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基于纤维束的空间统计学对临床表现为耳鸣病人白质完整性的分析

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国际医学放射学杂志 2016年第5期 585-586页

作者： C.W.Ryu m.S.Park j.Y.Byun G.h.jahng S.Park 郑永利 Department of Radiology Kyung Hee University Hospital at GangdongSchoolof Medicine Kyung Hee University

摘要目的应用扩散张量成像(DTI)技术分析白质束完整性与耳鸣病人不同临床变量之间的关系。方法纳入耳鸣病人67例、正常对照组39例。将耳鸣持续时间、侧别、音调、特征以及两种心理学自我分级测试结果作为独立变量。采用基于空间统计分析... 详细信息

摘要目的应用扩散张量成像(DTI)技术分析白质束完整性与耳鸣病人不同临床变量之间的关系。方法纳入耳鸣病人67例、正常对照组39例。将耳鸣持续时间、侧别、音调、特征以及两种心理学自我分级测试结果作为独立变量。采用基于空间统计分析(TBSS)方法评价耳鸣组及对照组扩散指

关键词：白质髓质病人 DTI

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex Ⅰ deficiency

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Felix Distelmaier henk-jan Visch jan A.m.Smeitink Ertan mayatepek Werner j.h.Koopman Peter h.G.m.Willems

malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative *** work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ROS） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]C;[Ca2+]m) and ATP（[ATP]C;[ATP]m） ***,we determined the mitochondrial membrane potential（Aw） in patient skin fibroblasts and show significant correlations with cellular ROS levels and ERCa,i.e.,the less negative Aw,the higher these levels and the lower *** with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized △Ψ and Bk-induced increases in[Ca2+]mand[ATP]*** effects were accompanied by an increase in ERCaand Bkinduced increase in[Ca2+]***,these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress mitochondrial membrane potential Endoplasmic reticulum Ca2+ content mitochondrial disease Antioxidant human skin fibroblasts

奥利司他联合二甲双胍治疗对肥胖型PCOS患者体质量、糖脂代谢及诱导排卵妊娠结局的影响

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实用妇产科杂志 2022年第3期38卷 218-222页

作者：郭丽娜王楠吕翠婷贾新转董翠河北医科大学第四医院生殖医学科河北石家庄050011

目的:探讨奥利司他联合二甲双胍治疗对肥胖型多囊卵巢综合征(PCOS)患者体质量、糖脂代谢及诱导排卵妊娠结局的影响。方法:对2018年6月至2019年12月于河北医科大学第四医院生殖医学科就诊的110例肥胖型[体质量指数(BmI)≥28 kg/m^(2)]PCO... 详细信息

目的:探讨奥利司他联合二甲双胍治疗对肥胖型多囊卵巢综合征(PCOS)患者体质量、糖脂代谢及诱导排卵妊娠结局的影响。方法:对2018年6月至2019年12月于河北医科大学第四医院生殖医学科就诊的110例肥胖型[体质量指数(BmI)≥28 kg/m^(2)]PCOS不孕患者的临床资料进行回顾性分析,根据临床用药情况分为二甲双胍组60例,采用二甲双胍联合生活方式干预治疗;奥利司他+二甲双胍组50例,在二甲双胍组治疗基础上同时口服奥利司他。两组治疗3个月后行诱导排卵指导性生活或人工授精助孕。评估两组治疗前后体质量、糖脂代谢指标变化及诱导排卵妊娠结局。结果:①治疗后两组体质量及BmI均较治疗前明显降低,奥利司他+二甲双胍组下降幅度高于二甲双胍组,差异有统计学意义(Ph)、性激素结合球蛋白(ShBG)较治疗前升高,黄体生成素(Lh)、雌二醇(E_(2))、雄烯二酮(A_(2))、硫酸脱氢表雄酮(DhEAS)、睾酮(T)较治疗前降低,变化幅度组间比较差异均无统计学意义(P>0.05)。③治疗后空腹血糖、空腹胰岛素、口服75 g葡萄糖后2小时血糖、2小时胰岛素、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)均较治疗前降低,高密度脂蛋白(hDL-C)较治疗前升高,奥利司他+二甲双胍组TG、TC、hDL-C变化幅度高于二甲双胍组,差异有统计学意义(P0.05)。结论:奥利司他联合二甲双胍治疗可以更好改善肥胖型PCOS患者体质量、血脂代谢;但诱导排卵累积妊娠率与单用二甲双胍组差异不明显,尚需进一步研究。

