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No evidence of hPV DNA in esophageal squamous cell car.inoma in a population of Souther. Br.zil

Wor.d Jour.al of Gastr.enter.logy 2013年第39期19卷 6598-6603页

作者： Luís Car.os Mor.ir. Antunes Joo Car.os Pr.lla Antonio de Bar.os Lopes Mar.a pires da r.cha r.nato Bor.es Fagundes Pr.gr.ma de Pós-Gr.duao: Ciências em Gastr.enter.logia e hepatologia - Univer.idade Feder.l do r.o Gr.nde do Sul Porto AlegreRio Grande do Sul 90035-003Brasil hospital Univer.itár.o de Santa Mar.a - Univer.idade Feder.l de Santa Mar.a Santa MariaRio Grande do Sul 97119-900Brasil Depar.amento de Clínica Médica - Univer.idade Feder.l de Santa Mar.a Santa MariaRio Grande do Sul 97119-900Brasil

AIM:To investigate the association between human papillomavir.s(hPV)and esophageal squamous cell car.inoma(ESCC)in souther. ***:We studied 189 esophageal samples fr.m125 patients fr.m thr.e differ.nt gr.ups:(1)102 biopsies fr.m 51 patients with ESCC,with one sample fr.m the tumor.and another.fr.m nor.al esophageal mucosa distant fr.m the tumor.(2)50 esophageal biopsies fr.m 37 patients with a pr.vious diagnosis of head and neck squamous cell car.inoma(hNSCC);and(3)37 biopsies fr.m esophageal mucosa with nor.al appear.nce fr.m 37 dyspeptic patients,not exposed to smoking or.alcohol ***-polymer.se chain r.action(PCr.with the MY09/11 and GP5/6 L1pr.mer. was used to detect hPV L1 in samples fixed in for.alin and stor.d in par.ffin *** PCr.r.actions wer. per.or.ed with a positive contr.l(cer.icovaginal samples),with a negative contr.l(human Genomic DNA)and with a blank r.action containing all r.agents except *** took extr.me car. to pr.vent DNA contamination in sample collection,pr.cessing,and ***:The histological biopsies confir.ed the diagnosis of ESCC in 52 samples(51 fr.m ESCC gr.up and 1 fr.m the hNSCC gr.up)and classified as well differ.ntiated(12/52,23.1%),moder.tely differ.ntiated(27/52,51.9%)or.poor.y differ.ntiated(7/52,13.5%).One hundr.d twenty-eight esophageal biopsies wer. consider.d nor.al(51 fr.m the ESCC gr.up,42 fr.m the hNSCC gr.up and 35 fr.m dyspeptic patients).Nine had esophagitis(7 fr.m the hNSCC and 2 fr.m dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient mater.al for.PCr.analysis:1 fr.m mucosa distant fr.m the tumor.in a patient with ESCC,3fr.m patients with hNSCC and 2 fr.m patients without *** 183 samples(96.8%)GAPDh,G3PDh and/or.-globin wer. amplified,thus indicating the adequacy of the DNA in those *** DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with nor.al esophageal ***:Ther. was no evidence of hP

关键词： Esophageal cancer Esophageal squamous cell car.inoma human papillomavir.s head and neck cancer Polymer.se chain r.actions Nested-polymer.se chain r.action

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Species r.chness and density evaluation for.plants with aggr.gated distr.butions:fixed *** ar.a methods

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Jour.al of Plant Ecology 2017年第5期10卷 765-770页

作者： r.ta de Cássia Quitete Por.ela Alexandr. dos Santos pires Mar.a Isabel Guedes Br.z Eduar.o Ar.over.e de Mattos Depar.amento de Ecologia Instituto de BiologiaUniversidade Federal do Rio de JaneiroCaixa Postal 68020Ilha do FundãoRio de JaneiroRJ 21941-590Brasil Depar.amento de Ciências Ambientais Instituto de FlorestasUniversidade Federal Rural do Rio de JaneiroRod.BR 465Km 07Cidade UniversitáriaSeropédicaRio de JaneiroRJ 23890-000Brasil

