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The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype

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Genes & Diseases 2023年第3期10卷 1114-1129页

作者： Leilei Qin Jianye Yang Xudong Su Xilan li Yiting Lei Lili Dong hong Chen Cheng Chen Chen Zhao huan Zhang Jun Deng Ning hu Wei huang Department of Orthopaedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Orthopedic Laboratory of Chongqing Medical University The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryArmy Medical UniversityChongqing 400038China

Macrophages (Mφs) play a crucial role in the pathological progression of osteoarthritis (OA) by regulating inflammation and tissue repair. Decreasing pro-inflammatory M1-Mφs and increasing anti-inflammatory M2-Mφs can alleviate OA-related inflammation and promote cartilage repair. Apoptosis is a natural process associated with tissue repair. A large number of apoptotic bodies (ABs), a type of extracellular vesicle, are produced during apoptosis, and this is associated with a reduction in inflammation. however, the functions of apoptotic bodies remain largely unknown. In this study, we investigated the role of M2-Mφs-derived apoptotic bodies (M2-ABs) in regulating the M1/M2 balance of macrophages in a mouse model of OA. Our data show that M2-ABs can be targeted for uptake by M1-Mφs, and this reprograms M1-to-M2 phenotypes within 24 h. The M2-ABs significantly ameliorated the severity of OA, alleviated the M1-mediated pro-inflammatory environment, and inhibited chondrocyte apoptosis in mice. RNA-seq revealed that M2-ABs were enriched with miR-21–5p, a microRNA that is negatively correlated with articular cartilage degeneration. Inhibiting the function of miR-21–5p in M1-Mφs significantly reduced M2-ABs-guided M1-to-M2 reprogramming following in vitro cell transfection. Together, these results suggest that M2-derived apoptotic bodies can prevent articular cartilage damage and improve gait abnormalities in OA mice by reversing the inflammatory response caused by M1 macrophages. The mechanism underlying these findings may be related to miR-21-5p-regulated inhibition of inflammatory factors. The application of M2-ABs may represent a novel cell therapy, and could provide a valuable strategy for the treatment of OA and/or chronic inflammation.

关键词： Apoptotic body Extracellular vesicles Macrophage phenotype switch Micr oRNA-21 Osteoarthritis

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Identification and characterization of murine adipose tissue-derived somatic stem cells of Shenque(CV8)acupoint

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Chinese Medical Journal 2021年第22期134卷 2730-2737页

作者： Yu-hui hao Zhi-Zhen Liu hong Zhao Lei Wang Ajab Khan Jian-Bin Mu Yu-Fei Wang Li-hong Yang Ran Zhou Jun Xie Shanxi Key Laboratory of Birth Defect and Cell Regeneration Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Basic Medicine Xinzhou Vocational and Technical CollegeXinzhouShanxi 034000China Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMA 20852USA Basic Medical College Shanxi University of Chinese MedicineJinzhongShanxi 030619China.

Background:Shenque(CV8)acupoint is located on the navel and has been therapeutically used for more than 2000 years in Traditional Chinese Medicine(TCM).however,clinical research on the underlying therapeutic molecular mechanisms of the CV8 acupoint lags far *** study aimed to study the mechanisms of umbilical acupoint therapy by using stem ***:The morphological characteristics of CV8 acupoint were detected under a stereomicroscope using hematoxylin and eosin(h&E)*** Red,Masson,and immunohistochemical staining on multi-layered slices were used to identify the type of cells at the CV8 *** proliferation was measured by a cell counting kit-8(CCK-8)*** cytometry and immunohistochemistry were used for cell *** differentiation was used to compare the differentiation of cells derived from CV8 acupoint and non-acupoint somatic stem cells into other cell types,such as osteogenic,adipogenic,and neural stem cell-like ***:Morphological observations showed that adipose tissues at the linea alba of the CV8 acupoint in mice had a mass-like *** staining confirmed the distribution of stem cell antigen-1(Sca-1)positive cells in the multi-layered slices of CV8 acupoint *** isolated from adipose tissues at the CV8 acupoint exhibited high expression of Sca-1 and CD44 and low expression of CD31 and CD34,and these cells possessed osteogenic,adipogenic,and neurogenic stem cell-like cell differentiation *** cell proliferation(day 4:0.5138±0.0111 vs.0.4107±0.0180,t=8.447,P=0.0011;day 5:0.6890±0.0070 vs.0.5520±0.0118,t=17.310,P<0.0001;day 6:0.7320±0.0090 vs.0.6157±0.0123,t=13.190,P=0.0002;and day 7:0.7550±0.0050 vs.0.6313±0.0051,t=42.560,P<0.0001),adipogenic([9.224±0.345]%vs.[3.933±1.800]%,t=5.000,P=0.0075),and neurogenic stem cell-like cell differentiation(diameter<50 mm:7.2000±1.3040 vs.2.6000±0.5477,t=7.273,P<0.0001;diameter 50–100 mm:2.6000±0.5477 vs.1.0000±0.7071,t=4.00

关键词： Shenque(CV8)acupoint Non-acupoint site Navel Adipose tissue Somatic stem cells Stem cell antigen-1(Sca-1) Umbilical therapy

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Decreases of voltage-dependent K~+ currents densities in ventricular myocytes of guinea pigs by chronic oxidant stress

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Acta Pharmacologica Sinica 2004年第6期25卷 49-53页

作者： De-li DONG, Yan LIU, Yu-hong ZhOU,Wei-hua SONG, he WANG, Bao-feng YANG2 Department ofpharmacology, harbin Medical University, harbin 150086, China Department of pharmacology Harbin Medical University Harbin 150086

