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雷替曲塞联合奥沙利铂治疗晚期肠癌的效果观察

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中国当代医药 2014年第22期21卷 75-76页

作者：杭兆康南京市六合区人民医院肿瘤内科南京210000

目的：探讨雷替曲塞联合奥沙利铂治疗晚期肠癌的临床效果。方法选择2012年5月∽2013年8月在本院进行治疗的晚期肠癌患者36例，将其随机分为观察组和对照组各18例，对照组采用奥沙利铂联合氟尿嘧啶与亚叶酸钙进行治疗，观察组采用雷替曲... 详细信息

目的：探讨雷替曲塞联合奥沙利铂治疗晚期肠癌的临床效果。方法选择2012年5月∽2013年8月在本院进行治疗的晚期肠癌患者36例，将其随机分为观察组和对照组各18例，对照组采用奥沙利铂联合氟尿嘧啶与亚叶酸钙进行治疗，观察组采用雷替曲塞联合奥沙利铂进行治疗，比较两组的临床治疗效果。结果观察组总有效率为38.9%，对照组总有效率为16.7%，两组差异有统计学意义（p〈0.05）；观察组不良反应发生率为5.6%，对照组不良反应发生率为27.8%，两组差异有统计学意义（p〈0.05）。结论雷替曲塞联合奥沙利铂治疗晚期肠癌可取得较好的临床效果，能够有效缓解临床症状，显著改善肠道功能，有效提高患者的生活质量及生命质量，是一种比较理想的治疗方法，值得临床广泛应用。

关键词：晚期肠癌雷替曲塞奥沙利铂

Comments on the coordination number models and equations of state of Tsai and Chen[Fluid phase Equilibria 187-188(2001)39-59 and 232(2005)100-112]

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Comments on the coordination number models and equations of ...

超声刀联合弹力线套扎术治疗混合痔的临床研究

中国科学院地质与地球物理研究所2006学术年会

作者： J.Hu~a and S.Sang~b a The Key Laboratory of Mineral Resources,Institute of Geology and Geophysics,Chinese Academy of Sciences, p.O.box 9825,beijing 100029,pR China b CoIlege of Materials,Chemistry and Chemical Engineering,Chengdu University of Technology,Chengdu 610059, pR China

This paper notes typographical errors in the coordination number model of Tsai and Chen[Fluid phase Equilib.232(2005) 100-112]for square-well mixtures and in the equations of state of Tsai and Chen[Fluid phase Equilib.187-188(2001) 39-59;Fluid phase Equilib.232 (2005) 100-112]for pure square-well fluids and their *** addition,the divergence condition and applicable range of the coordination number model of Tsai and Chen(2005) for mixtures are described.

关键词： Square-well fluid Coordination number model Equation of state Divergent Unequal-sized mixture

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中外医疗 2018年第31期37卷 57-59页

作者：杭春平江苏省盐城市大丰中医院肛肠科江苏盐城224100

目的研究超声刀联合弹力线套扎治疗混合痔的临床应用疗效。方法方便选取2016年6月—2017年8月该院肛肠病房需手术治疗的90例混合痔患者作为研究对象,按就诊先后顺序分为观察组和对照组,每组45例。观察组行超声刀外痔切除联合弹力线内痔... 详细信息

目的研究超声刀联合弹力线套扎治疗混合痔的临床应用疗效。方法方便选取2016年6月—2017年8月该院肛肠病房需手术治疗的90例混合痔患者作为研究对象,按就诊先后顺序分为观察组和对照组,每组45例。观察组行超声刀外痔切除联合弹力线内痔套扎术,对照组行混合痔外切内扎术(M-M术)。比较两组患者手术疗效、围术期恢复及术后并发症的发生情况。结果两组手术总体疗效和显效率差异均无统计学意义(治疗组总疗效93.33%,对照组总疗效88.89%,χ~2=0.137,p>0.05),观察组术中出血量、术后住院时间及创面愈合时间均显著低于对照组,差异有统计学意义(t=7.418、4.098、4.523,pp<0.05)。结论超声刀联合弹力线套扎术与M-M术治疗混合痔疗效相近。前者术中损伤小,术后并发症少,恢复快。

关键词：超声刀弹力线套扎术外痔切除内痔套扎混合痔

异氟醚或七氟醚复合右美托咪定麻醉对老年患者腹腔镜胆囊切除术后认知功能的影响

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检验医学与临床 2018年第17期15卷 2591-2594页

作者：哈斌钟卫重庆市第九人民医院麻醉科 400700

目的研究异氟醚或七氟醚复合右美托咪定麻醉对老年腹腔镜胆囊切除术(LC)患者术后认知功能的影响。方法选择2015年1月至2017年1月在重庆市第九人民医院择期行LC的120例老年患者,按随机数字表法分为4组:异氟醚组(A组)、七氟醚组(b组)、异... 详细信息

