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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

Disaster Risk Resilience:Conceptual Evolution,Key Issues,and Opportunities

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International Journal of Disaster Risk Science 2022年第3期13卷 330-341页

作者： Marie-h.l.ne Graveline Daniel Germain Institut des Sciences de l’Environnement(ISE) Universitédu QuébecàMontréalMontréalH3C 3P8Canada Department of Geography Universitédu QuébecàMontréalMontréalH3C 3P8Canada

Resilience has become a cornerstone for risk management and disaster ***,it has evolved extensively both etymologically and conceptually in time and across scientific *** concept has been(re)shaped by the evolution of research and practice *** the opposite of vulnerability for a long time,resilience was first defined as the ability to resist,bounce back,cope with,and recover quickly from the impacts of *** avoid the possible return to conditions of vulnerability and exposure to hazards,the notions of post-disaster development,transformation,and adaptation(build back better)and anticipation,innovation,and proactivity(bounce forward)were then ***,resilience is characterized by a multitude of components and several *** present a selection of 25 components used to define resilience,and an interesting linkage emerges between these components and the dimensions of risk management(prevention,preparedness,response,and recovery),offering a perspective to strengthen resilience through the development of *** its potential,resilience is subject to challenges regarding its operationalization,effectiveness,measurement,credibility,equity,and even its ***,it offers applicability and opportunities for local communities as well as an interdisciplinary look at global challenges.

关键词： Community Disaster risk Resilience Sustainable development

Application of high silica zeolite ZSM-5 in a hybrid treatment process based on sequential adsorption and ozonation for VOCs elimination

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Journal of Environmental Sciences 2016年第3期28卷 59-68页

作者： hicham Zaitan Marie h.l.ne Manero héctor Valdés laboratoire de Chirmie de la Matiere Condensee(lCMC) Faculte des Sciences et TechniquesUniversite Sidi Mohamed Ben AbdellahB.P.2202FesMaroc Universite de Toulouse INPTUPSLaboratoire de Genie Chimique4Allee Emile MonsoF-31030 ToulouseFrance CNRS Laboratoire de Genie ChimiqueF-31030 ToulouseFrance laboratorio de Tecnologias limpias(F.Ingenieria) Universidad Catolica de la Santisima ConcepcionAlonso de Ribera 2850ConcepcionChile

In this study,a hydrophobic synthetic zeolite,namely ZSM-5 is chosen as an adsorbent/catalyst for toluene *** results showed that toluene adsorption onto ZSM-5 was favourable,following a langmuir adsorption isotherm ***-5 zeolite was regenerated using gaseous ozone at low *** toluene was oxidised,releasing mainly CO_2 and h_*** of oxidation by-products such as acetic acid and acetaldehyde were formed and remained adsorbed after the oxidativate regeneration with *** four successive cycles of adsorption/ozonation,the adsorption efficiency was not affected（92%-99%）.These results showed that volatile organic compound（VOC）removal by adsorption onto ZSM-5 zeolite followed by ozone regeneration could be used as a promising hybrid process for the control of VOC emissions in terms of efficiency.

关键词： Adsorption Ozone Toluene VOCs Zeolite

Effect of Soluble Components From Plant Aggregates on the Setting of the lime-Based Binder

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Journal of Renewable Materials 2019年第9期7卷 903-913页

作者： lepeng Wang h.l.ne lenormand hafida Zmamou Nathalie leblanc UnilaSalle Transformations&Agro-Resources Research UnitVAM²IN(EA 7519 UniLaSalle-Universitéd’Artois)3 rue du Tronquet76130 Mont-Saint-AignanFrance

Plant aggregate-based building materials are a viable solution for reducing greenhouse gas emissions and providing good thermal and acoustic *** this study,the investigated lightweight mortars require a hydraulic *** and on-site empirical observations about plant aggregate-based materials indicate a delay in setting time and a decrease in the mechanical performances of concretes based on plant *** natural origin of plant-aggregates causes a lot of variability in their *** studies have shown that the incompatibility between plant aggregates and cement is mainly caused by the dissolved and decomposed components of plant aggregates in alkaline ***,no research on the specific impact of each component on the setting time of lime-based binder *** this work,the impact of some soluble compounds(e.g.,sucrose,glucose,fructose,pectin)on the setting reaction of the lime matrix was studied using Vicat test,thermogravimetric analysis(TGA)and FT-IR *** results showed that carbohydrates such as glucose and sucrose not only affect the setting time but also have a long-term impact on the carbonation of *** measure of the setting time by Vicat test appears as a possible indicator to predict the compatibility between the matrix and plant aggregates.

