Z = 4 and V = 1826.98(19) A3. The mean planes of fluro-phenyl moiety makes a dihedral angle of 21.51 (7)0 with biphenyl moiety. The molecules are connected by hydrogen bonds of the type C---H...O and C---H...F. In addition, crystal structure is stabilized with π … π (exhibits intramolecular interaction) and C---O... π interactions. The intercontacts in the crystal structure are analyzed using Hirshfeld surfaces computational method.

关键词： Crystal Structure Intermolecular Interactions Hirshfeld Surfaces

Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease

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Gastroenterology Report 2014年第4期2卷 276-280页

作者： Elliot b.Tapper Katherine Krajewski Michelle Lai Tracy Challies Robert Kane Nezam Afdhal Daryl Lau Division of Gastroenterology Beth Israel Deaconess Medical CenterBostonMA USA Division of Radiology Beth Israel Deaconess Medical CenterBostonMAUSA Division of pathology Beth Israel Deaconess Medical CenterBostonMAUSA

background and ***-alcoholic fatty liver disease(NAFLD)is a common,morbid disease with profound implications for the overall health of the *** set out to determine the clinical predictors of advanced histology in the referral *** performed a retrospective review of all biopsy-proven NAFLD patients,including 358 unique patients first seen between 1996 and *** histology and ultrasound images were reviewed prospectively by clinicians who were blinded to clinical information and test *** with men,women tended to present at an older age(51.4-10.6 vs 45.3-11.2 years,pbe Caucasian(p=0.003),less likely to present with an elevated alanine aminotransferase(ALT)(75.2%vs 88.8%),and more likely to have advanced non-alcoholic steatohepatitis(NASH)(44.7%vs 29.9%;p=0.04)and advanced fibrosis(23.3%vs 14.1%;p=0.03).In multivariate logistic regression,body mass index(bMI)-30 kg/m^(2)(odds ratio(OR)2.21;95%confidential interval(CI):1.23–4.08),female gender(OR 1.76;95%CI:1.01–3.10)and aspartate aminotransferase(AST)>40 IU/L(OR 2.00;95%CI:1.14–3.55)were associated with a NAFLD activity score>*** sensitivity and specificity of an AST to platelet ratio index(ApRI)>1 for significant fibrosis was 30.0%(95%CI:17.2–45.4%)and 92.8%(95%CI:88.2-95.8%),respectively;the likelihood ratio is *** multivariate logistic regression,ApRI>1 was the most significant predictor of advanced fibrosis(OR 3.85;95%CI:1.55–9.59).In patients without ultrasound-detected steatosis,20%had advanced fibrosis and 16.7%had active *** with suspected NAFLD should routinely be evaluated for advanced liver disease,including non-invasive indices of fibrosis such as ApRI,and serious consideration given to liver biopsy.

关键词： cirrhosis non-alcoholic fatty liver disease non-alcoholic steatohepatitis aspartate aminotransferase-to-platelet ratio index

以减毒沙门氏菌为载体的肝细胞生长因子基因对大鼠应激性胃黏膜溃疡模型的影响

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中国组织工程研究与临床康复 2008年第37期12卷 7286-7289页

作者：于淼哈小琴吕同德张岫兰牛廷献兰州大学甘肃省兰州市730000 解放军兰州军区兰州总医院实验中心甘肃省兰州市730050 甘肃省人民医院甘肃省兰州市730000

背景:近年来对肝细胞生长因子的研究已证实肝细胞生长因子具有促进血管生长,减轻胃黏膜损伤的作用。目的:观察以减毒沙门氏菌为载体携带肝细胞生长因子基因对束缚-水浸应激诱发大鼠应激性胃溃疡模型的影响。设计、时间及地点:随机区组设... 详细信息

