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Journal of Genetics and Genomics 2021年第3期48卷 173-183页

作者： Micah Silberstein Nicholas Nesbit Jacquelyn Cai Phil h.lee Center for Genomic Medicine Massachusetts General HospitalBostonMA 02114USA Department of Psychiatry Harvard Medical SchoolBostonMA 02115USA Stanley Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMA 02142USA

Pathway analysis,also known as gene-set enrichment analysis,is a multilocus analytic strategy that integrates a priori,biological knowledge into the statistical analysis of high-throughput genetics *** developed for the studies of gene expression data,it has become a powerful analytic procedure for indepth mining of genome-wide genetic variation *** discoveries were made in the past years,uncovering genes and biological mechanisms underlying common and complex ***,as massive amounts of diverse functional genomics data accrue,there is a pressing need for newer generations of pathway analysis methods that can utilize multiple layers of high-throughput genomics *** this review,we provide an intellectual foundation of this powerful analytic strategy,as well as an update of the state-of-the-art in recent method *** goal of this review is threefold:(1)introduce the motivation and basic steps of pathway analysis for genome-wide genetic variation data;(2)review the merits and the shortcomings of classic and newly emerging integrative pathway analysis tools;and(3)discuss remaining challenges and future directions for further method developments.

关键词： Pathway analysis Set-based association analysis Gene-set enrichment analysis Genome-wide association study Multilocus association analysis

Mapping microstructure to shock-induced temperature fields using deep learning

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npj Computational Materials 2023年第1期9卷 516-523页

作者： Chunyu Li Juan Carlos Verduzco Brian h.lee Robert J.Appleton Alejandro Strachan School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA

The response of materials to shock loading is important to planetary science,aerospace engineering,and energetic *** activated processes,including chemical reactions and phase transitions,are significantly accelerated by energy localization into *** result from the interaction of the shockwave with the materials’microstructure and are governed by complex,coupled processes,including the collapse of porosity,interfacial friction,and localized plastic *** mechanisms are not fully understood and the lack of models limits our ability to predict shock to detonation transition from chemistry and microstructure *** demonstrate that deep learning can be used to predict the resulting shock-induced temperature fields in composite materials obtained from large-scale molecular dynamics simulations with the initial microstructure as the only *** accuracy of the Microstructure-Informed Shock-induced Temperature net(MISTnet)model is higher than the current state of the art and its evaluation requires a fraction of the computation cost.

关键词： microstructure Microstructure friction

The recent advances in scaffolds for integrated periodontal regeneration

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Bioactive Materials 2021年第10期6卷 3328-3342页

作者： hyun Nyun Woo Young Joon Cho Solaiman Tarafder Chang h.lee Center for Dental and Craniofacial Research Columbia University Medical Center630 W.168 St.VC12-212New YorkNY10032USA

The periodontium is an integrated,functional unit of multiple tissues surrounding and supporting the tooth,including but not limited to cementum(CM),periodontal ligament(PDL)and alveolar bone(AB).Periodontal tissues can be destructed by chronic periodontal disease,which can lead to tooth *** support of the treatment for periodontally diseased tooth,various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration(GTR)that is the current gold standard in dental ***,various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal *** a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium,technologies for scaffold fabrication have emerged in last *** review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested in vitro and in *** and Cons of different biomaterials and design parameters implemented for periodontal tissue regeneration are also discussed,including future perspectives.

关键词： Periodontium Periodontitis Bioactive scaffold Multi-phase scaffold Periodontal regeneration

New perspectives on probiotics in health and disease

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Food Science and human Wellness 2015年第2期4卷 56-65页

作者： Eric Banan-Mwine Daliri Byong h.lee School of Biotechnology Jiangnan University1800 Lihu AvenueWuxi 214122China Department of Food Science and Biotechnology Kangwon National UniversityChuncheon 200-701South Korea Department of Food Science/Agricultural Chemistry McGill UniversitySte-Anne-de-BellevueQCCanada H9X 3V9

The gut microbiota continues to fascinate scientists in many realms when it is considered that humans contain 90%*** between changes in composition and activity of the gut microbiota and common disorders such as cancer,hypertension,hypercholesterolemia,inflammatory bowel diseases,obesity,oral health,*** been *** is the real role of probiotics,prebiotics and synbiotics in influencing a healthy microbiota?Both in vitro evidences and in vivo clinical data have supported some of these new health claims,while recent molecular advancement has provided strong indications to support and justify the ***,probiotics validity and health claims have continuously been rejected on the basis of“biomarker deficiency”.To battle the increase in health care costs,a preventive approach to medicine with the development of probiotics and prebiotics or symbiotic products is being *** review discusses the potential beneficial effects of probiotics in preventing and treating certain diseases as well as current and future perspectives of probiotic research.