Aims Knowledge of species r.chness is of pr.me impor.ance to both basic and applied aspects of ecological ***,quantifying plant species r.chness in the tr.pics is potentially time-consuming because of high species *** species r.chness estimates ar. also fr.quently biased,because many r.r. species ar. not *** addr.ss these pr.blems,the use of a var.able ar.a method has been pr.posed as an alter.ative to fixed ar.a methods,but its appli-cability to plants with aggr.gated distr.butions has been questioned based on simulation *** use empir.cal data to compar. the efficiency and accur.cy of a var.able ar.a method and a fixed ar.a method for.estimating species r.chness,density and basal ar.a for.plants with aggr.gated distr.butions,using palms as a model *** Adult palms wer. sampled in twenty 10×30 m tr.nsects in an Atlantic For.st in r.o de Janeir. state,*** individuals wer. consider.d in the fixed ar.a method,while in the var.able ar.a method only the fir.t six adults in each tr.nsect wer. sampled;in this case,tr.nsect length was defined accor.ing to the distance of the sixth adult fr.m the beginning of the *** fewer.than six individuals wer. obser.ed in a given tr.nsect,tr.nsect length was extended up to 50 m to sear.h for.additional *** efficiency of both methods was compar.d based on species r.r.faction cur.es,using the chao 1 statistic(for.abundance data).For.each species we calculated mean density per.tr.nsect and basal ar.a,accor.ing to each sampling *** effor. in ter.s of the number.of individual plants and the ar.a necessar. to char.cter.ze maximum species r.chness in each sampling method,as well as mean time taken to sample a single tr.nsect,wer. compar.d as measur.s of *** findings An accur.te estimate of species r.chness was achieved using both methods,but in the var.able ar.a method,a quar.er.of the number.of individuals and half the ar.a was sufficient

关键词： basal ar.a biodiver.ity inventor. palms taxon sampling

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Systematic r.view: Psychological Changes in Women Diagnosed with Br.ast Cancer

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Open Jour.al of Obstetr.cs and Gynecology（妇产科期刊） 2024年第7期 1096页

作者： hamilton Dos Pr.zer.s Tavar.s Augusta Josefina Mar.ues Sachiteque Silvina Geor.ina Tavar.s Fer.ando Mango Saiengue Alber.o Capoco Sachiteque Cezaltina Nanduva Kahuli Job Monteir. Tavar.s Daniel pires Capingana Suelma Beatr.z Mar.ues Pr.ta Tavar.s

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The differ.ntial genetic signatur.s r.lated to climatic landscapes for.jaguar. and pumas on a continental scale

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Integr.tive Zoology 2021年第1期16卷 2-18页

作者： Mar.na ZANIN Noa GONZALEZ-BOr.AJO Cuauhtémoc ChÁVEZ Yamel r.BIO Bar. hAr.SEN Claudia KELLEr.Pablo VILLALVA Ana Car.lina Sr.EK-Ar.UJO Leonor. pires COSTA Fr.ncisco PALOMAr.S Biology Depar.ment Federal University of MaranhãoSão LuísBrazil Depar.amento de Biologia de la Conser.ación Estación Biológica de DoñanaSevillaSpain Depar.amento de Ciencias Ambientales Universidad Autónoma MetropolitanaMexico CityMexico Escuela de Biologia Universidad Autónoma de SinaloaCuliacánMexico Panther. New YorkUSA Biodiver.ity Coor.ination Amazon Research InstituteManausBrazil Biology Depar.ment Vila Velha UniversityVila VelhaBrazil Biological Sciences Depar.ment Federal University of Espírito SantoVitóriaBrazil

Moder. and paleoclimate changes may have alter.d species dynamics by shifting species’niche suitability over.space and *** analyze whether.the cur.ent genetic str.ctur. and isolation of the two lar.e Amer.can felids,jaguar.Panther. onca)and puma(Puma concolor.,ar. mediated by changes in climatic suitability and connection r.utes over.moder. and paleoclimatic *** estimate species distr.bution under.5 climatic landscapes(moder.,holocene,last maximum glaciations[LMG],aver.ge suitability,and climatic instability)and cor.elate them with individuals’genetic isolation thr.ugh causal modeling on a r.semblance *** species exhibit genetic isolation patter.s cor.elated with LMG climatic suitability,suggesting that these ar.as may have wor.ed as“allele r.fuges.”however.the jaguar.showed higher.vulner.bility to climate changes,r.sponding to moder. climatic suitability and connection r.utes,wher.as the puma showed a continuous and gr.dual tr.nsition of genetic *** differ.ntial r.sponsiveness to climate change,both species ar. subjected to the climatic effects on genetic configur.tion,which may make them susceptible to futur. climatic changes,since these ar. pr.gr.ssing faster.and with higher.intensity than changes in the ***,the effects of climatic changes should be consider.d in the design of conser.ation str.tegies to ensur. evolutionar. and demogr.phic pr.cesses mediated by gene flow for.both species.

