检索结果-南通市图书馆

Optimization of performance of the KM2A full array using the Crab Nebula

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LhAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China hebei Normal University Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large high Altitude Air Shower Observatory(LhAASO)has been in operation since July *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LhAASO and other experiments.

关键词： γ-ray Crab Nebula significance

Geometrical reconstruction of fluorescence events observed by the LhAASO experiment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第4期45卷 416-425页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi h.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.h.Chen S.h.Chen S.Z.Chen T.L.Chen X.L.Chen y.Chen N.Cheng y.D.Cheng S.W.Cui X.h.Cui y.D.Cui B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu D.della Volpe B.DEtorre Piazzoli X.J.Dong J.h.Fan y.Z.Fan Z.X.Fan J.Fang J.Fang C.F.Feng L.Feng S.h.Feng y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.h.Gong Q.B.Gou M.h.Gu J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.han h.h.he h.N.he J.C.he S.L.he X.B.he y.he M.heller y.K.hor C.hou X.hou h.B.hu S.hu S.C.hu X.J.hu D.h.huang Q.L.huang W.h.huang X.T.huang Z.C.huang F.Ji X.L.Ji h.y.jia K.jiang Z.J.jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li h.B.Li h.C.Li h.y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li y.Li y.Z.Li Z.Li Z.Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu h.Liu h.D.Liu J.Liu J.L.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.N.Liu Z.X.Liu W.J.Long R.Lu h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli y.C.Nan B.y..Pang P.Pattarakijwanich Z.y.Pei M.y.Qi D.Ruffolo V.Rulev A.Saiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi h.C.Song yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.h.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang h.Wang h.G.Wang J.C.Wang J.S.Wang L.P.Wang L.y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.y.Wang y.D.Wang y.J.Wang y.P.Wang Z.Wang Z.Wang Z.h.Wang Z.X.Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu h.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao h.B.Xiao G.G.Xin y.L.Xin y.Xing D.L.Xu R.X.Xu L.Xue D.h.yan C.W.yang F.F.yang J.y.yang L.L.yang M.J.yang R.Z.yang S.B.yang y.h.yao Z.G.yao y.M.ye L.Q.yin N.yin X.h.you Z.y.you y.h.yu Q.yuan h.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang h.M.Zhang h.y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.F.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang y.Zhang y.Zhang y.F.Zhang y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng y.Zheng B.Zhou h.Zhou J.N.Zhou P Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Paricle Detection and Electronics China University of Science and Technology of China HefeiAnhui 230026China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhouGuangdong 510006China School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhaiGuangdong 519000China School of Physical Science and Technology Guangxi UniversityNanningGuangxi 530004China hebei Normal University ShijiazhuangHebei 050024China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Astronomy and Space Science Nanjing UniversityNanjingJiangsu 210023China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjingJiangsu 210023China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdaoShandong 266237China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology Southwest Jiaotong UniversityChengduSichuan 610031China College of Physics Sichuan UniversityChengduSichuan 610065China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasaTibet 850000China School of physics and technology Wuhan UniversityWuhanHubei 430072Ch

The LhAASO-WFCTA experiment,which aims to observe cosmic rays in the sub-EeV range using the fluorescence technique,uses a new generation of high-performance *** ensure that the experiment has ex-cellent detection capability associated with the measurement of the energy spectrum,the primary composition of cosmic rays,and so on,an accurate geometrical reconstruction of air-shower events is *** paper de-scribes the development and testing of geometrical reconstruction for stereo viewed events using the WFCTA(Wide Field of view Cherenkov/Fluorescence Telescope Array)*** approaches,which take full advantage ofthe WFCTA *** *** is the stereo-angular method,which uses the pointing of triggered SiPMs in the shower trajectory,and the other is the stereo-timing method,which uses the triggering time of the fired *** results show that both methods have good geometrical resolution:the resolution of the stereo-timing method is slightly better than the stereo-angular method because the resolution of the latter is slightly limited by the shower track length.

