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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TMe)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells exosomal PD-L1 exosomes biogenesis Immunosuppression Immunotherapy

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Trehalose:A sugar molecule involved in temperature stress management in plants

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The Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bhardwaj md Atikur Rahman Pedro García-Caparrós Madiha habib Faisal Saeed Sidra Charagh Christine h.Foyer Kadambot h.M.Siddique Rajeev K.Varshney College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior School engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotechnology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK The UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Trehalose(Tre)is a non-reducing disaccharide found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,where it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-phosphate,a precursor of Tre,has regulatory functions in sugar metabolism,crop production,and stress *** the various abiotic stresses,temperature extremes(heat or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative physiological,metabolic,and molecular responses triggered by temperature *** also interacts with other sugars,osmoprotectants,amino acids,and phytohormones to regulate metabolic reprogramming that underpins temperature stress *** plants expressing Tre-synthesis genes accumulate Tre and show improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth,development,and stress *** review discusses the functions of Tre in mitigating temperature stress—highlighting genetic engineering approaches to modify Tre metabolism,crosstalk,and interactions with other molecules—and in-silico approaches for identifying novel Tre-encoding genes in diverse plant *** consider how this knowledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Trehalose-6-phosphate

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Thornthwaite moisture index and depth of suction change under current and future climate‒An Australian study

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Journal of Rock Mechanics and Geotechnical engineering 2024年第5期16卷 1761-1775页

作者： md Rajibul Karim Bikash Devkota md Mizanur Rahman hoang Bao Khoi Nguyen UniSA STeM University of South AustraliaMawson Lakes CampusMawson LakesSouth Australia5095Australia

Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical *** changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive *** volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such *** change is likely to amplify the ground movement potential and the associated problems are likely to *** effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for *** changes in TMI were then correlated to the depth of suction change(h s),an important input in ground movement *** all climate scenarios considered,reductions in TMI and increases in h s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is *** is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.

关键词： Climate change Future prediction Thornthwaite moisture index(TMI) Characteristic surface movement Infrastructure resilience

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Net effect of air pollution controls on health risk in the Beijing-Tianjin-hebei region during the 2022 winter Olympics and Paralympics

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Journal of environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter K.K.Louie Alexis K.h.Lau Jimmy C.h.Fung Zibing Yuan Minghui Tao Xuguo Zhang md.Shakhaoat hossain Chengcai Li Xiang Qian Lao Division of environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and environmental engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of environment and energy South China University of TechnologyGuangzhou 510006China hubei Key Laboratory of Critical Zone evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–hebei(BTh)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTh(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide health risk Carbon neutrality Mega-events

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Toward carbon neutrality by artificial photosynthesis

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Frontiers in energy 2024年第1期18卷 54-55页

作者： Baowen ZhOU Minhua ShAO Sharif md.SADAF Shuhui SUN Key Laboratory for Power Machinery and engineering of the Ministry of education Research Center of Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemical and Biological engineering Energy InstituteThe Hong Kong University of Science and TechnologyHong KongChina Institut National de la Recherche Scientifique(INRS)-CenterÉnergie Matériaux Télécommunications VarennesQuebec J3X 1P7Canada

CO_(2)is not only the primary cause of climate change but also an abundant and recyclable carbon *** breakthrough in emerging disruptive technologies such as carbon capture and storage(CCS),power-to-X,and direct air capture(DAC)is fundamental to achieving carbon *** these technologies,artificial photosynthesis offers an attractive method for recycling carbon dioxide and water into fuels and chemicals using solar energy(CO_(2)+h_(2)O+sunlight→fuels+chemicals).It holds great promise for addressing the critical challenges associated with elevated CO_(2)concentrations and securing a sustainable supply of fuels and chemicals for economic sectors.

