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A Systematic r.view of Computer.Vision Techniques for.Quality Contr.l in End-of-Line Visual Inspection of Antenna Par.s

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Computer., Mater.als & Continua 2024年第8期80卷 2387-2421页

作者： Zia Ullah Lin Qi E.J.Solteir. pires Ar.énio r.is r.car.o r.dr.gues Nunes School of Electr.cal and Infor.ation Engineer.ng Zhengzhou UniversityZhengzhou450001China School of Science and Technology Universidade de Trás-os-Montes e Alto DouroVila Real5000-801Portugal

The r.pid evolution of wir.less communication technologies has under.cor.d the cr.tical r.le of antennas in ensur.ng seamless *** defects,r.nging fr.m manufactur.ng imper.ections to envir.nmental wear.pose significant challenges to the r.liability and per.or.ance of communication *** r.view paper.navigates the landscape of antenna defect detection,emphasizing the need for.a nuanced under.tanding of var.ous defect types and the associated challenges in visual *** r.view paper.ser.es as a valuable r.sour.e for.r.sear.her.,engineer.,and pr.ctitioner. engaged in the design and maintenance of communication *** insights pr.sented her. pave the way for.enhanced r.liability in antenna systems thr.ugh tar.eted defect detection *** this study,a compr.hensive liter.tur. analysis on computer.vision algor.thms that ar. employed in end-of-line visual inspection of antenna par.s is *** Pr.SMA pr.nciples will be followed thr.ughout the r.view,and its goals ar. to pr.vide a summar. of r.cent r.sear.h,identify r.levant computer.vision techniques,and evaluate how effective these techniques ar. in discover.ng defects dur.ng *** contains ar.icles fr.m scholar.y jour.als as well as paper. pr.sented at confer.nces up until June *** r.sear.h utilized sear.h phr.ses that wer. r.levant,and paper. wer. chosen based on whether.or.not they met cer.ain inclusion and exclusion *** this study,sever.l differ.nt computer.vision appr.aches,such as featur. extr.ction and defect classification,ar. br.ken down and ***,their.applicability and per.or.ance ar. *** r.view highlights the significance of utilizing a wide var.ety of datasets and measur.ment *** findings of this study add to the existing body of knowledge and point r.sear.her. in the dir.ction of pr.mising new ar.as of investigation,such as r.al-time inspection systems and multispectr.l *** r.view,on its whole,of

关键词： Computer.vision end-of-line visual inspection of antenna par.s machine lear.ing algor.thms image pr.cessing techniques deep lear.ing models

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The Use of Insulin Negatively Impacts the Mor.ality of Sever. COVID-19 in Patients with Type 2 Diabetes—A Systematic r.view

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Jour.al of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti Mar.ela r. Simoes Thais P. Pr.do Milena Monfor.-pires Licio A. Velloso Obesity and Comor.idities r.sear.h Center Campinas Brazil Tur.u PET Centr. University of Turku Turku Finland National Institute of Science and Technology on Neur.immunomodulation Campinas Brazil

Obesity and type 2 diabetes ar. among the most impor.ant r.sk factor. for.sever. cor.navir.s disease-19. Some studies have suggested that the use of insulin as a ther.peutic agent to tr.at hyper.lycemia and the metabolic abnor.alities associated with type 2 diabetes dur.ng the acute phase of sever. cor.navir.s disease-19 could have a negative impact on the disease’s pr.gr.ssion;however. ther. is no consensus on this issue. her., we per.or.ed a systematic r.view in an attempt to answer.this impor.ant question. We included 29 ar.icles published fr.m December.2019 to August 2023, which r.por.ed the outcomes of 3,070,657 patients with sever. cor.navir.s disease-19 that had the diagnosis of diabetes and wer. tr.ated with either.insulin or.other.glucose-r.ducing agents. The r.sults show that using insulin as a phar.acological inter.ention to tr.at type 2 diabetes in patients with sever. cor.navir.s disease-19 incr.ases the likelihood of mor.ality by 193%.