关键词： cosmic ray fluorescence telescope stereo observation geometrical reconstruction

Observation of the Crab Nebula with LhAASO-KM2A−a performance study

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第2期45卷 518-530页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi h.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen M.J.Chen M.L.Chen Q.h.Chen S.h.Chen S.Z.Chen T.L.Chen X.L.Chen y.Chen N.Cheng y.D.Cheng S.W.Cui X.h.Cui y.D.Cui B.Z.Dai h.L.Dai Z.G.Dai D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.h.Fan y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.h.Feng y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.h.Gong Q.B.Gou M.h.Gu J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.han h.h.he h.N.he J.C.he S.L.he X.B.he y.he M.heller y.K.hor C.hou X.hou h.B.hu S.hu S.C.hu X.J.hu D.h.huang Q.L.huang W.h.huang X.T.huang Z.C.huang F.Ji X.L.Ji h.y.jia K.jiang Z.J.jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li F.Li h.B.Li h.C.Li h.y.Li J.Li K.Li W.L.Li X.Li X.R.Li y.Li y.Z.Li Z.Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu h.Liu h.D.Liu J.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.N.Liu Z.X.Liu W.J.Long R.Lu h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli y.C.Nan B.y.Pang P.Pattarakijwanich Z.y.Pei M.y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi h.C.Song yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.h.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang h.Wang h.G.Wang J.C.Wang J.S.Wang L.P.Wang L.y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.y.Wang y.D.Wang y.J.Wang y.P.Wang Z.Wang Z.h.Wang Z.X.Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu h.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao h.B.Xiao G.G.Xin y.L.Xin y.Xing D.L.Xu R.X.Xu L.Xue D.h.yan C.W.yang F.F.yang J.y.yang L.L.yang M.J.yang R.Z.yang S.B.yang y.h.yao Z.G.yao y.M.ye L.Q.yin N.yin X.h.you Z.y.you y.h.yu Q.yuan h.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang h.M.Zhang h.y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang y.Zhang y.F.Zhang y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng y.Zheng B.Zhou h.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu h.Zhu K.J.Zhu X.Zuo Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of Sciences100049 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China 230026 HefeiAnhuiChina Department of Engineering Physics Tsinghua University100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen University519000 ZhuhaiGuangdongChina School of Physical Science and Technology Guangxi University530004 NanningGuangxiChina hebei Normal University 050024 ShijiazhuangHebeiChina School of Physics and Microelectronics Zhengzhou University450001 ZhengzhouHenanChina School of Astronomy and Space Science Nanjing University210023 NanjingJiangsuChina Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210023 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences200030 ShanghaiChina Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong University200240 ShanghaiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina College of Physics Sichuan University610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of Physics and Tec

A sub-array of the Large high Altitude Air Shower Observatory(LhAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 *** though the detector construction is still underway,half of the KM2A array has been operating stably since the end of *** this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray *** detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May *** the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection *** energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other *** opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.

关键词： γ-ray Crab Nebula extensive air showers cosmic rays

A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

在线全文

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： hai-yan Zhang jia-Jie Zhu Zong-Ming Liu yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:hepatocellular carcinoma(hCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting hCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to hCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in hCC ***-hCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,hDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk hCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on hCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for hCC.

关键词： hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

Reconstruction of Cherenkov image bymultiple telescopes of LhAASO-WFCTA

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.Bai y.X.Bai y.W.Bao D.Bastieri X.J.Bi y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.h.Chen S.h.Chen S.Z.Chen T.L.Chen y.Chen h.L.Cheng N.Cheng y.D.Cheng S.W.Cui X.h.Cui y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.h.Fan y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.h.Feng X.T.Feng y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.h.Gong Q.B.Gou M.h.Gu F.L.Guo J.G.Guo X.L.Guo y.Q.Guo y.y.Guo y.A.han h.h.he h.N.he S.L.he X.B.he y.he M.heller y.K.hor C.hou X.hou h.B.hu Q.hu S.hu S.C.hu X.J.hu D.h.huang W.h.huang X.T.huang X.y.huang y.huang Z.C.huang X.L.Ji h.y.jia K.jia K.jiang Z.J.jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li h.B.Li h.C.Li h.y.Li J.Li jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li yZLi Zhe Li Zhuo Li E.W.Liang y.F.Liang S.J.Lin B.Liu C.Liu D.Liu h.Liu h.D.Liu J.Liu J.L.Liu J.S.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.Liu y.N.Liu W.J.Long R.Lu Q.Luo h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao A.Masood Z.Min W.Mitthumsiri y.C.Nan Z.W.Ou B.y.Pang P.Pattarakijwanich Z.y.Pei M.y.Qi y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.y.Shao L.Shao O.Shchegolev X.D.Sheng J.y.Shi h.C.Song yu.V.Stenkin V.Stepanov y.Su Q.N.Sun X.N.Sun Z.B.Sun P.h.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang h.Wang h.G.Wang J.C.Wang J.S.Wang L.P.Wang L.y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.y.Wang y.Wang y.D.Wang y.J.Wang y.P.Wang Z.h.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei y.J.Wei T.Wen C.y.Wu h.R.Wu S.Wu X.F.Wu y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin y.L.Xin y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.h.yan J.Z.yan C.W.yang F.F.yang h.W.yang J.y.yang L.L.yang M.J.yang R.Z.yang S.B.yang y.h.yao Z.G.yao y.M.ye L.Q.yin N.yin X.h.you Z.y.you y.h.yu Q.yuan h.yue h.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang h.M.Zhang h.y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S. Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of Physics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large high Altitude Air Shower Observatory(LhAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LhAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.

