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Genetic Analysis of Earliness Traits in Short Season Cotton (Gossypium hirsutum L.)

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journal of Integrative Agriculture 2012年第12期11卷 1968-1975页

作者： SONG Mei-zhen FAN Shu-li yuan Ri-hong PANG Chao-you YU Shu-xun Cotton Research Institute Chinese Academy of Agricultural Sciences/State Key Laboratory of Cotton Biology Ministry of Science and Technology

Inheritance and interrelationship of phenotype and genotype of earliness traits were evaluated in a diallel analysis involving six early-maturing parents. Date of first square （DFS）, date of first flower （DFF）, date of first open boll （DFOB）, number of node first sympodial branch （NNFSB）, and harvested rate before frost （hRBF） as earliness traits of six parents, 15 F1 hybrids and 15 F2 progenies were investigated from 2005 to 2008. The experiment design was a randomized complete block design with three replications. Additive, dominance and epistasis effects were analyzed with ADAA （additive- dominance-epistasis） model. hRBF, DFF, and DFOB showed significant additive genetic variances. heritability estimates ranged from 0.088 （hN, narrow sense） and 0.416 （hNE, environment interaction） for hRBF, to 0.103 （hN） and 0.524 （hNE） for DFF, and to 0.187 （hN） and 0.519 （h~） for DFOB. Dominance genetic effects for DFS, DFF, DFOB, and NNSFB were stronger than additive effects. Additive-by-additive epistatic effects for DFS, DFOB, and NNSFB were detected and affected by environment. Correlation analysis showed generally that hRBF had a significant negative genetic and phenotypic correlation with DFS, DFOB, and NNFSB; DFS had significant positive genetic and phenotypic correlations with DFF, DFOB, and NNFSB; significant positive genetic and phenotypic correlations were also detected between DFF and DFOB, DFF and NNFSB, DFOB and NNFSB. The results showed that the lower the node to the first fruiting branch and the shorter the plant, the earlier was the onset of squaring, flowering, and boll opening, the higher was the harvest rate before frost. heredity of earliness traits among parents and their hybrids were also detected and parents A1, A2, Bl, B2, and B3 could be used to improve earliness traits of short season cotton cultivars.

关键词： cotton earliness traits inheritance additive effect dominant effect additive-by-additive effect

马钱苷元对白血病细胞增殖及CDC20/MAD2表达的影响

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时珍国医国药 2024年第9期35卷 2058-2061页

作者：张月明罗雅琴张玉梅丁继元王敬毅山东中医药大学第一临床医学院山东济南250000 山东中医药大学附属医院山东济南250000 山东中医药大学中医学院山东济南250000

目的探讨马钱苷元对人急性髓系白血病MOLM-13细胞增殖过程中Cdc20及Mad2的影响。方法不同浓度马钱苷元处理MOLM-13细胞24、48、72 h后CCK-8法检测细胞增殖情况;流式细胞术检测不同浓度马钱苷元作用于MOLM-13细胞24h后细胞周期及凋亡的变... 详细信息

目的探讨马钱苷元对人急性髓系白血病MOLM-13细胞增殖过程中Cdc20及Mad2的影响。方法不同浓度马钱苷元处理MOLM-13细胞24、48、72 h后CCK-8法检测细胞增殖情况;流式细胞术检测不同浓度马钱苷元作用于MOLM-13细胞24h后细胞周期及凋亡的变化;Western blot检测不同浓度马钱苷元作用于MOLM-13细胞48h后Mad2和Cdc20蛋白表达情况。结果马钱苷元能显著抑制MOLM-13细胞增殖,促进MOLM-13细胞凋亡,细胞周期阻滞于G2/M期,Mad2和Cdc20蛋白表达水平均降低。结论马钱苷元对人急性髓系白血Molm细胞增殖具有较明显的抑制作用,其机制可能与调节Mad2和Cdc20的蛋白表达水平,影响细胞有丝分裂有关。

关键词：马钱苷元急性髓系白血病 Cdc20 Mad2 有丝分裂

Molecular evolution of Na^(+) channels in teleost fishes

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Integrative Zoology 2009年第1期4卷 64-74页

作者： harold h.ZAKON Manda C.jOST Derrick j.ZWICKL Ying LU David M.hILLIS Section of Neurobiology Section of Integrative Biology The University of TexasAustinTXUSA