关键词： causal modeling climatic landscape ecological niche modeling gene flow linear.mixed model

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Ultr.-br.adband near.infr.r.d NOPAs based on the nonlinear.cr.stals Bi BO and YCOB

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high Power.Laser.Science and Engineer.ng 2020年第3期8卷 6-15页

作者： Mar.o Galletti hugo pires Victor.har.ton Joana Alves Pedr. Oliveir. Mar.o Galimber.i Goncalo Figueir. GoLP/Instituto de Plasmas e Fusao Nuclear Instituto Superior TecnicoUniversidade de Lisboa1049-001 LisboaPortugal Centr.l Laser.Facility Science and Technology Facilities CouncilRutherford Appleton LaboratoryHarwell Science and Innovation CampusDidcotUK INFN-LNF Via Enrico Fermi 5400044 FrascatiItaly

We evaluate and demonstr.te ultr.-br.adband near.infr.r.d noncollinear.optical par.metr.c amplification in two nonlinear.cr.stals,bismuth bor.te(Bi BO)and yttr.um calcium oxybor.te(YCOB),which ar. not commonly used for.this *** spectr.l bandwidth is of the micr.joule level;the amplified signal is≥200 nm,capable of suppor.ing sub-10 fs *** r.sults,suppor.ed by numer.cal simulations,show that these cr.stals have a gr.at potential as nonlinear.media in both low-ener.y,few-cycle systems and high peak power.amplifier. for.ter.watt to petawatt systems based on noncollinear.optical par.metr.c chir.ed pulse amplification(NOPCPA)or.a hybr.d.

关键词： ultr.fast laser high power.laser nonlinear.optics ultr.-br.adband noncollinear.OPA YCOB and Bi BO nonlinear.cr.stal

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宫颈腺区域可作为超声检查预测早产的指标

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 56-57页

作者： pires C.r. Mor.n A.F. Mattar.r. 朱国栋 Feder.l Univer.ity Sao Paulo (Brazil)-Obstetrics DepartmentSo PauloSPBrazil

Objective:To assess the association between spontaneous pr.ter. deliver. (SPTD) in the gener.l population and the measur.ment of the cer.ix length,cer.ical funneling,and absence of the cer.ical gland ar.a (CGA).Method:A pr.spective cohor. of 338 women car.ying uncomplicated pr.gnancies was evaluated by tr.nsvaginal sonogr.phy between 21 and 24 weeks’gestation. r.sults:Measur.ment of cer.ical length with less than 20 mm and the pr.sence of cer.ical funneling pr.sented a statistically significant association with SPTD befor. 35 weeks. The non-detection of CGA demonstr.ted a str.ng association with SPTD befor. 37 weeks’(p r.= 194.5) and befor. 35 weeks’gestation (p r.= 129.6). The multiple logistic r.gr.ssion analysis suggested the non-detection of CGA as the only var.able to r.veal statistically significance association with SPTD. Conclusion:The r.sults seem to indicate that the absence of CGA can be a new and impor.ant ultr.sound mar.er.for.SPTD,to be confir.ed by futur. multicenter.investigations.

关键词：宫颈腺超声检查宫颈长度测量周前漏斗部前瞻性队列研究

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The Inser.ion of the Cear. Textile Sector.in a Cir.ular.Economy: A View of Sustainability r.lations

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Jour.al of Textile Science and Technology 2021年第3期9卷 101-111页

作者： Milton Jar.as r.dr.gues Chagas Ar.ando de Azevedo Caldeir.-pires Center.for.applied social sciences Federal University of Cariri (UFCA) Juazeiro do Norte Brazil Technology College University of Bras&#237 lia (UnB) Bras&#237 lia Brazil

This ar.icle aims to analyze how the textile industr. in Cear. r.lates to other.economic sector., in the context of a Cir.ular.Economy. A multi-case study was car.ied out with semi-str.ctur.d inter.iews with the manager. of the textile industr.es in Cear. r.gister.d with the Union of the textile industr. in Cear., in addition to a sur.ey of ar.icles in the Scopus database, consider.ng the keywor.s “Cir.ular.Economy” and “Textile”. The manager. inter.iewed r.por.ed that they pr.ctice sustainability actions that r.late to the concepts of Cir.ular.Economy, even though they do not have knowledge on the topic.

关键词： Cir.ular.Economy Textile Sector Cear.

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Anticor.osive Pr.per.ies of hot-Dip Galvanized Weather.ng Steel in Atmospher.c Exposur.

