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Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metabolic Syndrome

International Journal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-h. Wang R. Zhao Z.-K. Zh.ng Y. Sun J. Zh.ng x. Ding x.-Y. Bai J. Liang x.-Q. Wei x.-J. Liu x.-L. Yang T. Liang x.-L. Li C.-x. Lin B.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Objective: Psoriasis is associated with a high prevalence of metabolic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. however, the molecular mech.nisms beh.nd these effects are unknown. Recent studies have shown that leptin may serve as a molecular link between psoriasis and MS, suggesting that high leptin concentrations may ex.cerbate psoriasis. however, the molecular mech.nism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From January 2021 to June 2022 in PLA General hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. We th.n performed correlation analyses to compare these proteins' concentrations between patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western blotting after in vitro culture of haCaT cells with different concentrations of leptin and measured the ex.ression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of haCat cells. nex., we transfected ATG5 into haCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The ex.ression levels of K10, K16, and K17 of haCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison between the 2 groups. The counting data were analyzed by the chi-square test. Correlations were evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathway

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Virtually coupled train set control subject to space-time separation: A distributed economic MPC approach with emergency braking configuration

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high-speed Railway 2024年第3期2卷 143-152页

作者： Luo x. Tang T. Wang L. Liu h. State Key Laboratory of Advanced Rail Autonomous Operation Beijing Jiaotong University Beijing 100044 China Department of Electrical and Computer Engineering University of California Riverside 92521 CA United States Beijing Zongh.ng Electro-Mech.nical Technology Development Co. Ltd. Beijing 100081 China School of Automation and Intelligence Beijing Jiaotong University Beijing 100044 China national Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University Beijing 100044 China

The emerging virtual coupling technology aims to operate multiple train units in a Virtually Coupled Train Set (VCTS) at a minimal but safe distance. To guarantee collision avoidance, the safety distance should be calculated using the state-of-the-art space-time separation principle that separates the Emergency Braking (EB) trajectories of two successive units during the whole EB process. In this case, the minimal safety distance is usually numerically calculated without an analytic formulation. Thus, the constrained VCTS control problem is hard to address with space-time separation, which is still a gap in the ex.sting literature. To solve this problem, we propose a Distributed Economic Model Predictive Control (DEMPC) approach with computation efficiency and theoretical guarantee. Specifically, to alleviate the computation burden, we transform implicit safety constraints into ex.licitly linear ones, such that the optimal control problem in DEMPC is a quadratic programming problem that can be solved efficiently. For theoretical analysis, sufficient conditions are derived to guarantee the recursive feasibility and stability of DEMPC, employing compatibility constraints, tube techniques and terminal ingredient tuning. Moreover, we ex.end our approach with globally optimal and distributed online EB configuration methods to shorten the minimal distance among VCTS. Finally, ex.erimental results demonstrate the performance and advantages of the proposed approaches. © 2024 Beijing Jiaotong University

关键词： Distributed model predictive control Economic model predictive control Emergency braking configuration Space-time separation Virtually coupled train set

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Ch.nese Ex.ert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao h. Ch.n A.-J. Cui Y. Deng D.-Q. Gao x.-h. he Y.-L. Kang x.-J. Jin h.-Z. Li C.-x. Li F. Li h.-J. Liao W.-J. Liu x.-M. Lu Q.-J. Lu Y. Pan M. Pan W.-h. Shu x.-M. Sun Q. Tang K.-Y. Tao J. Wang Y. x.ao T. Zh.ng F.-R. Zh.ng h.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, prox.mal muscle weakness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, ex.erts from the Dermatology Branch of the Ch.na International Ex.h.nge and Promotion Association for Medical and health Care and the national Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Ch.nese and international literature and ex.ert advice. © 2024 Wolters Kluwer health. All rights reserved.

关键词： adult clinical protocols dermatomyositis diagnosis ex.ert consensus treatment

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Fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Ex.remes 2024年第3期9卷 11-18页

作者： Y.x.Wang x.L.Zhu S.M.Weng P.Li x.F.Li h.Ai h.R.Pan Z.M.Sh.ng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser Fusion of Ch.na Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of high Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(Thz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or Thz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or Thz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index.in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enh.nces the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and Thz spectral ranges.

关键词： laser ultrashort photon

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Distinct Electrical and Mech.nical Responses of a Cu-10Fe Composite Prepared by hot-Pressed Sintering and Post Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 255-265页

作者： x.Y.Yue S.Y.Peng x.Zh.ng C.n.he Y.Z.Tian Key Laboratory for Anisotropy and Tex.ure of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang110819China School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin300350China Research Centre for Metallic Wires Northeastern UniversityShenyang110819China

A Cu-10wt%Fe composite was prepared through hot-pressed sintering,and the material was subsequently solution *** hot-pressed sintered and solution treated materials were rolled and *** precipitation behavior and performance ch.nges were systematically studied by using scanning electron microscopy and transmission electron *** contrast to the hot-pressed sintered specimen,the solution treatment significantly affects the thermal stability and properties of the Cu-10wt%Fe *** Cu-10wt%Fe composite was prepared after solid solution,cold rolling and aging at 773 K for 1 h,and it obtained ex.ellent tensile strength of 494 MPa,uniform elongation of 16.3%,electrical conductivity of 51.1%IACS and softening temperature of 838 *** for the distinct difference in thermal stability and properties between hot-pressed sintered and solution treated specimens were *** findings provide a theoretical basis for designing high-performance Cu-based in-situ composites by post treatment.