关键词： SAr.-CoV2 Obesity Inflammation Metabolism Glucose

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The occur.ence,inher.tance,and segr.gation of complex genomic str.ctur.l var.ation in synthetic Br.ssica napus

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The Cr.p Jour.al 2024年第2期12卷 515-528页

作者： Dandan hu Jin Lu Wenwen Li Yinghui Yang Junxiong Xu han Qin hao Wang Yan Niu huaiqi Zhang Qingqing Liu Xiangxiang he Annaliese S.Mason JChr.s pires Zhiyong Xiong Jun Zou National Key Labor.tor. of Cr.p Genetic Impr.vement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Agr.nomy Henan Agricultural UniversityZhengzhou 450002HenanChina Key Labor.tor. of her.age and Endemic Cr.p Biotechnology Inner Mongolia UniversityHohhot 010070Inner MongoliaChina Plant Br.eding Depar.ment University of BonnBonn 53115Germany Depar.ment of Soil and Cr.p Sciences Colorado State UniversityFort CollinsCO 80523USA

"Synthetic"allopolyploids r.cr.ated by inter.pecific hybr.dization play an impor.ant r.le in pr.viding novel genomic var.ation for.cr.p *** synthetic allopolyploids often under.o r.pid genomic str.ctur.l var.ation(SV).however.how such SV ar.ses,is inher.ted and fixed,and how it affects impor.ant tr.its,has r.r.ly been compr.hensively and quantitively studied in advanced gener.tion synthetic lines.A better.under.tanding of these pr.cesses will aid br.eder. in knowing how to best utilize synthetic allopolyploids in br.eding ***,we analyzed thr.e genetic mapping populations(735 Dh lines)der.ved fr.m cr.sses between advanced synthetic and conventional Br.ssica napus(r.peseed)lines,using whole-genome sequencing to deter.ine genome *** obser.ed high toler.nce of lar.e str.ctur.l var.ants,par.icular.y towar. the telomer.s,and pr.fer.ntial selection for.balanced homoeologous exchanges(duplication/deletion events between the A and C genomes r.sulting in r.tention of gene/chr.mosome dosage between homoeologous chr.mosome pair.),including stable events involving whole chr.mosomes("pseudoeuploidy").Given the exper.mental design(all thr.e populations shar.d a common par.nt),we wer. able to obser.e that par.ntal SV was r.gular.y inher.ted,showed genetic hitchhiking effects on segr.gation,and was one of the major.factor. inducing adjacent novel and lar.er.***,novel SV occur.ed at low fr.quencies with no significant impacts on obser.ed fer.ility and yield-r.lated tr.its in the advanced gener.tion synthetic ***,incor.or.ting genome-wide SV in linkage mapping explained significantly mor. genetic var.ance for.*** r.sults pr.vide a fr.mewor. for.detecting and under.tanding the occur.ence and inher.tance of genomic SV in br.eding pr.gr.ms,and suppor. the use of synthetic par.nts as an impor.ant sour.e of novel tr.it var.ation.

关键词： Allopolyploid Lar.e Genome str.ctur.l var.ation Linkage mapping Synthetic polyploids Inher.tance and segr.gation

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山药多糖对地塞米松诱导Ir.3T3-L1脂肪细胞的降血糖作用及机制研究