背景:近年来对肝细胞生长因子的研究已证实肝细胞生长因子具有促进血管生长,减轻胃黏膜损伤的作用。目的:观察以减毒沙门氏菌为载体携带肝细胞生长因子基因对束缚-水浸应激诱发大鼠应激性胃溃疡模型的影响。设计、时间及地点:随机区组设计,实验于2007-03/09在解放军兰州军区兰州总医院和甘肃省中医学院进行。材料:40只雄性Wistar大鼠随机分为4组:正常组、模型组、预防组、对照组,每组10只。方法:应激前用1×1012cfu/L携带肝细胞生长因子基因的减毒沙门氏菌给预防组大鼠灌胃,隔天一次,共灌胃6次,每只大鼠0.3mL/次,同时用同剂量单纯减毒沙门氏菌同方法给对照组大鼠灌胃,正常组与模型组用等体积的碳酸氢钠(10%NaHCO3)同法灌胃。将模型组、预防组和对照组大鼠用束缚-水浸应激法复制应激性胃溃疡模型,18h后,麻醉后将4组大鼠处死。主要观察指标:采用比色法和放射免疫分析法检测大鼠血清一氧化氮和血清皮质醇含量,大体及光镜下观察大鼠胃黏膜病理改变,测定胃溃疡指数。结果:40只大鼠均进入结果分析。①模型组大鼠胃黏膜出现明显的出血及糜烂,预防组的黏膜损伤明显轻于模型组和对照组,应激后预防组的溃疡指数明显低于模型组和对照组(ppppp<0.01)。结论:携带肝细胞生长因子基因的减毒沙门氏菌可通过减少血清中的一氧化氮和皮质醇的含量,预防应激性胃溃疡的发生。

关键词：应激胃溃疡肝细胞生长因子减毒沙门氏菌基因

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堆石坝的锚杆荷载分析

水利水电科技进展 1984年第3期 171-174页

作者： b.S.布朗 p.J.N.佩尔许杏陶

本文采用数值分析以检验堆石坝的锚杆在施工期间和漫顶溢流期间所产生的负荷;同时以极限平衡分析所得到的负荷加以比较。加强堆石坝的下游坡面,使其能够在部分完工的坝体上宣泄施工洪水。此项技术在提供坝顶分洪措施方面具有重大的经济... 详细信息

本文采用数值分析以检验堆石坝的锚杆在施工期间和漫顶溢流期间所产生的负荷;同时以极限平衡分析所得到的负荷加以比较。加强堆石坝的下游坡面,使其能够在部分完工的坝体上宣泄施工洪水。此项技术在提供坝顶分洪措施方面具有重大的经济意义。加强的结构包括:坡面设置钢筋网以防溢流冲刷。采用长水平锚杆和钢筋网相连,以防渗透压力引起的深层滑动。长水平锚杆的费用相当可观,而坡面钢筋网的设计和施工对于堆石坝的正常运行至关重要。锚杆通常采用极限平衡分析来进行设计,或用修正的园弧滑动,或用滑动楔体。然而该法未考虑施工期间锚杆的应力,也未考虑在溢流期间堆石的应力应变特性。

关键词：锚杆安全系数溢流漫顶极限平衡安全计量学流体流动堆石坝钢筋网

应用320层螺旋CT冠状动脉成像减少对比剂剂量的可行性研究

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国际医学放射学杂志 2010年第4期 402-403页

作者： p.A.Hein J.May p.Rogalla C.butler b.hamm A.Lembcke 庞国栋 Department of Radiology Charité-University HospitalCampus MitteCharitéplatz 110117 BerlinGermany

目的利用320层CT单心动周期心脏成像时,评估减少对比剂剂量对于冠状动脉成像质量的影响。材料与方法选取40例男性病人进行冠状动脉CT成像(CCTA),体质量≤85kg,心率

关键词：冠状动脉成像对比剂螺旋 CCTA 剂量用药量 CT

EXpERIMENTAL RESEARCH ON INTERNAL WAVES GENERATED bY A MOVING bODY IN A STRATIFIED FLUID

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Journal of Hydrodynamics 1989年第2期1卷 10-19页

作者： Zhang She-guang Dai Shi-qiang Shanghai Inst.of Appl.Math.and Mech.,Shanghai,p.R.ChinaHuhe Aode Institute of Mechanics,Academia Sinica,beijing,p.R.China

Two-dimensional internal waves generated by a moving flat body in a continuous- ly stratified fluid are investigated by using three kinds of flow-visualization methods:electrolytic precipitation,hydrogen bubbles,and dye *** are paid mainly to the generation and propagation process in the upstream region under low internal Froude number(1/10πpstream disturbances as well as their relationship with stratification number K (K=1/F_r) are *** corresponding theoretical analysis is briefly presented,and by comparison,the experimental and theoretical results agree well.