Voltage-dependent sodium channels are critical for electrical *** possess a single sodium channel gene;two rounds of genome duplication early in vertebrates increased the number to *** the teleost-tetrapod split,independent gene duplications in each lineage have further increased the number of sodium channel genes to 10 in tetrapods and 8 in *** we review how the occurrence of multiple sodium channel paralogs has influenced the evolutionary history of three groups of fishes:pufferfish,gymnotiform and mor-myriform electric ***(tetraodontidae)produce a neurotoxin,tetrodotoxin,that binds to and blocks the pore of sodium *** evolved resistance to their own toxins by amino acid substitutions in the pore of their sodium *** substitutions had to occur in parallel across multiple paralogs for organismal re-sistance to *** and mormyriform fishes independently evolved electric organs to generate elec-tricity for communication and object *** sodium channel genes are expressed in muscle in most *** both groups of weakly electric fishes,one gene lost its expression in muscle and became compartmen-talized in the evolutionary novel electric organ,which is a muscle *** gene then evolved at elevated rates,whereas the gene that is still expressed in muscle does not show elevated rates of *** the electric organ-expressing gene,amino acid substitutions occur in parts of the channel involved in determining how long the channel will be open or *** enhanced rate of sequence evolution of this gene likely underlies the spe-cies-level variations in the electric signal.

关键词： electric fish molecular evolution pufferfish sodium channels tetrodotoxin.

Source-specific risk assessment for cadmium in wheat and maize:Towards an enrichment model for China

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journal of Environmental Sciences 2023年第3期125卷 723-734页

作者： Zhong Zhuang Qiqi Wang Siyu huang Andrea Giovanna NinoSavala Yanan Wan huafen Li Andreas h.Schweiger Andreas Fangmeier jürgen Franzaring Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation Key Laboratory of Plant-Soil Interactions of the Ministry of EducationCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001China Institute of Landscape and Plant Ecology University of Hohenheim70599 StuttgartGermany

Cadmium (Cd) pollution of agricultural soil is of public concern due to its high potential toxicity and *** study aimed to reveal the risk of Cd accumulation in soil and wheat/maize systems,with a specific focus on the source-specific ecological risk,human health risk and Cd enrichment *** this we investigated more than 6100 paired soil and grain samples with 216 datasets including soil Cd contents,soil ph and grain Cd contents of 85 sites from *** results showed that mining activities,sewage irrigation,industrial activities and agricultural practices were the critical factors causing Cd accumulation in wheat and maize cultivated ***,mining activities contributed to a higher Cd accumulation risk in the southwest China and Middle Yellow River regions;sewage irrigation influenced the Cd accumulation in the North China *** addition,the investigated sites were classified into different categories by comparing their soil and grain Cd contents with the Chinese soil screening values and food safety values,*** enrichment models were developed to predict the Cd levels in wheat and maize *** results showed that the models exhibited a good performance for predicting the grain Cd contents among safe and warning sites of wheat (R2=0.61 and 0.72,respectively);while the well-fitted model for maize was prone to the overestimated sites (R2=0.77).This study will provide national viewpoints for the risk assessments and prediction of Cd accumulation in soil and wheat/maize systems.

关键词： Ecological risk Enrichment models Cadmium health risk assessment Pollution sources

The Synthesis of 1-Aryl-5-Fluorouracil

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Chinese Chemical Letters 2000年第10期11卷 865-866页

作者： jin Zong YOU Shao yuan ChEN Omar IShRUD Yan Guang WANG Yao Zu ChEN Department of Chemistry Zhejiang UniversityHangzhou 310027 National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhou 730000

A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. h-1-NMR. M... 详细信息

关键词： synthesis 1-aryl-5-fluorouracil

Intercalation,Cytotoxicity,and Molecular Modeling of Acenaphtho[1,2-b]pyrrole Chromophores as a New Family of Antitumor Agents

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Chemical Research in Chinese Universities 2008年第4期24卷 449-453页

作者： ZhANG Zhi-chao ZhANG jing yuan Chun-li WU Gui-ye QIAN Xu-hong State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China School of Environmental and Biological Science and Technology Dalian University of Technology Dalian 116024 P. R. China The First Clinic hospital Jilin University Changchun 130021 P. R. China State Key Laboratory of Natural and Biomimetic Drugs Beijing 100083 P. R. China Shanghai Key Laboratory of Chemical Biology East China University of Science and Technology Shanghai 200237 P. R. China

To explore new platform for DNA intercalation and potent antitumor agent, a series of 8-oxo-8h- acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters chromophores has been studied. Their intercalation geometries with DNA were rex;ealed through absorption titration, SYBR Green-DNA melt curve, circular dichroism（CD）, and docking studies. It was identified that some of the compounds could intercalate into DNA along their long axis parallel to the base-pair long axis, making right-handed B form DNA transform to A-like conformation. Their binding potency varied with the different steric hindrance. Their cytotoxicity（IC50） against MCF-7 cells was found to range between 1.3 to 40.9 umol/L by MTT assay. Interestingly, the IC50 values did not show any obvious correlation to their binding constants with DNA. The chromophore with a carboxyl group exhibited the most potency of intercalating DNA and could be the promising precursor for the future intercalator for DNA, while the bromide demonstrated the highest cytotoxic activity in this series of compounds.