关键词：多囊卵巢综合征肥胖奥利司他二甲双胍诱导排卵

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采用3D影像融合CT全肝容积灌注成像提高肝转移瘤的检出和特征显示

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国际医学放射学杂志 2008年第A6期31卷 527-528页

作者： m.R.meijerink j.h.T.m.van Waesberghe L.van der Weide P.van den Tol S.meijer C.van Kuijk 胡涛 Department of Radiology Vrije Universiteit Medical Center (VUMC) De Boelelaan 1117 1081HV Amsterdam The Netherlands.

评价CT全肝容积灌注技术对肝转移瘤的检出及显示转移瘤特征的可行性。对20例病人进行平扫及静脉注射对比剂后的11次全肝容积螺旋CT扫描。

关键词：灌注 CT 肝转移瘤

维普期刊数据库

Inequalities and Separation for a Biharmonic Laplace-Beltrami Differential Operator in a hilbert Space Associated with the Existence and Uniqueness Theorem

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journal of Partial Differential Equations 2016年第1期29卷 59-70页

作者： ZAYED E. m. E. Department of mathematics Faculty of Science Zagazig University P.O. Box 44519 Zagazig Egypt.

In this paper, we have studied the separation for the biharmonic Laplace-Beltrami differential operatorAu（x） = -△△u（x）＋ V（x）u（x）,for all x ∈ R^n, in the hilbert space h = L2（R^n,h1） with the operator potential V（x） ∈ C^1 （R^n, L （h1））, where L （h1 ） is the space of all bounded linear operators on the hilbert space h1, while AAu is the biharmonic differential operator and△u=-∑i,j=1^n 1/√detg δ/δxi[√detgg-1（x）δu/δxj]is the Laplace-Beltrami differential operator in R^n. here g（x） = （gij（x）） is the Riemannian matrix, while g^-1 （x） is the inverse of the matrix g（x）. moreover, we have studied the existence and uniqueness Theorem for the solution of the non-homogeneous biharmonic Laplace-Beltrami differential equation Au = - △△u ＋ V（x） u （x） = f（x） in the hilbert space h where f（x） ∈ h as an application of the separation approach.

关键词： Separation biharmonic Laplace-Beltrami operator operator potential hilbert space L2 (R^n, h1) coercive estimate existence and uniqueness Theorem.

Raman spectra of fine-grained materials from first principles

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npj Computational materials 2020年第1期6卷 616-622页

作者： maxim N.Popov jürgen Spitaler Vignaswaran K.Veerapandiyan Eric Bousquet jiri hlinka marco Deluca materials Center Leoben(mCL)Forschung Gmbh Roseggerstrasse 12A-8700 LeobenAustria Physique Théorique des matériaux QMATCESAMUniversite de LiègeB-4000 Sart-TilmanBelgium Institute of Physics Academy of Sciences of the Czech RepublicNa Slovance 218221 PragueCzech Republic

Raman spectroscopy is an advantageous method for studying the local structure of materials,but the interpretation of measured spectra is complicated by the presence of oblique phonons in polycrystals of polar *** group theory considerations and standard ab initio calculations are helpful,they are often valid only for single *** this paper,we introduce a method for computing Raman spectra of polycrystalline materials from first principles.