关键词： neutral holds breakthrough

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Recent progress in two-dimensional metallenes and their potential application as electrocatalyst

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Journal of energy Chemistry 2024年第7期94卷 577-598页

作者： Umer Shahzad Mohsin Saeed Muhammad Fazle Rabbee hadi M.Marwani Jehan Y.Al-humaidi Muhammad Altaf Raed h.Althomali Kwang-hyun Baek md.Rabiul Awual Mohammed M.Rahman Department of Chemistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongsanSouth Korea Center of excellence for Advanced Materials Research(CeAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Chemistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In this article,we looked at metallenes,a novel class of two-dimensional(2D)metals that are attracting interest in the energy and catalysis *** is one area where their exceptional physicochemical and electrical characteristics might be *** are unique because they include several metal atoms that are not in a coordinated *** makes them more active and improves their atomic uti-lization,which in turn increases their catalytic *** article delves into the potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in the context of sustainable energy *** to the exception-ally high surface-to-volume ratio,large surface area as well as their optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such as high conductivity and the ability to enhance the exposure of active metal sites,2D metallenes have recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** their highly mobility,adjustable surface states,and electrical struc-tures that can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with the sustainable applications.

关键词： Metallenes electrocatalysts electrochemical processes Atomically thin structure

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Post Thyroidectomy Assessment of Intact Parathyroid hormone for early Prediction of hypocalcaemia

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International Journal of Otolaryngology and head & Neck Surgery 2024年第2期13卷 71-84页

作者： md. Masum Billah Ripon Kumar Sarkar md. Yousuf Ali Saad Zaman md. Nazmul hasan md. Shehab Uddin md. Mosleh Uddin Kazi Shameemus Salam Farzana Binte Abedin Leera Department of Otolaryngology-head & Neck Surgery Universal Medical College Hospital Dhaka Bangladesh Department of Otolaryngology-head & Neck Surgery National Institute of Ear Nose and Throat Dhaka Bangladesh Shaheed Ahsan Ullah Master General hospital Gazipur Bangladesh Department of Otolaryngology-head & Neck Surgery Cumilla Medical College Cumilla Bangladesh Department of eNT Oncology National Institute of Cancer Research & Hospital Dhaka Bangladesh Department of eNT Outdoor Rajshahi Medical College Hospital Rajshahi Bangladesh Department of Otolaryngology-head & Neck Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Biochemistry Delta Medical College Hospital Dhaka Bangladesh

Background: As the half-life of intact parathyroid hormone (iPTh) is very low, it reflects parathyroid insufficiency within minutes to hours after total thyroidectomy. Therefore, iPTh level assessment in the postoperative period can be used to predict the development of hypocalcaemia. The optimal time point to measure serum iPTh is important for the accurate prediction of hypocalcaemia. Aim: This paper aims to evaluate the ability of iPTh as an early predictive marker of hypocalcaemia and determine which time iPTh is more able to predict postoperative hypocalcaemia. Method: This prospective observational study was conducted in the Department of Otolaryngology-head & Neck Surgery, BSMMU, Dhaka, from July 2020 to December 2021, with 67 patients who underwent total thyroidectomy. iPTh levels were measured on the day before the operation and at 1 hour, 4 hours, and 24 hours after the operation. *** levels were measured on the day before the operation and 1st postoperative day. All the data were compiled and sorted properly and were analyzed statistically. Results: Postoperative hypocalcaemia developed in 18 cases, with an incidence of 26.9%. Pearson correlation showed a significant correlation between postoperative iPTh at 1 hr, 4 h, and 24 hr with 1st postoperative calcium value. The Receiver operating characteristic (ROC) curve was processed for the postoperative iPTh at 1 hr, 4 h, and 24 hr. The sensitivity, specificity, cut-off value, and mean AUC found 93.9%, 94.4%, ≤14.0, 0.988;95.9%, 94.4%, ≤09.5, 0.993 and 91.8%, 94.4%, ≤11.0, 0.993 respectively. Conclusion: iPTh can be used as an early predictor of post-thy-roidectomy hypocalcaemia. 4 hr iPTh showed more sensitivity and specificity for a cut-off value near the laboratory reference range.