关键词： mode EXpERIMENTAL RESEARCH ON INTERNAL WAVES GENERATED bY A MOVING bODY IN A STRATIFIED FLUID bODY

passive Heating Systems:A Case Study in a brazilian Mountainous Region

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Journal of Civil Engineering and Architecture 2019年第11期13卷 676-685页

作者： Ana Clara L.pereira Ana Lúcia T.S.da Motta bruno b.F.da Costa priscilla C.p.F.de Oliveira Thiago V.Miranda programa de pós-graduacao em Engenharia Civil Universidade Federal FluminenseRio de Janeiro 22211-200Brazil Departamento de Engenharia Civil da Universidade Federal do Rio de Janeiro—Campus Macaé Rio de Janeiro 22211-200Brazil

The study of thermal comfort in the built environment is of great relevance since it stimulates the development of more sustainable buildings suited to the local climate and able to meet the human need for *** objective of this research was to develop,construct and test a passive heating system adaptable to existing buildings,reducing the need for major interventions and increasing thermal comfort in the indoor *** adopted methodological approach was a case study in a single-family residence located in the brazilian city of petrópolis,a mountainous region with a humid subtropical climate and a rigorous *** proposed passive heating system is totally isolated,thus mitigating air infiltration and promoting increase of temperature in the internal environment through the absorption of solar energy and greenhouse *** kind of solution is especially interesting for residents of this region,since most of the city buildings are not adequately prepared to handle low ***,given local climatic conditions,residents need to spend a lot of money on the acquisition and operation of electric or gas heating *** results indicated that the developed system,in fact,increased the temperature of the studied room when compared to an adjacent room,which did not receive the *** findings of this paper,therefore,provide a valuable reference for experts and practitioners in the selection of heating systems to be used in cold regions,and proved that passive systems can provide thermal comfort at the same time that optimize the interaction of the building with the local ecosystem.

关键词： passive heating systems thermal comfort bioclimatic architecture sustainable buildings

艾烟经嗅觉途径对快速老化小鼠学习记忆能力的影响

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中国针灸 2023年第7期43卷 800-806页

作者：左滢竹林瑶哈略赵百孝北京中医药大学针灸推拿学院北京100029 陕西中医药大学针灸推拿学院北京中医药大学东直门医院针灸科北京100700

目的:观察艾烟干预经嗅觉途径对快速老化(SAMp8)小鼠学习记忆的影响,探究艾烟的作用途径。方法:将48只6月龄雄性SAMp8小鼠随机分为模型组、嗅觉障碍组、艾烟组、嗅觉障碍+艾烟组,每组12只;以12只同月龄雄性正常老化(SAMR1)小鼠作为空白... 详细信息

目的:观察艾烟干预经嗅觉途径对快速老化(SAMp8)小鼠学习记忆的影响,探究艾烟的作用途径。方法:将48只6月龄雄性SAMp8小鼠随机分为模型组、嗅觉障碍组、艾烟组、嗅觉障碍+艾烟组,每组12只;以12只同月龄雄性正常老化(SAMR1)小鼠作为空白组。嗅觉障碍组和嗅觉障碍+艾烟组以300mg/kg3-甲基吲哚(3-MI)腹腔注射制备嗅觉障碍模型,艾烟组和嗅觉障碍+艾烟组每日以10~15 mg/m3浓度艾烟干预30 min,每周干预6d。6周后进行旷场实验、Morris水迷宫实验检测小鼠的情绪和学习记忆能力,HE染色观察海马CAI区神经元形态,ELISA法检测小鼠海马组织神经递质[谷氨酸(Glu)、γ-氨基丁酸(GAbA)、多巴胺(DA)、5-羟色胺(5-HT)]含量。结果:空白组、模型组和艾烟组小鼠均可在300 s内寻找到埋藏的食物小球;嗅觉障碍组和嗅觉障碍+艾烟组小鼠找寻时间均>300s,提示嗅觉障碍模型制备成功。与空白组比较,模型组小鼠旷场实验垂直运动次数、水平运动次数增加(pppbA、DA、5-HT含量均降低(ppppppppppppppp8小鼠的学习记忆能力,且嗅觉并非艾烟起效的唯一途径。

关键词：阿尔茨海默病艾烟学习记忆能力神经递质嗅觉嗅觉障碍

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急性心肌梗死后左室功能不全患者中卡维地洛与美托洛尔治疗比较:一项随机、阳性药物对照研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 19-20页

作者： Mrdovic I.b. Savic L.Z. perunicic J.p. 黄欣 Institute for Cardiovascular Diseases Emergency Hospital Clinical Centre of Serbia belgrade Serbia Dr.

背景:先前的研究证实,卡维地洛对于急性心肌梗死(AMI)伴左室(LV)功能不全的患者有益。但是,迄今为止,尚未在此类人群中对美托洛尔进行随机评估。

关键词：卡维地洛功能不全 AM 美托洛尔健康相关生活质量患者