关键词： materials spectra principles

双能CT量化肝细胞外体积：预测肝硬化中肝脏相关事件的效能

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国际医学放射学杂志 2020年第6期 749-749页

作者：王慧慧 S.Bak j.E.Kim K.Bae j.m.Cho h.C.Choi m.j.Park Department of Radiology Gyeongsang National University College of Medicine and Gyeongsang National University Hospital

摘要目的探究双能CT(DECT)量化肝细胞外体积分数(f ECV)可否预测肝硬化病人的肝脏相关事件(LRE)。方法本研究回顾性纳入305例肝硬化病人,这些病人均接受了

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The Glucosinolate Biosynthetic Gene A OP2 mediates Feed-back Regulation of jasmonic Acid Signaling in Arabidopsis

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molecular Plant 2015年第8期8卷 1201-1212页

作者： meike Burow Susanna Atwell marta Francisco Rachel E. Kerwin Barbara A. halkier Daniel j. Kliebenstein Dynamo Center of Excellence Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Copenhagen Plant Science Centre Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Department of Plant Sciences University of California at Davis Davis CA 95616 USA mision Biologica de Galicia (MBG-CSIC) PO Box 28 36080 Pontevedra Spain

Survival in changing and challenging environments requires an organism to efficiently obtain and use its resources. Due to their sessile nature, it is particularly critical for plants to dynamically optimize their meta- bolism. In plant primary metabolism, metabolic fine-tuning involves feed-back mechanisms whereby the output of a pathway controls its input to generate a precise and robust response to environmental changes. By contrast, few studies have addressed the potential for feed-back regulation of secondary metabolism. In Arabidopsis, accumulation of the defense compounds glucosinolates has previously been linked to genetic variation in the glucosinolate biosynthetic gene AOP2. AOP2 expression can increase the transcript levels of two known regulators （mYB28 and mYB29） of the pathway, suggesting thatAOP2 plays a role in positive feed-back regulation controlling glucosinolate biosynthesis. We generated mutants affecting AOP2, mYB28/29, or both. Transcriptome analysis of these mutants identified a so far unrecognized link between AOP2 and jasmonic acid （jA） signaling independent of mYB28 and mYB29. Thus, AOP2 is part of a regulatory feed-back loop linking glucosinolate biosynthesis and jA signaling and thereby allows the glucosinolate pathway to influence jA sensitivity. The discovery of this regulatory feed-back loop provides insight into how plants optimize the use of resources for defensive metabolites.

关键词： feed-back regulation jasmonates jA signaling glucosinolates Arabidopsis

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Felix Distelmaier henk-jan Visch jan A.m.Smeitink Ertan mayatepek Werner j.h.Koopman Peter h.G.m.Willems

malfunction of mitochondrial complex I caused by nuclear gene mutations causes early-onset neurodegenerative diseases. Previous work using cultured fibroblasts of complex-I-deficient patients revealed elevated levels of reactive oxygen species（ros） and reductions in both total Ca2+content of the endoplasmic reticulum(ERCa) and bradykinin（Bk）-induced increases in cytosolic and mitochondrial free Ca2+([Ca2+]c; [Ca2+]m) and ATP（[ATP]C; [ATP]m） concentration. here, we determined the mitochondrial membrane potential（Δψ） in patient skin fibroblasts and show significant correlations with cellular ros levels and ERCa, i.e., the less negative Δψ, the higher these levels and the lower ERCa. Treatment with 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid（Trolox） normalized Δψ and Bk-induced increases in [Ca2+]mand [ATP]m. these effects were accompanied by an increase in ERCaand Bkinduced increase in [Ca2+]c. together, these results provide evidence for an integral role of increased ROS levels in complex I deficiency and point to the potential therapeutic value of antioxidant treatment.

关键词： Reactive oxygen species Oxidative stress mitochondrial membrane potential Endoplasmic reticulum Ca2+ content mitochondrial disease Antioxidant human skin fibroblasts