关键词： Plant aggregates setting time lime-based binder carbohydrates hydration

The Sav-AQ Project:Study of Obstacles and levers Related to the Use of a Website Dedicated to Breast Cancer Patients;the Example of the Nouvelle-Aquitaine Region

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Psycho-Oncologie 2023年第3期17卷 159-166页

作者： Valérie Berger h.l.ne hoarau Florence Saillour Unitéde Recherche et d’Innovation et Soins et en Sciences humaines(URISh) CHU de BordeauxBordeaux33000France laboratoire Culture et Diffusion des Savoirs(CeDS) Universitéde BordeauxBordeaux33000France Pôle santépublique Méthodes d’évaluation en santé(UMES) CHU BordeauxBordeaux33000France ISPED Centre INSERM U1219Bordeaux Population Health–UnitéPHARes FUniversity de BordeauxBordeaux33000France

The development of digital platforms is transforming caregiver-patient interactions and the dissemination of *** information from the Internet has become a habit for many patients and must be considered by ***,understanding the use of digital tools by patients is a public health *** Sav-AQ study aims to understand patterns of use by women with breast cancer and the role of health ***-AQ is an exploratory feasibility study with a mixed design,exploring patient and healthcare experience before and after the integration of a specific website into their care *** research is based on the digital platform“My Breast Cancer network”,which was built by and for patients with breast cancer.A group of 30 breast cancer patients and six healthcare professionals using the platform were *** results show that for all users,the activity on the website decreases over *** the beginning of the course,patients were more assiduous,which can be explained by the search for elements related to an unknown care *** results also show that technical skills to use the platform are necessary for patients and must be accompanied by a health *** is of interest to devise a larger study to assessing the impact of such a platform on patient healthcare uptake and health skills development.

关键词： Breast cancer knowledge transfer interdisciplinarity digital health

Follicle-stimulating hormone(FSh)levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer

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Asian Journal of Andrology 2022年第1期24卷 21-25页

作者： Kassim Kourbanhoussen France-h.l.ne Joncas Christopher JD Wallis h.l.ne hovington Francois Dagenais Yves Fradet Chantal Guillemette louis lacombe Paul Toren Department of Surgery Faculty of MedicineUniversitéLavalCHU de Québec Research CenterOncology DivisionQuebec City G1R3S1Canada Department of Urology Vanderbilt University Medical CenterNashvilleTN 37232USA Institut Universitaire Cardiologie et Pneumologie de Québec Quebec City G1V 4G5Canada Faculty of Pharmacy UniversitéLavalCHU de Québec Research CenterQuebec City G1V 4G2Canada

Prior research suggests a link between circulating levels of follicle-stimulating hormone(FSh)and prostate cancer *** levels may also explain some of the observed differences in cardiovascular events among men treated with gonadotropin-releasing hormone(GnRh)antagonists compared to GnRh *** study evaluates the association between preoperative FSh and long-term cardiovascular and oncologic outcomes in a cohort of men with long follow-up after radical *** performed a cohort study utilizing an institutional biobank with annotated clinical *** levels were measured from cryopreserved plasma and compared with sex steroids previously measured from the same *** in oncologic outcomes between tertiles of FSh levels were compared using adjusted cox regression *** adverse cardiovascular events(MACE)were similarly assessed using hospital admission diagnostic codes.A total of 492 patients were included,with a median follow-up of 13.1(interquartile range:8.9–15.9)*** sulfate(DhEA-S)levels,but not other androgens,negatively correlated with FSh levels on linear regression analysis(P=0.03).There was no association between FSh tertile and outcomes of biochemical recurrence,time to castrate-resistant prostate cancer,or time to *** were identified in 50 patients(10.2%),with a mean time to first event of 8.8 *** association with FSh tertile and occurrence of MACE was *** results do not suggest that preoperative FSh levels are significantly associated with oncologic outcomes among prostate cancer patients treated with radical prostatectomy,nor do these levels appear to be predictors of long-term cardiovascular risk.

关键词： cardiovascular events follicle-stimulating hormone prostate cancer recurrence

Formation building and collision avoidance for a fleet of NAOs based on optical sensor with local positions and minimum communication

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Science China(Information Sciences) 2019年第5期62卷 214-236页

作者： Xiaomin WANG lorenzo BENOZZI Benoit ZERR Zexiao XIE h.l.ne ThOMAS Benoit ClEMENT Engineering college Ocean University of China

Multi-robot system has become a research hotspot because of low demand on the sensors’ accuracy, high reliability, and high efficiency. To put all the robots together, formation control is a crucial problem. In this paper, we propose a local position-based method to plan trajectories and build a pyramid pattern for a fleet of NAOs in the obstacle-free environment by refering to the position-based method and giving an O(n log n) collision avoidance strategy inspired from one graph theory, where the local positions are estimated from optical sensors. To get the local positions, an integrated image processing method is developped. Firstly a mask-base is generated to store the features of NAOs, and a cross-correlation method is introduced to recognize the NAO. Subsequently, the distance and angle models are proposed to get the local information from a single image. Then, a visual compass is introduced to obtain the orientation of one NAO. After the local information exchange by the WiFi communication, a neighbor-check method is put foward to distinguish the homogeneous NAOs(all the NAOs look like the same). Further, a common frame is constructed as an artificial global frame, and straight non-intercrossing trajectories are planned according to the O(n log n) collision avoidance strategy. At last, the performance of our proposed local position-based method is verified by the simulations with up to 15 robots and the indoor experiments with 3 NAOs in a real environment. The convergence of the method has been demonstrated in both obstacle-free and static obstacle environments.

