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Progress of machine learning in geosciences:Preface

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Geoscience Frontiers 2016年第1期7卷 1-2页

作者： Amir h.Alavi Amir h.Gandomi David J.Lary Department of Civil and Environmental Engineering Michigan State University BEACON Center for the Study of Evolution in Action Michigan State University hanson Center for Space Science University of Texas at Dallas

in the past two decades, artificial intelligence （Ai） algorithms have proved to be promising tools for solving several tough scientific problems, As a broad subfield of Ai, machine learning is concerned with algorithms and tech.iques that allow computers to ＂learn＂. The machine learning approach covers main domains such as data mining, difficult-to-program applications, and soft- ware applications. it is a collection of a variety of algorithms that can provide multivariate, nonlinear, nonparametric regression or classification. The remarkable simulation capabilities of the ma- chine learning-based methods have resulted in th.ir extensive ap- plications in science and engineering. Recently, the machine learning tech.iques have found many applications in the geoscien- ces and remote sensing. More specifically, these tech.iques are proved to be practical for cases where the system＇s deterministic model is computationally expensive or there is no deterministic model to solve the problem （Lary, 2010）.

关键词： Progress of machine learning in geosciences BPNN

霉酚酸酯对高糖培养下人肾小球系膜细胞MCP-1和FN表达的影响

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细胞与分子免疫学杂志 2012年第5期28卷 455-457页

作者：陈芬琴王秋月魏国柱马小羽马东蔚邓娓娓孙文波中国医科大学附属第一医院老年病干诊科中国医科大学附属第一医院内分泌科辽宁沈阳110001 沈阳市骨科医院放射线科辽宁沈阳110044

目的:探讨高糖以及霉酚酸酯(MMF)对人肾小球系膜细胞(hMCs)单核细胞趋化蛋白-1(MCP-1)和纤维连接蛋白(FN)表达的影响。方法:将培养的hMCs分为正常对照组(5 mmol/L葡萄糖);高糖组(30 mmol/L葡萄糖);甘露醇渗透压对照组(5 mmol/L葡萄糖+25... 详细信息

目的:探讨高糖以及霉酚酸酯(MMF)对人肾小球系膜细胞(hMCs)单核细胞趋化蛋白-1(MCP-1)和纤维连接蛋白(FN)表达的影响。方法:将培养的hMCs分为正常对照组(5 mmol/L葡萄糖);高糖组(30 mmol/L葡萄糖);甘露醇渗透压对照组(5 mmol/L葡萄糖+25 mmol/L甘露醇);高糖+MMF-10组(30 mmol/L葡萄糖+10μg/mL MMF);高糖+MMF-100组(30 mmol/L葡萄糖+100μg/mL MMF),采用RT-PCR检测每组不同时间点(24、48、72 h)MCP-1 mRNA的表达,ELiSA法检测培养上清液MCP-1及FN蛋白的表达。结果:高糖组hMCs MCP-1 mRNA、蛋白的表达及FN的分泌较正常对照组显著增加(Ph表达最高;不同浓度的MMF均能下调MCP-1 mRNA、蛋白及FN的表达(P<0.01);不同浓度的MMF对MCP-1 mRNA、蛋白的表达及FN分泌的抑制程度不同,呈时间剂量依赖性(P<0.05)。结论:MMF可以阻抑MCP-1的表达及FN的分泌,可能对延缓肾小球硬化及间质纤维化有一定作用。

关键词：人肾小球系膜细胞单核细胞趋化蛋白-1 霉酚酸酯纤维连接蛋白

Performance study of a complex thermal barrier functional coating with an electro-spark deposited burn-resistant layer

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China Welding 2019年第2期28卷 24-28页

作者： Wang Ruijun Xu Tianyang ma Xiaobin Luo Zhiheng Chinese Academy of Agricultural Mechanization Sciences Beijing 100083China

it is necessary to develop burn-resistant and thermal barrier complex functional coatings on the titanium alloys surface due to the poor high temperature performance for titanium materials and the problem of“titanium fire”which.is easily *** Aero Engines Gmbh has developed a complex functional coating which has great performance of burn resistant and sealing,the coatings has already been applied on compressor blades and casing for aero-engines and showed great *** this study,the complex functional coating which.is composed of an electro-spark deposited amorphous Ti40Zr25Ni3 burn-resistant layer and a high-energy plasma spraying prepared YSZ thermal barrier layer was prepared on titanium alloys *** the heat insulation ability,burn resistant performance and the bonding strength were *** experimental results showed that the interface between the coating and the matrix was typical metallurgical bonded,and the average bonding strength was 36.335 MPa;when the temperature of the flame on the one side of the specimen reached 600℃,the average insulated temperature of the coating samples was 70.67℃;when the flame temperature was 350℃,the titanium samples without the complex functional coatings were burned,while the samples with the coating showed great performance of burn resistant even when the temperature was 750℃.This indicates that the new functional coating has good heat-insulating and burn-resistant performance.