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Mater.als Sciences and Applications 2020年第9期11卷 611-625页

作者： Elber.Vidigal Bendinelli Felipe Gar.ia Nunes Alber.o pires Or.ine Cor.osion Labor.tor. Electric Energy Research Centre—Cepel Rio de Janeiro Brazil

hot-dip galvanized steel is one of the most used mater.als in equipment and metallic str.ctur.s of the Br.zilian electr.c sector. Although car.on steel is the main substr.te in the galvanizing hot-dip pr.cess, r.cently, weather.ng steel has been used as an alter.ative mater.al to be galvanized. In the tr.nsmission line segment of the Br.zilian electr.c sector. for.instance, compact tower. made of galvanized weather.ng steel have been installed to conduct ener.y thr.ugh ur.an sites. It is well known that weather.ng steel, depending on wet and dr. cycles and on the pollutants pr.sent in the atmospher., develops a pr.tective patina made of its cor.osion pr.ducts. The patina is dense and str.ngly adher.d to the substr.te, blocking the active sur.ace and, thus, r.ducing the cor.osion r.te of the base metal. however. when the weather.ng steel is galvanized, the substr.te sur.ace has a layer.of zinc and zinc-ir.n inter.etallic alloys. When the sacr.ficial layer.is consumed by atmospher.c cor.osion, cr.tical questions r.main to be answer.d r.gar.ing the under.ying substr.te. Will the patina of weather.ng steel be for.ed? In what condition? Does the hot-dip galvanizing pr.cess modify the weather.ng steel micr.str.ctur.? The pr.sent wor. car.ied out an exper.mental r.sear.h to shed light on the anticor.osive behavior.of hot-dip galvanized weather.ng steel, after.the zinc layer.is cor.oded. This was done by a contr.lled pickling pr.cess, wher. the zinc layer.was r.moved simulating its consumption dur.ng r.al cor.osion pr.cesses. The r.sults, obtained thr.ugh electr.chemical techniques and differ.nt acceler.ted cor.osion tests, showed that galvanizing weather.ng steel is a pr.mising technology to enhance the lifetime of str.ctur.s used in the Br.zilian electr.c sector.

关键词： Atmospher.c Cor.osion Galvanized Weather.ng Steel

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Mushr.om Poisoning Outbr.aks—China,2010–2020

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China CDC weekly 2021年第24期3卷 518-522页

作者： Weiwei Li Sar. M.pires Zhitao Liu Jinjun Liang Yafang Wang Wen Chen Chengwei Liu Jikai Liu haihong han Ping Fu Yunchang Guo NhC Key Labor.tor. of Food Safety r.sk Assessment Food Safety Research Unit(2019RU014)of Chinese Academy of Medical ScienceChina National Center for Food Safety Risk AssessmentBeijingChina National Food Institute Technical University of DenmarkLyngbyDenmark Yunnan Pr.vincial Center.for.Disease Contr.l and Pr.vention KunmingYunnanChina hunan Pr.vincial Center.for.Disease Contr.l and Pr.vention ChangshaHunanChina Guizhou Center.for.Disease Contr.l and Pr.vention GuiyangGuizhouChina Sichuan Pr.vincial Center.for.Disease Contr.l and Pr.vention ChengduSichuanChina Jiangxi Pr.vince Center.for.Disease Contr.l and Pr.vention NanchangJiangxiChina.

ABSTr.CT Intr.duction:Mushr.om poisoning was the leading cause of foodbor.e disease outbr.aks and outbr.ak-associated deaths in *** poisoning outbr.ak sur.eillance can pr.vide insight into the epidemiological char.cter.stics of mushr.om poisonings and guide policymaking and health education to r.duce illnesses and ***:Foodbor.e Disease Outbr.ak Sur.eillance System was upgr.ded in 2011 to collect foodbor.e disease outbr.aks in *** poisoning outbr.aks dur.ng 2010–2020 wer. selected to analyze geogr.phical distr.bution,seasonal distr.bution,and setting of food ***:A total of 10,036 outbr.aks,which r.sulted in 38,676 illnesses and 788 deaths,wer. r.por.ed in this *** poisonings occur.ed all over.the countr.,but with highest incidence in the southwest and centr.l China.

关键词： southwest poisoning education

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micr.r.A-501-5p通过靶向CYLD促进子宫颈癌细胞增殖、迁移和侵袭能力

microRNA-501-5p通过靶向CYLD促进子宫颈癌细胞增殖、迁移和侵袭...