目的研究异氟醚或七氟醚复合右美托咪定麻醉对老年腹腔镜胆囊切除术(LC)患者术后认知功能的影响。方法选择2015年1月至2017年1月在重庆市第九人民医院择期行LC的120例老年患者,按随机数字表法分为4组:异氟醚组(A组)、七氟醚组(b组)、异氟醚复合右美托咪定组(C组)和七氟醚复合右美托咪定组(D组),每组30例。在不同时间点对比分析4组患者的平均动脉压(MAp)和心率(HR),采用简易精神状态检查量表(MMSE)评定患者的认知功能。结果 C组患者MAp和HR比A组下降明显,D组患者MAp和HR比b组也有所下降。在手术后6h和24h,b组和C组MMSE评分高于A组(pb组(pp>0.05)。结论 LC老年患者采用七氟醚进行全身麻醉对患者认知功能的影响要稍低于异氟醚,而当复合右美托咪定能有效降低全身麻醉对患者认知功能的影响,复合右美托咪定进行全身麻醉可能是一种优选的方式。

关键词：七氟醚异氟醚认知障碍手术后期间

Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol

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World Journal of Gastroenterology 2008年第28期14卷 4486-4491页

作者： Venkata Muddana Janette Lamb Julia b Greer beth Elinoff Robert H hawes peter b Cotton Michelle A Anderson Randall E brand Adam Slivka David C Whitcomb Division of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Digestive Disorder Center Medical University of South CarolinaCharleston SC 29403United States Department of Medicine University of Michigan Medical CenterAnn Arbor MI 48109United States Department of medicine Northwestern Universityand Currently at University of Pittsburgh Medical CenterPittsburgh PA 15213United States Division of Gastroenterology Hepatology and NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburgh PA 15213United States Department of Human GeneticsUniversity of PittsburghPittsburgh PA 15213United States

AIM： To test the hypothesis that calcium sensing receptor （CASR） polymorphisms are associated with chronic pancreatitis （Cp）, and to determine whether serine protease inhibitor Kazal 1type （SpINK1） N34S or alcohol are necessary co-factors in its etiology. METHODS： Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SpINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms （SNps） in exon 7 （A986S, R990G, and Q1011E）. RESULTS： The CASR exon 7 R990G polyrnorphism was significantly associated with Cp （OR, 2.01; 95% CI, 1.12-3.59; p = 0.015）. The association between CASR R990G and Cp was stronger in subjects who reported moderate or heavy alcohol consumption （OR, 3.12; 95% CI, 1.14-9.13; p = 0.018）. There was no association between the various CASR genotypes and SpINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION： Our United States-based study confirmed an association of CASR and Cp and for the first time demonstrated that CASR R990G is a significant risk factor for Cp. We also conclude that the risk of Cp with CASR R990G is increased in subjects with moderate to heavy alcohol consumption.

关键词： Calcium sensing receptor Serine protease inhibitor Kazal llype Chronic pancreatitis Alcohol

Germplasm Innovation of Heat Tolerance in Rice for Irrigated Lowland Conditions in the philippines

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Rice science 2014年第3期21卷 162-169页

作者： Norvie L.MANIGbAS Leslie Angela F.LAMbIO Luvina b.MADRID Corazon C.CARDENAS plant breeding and biotechnology Division DA-Philippine Rice Research InstituteScience City of MunozNueva Ecija 3119the Philippines Crop Science Cluster Department of AgronomyU.P.Los BanosCollegeLaguna 4031the Philippines Department of Agriculture-Southern Cagayan Research Center IguigCagayan3504the Philippines

Heat-tolerant varieties, such as N22 and Dular, which were used in this study, usually have low yield potential and undesirable plant characteristics but combining them with high yielding and improved rice varieties, new heat-tolerant rice genotypes with high yield potential can be achieved. In this study, phenotyping and selecting desirable materials from various crosses were performed under high temperature conditions during the reproductive stage. Screening was performed in the field and glasshouse to select individuals with heat tolerance and high yield potential. Several advanced breeding lines from Gayabyeo/N22 cross produced desirable individuals with heat tolerance, resistance to pests and diseases, and high yield potential. The genetic variation in percent sterility among the selected backcross populations grown in high temperature environments showed that large number of plants can be identified and selected with lower percent sterility.

关键词： heat tolerance high temperature irrigated lowland rice

Interferon Gamma Restores breast Cancer Sensitivity to Fulvestrant by Regulating STAT1,IRF1,NFκb,Specific bCL2 Family Members,and Signaling to Caspase-dependent Apoptosis

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Interferon Gamma Restores Breast Cancer Sensitivity to Fulve...