关键词： complex functional coatings burn resistance heat insulation

Degradation of Microcystin-RR by Combination of UV/h_2O_2 Tech.ique

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Chinese Chemical Letters 2005年第9期16卷 1271-1274页

作者： Rui Ping QiAO Yong Min ma Xin hua Qi Nan Li Xiang Can JiN Qi Shan WANG Yuan Yi ZhUANG College of Environmental Science and Engineering Nankai University Tianjin 300071 2Centers of Disease Control and Prevention of Tianjin Tianjin 300011 Centers of Disease Control and Prevention of Tianjin Tianjin 300011 Chinese Research Academy of Environmental Sciences Beijing 100012

The experiments were performed to investigate the degradation of microcystins in order to assess the effectiveness and feasibility of UV/h2O2 system for the disinfection of water polluted by microcystins. The influence factors such as h2O2, ph and UV light intensities were investigated respectively. Degradation of microcystin-RR （MC-RR） could be fitted by either the pseudo-first-order or second-order rate equations. This homogenous system could significantly enhance the degradation rate due to the synergetic effect between UV and h2O2. The degradation mainly followed the mechanism of direct photolysis and .Oh oxidation reactions. Experimental results showed that 94.83% of MC-RR was removed under optimal experimental conditions and the UV/h2O2 system provided an alternative to promote the removal of microcystins in drinking water supplies.

关键词： Microcystin-RR degradation kinetics UV/h2O2 photo-oxidation

Design and Synthesis of 3-Substituedmethylenethiochroman-4-ones as Anticancer Agents

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Chemical Research.in Chinese Universities 2011年第5期27卷 787-791页

作者： ma Zheng-yue ZhANG Xing-hua Li Chun-na ZhENG Ya-jun YANG Geng-liang WANG Shi-kui hE Yang Key Laboratory for Pharmaceutical Quality Control of hebei Province College of Pharmaceutical Sciences Hebei University Baoding 071002 P R. China

A series of 3-substituedmethylenethiochroman-4-ones was designed and synthesized, and th.ir structures were confirmed by 1h NMR, 13C NMR, MS, iR, UV and elemental analysis. The results of th.ir anticancer activity studies show that almost all 3-chloromethylenethiochroman-4-ones exhibit high anticancer activities and th.ir activities are all better than reference cisplatin. Th.ir iC50 against cancer cells is in a range of 0.80―9.17 μg/mL. Thus they could be promising candidates for anticancer drugs. however, compound 5 has no activity against cancer cells, thus chloromethylene at the 3 position of thiochroman-4-ones seems to play an important role in observed anticancer activities.

关键词： Anticancer activity 3-Chloromethylene Thiochromanone

抑郁在老年人慢性病共病和睡眠时长之间的中介效应研究

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现代预防医学 2024年第19期51卷 3583-3587+3593页

作者：于晴李雪莹官为民苏文钰葛怀举董士红马桂峰刘建明山东第二医科大学公共卫生学院山东第二医科大学基础医学院

目的探讨抑郁在老年人慢性病共病和睡眠时长间的中介作用。方法采用2018年中国健康与养老追踪调查追访数据，选取60岁及以上老年人样本共8 187例，采用流调中心抑郁水平评定量表(CES-D 10)测量抑郁状况，PROCESS 4.0程序检验抑郁在慢... 详细信息

目的探讨抑郁在老年人慢性病共病和睡眠时长间的中介作用。方法采用2018年中国健康与养老追踪调查追访数据，选取60岁及以上老年人样本共8 187例，采用流调中心抑郁水平评定量表(CES-D 10)测量抑郁状况，PROCESS 4.0程序检验抑郁在慢性病共病与睡眠时长间的中介效应，bootstrap法进行中介变量验证。结果老年人抑郁症状检出3 109例，检出率为37.97%，慢性病共病患者5 270例，占64.37%，睡眠时长小于6 h者3 045例，占37.19%。老年人慢性病共病与抑郁间呈正相关关系(r=0.21,P<0.01)，慢性病共病和抑郁均与睡眠时长呈负相关关系(r=-0.13、-0.27,P<0.01)。回归结果表示，慢性病共病情况和抑郁得分均对睡眠时长有影响(β=-0.31、-0.08,P<0.001)。慢性病共病对睡眠时长的总效应值为-0.52，直接效应值为-0.31，抑郁对睡眠时长的中介效应值为-0.21，占总效应的40.38%。结论老年人睡眠时长不足问题不容忽视，慢性病共病、抑郁均是影响老年人睡眠时长的重要因素，抑郁在老年人慢性病共病与睡眠时长间起部分中介作用。

关键词：老年人睡眠时长慢性病共病抑郁症状中介效应

黄精多糖酶辅助法提取工艺优化及活性分析研究

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中国酿造 2024年第6期43卷 245-251页

作者：古丽扎旦姆·达吾提刘晓风杨家珺马文锦张魁李军魏孔斌吕志刚兰州理工大学生命科学与工程学院甘肃兰州730050 陇东学院甘肃省陇东生物资源保护利用与生态修复重点实验室甘肃庆阳745000 兰州十百农业生物科技有限公司甘肃兰州730050 兰州市七里河区农业产业化办公室甘肃兰州730050 兰州市七里河区农业技术推广站甘肃兰州730050