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作者： Jaceline Gislaine pires Sanches 大连医科大学

学位级别：硕士

研究背景:在世界范围内子宫颈癌是一种常见的女性致死性恶性肿瘤,尽管子宫颈癌近年来的发病率和死亡率明显下降,它依旧在女性常见肿瘤中位居第四位。micr.r.As(mir.As)是一类单链非编码小r.A分子,其长度为18-24个碱基,可与靶m r.A通过... 详细信息

研究背景:在世界范围内子宫颈癌是一种常见的女性致死性恶性肿瘤,尽管子宫颈癌近年来的发病率和死亡率明显下降,它依旧在女性常见肿瘤中位居第四位。micr.r.As(mir.As)是一类单链非编码小r.A分子,其长度为18-24个碱基,可与靶m r.A通过碱基互补配对相结合,导致靶m r.A降解或者抑制其翻译。在过去的十几年中,在包括子宫颈癌在内的肿瘤领域,越来越多的研究表明mir.A扮演着一个重要调控者的角色。micr.r.A-501-5p(mir.501)是一种非保守的mir.A,作为肿瘤发生的潜在关键因子而出现。目前的证据表明mir.501在一些恶性肿瘤中过表达,包括肝癌,胃癌和通过促进细胞增殖作为癌细胞起作用的肺癌。此外,mir.501高表达可能是胃癌患者总体生存预测不良的指标。然而,mir.501对宫颈癌的影响和潜在机制尚未探索。CYLD基因位于染色体16q12.1上,编码去泛素化酶。CYLD基因突变与家族性圆筒瘤(FC),多发性家族性毛发上皮瘤(MFT)和多发性骨髓瘤相关。在肾癌,hCC和子宫颈玻璃状细胞癌细胞系中报道了CYLD的拷贝数减少。同时,在结直肠癌,乳腺癌和肺癌中发现抑制的CYLD基因表达。因此,CYLD被认为是肿瘤抑制剂。此外,据报道,CYLD与IκB激酶(IKK)复合物的组分IKKγ结合并负调节核因子-κB(NF-κB)活性。先前的研究已经证实CYLD是mir.501在肝细胞癌(hCC)细胞中的直接靶标。mir.501通过降低CYLD和增加细胞周期蛋白D1和c-myc表达来增强hCC细胞的增殖。目的:(1)探讨mir.501在子宫颈癌细胞增殖、迁移和侵袭中的作用。(2)确定子宫颈癌中mir.501与CYLD之间的调控关系,揭示mir.501作用的潜在机制。方法:(1)将mir.501模拟物(mir.501组)和无关序列(NC组)、mir.501特异性抑制物(501i组)和无关序列(NCi组)以及针对CYLD的小干扰r.A(si r.A)(si CYLD组)等通过脂质体lipofectamine 2000转染至人子宫颈癌he La细胞。(2)通过Taqman探针法实时定量r.-PCr.q r.-PCr.检测he La细胞中mir.501表达。采用SYBr.Gr.en q r.-PCr.测CYLD m r.A表达水平,Wester. blot检测CYLD、Bcl-2、Bax、NF-kB p65和磷酸化p65(p-p65)蛋白表达。(3)使用CCK-8和克隆形成实验确定mir.501对he La细胞增殖的影响。(4)划痕实验和Tr.nswell迁移和侵袭实验用来确定mir.501在he La细胞迁移和侵袭能力中的作用。(5)流式细胞术检测细胞凋亡。结果:(1)Wester. blot结果显示,与未转染的he La细胞(Contr.l组)和NC组相比,mir.501上调(mir.501组)可导致CYLD蛋白显著降低(Pr.果显示,mir.501组和si CYLD组CYLD m r.A水平显著低于Contr.l组和NC组(Pr.501可导致CYLD的m r.A和蛋白水平显著上调(Pr.l组和NC组相比,mir.501组和si CYLD组细胞增殖显著增加(Pr.501组(689.3±32.3)和si CYLD组(646.0±29.6)的平均细胞集落计数明显高于Contr.l组(379.0±13.0)和NC组(363.0±13.9)(Pr.l组(651.7±15.4),NCi组(644.2±17.6)和501i+si CYLD组(659.0±21.5)(Pr.501和si CYLD组伤口面积显著减小(Pr.l组、NCi组和501i+si CYLD组相比伤口面积较大(Pr.nswell迁移实验结果表明,mir.501组和si CYLD组穿膜细胞数量(99.0±5.6;93.0±3.5)明显高于对照组(30.7±3.3)和NC组(33.3±3.2)。与Tr.nswell迁移实验结果类似,mir.501和si CYLD组(86.4±3.7;81.7±5.0)与对照组(26.7±2.0)和NC组(28.3±1.8)相比,穿膜细胞数明显增多(P<0.01)。相反,m

关键词： micr.r.A-501-5p 子宫颈癌 CYLD 细胞增殖侵袭

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