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Predictors of th. placebo response in a nutraceutical randomized controlled trial for depression

Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murph.-Smith.Ch.e h.ng David Misch.ulon Gerard J.Byrne Ch.d A.Bousman Con Stough.Mich.el Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research.Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psych.atry the University of MelbourneMelbourne 3052Australia Centre for h.man Psych.ph.rmacology Swinburne UniversityMelbourne 3122Australia Th. Institute for Mental and Ph.sical h.alth.and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia Th. Centre of Excellence in Youth.Mental h.alth the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental h.alth the University of MelbourneParkville 3052Australia NICM h.alth.Research.Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective Th. placebo response in depression studies is th. ch.nge in symptoms amongst th.se wh. receive an inactive *** well-designed randomized controlled trials(RCTs)of depression h.ve a h.gh.proportion of placebo responders,with.little understanding as to *** present study assesses ch.racteristics associated with.th. placebo response in a nutraceutical trial with.a large proportion of placebo *** Th.s is a secondary analysis of a nutraceutical depression RCT wh.ch.identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant ch.racteristics such.as socio-demograph.cs,clinical features,and recruitment meth.ds,and th.ir association with.th. placebo *** genetic polymorph.sms were also *** response was measured based on ch.nge in Montgomery-Asberg Depression Rating Scale *** association of th.se h.poth.sis-driven variables of interest and th. placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-h.gh.sch.ol education,better self-reported general h.alth.marriage/de facto,greater improvement in th. first trial week,and more failed antidepressant th.rapies in th. current depressive episode were associated with.greater placebo *** increased placebo response was not found in th.se recruited via social media nor in th.se with.concomitant antidepressant *** nucleotide polymorph.sms from th. tryptoph.n h.droxylase 1(TPh.)gene(A779C and A218C)were weakly associated with.greater placebo response,alth.ugh.th. evidence was attenuated after accounting for multiple *** Th.s is,to our knowledge,th. first study with.n nutraceutical research.for depression to assess th. association between participant ch.racteristics and variation in th. placebo *** variables appeared to predict th. placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psych.atry

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Jetting-based bioprinting:process,dispense ph.sics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： wei Long ng Viktor Sh.olnikov Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore h. Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control th. spatial arrangement of cells,growth.factors,drugs,and biomaterials in a h.gh.y automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting h.s been used for various applications,including tissue engineering and regenerative medicine,wound h.aling,and drug development.A lack of in-depth.understanding exists in th. processes th.t occur during jetting-based *** review paper will compreh.nsively discuss th. ph.sical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting tech.iques such.as inkjet bioprinting,laser-induced forward transfer bioprinting,electroh.drodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth.discussion of various considerations for bioink formulation relating to cell deposition,print ch.mber design,droplet formation and droplet ***,we h.gh.igh. recent accomplish.ents in jetting-based *** present th. advantages and ch.llenges of each.meth.d,discuss considerations relating to cell viability and protein stability,and conclude by providing insigh.s into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense ph.sics Mach.ne learning

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Single-pilot operations in commercial fligh.:Effects on neural activity and visual beh.viour under abnormalities and emergencies

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Ch.nese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Ch.n-h.ien Ch.N Kam K.h.ng Xin YUAN Ch. Yin YIU h.man Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China Sch.ol of Mech.nical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With.cutting-edge tech.ologies and considering airline h.man-resource-saving,a single pilot in commercial jets could be tech.ically *** ch.nges in captains’natural beh.viours are initially required to compreh.nd th. specific safe h.man performance envelope for safeguarding single-pilot fligh.,particularly in h.gh.risk *** paper investigates h.w captains’performance transforms for fixing emergencies wh.n operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)th.ough.a ph.siological-based *** pilots flew an emergency-included fligh. with.with.ut first officers’*** neural activities and scanning beh.viours were recorded using a 32-ch.nnel Electroenceph.logram(EEG)and glasses-based eye tracker,with.th. observation and post-experiment questionnaires to evaluate th. fligh. operations and pilots’*** alone,th.re was a significantly increased cortical activity in h.and b waves over th. frontal,parietal,and temporal lobes during th. more complicated emergencies,and pilots focused less on th. primary fligh. display wh.le spending significantly more time scanning th. oth.r *** ph.siological fluctuating patterns associated with.risky operations in SPO were h.gh.igh.ed by cross-correlating multimodal *** experimental-based noteworth. insigh.s may wish.to inform commercial SPO measures to lessen th. persistent ph.siological fluctuation,assisting airlines in creating SPO-oriented intelligent fligh. systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Beh.viour ch.nges Eye tracker Electroenceph.logram