该试验以黄精为原材料,采用酶辅助法提取黄精多糖,通过单因素及正交试验优化提取工艺,通过透析获得不同截留分子质量黄精多糖片段进行吸湿保湿性试验,并考察最佳保湿片段的抗氧化能力及结构表征分析。结果表明,在复合酶添加量6%、酶解时... 详细信息

该试验以黄精为原材料,采用酶辅助法提取黄精多糖,通过单因素及正交试验优化提取工艺,通过透析获得不同截留分子质量黄精多糖片段进行吸湿保湿性试验,并考察最佳保湿片段的抗氧化能力及结构表征分析。结果表明,在复合酶添加量6%、酶解时间90 min、酶解温度50℃、料液比1∶30(g∶mL)的条件下,黄精多糖得率达到24.18%。当黄精多糖分子质量>8 000 Da时,其保湿性能最佳;当黄精多糖最佳保湿片段质量浓度为6 mg/mL时,对1,1-二苯基-2-三硝基苯肼(DPPh)、2,2’-联氮-双-3-乙基苯并噻唑啉-6-磺酸(ABTS)、羟基自由基的清除率分别为50.54%、48.65%、26.41%,具有一定的抗氧化活性;同时发现,最佳保湿片段表面基本平滑,呈不规则的薄片且分子间存在-Oh、C-h、C=O等官能团。

关键词：黄精多糖工艺优化吸湿保湿性抗氧化活性结构表征

粗糙脉孢菌固态发酵产β-胡萝卜素及对蛋鸡饲喂的影响

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应用与环境生物学报 2024年第3期30卷 600-606页

作者：何跃田雪平马艳丽姬高升刘杨许力山康宇王新惠吴红雷珂田彬刘元兴闫志英成都大学食品与生物工程学院成都610106 中国科学院环境与应用微生物重点实验室环境微生物四川省重点实验室中国科学院成都生物研究所成都610041 乐山市乐其业商贸有限公司乐山614000 西安工程大学环境与化学工程学院西安710600 四川瑞象农业科技发展有限公司眉山620000

粗糙脉孢菌(Neurospora crassa)能够利用农产品副产物为原料经固态发酵产生β-胡萝卜素并应用于动物饲料中,然而目前缺乏其发酵产物的动物饲喂评价研究.通过单因素和正交试验对粗糙脉孢菌发酵豆渣过程的参数进行优化,并根据最优发酵条... 详细信息

粗糙脉孢菌(Neurospora crassa)能够利用农产品副产物为原料经固态发酵产生β-胡萝卜素并应用于动物饲料中,然而目前缺乏其发酵产物的动物饲喂评价研究.通过单因素和正交试验对粗糙脉孢菌发酵豆渣过程的参数进行优化,并根据最优发酵条件进行浅盘放大试验,最后直接利用发酵物替代日粮中的豆粕成分进行蛋鸡饲喂试验.结果表明:粗糙脉孢菌发酵生产β-胡萝卜素的最佳条件为发酵温度为30℃,基质含水率为60%,ph为6,发酵时间72 h,此条件下β-胡萝卜素产量为202.20μg/g(发酵物),浅盘放大试验获得β-胡萝卜素的产量为210μg/g(发酵物).饲喂试验表明发酵物替代豆粕可使蛋鸡的产蛋率从75.25%提升至85.75%,显著降低料蛋比,提高日采食量和日增重,提升鸡蛋的色泽,显著提高鸡蛋中β-胡萝卜素的含量.因此,粗糙脉孢菌的发酵产物直接替代豆粕进行蛋鸡饲喂能够简化发酵饲料制备工艺,显著改善蛋鸡的生长和生产性能,促使β-胡萝卜素在鸡蛋中积累.本研究对于利用粗糙脉孢菌生产富含β-胡萝卜素的动物饲料具有重要参考价值.

关键词：粗糙脉孢菌固态发酵 β-胡萝卜素蛋鸡

STUDiES ON ThE CERAMiC MEMBRANE REACTOR FOR OXiDATiVE COUPLiNG OF METhANE

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Journal of Energy Chemistry 1996年第4期 306-319页

作者： hE Ren-Jin(Department of Chemistry Jinan University Guangzhou, Guangdong 510632)ma Yi-hua(Department of Chemical Engineering Worcester Polytech.ic instituteWorcester, ma 01609-228O USA)

A membrane reactor tube prepared by an adhesive-welding method is reported. it was shown that compard with packed bed reactors,the C2 selectivity of the membrane reactor for oxidative coupling of methane inereased obviously by 50~200%. The alumina membrane was proved to be better than zirconia membrane. The crystallinity of the catalyst, lithium promoted samarium oxide, increased remarkably after reaction and it seems that the main active component for this catalyst is cubic samarium *** stability of the catalyst doped on the membrane was much stronger than that of the undoped, but its initial selectivity was lower. After a 30 h continuous test at 800℃, there was no significant change of selech.ity.

关键词： membrane reactor ceramic alumina zirconia oxidative coupling of methane samarium oxide lithium oxide