关键词： Total Thyroidectomy hypocalcaemia Serum Intact Parathyroid hormone early Predictor of hypocalcaemia

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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja h W M Lemlijn-Slenter Karolina AP Wijnands Gijs van der hamsvoort Luuk P van Iperen Nico Wolter Angelique e de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(Ph)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-hPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-hPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIhPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of Ph in patients with chronic GI-hPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIhPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valueered *** The GI-hPB patients scored significantly worse in all dimensions of Ph compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-hPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-hPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of Ph are impaired in the GI-hPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders hepato-pancreatico-biliary disorders Integrated care

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Multinuclear MR and MRI study of lithium-ion cells using a variable field magnet and a fixed frequency RF probe

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Magnetic Resonance Letters 2024年第1期4卷 10-20页

作者： Andrés Ramírez Aguilera Florin Marica Kevin J.Sanders md Al Raihan C.Adam Dyker Gillian R.Goward Bruce *** UNB MRI Centre Department of PhysicsUniversity of New BrunswickFrederictonNew BrunswickE3B 5A3Canada Department of Chemistry McMaster UniversityHamiltonOntarioL8S 4L8Canada Department of Chemistry University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada

An exploratory multinuclear magnetic resonance(MR)and magnetic resonance imaging(MRI)study was performed on lithium-ion battery cells with ^(7)Li,^(19)F,and ^(1)h measurements.A variable field superconducting magnet with a fixed frequency parallel-plate radiofrequency(RF)probe was employed in the *** magnetic field was changed to set the resonance frequency of each nucleus to the fixed RF probe frequency of 33.7 *** cartridge-like lithium-ion cells,with graphite anodes and LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC)cathodes,were *** cell was pristine,and one was charged to a cell voltage of 4.2 *** results presented demonstrate the great potential of the variable field magnet approach in multinuclear measurement of lithium-ion *** methods open the door for developing faster and simpler methods for detecting,quantifying,and interpreting MR and MRI data from lithium-ion and other batteries.

关键词： Multinuclear MR/MRI Variable field magnet Lithium-ion battery Parallel-plate rf probe

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Natural high-porous diatomaceous-earth based self-floating aerogel for efficient solar steam power generation

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Green energy & environment 2024年第2期9卷 378-389页

作者： Aitang Zhang Kai Wang md Julker Nine Mengyu Cao hanwen Zong Zhiqiang Liu hanwen Guo Jingquan Liu Dusan Losic College of Materials Science and engineering Institute for Graphene Applied Technology InnovationCollaborative Innovation Center for Marine Biomass Fibers Materials and Textiles of Shandong ProvinceQingdao UniversityQingdao266071China The University of Adelaide School of Chemical Engineering and Advanced MaterialsARC Graphene Research HubNorth Engineering BuildingN206 AdelaideSA 5005Australia

The application of solar steam generation in seawater desalination is an effective way to solve the shortage of fresh water *** present,many kinds of photothermal conversion materials have been developed and used as evaporators in seawater ***,some evaporators need additional thermal insulation or water supply devices to achieve efficient photothermal *** addition,their complex,time consuming and no scalable preparation process,high cost of raw materials and poor salt resistance hinder the practical application of these *** to its distinctive nanoporous structure,diatomite as fossilized single-cells algae diatoms is a promising natural silica-based material for seawater *** are taken from sea and that makes true sense to use them in the ***,we report the first example of synthesis robust three-dimensional(3D)natural-diatomite composite by assembling polyaniline nanoparticles covered diatomite into the polyvinyl alcohol pre-treated melamine foam frameworks and demonstrate its application as new evaporator for seawater *** porous framework does not only improve the sunlight scattering efficiency,but also offer large network of channels for water *** inherent mechanism behind salt desalination process involves the absorption of water molecules on the surface of the internal silica micro-nano pores,and evaporation under the heat induced by the polyaniline absorbed ***,the metal ions are segregated by many available pores and channels to achieve the self-desalting *** developed evaporator possesses the superiority of multi-stage pore structure,strong hydrophilicity,low thermal conductivity,excellent light absorption,fast water transportation and salt-resistant crystallization as well as good *** evaporation rate without an additional device is found to be 1.689 kg m^(-2)h^(-1)under 1-Sun irradiation,and the energy conversion efficiency is as

关键词： Diatomite Micro/nanopores Polyaniline Three-dimensional composite Solar steam generation

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