关键词： rejected diseases continuously

Robust cost efficacy of a novel,validated screening test at 12–20 Weeks gestation for the prediction of preterm birth(PTB)at or before 32 Weeks in singletons

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Gynecology and Obstetrics Clinical Medicine 2021年第3期1卷 107-111页

作者： Robert h.lee Carl P.Weiner Departments of Population health University of Kansas School of MedicineUSA Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology University of Kansas School of MedicineKansas CityKS66160USA

Objective:Preterm birth(PTB)at or before 32 weeks complicates up to 2%of United States(US)births and accounts for 80%of perinatal expenditures in the first year of *** screening tests for PTB performed from 12 weeks to 19 weeks 5 days have receiver operated area under the curve(AUC)indices ofh™,a unique maternal screening test comprised of plasma cell-free RNA for the prediction of PTB≦32 weeks due to spontaneous labor(sPTB)with or without preterm premature rupture of the membranes(PPROM)or early-onset pre-eclampsia before 34 weeks(EOP).FutureBIRTh™is supported by multiple validation studies derived from 12 weeks to 19 weeks 5 days gestation achieving AUCs of 84.2%for sPTB and 94.1%for ***:Using the US rates for EOP(0.5%)and sPTB≦32 weeks(1.8%)and adjusting the US pregnancy/neonatal medical costs to US dollars(2017 value),we calculated the cost per 100,000 singletons with or without universal FutureBIRTh™testing before 19 weeks and 6 days using three detection rates and assuming screenpositive women would be treated with and respond to aspirin(assumed 80%efficacy for EOP)and vaginal progesterone(assumed 38%efficacy for sPTB).We also assessed test performance at disease incidence rates below that of the US(down to 0.46%).For considering screening costs,we assumed test costs of$750,and treatment costs of$1000 for patients over 20 weeks gestational ***:The identification and treatment of‘at-risk’pregnancies by FutureBIRTh™with existing therapies would reduce direct healthcare costs by up to$95 million per 100,000 *** projected savings were robust and achievable at each FutureBIRTh™price despite the conservative costs,efficacy,and detection rate *** incidence of PTB≦32 weeks would decline by 40%–50%with a test cost of$750 and an 80%detection ***:The accurate risk assessment provided by universal FutureBIRTh™screening coupled with existing preventative treatments could lea

关键词： Pregnancy Preterm birth Transcriptome Plasma RNA Precision medicine

Review of vortex methods for rotor aerodynamics and wake dynamics

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Advances in Aerodynamics 2022年第1期4卷 413-448页

作者： h.lee B.Sengupta M.S.Araghizadeh R.S.Myong School of Mechanical and Aerospace Engineering Gyeongsang National UniversityJinjuGyeongnam52828South Korea

Electric vertical take-off and landing(eVTOL)aircraft with multiple lifting rotors or prop-rotors have received significant attention in recent years due to their great potential for next-generation urban air mobility(UAM).Numerical models have been developed and validated as predictive tools to analyze rotor aerodynamics and wake *** various numerical approaches,the vortex method is one of the most suitable because it can provide accurate solutions with an affordable computational cost and can represent vorticity fields downstream without numerical dissipation *** paper presents a brief review of the progress of vortex methods,along with their principles,advantages,and *** of the vortex methods for modeling the rotor aerodynamics and wake dynamics are also ***,the vortex methods suffer from the problem that it cannot deal with the nonlinear aerodynamic characteristics associated with the viscous effects and the flow behaviors in the post-stall *** overcome the intrinsic drawbacks of the vortex methods,recent progress in a numerical method proposed by the authors is introduced,and model validation against experimental data is discussed in *** validation works show that nonlinear vortex lattice method(NVLM)coupled with vortex particle method(VPM)can predict the unsteady aerodynamic forces and complex evolution of the rotor wake.

关键词： Vortex methods Nonlinear vortex lattice method Viscous vortex particle method Rotor aerodynamics Wake dynamics

Unassisted overall water splitting with a solar-to-hydrogen efficiency of over 10% by coupled lead halide perovskite photoelectrodes

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Carbon Energy 2023年第1期5卷 134-143页

作者： Ryan Rhee Tae G.Kim Gyu Y.Jang Gwangmin Bae Jung h.lee Sunje lee Sungsoon Kim Seokwoo Jeon Jong h.Park Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea Department of Materials Science and Engineering KAIST Institute for The Nanocentury(KINC)Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea

hydrogen is a promising future sustainable fuel candidate with boundless *** into photoelectrochemical(PEC)water splitting based on a lead halide perovskite(LhP)has progressed significantly with the aim of more efficient solar hydrogen ***,we unite a well-known photo-absorbing LhP with cost-effective water-splitting catalysts,and we introduce two types of monolithic LhP-based PEC devices that act as a photocathode and a photoanode for the hydrogen evolution reaction and oxygen evolution reaction,leading to efficient unbiased overall water *** the integration of these two monolithic LhP-based photoelectrodes,an unbiased solar-to-hydrogen conversion efficiency of 10.64%and a photocurrent density of 8.65 mA cm^(−2) are achieved.