关键词： method directions conclusion

Chimeric Monkey Born Alive with a high Contribution of Donor Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第6期40卷 849-851页

作者： jia huang Jun Wu Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTX75390USA hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTX75390USA Cecil h.and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical CenterDallasTX75390USA

Chimeras,which consist of cells from different individuals or different species,represent an important tool in biological *** in the early twentieth century,studies on chimeras have been focusing on understanding fundamental genetic and cellular developmental *** the advances in genetic engineering and embryonic stem cell(ESC)technology,chimeras have become an important tool for the generation of transgenic animals.

关键词： mechanisms advances developmental

Neuropeptide y receptor y8b(npy8br)regulates feeding and digestion in Japanese medaka(Oryzias latipes)larvae:evidence from gene knockout

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 605-616页

作者： Xiaodan jia Ke LU Xufang LIANG College of Fisheries Chinese Perch Research CenterHuazhong Agricultural UniversityWuhan 430070China Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the yangtze River Economic Belt Ministry of EducationWuhan 430070China

Neuropeptide y receptor y8(NPy8R)is a fish-specific receptor with two subtypes,NPy8AR and *** in expression levels during physiological processes or in vivo regulation after ventricular injection suggest that NPy8BR plays an important role in feeding regulation;this has been found in only a few fish,at *** order to better understand the physiological function of npy8br,especially in digestion,we used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology to generate npy8br-/-japanese medaka(Oryzias latipes).We found that the deletion of npy8br in medaka larvae affected their feeding and digestion ability,ultimately affecting their ***,npy8br deficiency in medaka larvae resulted in decreased feed intake and decreased expression levels of orexigenic genes(npy and agrp).npy8br-/-medaka larvae fed for 10 d(10th day of feeding)still had incompletely digested brine shrimp(Artemia nauplii)in the digestive tract 8 h after feeding,the messenger RNA(mRNA)expression levels of digestion-related genes(amy,lpl,ctra,and ctrb)were significantly decreased,and the activity of amylase,trypsin,and lipase also significantly *** deletion of npy8br in medaka larvae inhibited the growth and significantly decreased the expression of growth-related genes(gh and igf1).hematoxylin and eosin(h&E)sections of intestinal tissue showed that npy8br-/-medaka larvae had damaged intestine,thinned intestinal wall,and shortened intestinal *** far,this is the first npy8br gene knockout model established in fish and the first demonstration that npy8br plays an important role in digestion.

关键词： Neuropeptide y receptor y8b(npy8br) Japanese medaka(Oryzias latipes) Knockout Feeding Digestion

Anti-OX40 Antibody Combined with hBc VLPs Delays Tumor Growth in a Mouse Colon Cancer Model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第2期37卷 187-195页

作者： LIU jia jia SU Qiu Dong yI yao ShEN Li Ping BI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic *** this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(hBc VLPs)therapy using a mouse colon cancer *** humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with hBc VLPs+anti-h OX40 *** growth was *** cytometric analysis was performed to evaluate the populations of T cell subsets in the *** The combination of anti-OX40 with hBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination *** studies revealed that hBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with hBc *** Combination therapy of anti-h OX40 and hBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.

