检索结果-南通市图书馆

Advances in the development of molecular genetic tools for Mycobacterium tuberculosis

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2018年第6期45卷 281-297页

作者： Chiranjibi Chhotaray Yaoju Tan Julius Mugweru Md Mah.udul Islam h.M.Adnan hameed Shuai Wang Zhili Lu Changwei Wang Xinjie Li Sh.uyong Tan Jianxiong Liu Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China university of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Respiratary Disease Department of Clinical LaboratoryCuangzhou Chest HospitalGuangzhou 510095China Department of Biological Sciences University of EmbuP.O Box 6-60100EmbuKenya

Mycobacterium tuberculosis, a Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M. tuberculosis pathogenesis. here, we review various molecular genetic tools used in the study of M. tuberculosis. Further, we discuss the applications of clustered regularly interspaced short palindromic repeat interference（CRISPRi）, a novel technology recently applied in M. tuberculosis research to study target gene functions. Finally, prospective outcomes of the applications of molecular techniques in the field of M. tuberculosis genetic research are also discussed.

关键词： Mycobacterium tuberculosis Molecular genetic tools Gram-positive Recombineering Drug resistance

LiFePO_(4)and LiMn_(2)O_(4)nanocomposite coating of LiNi_(0.815)Co_(0.15)Al_(0.035)O_(2)cathode material for high-performance lith.um-ion battery

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第8期41卷 2560-2566页

作者： Zi-Wei Lan Jian-Ru Zhang Yuan-Yuan Li Ru-heng Xi Yong-Xiang Yuan Lei Zhao Xiao-Yi h.u Jia-Tai Wang Dickon h.L.Ng Cai-hong Zhang College of Physics and Electronic Information Engineering Qinghai Normal UniversityXining810008China Department of Physical Science and Technology Lingnan Normal UniversityZhanjiang524048China Department of Physics The Chinese University of Hong KongHong Kong999077China

To solve the multiple problems of low ionic conductivity,fast capacity decay,and poor cycling performance of Nirich layered cathode materials,LiNi_(0.815)Co_(0.15)Al_(0.035)O_(2)@LiFePO_(4)@LiMn_(2)O_(4)(NCA@LFP@LMO,abbreviated as AFM)series cathode materials with different coating ratios were synthesized by a two-step ball milling method and precise control of the mass coating ratio of LFP and *** cathode material of NCA,LFP and LMO with a mass ratio of 8:1:1(A_(8)F_(1)M_(1))presents a more desirable nanocomposite coating and still can deliver a discharge capacity of 151.67 mAh·g^(-1)(with a 94.52%capacity retention)after 200 cycles at 1.0 ***.

关键词： coating cycling performance

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2017年第1期44卷 21-37页

作者： Md Mah.udul Islam h.M. Adnan hameed Julius Mugweru Chiranjibi Chhotaray Changwei Wang Yaoju Tan Jianxiong Liu Xinjie Li Sh.uyong Tan Iwao Ojima Wing Wai Yew Eric Nuermberger Gyanu Lamichhane Tianyu Zhang State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China university of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Respiratory Disease Department of Clinical Laboratory The Guangzhou Chest Hospital Guangzhou 510095 China Institute of Chemical Biology and Drug Discovery Stony Brook University-State University of New York Stony Brook NY 11794-3400 USA Stanley ho Centre for Emerging Infectious Diseases The Chinese University of Hong Kong Hong Kong Special Administrative Region China Center for Tuberculosis Research Department of Medicine Johns Hopkins University Baltimore MD 21231-1002 USA

Drug-resistant tuberculosis （TB） poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug- resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuber- culosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. however, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.

关键词： Tuberculosis Mycobacterium tuberculosis Resistance Drug target Mechanism

A none quilibrium model for spray evaporation desalination

在线全文

学校读者我要写书评

暂无评论

A none quilibrium model for spray evaporation desalination

The Effects of Secondary Pneumonia on the Curative Efficacy of Multidrug-resistant Tuberculosis: A Retrospective Cohort Study

第十七届全国化学热力学和热分析学术会议

作者： h.L.Qian F.W.Wu Z.Zh.u Z.B.Zhang C.Liu X.h.Lu Department of Pharmaceutical Engineering China Pharmaceutical University School of Chemistry and Chemical Engineering Nanjing Tech University School of Chemistry and Chemical Engineering Nanjing University

A general thermodynamic model is developed by combining organically the nonequilibrium thermodynamic analysis with the simulation of spray evaporation desalination processes. The model is capable of both simulating spray evaporation desalination processes and analyzing energy consumptions of the processes. The simulation results show that the structure parameters, physical property, operation parameters have significant influences on the entropy generation rate(EGR), and the nonequilibrium thermodynamic analysis is a potential tool to optimize the spray evaporation desalination operation and design. It is also found that the 1atomization effect of pressure-jet atomizers is lower than that of plain-jet airblast atomizers under the same condition.