关键词： perovskite photoelectrochemical cell photoelectrode unassisted

Expression of micro RNAs in fibroblast of pterygium

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International Journal of Ophthalmology(English edition) 2016年第7期9卷 967-972页

作者： Joon h.lee Sun-Ah Jung Young-A Kwon Jea-Lim Chung Ungsoo Samuel Kim Myung-Gok Eye Research Institute Konyang University College of Medicine Seoul 07301 Korea Department of Ophthalmology Kim's Eye Hospital Seoul 07301 Korea Department of Ophthalmology Konyang University College of Medicine Daejeon 35356 Korea

AIM：To screen microRNAs（miRNAs） and set up target miRNAs in ***：Primary fibroblasts were isolated from pterygium and Tenon＇s capsule and *** analysis and Western blotting were performed to confirm the culture of *** all,1733 miRNAs were screened in the first step by using GeneChip miRNA3.0 *** miRNAs involved in the pathogenesis of pterygium were subsequently determined using the following criteria：1） high reproducibility in a repetitive test;2） base log value of 〉7.0 for both control and pterygial fibroblasts;and 3） log ratio of 〉1.0 between pterygial fibroblasts and control ***：Primary screening showed that 887/1733 miRNAs were up-regulated and 846/1733 miRNAs were down-regulated in pterygial fibroblasts compared with those in control *** the 1733 miRNAs screened,4 miRNAs,namely,miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p,met the above-mentioned *** screening showed that these 4 miRNAs were up-regulated in pterygial fibroblasts compared with control fibroblasts and that miRNA-143a-3p had the highest mean ratio compared with the miRNAs in control ***：miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5p and miRNA-411a-5p are up-regulated in pterygial fibroblasts compared with control fibroblasts,suggesting their involvement in the pathogenesis of pterygium.

关键词： microRNA pterygium fibroblast

An overview on development of miniature unmanned rotorcraft systems

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Frontiers of Electrical and Electronic Engineering in China 2010年第1期5卷 1-14页

作者： Guowei CAI Ben M.ChEN Tong h.lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore

In this article,we attempt to document a technical overview on modern miniature unmanned rotorcraft *** first give a brief review on the historical development of the rotorcraft unmanned aerial vehicles(UAVs),and then move on to present a fairly detailed and general overview on the hardware configuration,software integration,aerodynamic modeling and automatic flight control system involved in constructing the unmanned *** applications of the emerging technology in the military and civilian domains are also highlighted.

关键词： unmanned aerial vehicle(UAV) rotorcraft aerodynamic modeling avionic systems flight control systems

Quantum dots-labeled polymeric scaffolds for in vivo tracking of degradation and tissue formation

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Bioactive Materials 2022年第10期7卷 285-292页

作者： Kun hee Sim Seyed Mohammand Mir Sophia Jelke Solaiman Tarafder Jinho Kim Chang h.lee Regenerative Engineering Laboratory Center for Dental and Craniofacial ResearchColumbia University Irving Medical Center630 West 168th StreetVC12-211New YorkNY10032USA Department of Biomedical Engineering Stevens Institute of TechnologyHobokenNJ07030USA

The inevitable gap between in vitro and in vivo degradation rate of biomaterials has been a challenging factor in the optimal designing of scaffold’s degradation to be balanced with new tissue *** enable non-/minimum-invasive tracking of in vivo scaffold degradation,chemical modifications have been applied to label polymers with fluorescent ***,the previous approaches may have limited expandability due to complicated synthesis ***,we introduce a simple and efficient method to fluorescence labeling of polymeric scaffolds via blending with near-infrared(NIR)quantum dots(QDs),semiconductor nanocrystals with superior optical ***-labeled,3D-printed PCL scaffolds showed promising efficiency and reliability in quantitative measurement of degradation using a custom-built fiber-optic imaging ***,QDs-PCL scaffolds showed neither cytotoxicity nor secondary labeling of adjacent ***-PCL scaffolds also supported the engineering of fibrous,cartilaginous,and osteogenic tissues from mesenchymal stem/progenitor cells(MSCs).In addition,QDs-PCL enabled a distinction between newly forming tissue and the remaining mass of scaffolds through multi-channel ***,our findings suggest a simple and efficient QDs-labeling of PCL scaffolds and minimally invasive imaging modality that shows significant potential to enable in vivo tracking of scaffold degradation as well as new tissue formation.

关键词： Key terms:quantum dots Polycaprolactone Tissue engineering In vivo tracking Degradation