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中国比较医学杂志 2024年第4期34卷 73-83页

作者：刘昕玥王凤忠郑涵文 Alber.o Car.os pires Dias 范蓓王琼中国农业科学院农产品加工研究所/农业农村部农产品加工质量安全风险评估实验室/农业农村部农产品质量安全收贮运管控重点实验室北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究山药多糖(Chinese yam polysacchar.de,CYPS)在地塞米松(dexamethasone,DEX)诱导的3T3-L1胰岛素抵抗(Ir.3T3-L1)细胞模型中的降血糖作用。方法将Ir.3T3-L1脂肪细胞随机分为对照组(Con)、DEX组(DEX)、Met组(Met,阳性药组)、CYPS组(0.05、0.15、0.45 mg/mL),通过DEX(1μmol/L)诱导建立Ir.3T3-L1细胞模型,进行给药后细胞对葡萄糖的消耗量和细胞中血脂(总胆固醇(total cholester.l,TC)、甘油三酯(tr.glycer.de,TG)、低密度脂蛋白胆固醇(low-density lipopr.tein cholester.l,LDL-C)、高密度脂蛋白胆固醇(high-density lipopr.tein cholester.l,hDL-C))与丙二醛(malondialdehyde,MDA)和谷胱甘肽过氧化物酶(glutathione per.xidase,GSh-Px)、己糖激酶(hexokinase,hK)、丙酮酸激酶(pyr.vate kinase,PK)含量的检测,并采用qr.-PCr.AMPK-PI3K/Akt信号通路中相关基因表达进行检测。结果DEX组与Con组相比,1μmol/L DEX处理48 h显著降低了Ir.3T3-L1细胞的葡萄糖消耗量(Ph内维持稳定。0.05、0.15、0.45 mg/mL CYPS处理Ir.3T3-L1细胞显著增加了细胞中葡萄糖的消耗(PhK、PK、GSh-Px酶活性(PhDL-C含量(PhO、TG、LDL-C含量(Pr.-2、PPAr.、Adiponectin的mr.A水平(Pr.-1、GSK-3β、ACC、FAS的mr.A表达水平(Pr.3T3-L1细胞对葡萄糖的消耗,调节脂代谢紊乱,缓解氧化应激,其作用机制可能通过调控Ir.3T3-L1脂肪细胞的AMPK-PI3K/Akt信号通路来实现糖脂代谢紊乱和胰岛素抵抗调节来实现。

关键词：山药多糖胰岛素抵抗地塞米松 3T3-L1细胞二甲双胍 AMPK-PI3K/Akt信号通路

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黄花菜醇提物对斑马鱼抑郁样行为的改善作用研究

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中国比较医学杂志 2024年第4期34卷 20-27页

作者：郑涵文王梓航刘昕玥于佳玮 Alber.o Car.os pires Dias 王凤忠王琼西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 中国农业科学院农产品加工研究所北京100193 中国农业大学食品科学与营养工程学院北京100083 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究黄花菜醇提物(hemer.callis citr.na Bar.ni,hCE)在利血平(r.ser.ine)诱导的斑马鱼幼鱼(Danio r.r.o)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜... 详细信息

目的探究黄花菜醇提物(hemer.callis citr.na Bar.ni,hCE)在利血平(r.ser.ine)诱导的斑马鱼幼鱼(Danio r.r.o)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜中剂量组(3 mg/L)、黄花菜高剂量组(4.5 mg/L)。采用斑马鱼声音刺激和光刺激进行抑郁样行为学分析。利用r.-qPCr.究黄花菜醇提物对抑郁症有关的星状胶质细胞标志物及其衍生物基因(GFAP、C3、C4B、EMP-1和S100α-10)以及神经营养因子(BDNF)及其自身受体转录基因(P75、Tr.B)的调节功能。结果与对照组相比,模型组在440 hz声音刺激与8000 Lux光照刺激下运动距离缩短、运动时间减少(Pr.B下调(Pr.B表达显著上调(P<0.01,P<0.0001)。表明黄花菜醇提物抑制了星形胶质细胞激活诱发的炎症表现,同时促进了神经营养因子及其受体基因的生成,对抑郁起到了改善作用。结论黄花菜醇提物可以改善利血平诱导的斑马鱼幼鱼的抑郁样行为变化,斑马鱼脑中星形胶质细胞标志物的表达量减少,同时促进神经营养因子及其受体基因的生成,起到抗抑郁作用。