关键词： spray evaporation desalination nonequilibrium thermodynamics entropy generation rate

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2018年第12期31卷 908-912页

作者： TAN Sh.u Yong LIANG Zhuo Zhi Gift Chiwala KuANG hao Bin huANG Zhi Pei QIN hong Juan LI Yan LI Yan Qiong h.M.Adnan hameed ZhANG Tian Yu State Key Laboratory of Respiratory Disease Guangzhou Chest Hospital Guangzhou 510095 Guangdong China School of Public health Sun Yat-sen University Guangzhou 510080 Guangdong China State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 Guangdong China university of Chinese Academy of Sciences Beijing 100049 China

Tuberculosis(TB)is a formidable global health problem and ranks above hIV as the leading cause of death world ***2017,a total number of 10.0 million cases of TB were reported, which resulted in1.3 million TB deaths. R... 详细信息

关键词： TB In MDR A Retrospective Cohort Study

在线全文

学校读者我要写书评

暂无评论

Garcin综合征1例报告

空军军医大学学报 1999年第8期20卷 699-699页

作者：王者晋林宏陆薇 710038 第四军医大学唐都医院神经内科!陕西西安

0引言Garcln综合征又称偏侧颅底综合征，系指整个半侧颅神经的多发、合并性损害．报告1例，并做简要文献复习，以提高对本病的认识．l病例报告患儿，女性．6岁．1997年6月初出现左眼内斜，6月17日左眼闭不全并口角右歪，饮水呛咳．进食... 详细信息

0引言Garcln综合征又称偏侧颅底综合征，系指整个半侧颅神经的多发、合并性损害．报告1例，并做简要文献复习，以提高对本病的认识．l病例报告患儿，女性．6岁．1997年6月初出现左眼内斜，6月17日左眼闭不全并口角右歪，饮水呛咳．进食呕吐．左头面部阵发剧烈疼痛，当地查...

关键词：综合征病例

Inspirations from the scientific discovery of the anammox bacteria: A classic example of how scientific principles can guide discovery and development

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2016年第1期59卷 449-455页

作者： DANG hong Yue huANG Rong Fang JIAO Nian Zhi State Key Laboratory of Marine Environmental Science College of Ocean and Earth Sciences Xiamen University

Anaerobic ammonium oxidation(anammox) is a relatively new pathway within the N cycle discovered in the late 1990 s. This eminent discovery not only modified the classical theory of biological metabolism and matter cycling, but also profoundly influenced our understanding of the energy sources for life. A new member of chemolithoautotrophic microorganisms capable of carbon fixation was found in the vast deep dark ocean. If the discovery of the chemosynthetic ecosystems in the deep-sea hydrothermal vent environments once challenged the old dogma "all living things depend on the sun for growth," the discovery of anammox bacteria that are widespread in anoxic environments fortifies the victory over this dogma. Anammox bacteria catalyze the oxidization of Nh_4^+ by using NO_2^- as the terminal electron acceptor to produce N_2. Similar to the denitrifying microorganisms, anammox bacteria play a biogeochemical role of inorganic N removal from the environment. however, unlike heterotrophic denitrifying bacteria, anammox bacteria are chemolithoautotrophs that can generate transmembrane proton motive force, synthesize ATP molecules and further carry out CO_2 fixation through metabolic energy harvested from the anammox process. Alth.ugh anammox bacteria and the subsequently found ammonia-oxidizing archaea(AOA), another very important group of N cycling microorganisms are both chemolithoautotrophs, AOA use ammonia rather than ammonium as the electron donor and O_2 as the terminal electron acceptor in their energy metabolism. Therefore, the ecological process of AOA mainly takes place in oxic seawater and sediments, while anammox bacteria are widely distributed in anoxic water and sediments, and even in some typical extreme marine environments such as the deep-sea hydrothermal vents and methane seeps. Studies have shown that the anammox process may be responsible for 30%–70% N_2 production in the ocean. In environmental engineering related to nitrogenous wastewater treatment, an

关键词： Anaerobic ammonium oxidation Marine nitrogen cycle Chemolithoautotrophy Wastewater treatment Scientific inspiration

同方期刊数据库