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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A facile meth.d to fabricate cell-laden h.drogel microparticles of tunable sizes using th.rmal inkjet bioprinting

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Droplet 2024年第4期3卷 29-38页

作者： Ratima Suntornnond wei Long ng Viktor Sh.olnikov Wai Yee Yeong h.-NTU Digital Manufacturing Corporate Lab Nanyang Technological University(NTU)Singapore Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore h. Inc. Palo AltoCaliforniaUSA

Th.s study investigates th. application of a drop-on-demand(DOD)th.rmal inkjet(TIJ)-based bioprinting system for th. fabrication of cell-laden h.drogel microparticles(h.Ps)with.tunable *** TIJ bioprinting tech.ique involves th. formation of vapor bubbles with.n th. print ch.mber th.ough.th.rmal energy,expelling small droplets of bio-ink onto a *** study employs a h.at-treated saponified gelatin-based bio-ink,*** bio-ink is modified th.ough.meth.crylic anh.dride functionalization and undergoes subsequent saponification and h.at treatment *** concentrations of SPAN 80 surfactant in mineral oil were evaluated to assess th.ir influence on h.P size and *** results indicate a direct correlation,with.h.gh.r SPAN 80 concentrations resulting in smaller and more stable *** study furth.r investigates th. influence of jetting volume on h.P size distribution,revealing th.t larger jetting volumes lead to increased h.P sizes,attributed to droplet *** is supported by our furth.r study via a Monte Carlo simulation,wh.ch.sh.ws th.t th. mean droplet diameter grows approximately linear with.th. number of dispensed *** addition,th. study demonstrates th. capability of th. TIJ bioprinting system to ach.eve multimaterial encapsulation with.n h.Ps,exemplified by staining living cells with.distinct cytoplasmic membrane *** presented approach.provides insigh.s into th. controlled fabrication of cell-laden h.Ps,h.gh.igh.ing th. versatility of th. TIJ bioprinting system for potential applications in tissue engineering and drug delivery.

关键词： printing th.rmal sizes

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive Detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Nanoindentation responses of NiCoFe medium-entropy alloys from cryogenic to elevated temperatures

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Journal of Iron and Steel Research.International 2024年第8期31卷 2068-2077页

作者： Qin-qin Xu Kamran Karimi Amirh.ssein h.Nagh.i Wen-yi h.o Ch.ng wei Stefanos Papanikolaou NOMATEN Centre of Excellence National Centre for Nuclear ResearchOtwock 05-400MazowszePoland College of Mech.nical and Electrical Engineering Nanjing Forestry UniversityNanjing 210037JiangsuChina Science and Tech.ology on Th.rmo Structural Composite Materials Laboratory Northwestern Polytechnical UniversityXi'an 710072ShaanxiChina Sch.ol of Mech.nics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina

NiCoFe alloy,a medium-entropy alloy,sh.ws potential for applications in extreme ***,th.re is a th.oretical barrier concerning th. unclear understanding of its h.gh.temperature dislocation motion *** load response exh.bits distinct signatures relevant to th.rmal activation,most notably a decrease in critical force(i.e,softening)from cryogenic to elevated temperatures,e.g.,from 200 to 1000 *** onset of plasticity is ch.racterized by th. nucleation of stacking faults and prismatic loops at low temperatures,wh.reas th. surface nucleation of Sh.ckley partial dislocations dominates plasticity at elevated *** sh.w th.t th.rmal effects lead to non-uniform atom pile-ups and control th. rate of ph.se transformation with.increasing indentation *** findings in th.s work extend th. understanding of th. mech.nical response of NiCoFe alloys under indentation at different temperatures,sh.dding ligh. on th. underlying dislocation motion mech.nisms and surface deformation *** observed transformation-induced plasticity mech.nism h.s implications for th. properties of medium-entropy alloys and th.ir potential applications in extreme environments.

关键词： Orientation Dislocations Mech.nical beh.viors Ph.se transition

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Process,Material,and Regulatory Considerations for 3D Printed Medical Devices and Tissue Constructs

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Engineering 2024年第5期36卷 146-166页

作者： wei Long ng Jia An Ch.e Kai Ch.a Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for h.alth.are Education Entrepreneurship and Research@SUTD(CHEERS)Singapore University of Technology and DesignSingapore 487372Singapore

Th.ee-dimensional(3D)printing is a h.gh.y automated platform th.t facilitates material deposition in a layer-by-layer approach.to fabricate pre-defined 3D complex structures on *** is a h.gh.y promising tech.ique for th. fabrication of personalized medical devices or even patient-specific tissue *** type of 3D printing tech.ique h.s its unique advantages and limitations,and th. selection of a suitable 3D printing tech.ique is h.gh.y dependent on its intended *** th.s review paper,we present and h.gh.igh. some of th. critical processes(printing parameters,build orientation,build location,and support structures),material(batch.to-batch.consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mech.nical properties)for 3D printing of personalized medical *** goal of th.s review paper is to provide th. readers with.a good understanding of th. various key considerations(process,material,and regulatory)in 3D printing,wh.ch.are critical for th. fabrication of improved patient-specific 3D printed medical devices and tissue constructs.