关键词：黄花菜抑郁症利血平斑马鱼

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基于网络药理学和实验验证探究酸枣仁复方治疗抑郁症的作用机制

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中国实验动物学报 2024年第7期32卷 901-912页

作者：郑涵文刘昕玥赵海燕王佳音罗福龙范蓓 Alber.o Car.os pires Dias 王凤忠王琼中国农业科学院农产品加工研究所北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 西南医科大学附属中医医院脾胃病科四川泸州646000 首都医科大学宣武医院急诊科北京100053 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen for.ula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSP数据库检索酸枣仁复方的药物作用靶点... 详细信息

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen for.ula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSP数据库检索酸枣仁复方的药物作用靶点,利用UniPr.t数据库对靶点名称进行校正。采用GeneCar.s、OMIM、NCBI数据库检索抑郁症相关靶点,并对3个数据库的靶点结果进行汇总去比重。利用STr.NG数据库预测了交集靶点的蛋白质-蛋白质相互作用(pr.tein-pr.tein inter.ction, PPI)信息,利用Metascape数据库构建进行富集研究,并利用微生信对KEGG和GO的富集结果实现了可视化。通过利血平诱导的斑马鱼抑郁模型进行行为学实验和r.-qPCr.验,验证酸枣仁复方对抑郁症的治疗作用。结果筛选出抑郁症与酸枣仁复方的交集靶点188个,蛋白质-蛋白质相互作用结果显示,酸枣仁复方抗抑郁主要作用于肿瘤坏死因子-α(TNF-α)、血清白细胞介素2(IL-2)、血清白细胞介素6(IL-6)、血清白细胞介素1β(IL-1β)、血清白细胞介素10(IL-10)等靶点,KEGG通路富集分析表明,酸枣仁复方通过TNF信号通路、PI3K-Akt信号通路、cGMP-PKG信号通路等多种信号通路发挥其治疗抑郁症的作用。动物实验结果显示,与利血平组相比,酸枣仁复方高、中、低剂量组斑马鱼在声光刺激下的运动距离显著延长(Pr.-qPCr.果显示,与利血平组相比,酸枣仁复方高、中、低剂量给药组斑马鱼脑组织中TNF-α、IL-2、IL-6、IL-1β、IL-10 mr.A表达水平上调(P<0.001)。结论酸枣仁复方通过多成分、多靶点发挥抗抑郁作用,且其抗抑郁作用可能与抑制炎症因子的表达有关。

关键词：网络药理学酸枣仁复方抑郁症炎症因子

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The ULT1 and ULT2 tr.G Genes Play Over.apping r.les in Ar.bidopsis Development and Gene r.gulation

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Molecular.Plant 2013年第5期6卷 1564-1579页

作者： Mona M. Monfar.d Cr.stel C. Car.es Pascale r.ssignol h.lena r. pires Jennifer.C. Fletcher Plant Gene Expr.ssion Center USDA-ARS/UC Berkeley 800 Buchanan Street. Albany CA 94710 USA Depar.ment of Plant and Micr.bial Biology University of California Berkeley 111 Koshland Hall Berkeley CA 94720 USA CNr. UMR5168 F-38054 Grenoble France Univer.ite Gr.noble Alpes UMR5168 F-38041 Grenoble France CEA iRTSV Laboratoire Physiologie Cellulaire et Vegetale F-38054 Grenoble France INr. F-38054 Grenoble France Depar.ment of Molecular Cellular and Developmental Biology Yale University New Haven CT 06520 USA Faculdade de Ciencias da Univer.idade do Por.o Porto Portugal

