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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

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Dynamic robust optimal reorder point with uncertain lead time and changeable demand distribution

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 938-945页

作者： Masaki TAMURA Kazuko MORIZAWA hiroyuki nagasawa Department of Electrical and Information Systems Engineering Graduate School of EngineeringOsaka Prefecture University Osaka Prefectural College of Technology

In fixed order quantity systems,uncertainty in lead time is expressed as a set of scenarios with occurrence probabilities,and the mean and variance in demand distribution are supposed to be changeable according to a known pattern.A new concept of "dynamic robust optimal reorder point" is proposed in this paper and its value is calculated as a "robust optimal reorder point function with respect to reorder time".Two approaches were employed in determining the dynamic optimal reorder *** first is a shortage rate satisfaction approach and the second is a backorder cost minimization *** former aims at finding the minimum value of reorder point at each reorder time which satisfies the condition that the cumulative distribution function (CDF) of shortage rate under a given set of scenarios in lead time is greater than or equal to a basic CDF of shortage rate predetermined by a *** the latter approach,the CDF of closeness of reorder point is defined at each reorder time to express how close to the optimal reorder points under the set of scenarios,and the dynamic optimal reorder point is defined according to stochastic *** numerical examples demonstrate the features of these dynamic robust optimal reorder points.

关键词： Reorder point Lead time Robust optimum Uncertainty Scenario

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Applying machine learning to market analysis:Knowing your luxury consumer

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Journal of Management Analytics 2019年第4期6卷 404-419页

作者： Kuo Chi-hsien Shinya nagasawa Department of Commerce Waseda UniversityShinjuku-kuJapan

Chinese consumer research in the luxury sector is the emphasis in the business research ***,it can be cost-intensive or time-consuming to interpret big data from any research conducted in the *** this paper,the researchers created a machine-learning model to help minimize those research *** study analyzed Chinese luxury consumption behavior,while the Chinese contributed 33%of the global luxury market in 2018 and play as a growth engine in the luxury market(Bain&***://***/insights/whats-powering-chinas-market-for-luxury-goods/).The researchers interpreted this analysis using machine-learning algorithms through different sets of conditions and then proposed an understandable and highly accurate machine-learning *** traditional statistical methods,which rely on domain experts to create handcrafted features,this paper proposes an unsupervised end-to-end model that can directly and accurately process questionnaire data without human *** paper also demonstrates how to practically apply an automatic unsupervised analysis method(PCA)to find inferences in the big data,and helps interpret the implied meaning to the questions.

关键词： Luxury consumer machine learning end-to-end model unsupervised learning principal component analysis(PCA)

Biomarkers of graft-vs-host disease:Understanding and applications for the future

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World Journal of Transplantation 2021年第8期11卷 335-343页

作者： Masayuki nagasawa Department of Pediatrics Musashino Red Cross HospitalMusashino City 180-8610TokyoJapan

hematopoietic stem cell transplantation(hSCT)is widely performed as a treatment for malignant blood disorders,such as *** achieve good clinical outcomes in hSCT,it is necessary to minimize the unfavorable effects of acute graft-vs-host disease(GVhD)and induce the more tolerable,chronic form of the *** better management of GVhD,sensitive and specific biomarkers that predict the severity and prognosis of the disease have been intensively investigated using proteomics,transcriptomics,genomics,cytomics,and tandem mass spectrometry ***,I will briefly review the current understanding of GVhD biomarkers and future prospects.

关键词： Graft-vs-host disease hematopoietic stem cell transplantation Biomarker Cytokine Graft-vs-host reaction Organ damage

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Pathophysiology of acute graft-versus-host disease from the perspective of hemodynamics determined by dielectric analysis

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World Journal of Transplantation 2023年第6期13卷 379-390页

作者： Masayuki nagasawa Department of Pediatrics Musashino Red Cross HospitalMusashino City 180-8610TokyoJapan Department of Pediatrics and Developmental Biology Tokyo Medical and Dental UniversityTokyo 113-8519TokyoJapan

BACKGROUND Numerous reports have demonstrated that the pathophysiology of graft-versushost disease(GVhD)during hematopoietic stem cell transplantation(hSCT)is closely related to vascular endothelial disorders and coagulation *** previously presented the discovery of a principle and the development of a novel instrument for measuring whole blood *** was achieved by assessing the variations in the dielectric properties of whole *** To investigate how GVhD affects the changes of dielectric properties of whole blood in patients with *** We examined the changes of dielectric properties of whole blood and erythrocyte proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis sequentially in patients with hSCT and compared it with clinical symptoms and inflammatory parameters of *** During severe GVhD,the dielectric relaxation strength markedly increased and expression of band3 *** dielectric relaxation strength normalized with the improvement of *** vitro analysis confirmed that the increase of relaxation strength was associated with severe erythrocyte aggregates,but not with decreased expression of *** Severe erythrocyte aggregates observed in GVhD may cause coagulation abnormalities and circulatory failure,which,together with the irreversible erythrocyte dysfunction we recently reported,could lead to organ failure.

关键词： Graft-versus-host disease Dielectric relaxation Erythrocyte Stem cell transplantation Coagulation