Adjuvant interferon therapy for malignant melanoma:the debate

中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Rebecca b.Riggins Robert Clarke Lombardi Comprehensive Cancer Center and Department of Oncology Georgetown University School of Medicine

Antiestrogens are effective therapies for the management of estrogen receptor-alpha positive(ER+) breast ***,both de novo and acquired resistance occur and remain major problems in the clinical *** gamma(IFNγ) is an inflammatory cytokine that induces the expression and function of Interferon Regulatory Factor-1(IRF1),a tumor suppressor gene that can increase antiestrogen *** show that IFNγbut not IFNα,IFNβ,or ICI induces IRF1 expression in antiestrogen resistant MCF7/LCC9 and LY2 ***,IFNγrestores the responsiveness of these cells to Fulvestrant(ICI;ICI 182,780;Faslodex).Increased IRF1 activation suppresses NFκb p65(RELA) activity and inhibits the expression of prosurvival(bCL2,bCLW),and induces the expression of proapoptotic members(bAK,mitochondrial bAX) of the bCL2 *** molecular signaling is associated with activation of STAT1,and leads to increased mitochondrial membrane permeability,activation of CASp7,CASp8,and CASp9,and induction of apoptosis but not autophagy. While antiestrogen resistant cells are capable of inducing autophagy through IFN-mediated signaling,their ability to do so through antiestrogen-regulated signaling is *** abilities of IFNγto activate CASp8, induce apoptosis,and restore antiestrogen sensitivity,are prevented by siRNA targeting IRF1,while transient overexpression of IRF1 mimics the effects of IFNγ*** observations support the exploration of clinical trials combining antiestrogens and compounds that can induce IRF1,such as IFNγ, for the treatment of some ER-positive breast cancers.

关键词： apoptosis autophagy bCL2 breast neoplasms caspases cell death drug resistance estrogen receptor modulators Fulvestrant interferons Tamoxifen

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Chinese Journal of Cancer 2010年第11期29卷 907-913页

作者： Qiang Zhou1,2, Xiao-Shi Zhang1,2 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, p. R. China 2 biotherapy Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, p. R. China State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 PR China

based on the results of the Kirkwood high-dose interferon alpha-2b (HDI) adjuvant therapy trial of the Eastern Cooperative Oncology Group 1684, the US Food and Drug Administration (FDA) approved HDI as the postoperative adjuvant therapy for high-risk melanoma. Unfortunately, controversies continue regarding the use of interferon (IFN) as adjuvant therapy for melanoma owing to the inconsistent results of subsequent trials. Numerous trials of adjuvant interferon therapy demonstrated a benefit in terms of relapse-free survival (RFS), but without confirmed significant effect on overall survival (OS). The optimal timing, dose, and type of interferon are not yet defined. Therefore, adjuvant interferon treatment is preferentially applied in the randomized clinical trials in specialized centers. Decisions about the appropriateness of adjuvant interferon alfa-2b treatment for patients should be made on an individual basis, after discussion with the patient, including an explanation of the potential benefits and side effects of interferon therapy. Moreover, we also need to use available regimens reasonably, seek feasible and predictable prognostic factors to serve patients with individualized therapy.

关键词：恶性黑色素瘤干扰素α 辅助治疗治疗试验人类发展指数美国食品临床试验合理利用

乌鲁木齐市空气颗粒物对COpD患者肺功能的影响

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新疆医学 2021年第8期51卷 944-946页

作者：哈依那牛灵新疆维吾尔自治区人民医院乌鲁木齐830001

目的探究乌鲁木齐市空气颗粒物对慢性阻塞性肺疾病(COpD)患者急性加重和肺功能的影响。方法选择2016年至2019年6月本院收治的慢性阻塞性肺疾病患者31例为调查对象,每位受试者入组前需包括完善入组基线至少3次肺功能,记录每次随访日期及... 详细信息

目的探究乌鲁木齐市空气颗粒物对慢性阻塞性肺疾病(COpD)患者急性加重和肺功能的影响。方法选择2016年至2019年6月本院收治的慢性阻塞性肺疾病患者31例为调查对象,每位受试者入组前需包括完善入组基线至少3次肺功能,记录每次随访日期及肺功能,天气数值,比较每个人不同时期肺功能指标的变化,并找出肺功能变化与天气变化之间关系。采用问卷调查及专业人员随访的方式,每位入组人员需按照随访时间完成肺功能及临床控制CAT评分及呼吸困难mMRC评分,比较不同月份、不同空气颗粒物浓度下患者肺功能及各项评分的不同。结果pM2.5与FEV1/FVC的相关系数为-0.212,p值为0.018(p值为0.000(p值为0.000(pM2.5与FEV1/FVC存在显著的负向相关,与CAT、mMRC存在显著的正向相关关系。pM10与FEV1/FVC的相关系数为-0.224,p值为0.012(p值为0.001(p值为0.000(pM10与FEV1/FVC存在显著的负向相关,与CAT、mMRC存在显著的正向相关关系。结论乌鲁木齐市空气污染较重,空气颗粒物可引起慢性阻塞性肺疾病患者肺功能下降,增加呼吸困难程度,进一步造成呼吸系统与肺功能严重损伤,应积极防控空气颗粒物对人体造成的危害。

关键词：慢性阻塞性肺疾病空气颗粒物肺功能