The epigenetic r.gulation of gene expr.ssion is cr.tical for.ensur.ng the pr.per.deployment and stability of defined genome tr.nscr.ption pr.gr.ms at specific developmental stages. The cellular.memor. of stable gene expr.ssion states dur.ng animal and plant development is mediated by the opposing activities of Polycomb gr.up （PcG） factor. and tr.thor.x gr.up （tr.G） factor.. Yet, despite their.impor.ance, only a few tr.G factor. have been char.cter.zed in plants and their.r.tes in r.gulating plant development ar. poor.y defined. In this wor., we r.por. that the closely r.lated Ar.bidopsis tr.G genes ULTr.PETALA1 （ULT1） and ULT2 have over.apping functions in r.gulating shoot and flor.l stem cell accumula- tion, with ULT1 playing a major.r.le but ULT2 also making a minor.contr.bution. The two genes also have a novel, r.dun- dant activity in establishing the apical-basal polar.ty axis of the gynoecium, indicating that they function in differ.ntiating tissues. Like ULT1 pr.teins, ULT2 pr.teins have a dual nuclear.and cytoplasmic localization, and the two pr.teins physically associate in planta. Finally, we demonstr.te that ULT1 and ULT2 have ver. similar.over.xpr.ssion phenotypes and r.gulate a common set of key development tar.et genes, including flor.l MADS-box genes and class I KNOX genes. Our.r.sults r.veal that chr.matin r.modeling mediated by the ULT1 and ULT2 pr.teins is necessar. to contr.l the development of mer. istems and r.pr.ductive or.ans. They also suggest that, like their.animal counter.ar.s, plant tr.G pr.teins may function in multi-pr.tein complexes to up-r.gulate the expr.ssion of key stage- and tissue-specific developmental r.gulator. genes.

关键词： tr.G factor epigenetics stem cells Ar.bidopsis polar.ty ULTr.PETALA.

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Systematic r.view: Psychological Changes in Women Diagnosed with Br.ast Cancer

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Open Jour.al of Obstetr.cs and Gynecology 2024年第7期14卷 1096-1109页

作者： hamilton Dos Pr.zer.s Tavar.s Augusta Josefina Mar.ues Sachiteque Silvina Geor.ina Tavar.s Fer.ando Mango Saiengue Alber.o Capoco Sachiteque Cezaltina Nanduva Kahuli Job Monteir. Tavar.s Daniel pires Capingana Suelma Beatr.z Mar.ues Pr.ta Tavar.s Depar.ment of Gynecology and Obstetr.cs General Hospital of Huambo Huambo Angola Faculty of Medicine University Jos Eduardo dos Santos Huambo Huambo Angola Depar.ment of Gynecology and Obstetr.cs Hospital Municipal of Huambo Huambo Angola Depar.ment of Gynecology and Obstetr.cs Hospital Municipal of Bailundo Huambo Angola Depar.ment of Inter.al Medicine General Hospital of Huambo Huambo Angola Depar.ment of Gynecology and Obstetr.cs Hospital Municipal of Cala Huambo Angola

Br.ast cancer.is consider.d one of the most common cancer. among women, accounting for.25% - 29% of new cases wor.dwide each year. The diagnosis, living with the disease, as well as the differ.nt tr.atments can have impor.ant impacts on the Psychological and mental health of patients. Objective: To investigate the psychological aspects that women with br.ast cancer.develop or.may develop. Methodology: A systematic r.view using the Pr.SMA methodology was used. r.sults: 11 ar.icles that met the inclusion and exclusion cr.ter.a wer. analysed. The lar.est flow of publications in r.lation to the effects of the patient with cancer. wer. car.ied out between the year. 2000 and 2023. Conclusions: Psychological disor.er. (depr.ssion, anxiety, str.ss) ar. par. of the lives of women diagnosed with br.ast cancer. and their.pr.valence var.es fr.m one woman to another.