关键词： formation building a fleet of NAOs optical sensor visual compass local positions

The value does not exist!A motivation for extremal analysis

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Probability, Uncertainty and Quantitative Risk 2022年第3期7卷 195-214页

作者： Jean-Pierre Aubin h.l.ne Frankowska Retired 14Rue Domat75005 ParisFrance CNRS IMJ-PRGSorbonne Université4Place Jussieu75252 ParisFrance

Standard mathematical economics studies the production,exchange,and consumption of goods“provided with units of measurement,”as in physics,in order to be enumerated,quantified,added,***,“baskets of goods,”which should describe subsets of goods,are mathematically represented as commodity vectors of a vector space,linear combination of units of goods,evaluated by prices,which are linear numerical ***,in this sense,mathematical economics is a branch of ***,economics,and many other domains of life sciences,investigate also what will be called entities,defining elements deprived of units of measure,which thus cannot be enumerated.(1)Denoting by X the set of entities x∈X deprived of units of measurement,a“basket of goods”is actually a subset K■X of the set entities,i.e.,an element of the“hyperset”P(X),the family of subsets of X,and no longer a commodity vector of the vector space of commodities;(2)Entities can be“gathered”instead of being“added”;(3)Entities can still be evaluated by a family of functions A:x 2 X 7!A(x)2 Rregarded as a“valuators,”in lieu and place of linear“prices”evaluating the units of economic goods.(4)Subsets of entities can be evaluated by an“interval of values”between two extremal ones,the minimum and the maximum,instead of the sum of values of units of goods weighted by their *** sciences dealing with intertwined relations among many combinations of entities,hypersets offer metaphors of“lamarckian complexity”that keeps us away from binary relations,graphs of functions,and set-valued maps,to focus our attention on“multinary relations”between families of *** deprived of units of measurement,these“proletarian”entities still enjoy enough properties for this pauperization to be mathematically *** is the object of this extremal manifesto:in economics and other domains of life sciences,vector spaces should yield their imperial status of“state space”to hypersets and linear prices to hy

关键词： Valuators Extremal topologies Transfer of topologies Confined sets Extremal evolution Inert relation Viability kernel Regulator

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Clinical impact of hepatitis B and C virus envelope glycoproteins

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World Journal of Gastroenterology 2013年第5期19卷 654-664页

作者： h.l.ne Jeulin Aurélie Velay John Murray Evelyne Schvoerer Virology laboratory Centre Hospitalier Universitaire de NancyVandoeuvre-lès-NancyF-54511France EA RhEM 4369 Universitéde LorraineF-54000 NancyFrance School of Mathematics and Statistics University of New South WalesSydneyNSW 2052Australia The Kirby Institute University of New South WalesSydneyNSW 2052Australia

Chronic infection by either hepatitis B virus(hBV)or hepatitis C virus(hCV)share epidemiological characteristics with risks for development of severe complications such as liver cirrhosis and hepatocellular *** and hCV also share a high genetic variability. Among highly variable regions,viral genes encoding surface proteins(hepatitis B surface antigen,E1/E2 hCV glycoproteins)play key roles in the stimulation of the host-related immune response and viral entry into *** segments of hBV envelope proteins(preS1,"a"determinant)are crucial in the entry process into permissive *** entry is a complex multistep process involving multiple cell cofactors (glycosaminoglycans,low density lipoprotein receptor, SR-B1,CD81,claudin-1,occludin,EGFR,EphA2)in the interaction with hCV E1/E2 envelope *** vitro both viruses can be controlled by antibody-me-diated neutralization targeting viral envelope,also essential in preventing hBV infection in vivo as observed through successful vaccination using hBs *** preventive vaccination and/or therapeutic pressure can influence hBV and hCV *** hBV,the patterns of antiviral drug resistance in chronic hepatitis are complex and the original pol/S gene overlap has to be taken into ***-induced hBV mutations in pol could indeed generate S mutants with subsequent modified antigenicity or increased cancer *** of hBV and hCV envelope proteins combining high exposure to selective pressures and crucial functional roles require investigation in the context of diagnostic,vaccination and treatment *** this editorial a synthesis is performed of hBV and hCV envelope properties at the entry step and as antigenic proteins,and the subsequent clinical impact.

关键词： hepatitis B hepatitis C Viral envelope glycoproteins Clinical outcome