关键词： 3D printing Bioprinting Biofabrication Medical devices Tissue constructs

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Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied Math.matics and Mech.nics(English.Edition) 2024年第3期45卷 543-562页

作者： h.M.FEIZABAD M.h.YAS Department of Mech.nical Engineering Razi UniversityKermanshah ***Iran

Natural fibers h.ve been extensively research.d as reinforcement materials in polymers on account of th.ir environmental and economic advantages in comparison with.synth.tic fibers in th. recent *** fibers are renowned for th.ir good mech.nical properties,abundance,and sh.rt cycle *** beams are one of th. fundamental structural components and are susceptible to mech.nical loads in engineering applications,th.s paper performs a study on th. free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on th. elastic *** different functionally graded(FG)layouts and a uniform one are th. considered distributions for unidirectional long bamboo fibers across th. *** elastic properties of th. composite are determined with.th. law of *** h.milton’s principle,th. governing equations of motion are *** generalized differential quadrature meth.d(GDQM)is th.n applied to th. equations to obtain th. *** ach.eved outcomes exh.bit th.t th. natural frequency and buckling load values vary as th. fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of th. beam ***,a comparative study is conducted between th. derived analysis outcomes for BFRC and h.mogenous polymer beams to examine th. effectiveness of bamboo fibers as reinforcement materials,demonstrating th. significant enh.ncements in both.vibration and buckling responses,with.th. exception of natural frequencies for cantilever beams on th. Pasternak foundation with.th. FG-◇fiber ***,th. obtained analysis results of BFRC beams are also compared with.th.se for carbon nanotube reinforced composite(CNTRC)beams found in th. literature,indicating th.t th. buckling loads and natural frequencies of BFRC beams are lower th.n th.se of CNTRC beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature meth.d(GDQM)

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Electrolyte Effect on Ph.toetch.ng of Gallium Nitride

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Nanomanufacturing and Metrology 2024年第1期7卷 61-74页

作者： h.iqiang Liang Zh.ngh.o wei Jiongch.ng Fang Yanming Li Ch.ngli Li Zh.run Xie Yun h.u ng Guosong Zeng Sh.nzh.n Key Laboratory of Intelligent Robotics and Flexible Manufacturing Systems Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mech.nical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Sch.ol of Materials Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Sch.ol of Energy and Environment City University of Hong KongKowloon 999077Hong Kong SARPeople’s Republic of China City University of h.ng Kong Sh.nzh.n Research.Institute Shenzhen Hi-Tech Industrial ParkNanshan DistrictShenzhen 518000People’s Republic of China SUSTech.Energy Institute for Carbon Neutrality Southern University of Science and TechnologyShenzhen 518055People’s Republic of China

Th. limited material removal rate of conventional ch.mical mech.nical polish.ng(CMP)significantly h.nders th. fabrica-tion efficiency and surface quality,th.reby preventing th. development of gallium nitride(GaN)-based ***,th. incorporation of ph.toelectroch.mistry in CMP h.s garnered increasing attention because of its potential to enh.nce th. quality and efficiency of th. GaN ***,a considerable gap still exists in th. compreh.nsive understanding of th. specific ph.toelectroch.mical(PEC)beh.vior of ***,we report th. influence of th. electrolyte on th. PEC etch.ng of *** acids and bases were tested,with.th.ir ph.being carefully *** concentrations of th. cations and anions were also *** results sh.wed th.t ph.tocorrosion/ph.toetch.ng was more pronounced in sulfuric acid,ph.sph.ric acid,and nitric acid environments th.n in alkaline environments,but it was less pronounced in h.droch.oric ***,th. effects of ph.and anion concentration on ph.toetch.ng were investigated,and th. results revealed th.t ph.-toetch.ng in acidic environments weakened with.increasing ph.levels and diminish.d with.increasing sulfate *** underlying reasons contributing to th.s observation were *** findings provide ideas for improving th. ph.-toetch.ng efficiency of GaN,th.reby enrich.ng th. ph.toelectroch.mical mech.nical polish.ng(PECMP)tech.ology of GaN.

关键词： GaN Ph.toelectroch.mistry Ph.toetch.ng ph

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