关键词： Anxiety Depr.ssion Psychosis Sadness Cancer

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It takes mor. than tau to tangle:using pr.teomics to deter.ine how phosphor.lated tau mediates toxicity in neur.degener.tive diseases

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Neur.l r.gener.tion r.sear.h 2021年第11期16卷 2211-2212页

作者： Geoffr.y pires Eleanor.Dr.mmond Center.for.Cognitive Neur.logy Department of NeurologyNew York University School of MedicineNew YorkNYUSA Alzheimer.s and Pr.on Diseases Team Paris Brain InstituteCNRSUMR 7225INSERM 1127Sorbonne University UM75ParisFrance

Two of the most common causes of dementia ar. Alzheimer.s disease(AD)and fr.ntotempor.l dementia(FTD).AD is an ir.ever.ible,pr.gr.ssive neur.degener.tive disor.er.that is clinically char.cter.zed by sever. memor. loss and behavior.l impair.ent that eventually inter.er.s with ever.day *** is neur.pathologically defined by the pr.sence of extr.cellular.-amyloid plaques and intr.cellular.accumulation of neur.fibr.llar. tangles(NFTs)that pr.mar.ly contain aggr.gated,hyper.hosphor.lated tau(pTau).Intr.guingly,pTau is also the centr.l pr.tein in multiple subtypes of FTD(*** degener.tion,pr.gr.ssive supr.nuclear.palsy,Pick’s disease).FTD is an umbr.lla ter. for.a gr.up of neur.logical conditions that pr.mar.ly affect the tempor.l and fr.ntal r.gions of the *** in the tau gene(MAPT)can cause familial FTD,pr.viding fur.her.evidence of the integr.l r.le of tau in ***,tau r.gulates micr.tubule str.ctur. and dynamics,as well as axonal tr.nspor. thr.ugh inter.ction with *** is also involved in neur.nal development and *** AD and FTD,tau becomes hyper.hosphor.lated and under.oes major.confor.ational changes,causing it to aggr.gate into the char.cter.stic neur.pathological lesions that define AD and *** the known involvement of tau in these diseases,exactly how tau mediates toxicity is still unclear.

关键词： tau involvement media

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Development of metal or.anic fr.mwor.-199 immobilized zeolite foam for.adsor.tion of common indoor.VOCs

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Jour.al of Envir.nmental Sciences 2017年第5期29卷 321-330页

作者： Vipin K.Saini Joao pires School of Envir.nment and Natur.l r.sour.es Doon UniversityDehradun 248001India Depar.ment of Chemistr. and Biochemistr. Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

r.ticulated foam shaped adsor.ents ar. mor. efficient for.the r.moval of volatile or.anic compounds（VOCs）,par.icular.y fr.m low VOC-concentr.tion indoor.air.str.ams. In this study composite str.ctur. of zeolite and metal or.anic fr.mewor.s（MOFs）,r.fer.ed as ZMF,has been fabr.cated by immobilization of fine MOF-199 powder.on foam shaped Zeolite Socony Mobil-5（ZSM-5）Zeolitic str.ctur.,r.fer.ed as ZF. The ZMF possess a unifor. and well-disper.ed coating of MOF-199 on the por.us fr.mewor. of ZF. It shows higher.sur.ace ar.a,por. volume,and VOCs adsor.tion capacity,as compar.d to ***-fabr.cation changes in selective adsor.tion pr.per.ies of ZMF wer. studied with thr.e common indoor.VOCs（benzene,n-hexane,and cyclohexane）,using gr.vimetr.c adsor.tion technique. The adsor.tion capacity of ZMF with differ.nt VOCs follow the or.er.of benzene 〉 n-hexane 〉 cyclohexane. In compar.son with MOF-199 and ZF,the composite str.ctur. ZMF shows impr.vement in selectivity for.benzene fr.m other.two VOCs. Fur.her.impr.vement in efficiency and stability of pr.par.d ZMF was found to be associated with its high MOF loading capacity and unique mor.hological and str.ctur.l pr.per.ies. The developed composite str.ctur. with impr.ved VOCs r.moval and r.cyclability could be a pr.mising mater.al for.small to limited scale air.pollution tr.atment units.

关键词： VOCs Adsor.tion Composite mater.als Selectivity Zeolite foam MOFs hKUST-1

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