关键词： Anti-OX40 antibody hepatitis B core virus-like particles Tumor Combination therapy

Prospects for a multi-TeV gamma-ray sky survey with the LhAASO water Cherenkov detector array

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2020年第6期44卷 123-132页

作者： F.Aharonian V.Alekseenko Q.An Axikegu L.X.Bai y.W.Bao D.Bastieri9 X.J.Bi h.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang X.C.Chang S.P.Chao B.M.Chen J.Chen L.Chen L.Chen M.L.Chen M.J.Chen Q.h.Chen S.h.Chen S.Z.Chen T.L.Chen X.L.Chen y.Chen N.Cheng y.D.Cheng S.W.Cui X.h.Cui y.D.Cui B.Z.Dai h.L.Dai Z.G.Dai Danzengluobu B.D'Ettorre Piazzoli J.Fang J.h.Fan y.Z.Fan C.F Feng L.Feng S.h.Feng y.L.Feng B.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.h.Gong Q.B.Gou M.h.Gu y.Q.Guo y.y.Guo y.A.han h.h.he J.C.he M.heller S.L.he y.he C.hou D.h.huang Q.L.huang W.h.huang X.T.huang h.B.hu S.hu h.y.jia K.jiang F.Ji C.Jin X.L.Ji K.Levochkin E.W.Liang y.F Liang Cheng Li Cong Li F.Li h.Li h.B.Li h.C.Li h.M.Li J.Li K.Li W.L.Li X.Li X.R.Li y.Li Z.Li Z.Li B.Liu C.Liu D.Liu h.D.Liu h.Liu J.Liu J.y.Liu M.y.Liu R.y.Liu S.M.Liu W.Liu y.N.Liu Z.X.Liu W.J.Long R.Lu h.K.Lv B.Q.Ma L.L.Ma J.R.Mao A.Masood X.h.Ma W.Mitthumsiri T.Montaruli y.C.Nan P.Pattarakijwanich Z.y.Pei B.Q.Qiao M.y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi y.Stenkin V.Stepanov Z.B.Sun P.h.T.Tam Z.B.Tang W.W.Tian D.D.Volpe C.Wang h.Wang h.G.Wang J.C.Wang L.y.Wang W.Wang W.Wang X.G.Wang X.y.Wang X.J.Wang y.D.Wang y.J.Wang y.N.Wang y.P.Wang Z.Wang Z.h.Wang Z.X.Wang D.M.Wei J.J.Wei T.Wen C.y.Wu h.R.Wu S.Wu W.X.Wu X.F.Wu G.M.Xiang G.Xiao G.G.Xin y.Xing R.X.Xu L.Xue D.h.yan C.W.yang F.F.yang L.L.yang M.J.yang R.Z.yang S.B.yang y.h.yao Z.G.yao y.M.ye L.Q.yin N.yin X.h.you Z.y.you Q.yuan y.h.yu Z.J.jiang h.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha B.B.Zhang h.M.Zhang h.y.Zhang J.L.Zhang J.W.Zhang L.Zhang P.F.Zhang P.P.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang yi Zhang yong Zhang y.F.g Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao F.Zheng y.Zheng J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu h.Zhu K.J.Zhu X.Zuo Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduShichuanChina University of Science and Technology of China 230026 HefeiAnhuiChina Tsinghua University 100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina Sun yat-sen University 519000 ZhuhaiGuangdongChina Shool of Physics and Technology Guangxi University530004 NanningGuangxiChina hebei Normal University 050024 ShijiazhuangHebeiChina School of Physics and Engineering Zhengzhou University450001 ZhengzhouHenanChina Nanjing University 210023 NanjingJiangsuChina Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210034 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Shanghai Astronomical Observatory Chinese Academy of Sciences200030 ShanghaiChina School of Physical Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina Sichuan University 610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of physics and technology Wuhan university430072 WuhanChina yunnan University 650091 KunmingYunnanChina yunnan Astronomical Observatories Chinese Academy of Sciences650216 KunmingYunnanChina Institute for Nuclear Research Russian Academy of SciencesMoscowRussia Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde GenéveGenevaSwitzerland Department of Physics Faculty of ScienceMahidol UniversityBangkokThailand Dublin Institute for Advanced Studies 31 Fitzwilliam PlaceDublin 2Ireland Max-Planc

The Water Cherenkov Detector Array(WCDA) is a major component of the Large high Altitude Air Shower Array Observatory(LhAASO), a new generation cosmic-ray experiment with unprecedented sensitivity, currently under construction. WCDA is aimed at the study of TeV γ-rays. In order to evaluate the prospects of searching for TeV γ-ray sources with WCDA, we present a projection of the one-year sensitivity of WCDA to TeV γ-ray sources from TeVCat using an all-sky approach. Out of 128 TeVCat sources observable by WCDA up to a zenith angle of 45°, we estimate that 42 would be detectable in one year of observations at a median energy of 1 TeV. Most of them are Galactic sources, and the extragalactic sources are Active Galactic Nuclei(AGN).

关键词： TeVγ-ray astronomy observational prospect LhAASO-WCDA