关键词： Cu-Fe composite hot-pressed sintering Thermal stability Strength Electrical conductivity

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Marinoan glaciation in the Indian subcontinent——Anatomy and global implications

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Journal of Palaeogeography 2024年第2期13卷 293-308页

作者： h.n.Bhattacharya Department of Earth Sciences Techno India UniversityWest BengalSector VSalt LakeKolkata700091India

Detailed sedimentological analysis of the Pokaran Boulder Bed,representing the most basal unit of the neoproterozoic-Lower Cambrian Marwar Supergroup,clearly indicates its glacial *** glacial sediments are interpreted as an ice-contact submarine fan *** on the detrital and inherited zircon population of the Marwar Supergroup sediments and interlayered pyroclastic deposits,a Marinoan cryochron of the Cryogenian Period is envisaged for the Pokaran Boulder *** well-preserved Ediacaran elements in the post-glacial sedimentary succession also support a Cryogenian to Early Cambrian age of the Marwar *** glacial deposition at the base of the Marwar Supergroup strength.ns the regional correlation between the studied sediments with the Lesser himalayan Blaini-Krol-Tal sediments and the haqf Supergroup of *** available zircon ages and paleomagnetic data of the Malani Igneous suite,along with the Marinoan glacial deposits,detrital zircon ages,and Ediacaran fossil elements of the Marwar Supergroup add significant information to the neoproterozoic Earth history.

关键词： neoproterozoic Marinoan glaciation Diamictites Pokaran Boulder Bed Marwar Supergroup

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In situ TEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.Lv h.L.Ge Q.Q.Jin x.h.Shao Y.T.Zhou B.Zh.ng x.L.Ma Sh.nyang national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approx.mately 64% higher th.n that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mech.nical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation hardening Precipitates In-situ TEM

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Greatly enh.nced corrosion/wear resistances of epox. coating for Mg alloy through a synergistic effect between functionalized graph.ne and insulated blocking layer

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Journal of Magnesium and Alloys 2024年第1期12卷 332-344页

作者： Z.Y.x.e x.J.Li J.h.Chu M.M.Li D.n.Zou L.B.Tong School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China

The poor corrosion and wear resistances of Mg alloys seriously limit their potential applications in various *** conventional epox. coating easily forms many intrinsic defects during the solidification process,which cannot provide sufficient *** the current study,we design a double-layer epox. composite coating on Mg alloy with enh.nced anti-corrosion/wear properties,via the spin-assisted assembly *** outer layer is functionalized graph.ne(FG)in waterborne epox. resin(WEP)and the inner layer is Ce-based conversion(Ce)*** FG sheets can be homogeneously dispersed with.n the epox. matrix.to fill the intrinsic defects and improve the barrier *** Ce film connects the outer layer with the substrate,showing the transition *** corrosion rate of Ce/WEP/FG composite coating is 2131 times lower th.n that of bare Mg alloy,and the wear rate is decreased by~90%.The improved corrosion resistance is attributed to the labyrinth effect(h.ndering the penetration of corrosive medium)and the obstruction of galvanic coupling *** synergistic effect derived from the FG sheet and blocking layer ex.ibits great potential in realizing the improvement of multi-functional integration,which will open up a new avenue for the development of novel composite protection coatings of Mg alloys.

关键词： Mg alloy Functionalized graph.ne Epox. coating Corrosion/wear resistance Blocking layer

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Microstructure evolution and shape memory behaviors of ni_(47)Ti_(44)nb_(9)alloy subjected to multistep thermomech.nical loading with different prestrain levels

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Journal of Materials Science & Technology 2024年第4期171卷 80-93页

作者： Y.h.Zh.ng h.Li Z.W.Yang x.Liu Q.F.Gu State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Shaanx. Key Laboratory of high-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

ni_(47)Ti_(44)nb_(9)shape memory alloy(SMA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory effect depends on multistep thermomech.n-ical loading,viz.,low-temperature deformation and subsequent heating to ***-temperature deformation prestrain plays a pivotal role in shape memory properties tailoring of SMA ***,microstructure evolution and deformation mech.nisms of ni_(47)Ti_(44)nb_(9)SMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of ni_(47)Ti_(44)nb_(9)alloy subjected to multistep thermomech.nical loading with prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen ex.ibits four distinct stages at a max.mal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by the dislocation slip of the niTi matrix.andβ-nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced martensite variants(SIMVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density ofhaustenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and th.n ***ε_(re)^(T)obtains a max.mum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new SIMVs,the further growth of ex.sting SIMVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** effe

关键词： ni_(47)Ti_(44)nb_(9)shape memory alloy Wide transformation hysteresis Thermomech.nical loading Microstructure evolution Shape memory behaviors Stress-induced martensitic transformation Deformation twinning

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Spalling characteristics of high-temperature treated granitic rock at different strain rates

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Journal of Rock Mech.nics and Geotechnical Engineering 2024年第4期16卷 1280-1288页

作者： L.F.Fan Q.h.Yang x.L.Du The Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing100124China

The dynamic spalling characteristics of rock are important for stability analysis in rock *** paper presented an ex.erimental investigation on the dynamic spalling characteristics of granite with different temperatures and strain rates.A series of dynamic spalling tests with different impact velocities were conducted on thermally treated granite at different *** dynamic spalling strengths of granite with different temperatures and strain rates were determined.A model was proposed to correlate the dynamic spalling strength of granite,high temperature and strain *** results show that the spalling strength of granite decreases with increasing ***,the spalling strength of granite with a higher strain rate is larger th.n that with a lower strain *** proposed model can describe the relationship among dynamic spalling strength of granite,high temperature and strain rate.

关键词： Dynamic spalling characteristics high temperature Strain rate Dynamic loading Granite

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