关键词： Intercalation Cytotoxicity 8-Oxo-Sh-acenaphtho[1,2-b]pyrrole-9-carboxylic acid esters

Synthesis of C—N Axial Chirality N-Arylindoles via Pd(II)-Catalyzed Free Amine-Directed Atroposelective C—h Olefination

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Chinese journal of Chemistry 2023年第21期41卷 2788-2792页

作者： Lei Wang Wen-Kui yuan Zhen-Kai Wang jun Luo Tao Zhou Bing-Feng Shi Center of Chemistry for Frontier Technologies Department of ChemistryZhejiang UniversityHangzhouZhejiang310027 China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhouHenan450001 China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan453007 China

Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or ***,we report the direct synthesis of C—N axially chiral N-arylindoles through a Pd-catalyzed free amine-directed atroposelective C—h olefination enabled by a spiro phosphoric acid(SPA)ligand.A wide range of enantioenriched N-aromatic amine indoles were obtained in high yields with good enantioselectivities(35 examples,up to 91%yield and up to 96%ee).The chiral products with free amine group offer an effective functional handle for down-stream diversity-oriented synthesis.

关键词： C-N axial chirality Free amine-directed C-h activation Chiral spiro phosphoric acids Palladium Olefination Asymmetric synthesis

Selectively converting CO_(2) to hCOOh on Cu-alloys integrated in hematite-driven artificial photosynthetic cells

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journal of Energy Chemistry 2023年第4期79卷 601-610页

作者： jiwu Zhao Liang huang Lan Xue Zhenjie Niu Zizhong Zhang Zhengxin Ding Rusheng yuan Xu Lu jinlin Long State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350116FujianChina Clean Combustion Research Center(CCRC) Division of Physical Sciences and EngineeringKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

The integration of electrochemical CO_(2)reduction(CO_(2)RR) and photoelectrochemical water oxidation offers a sustainable access to valuable chemicals and fuels. here, we develop a rapidly annealed hematite photoanode with a photocurrent density of 2.83 mA cm^(-2)at 1.7 VRhEto drive the full-reaction. We also present Cu-alloys electrocatalysis extended from CuInSnS4, which are superior in both activity and selectivity for CO_(2)RR. Specifically, the screened CuInSn achieves a CO_(2)to hCOOh Faradaic efficiency of 93% at a cell voltage of-2.0 V by assembling into artificial photosynthesis cell. The stability test of IT exhibits less than 3% degradation over 24 h. Furthermore, in-situ Raman spectroscopy reveals that both CO_(3)^(-2)and CO_(2)are involved in CO_(2)RR as reactants. The preferential affinity of C for h in the ^(*)hCO_(2)intermediate enables an improved hCOOh-selectivity, highlighting the role of multifunctional Cu in reducing the cell voltage and enhancing the photocurrent density.

关键词： CO_(2)reduction Rapid annealing Fe_(2)O_(3)photoanode CuInSnS_(4) In-situ spectroscopy

Recurrent cyclops lesion after primary anterior cruciate ligament reconstruction using bone tendon bone allograft:A case report

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World journal of Orthopedics 2023年第11期14卷 836-842页

作者： Grayson Kelmer Andrea h johnson justin j Turcotte Daniel E Redziniak Orthopedic Research Anne Arundel Medical CenterAnnapolisMD 21401United States Medical School Campbell University School of Osteopathic MedicineLillingtonNC 27546United States Orthopedic Surgery Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Cyclops lesions are a known complication of anterior cruciate ligament(ACL)reconstruction,with symptomatic cyclops syndrome occurring in up to 11%of *** cyclops lesions have been rarely documented;this case study documents the successful treatment of a recurrent cyclops *** SUMMARY A 28-year-old female presented following a non-contact injury to the right *** and clinical exam revealed an ACL tear,and arthroscopic reconstruction was *** years later a cyclops lesion was discovered and removed via arthroscopic *** months postoperatively,the patient presented with pain,stiffness,and difficulty achieving terminal extension.A smaller recurrent cyclops lesion was diagnosed,and a repeat synovectomy was *** patient recovered *** To the best of our knowledge,this is the first documented case of recurrent cyclops lesion after bone-patellar tendon-bone allograft ACL reconstruction presenting as cyclops syndrome.

关键词： Anterior cruciate ligament Cyclops lesion Cyclops syndrome Knee arthroscopy Anterior cruciate ligament reconstruction Case report