AIM: To determine the changes of delayed rectifier K+ currents (Ik) and inward rectifier K+ currents (Ik1) in the ventricular myocytes of guinea pigs during the gradual apoptotic process by the chronic oxidant stress treatment. METhODS: h2O250 μmol/L (24 h) was used for inducing apoptosis in the cardiomyocytes culture of neonatal rats and to treat the isolated ventricular myocytes of adult guinea pigs in vitro for 24 h. Apoptosis was evaluated by TUNEL methods and voltage-dependent K+ currents were recorded by patch-clamp techniques. RESULTS: h2O2 50 μmol/L (24 h)induced cell apoptosis in the cardiomyocytes culture of neonatal rats. This concentration was used to treat the isolated ventricular myocytes of adult guinea pigs in vitro for 24 h and the voltage-dependent K+ currents densities (Ik, Ik1) were down-regulated. The densities of the delayed rectifier K+ currents (Ik) in 50 μmol/L h2O2 group were 2.52±0.57 pA/pF vs 5.73±1.84 pA/pF in the control group at +50 mV (n=8, Phe densities of the inward rectifier K+ currents (Ik1) in 50 μmol/L h2O2 group were -13.9± 2.70 pA/pF, 2.52±0.57 pA/pF vs -59.7±11.9 pA/pF, 5.73±1.84 pA/pF in the control group at -120 mV (n=8, Phe extent of inward rectifier property of Ik1 was weakened by 50 μmol/L h2O2treatment. CONCLUSION: The densities of Ik, Ik1 in the cardiomyocytes of guinea pigs were down- regulated and the inward rectifier property of Ik1 was weakened during the gradual apoptotic process after 50 μmol/L h2O2 treatment for 24 h.

关键词： hydrogen peroxide potassium apoptosis cardiac myocytes

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human Serum-derived Extracellular Vesicles Protect A549 from PM_(2.5)-induced Cell Apoptosis

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Biomedical and Environmental Sciences 2021年第1期34卷 40-49页

作者： ZhOU Qiu Lian BAI Yu Zheng GAO Juan DUAN Yi LYU Yi Cheng GUAN Long Fei ELKIN Kenneth XIE Yu Ling JIAO Zheng WANG hong Yun Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Shanghai Applied Radiation Institute School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China School of Medicine Shanghai UniversityShanghai 200444China China-America Institute of Neuroscience Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China Department of Neurosurgery Wayne State University School of MedicineDetroitMI 48201USA

Objective Epidemiological studies reveal that exposure to fine particulate matter(aerodynamic diameter≤2.5μm,PM_(2.5))increases the morbidity and mortality of respiratory *** evidence suggests that human circulating extracellular vesicles(EVs)may offer protective effects against injury caused by particulate ***,however,whether EVs attenuate PM_(2.5)-induced A549 cell apoptosis is *** EVs were isolated from the serum of healthy subjects,quantified via nanoparticle tracking analysis,and qualified by the marker protein ***_(2.5)-exposed(50μg/mL)A549 cells were pretreated with 10μg/mL EVs for 24 *** viability,cell apoptosis,and AKT activation were assessed via Cell Counting Kit-8,flow cytometry,and Western blot,respectively.A rescue experiment was also performed using MK2206,an AKT *** PM_(2.5)exposure caused a 100%in crease in cell *** treatme nt reduced cell apoptosis by 10%,promoted cell survival,and inhibited the PM_(2.5)-induced upregulation of Bax/Bcl2 and cleaved caspase 3/caspase 3 in PM_(2.5)-exposed A549 ***,EVs treatment reversed PM_(2.5)-induced reductions in p-AKT^(Thr308)and p-AKT^(Ser473).A KT inhibition attenuated the anti-apoptotic effect of EVs treatment on PM_(2.5)-exposed A549 *** EVs treatment promotes cell survival and attenuates PM_(2.5)-induced cell apoptosis via AKT *** serum-derived EVs may be an efficacious novel therapeutic strategy in PM_(2.5)-induced lung injury.

关键词： Cell apoptosis PM_(2.5) Extracellular vesicles Therapy AKT

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Generation and propagation of 21-day bottom pressure variability driven by wind stress curl in the East China Sea

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Acta Oceanologica Sinica 2020年第7期39卷 91-106页

作者： hua Zheng Xiao-hua Zhu hirohiko Nakamura Jae-hun Park Chanhyung Jeon Ruixiang Zhao Ayako Nishina Chuanzheng Zhang hanna Na Ze-Nan Zhu hong-Sik Min State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Faculty of Fisheries Kagoshima UniversityKagoshima 8900056Japan Department of Ocean Sciences Inha UniversityIncheon 22212Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridge 02139USA School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea Ocean Circulation and Climate Research Center Korea Institute of Ocean Science and TechnologyBusan 49111Korea

Between June 2015 and June 2017,two pressure-recording inverted echo sounders(PIESs)and five current and pressure-recording inverted echo sounders(CPIESs)deployed along a section across the Kerama Gap acquired a dataset of ocean bottom pressure records in which there was significant 21-day variability(Pbot21).The Pbot21,which was particularly strong from July-December 2016,was coherent with wind stress curl(WSC)on the continental shelf of the East China Sea(ECS)with a squared coherence of 0.65 for a 3-day time lag.A barotropic ocean model demonstrated the generation,propagation,and dissipation of *** modeled results show that the Pbot21 driven by coastal ocean WSC in the ECS propagated toward the Ryukyu Island Chain(RIC),while deep ocean WSC could not induce such *** the continental shelf,the Pbot21 was generated nearly synchronously with the WSC from the coastline to the southeast but dissipated within a few days due to the effect of bottom *** detection of Pbot21 by the moored array was dependent on the 21-day WSC patterns on the continental *** Pbot21 driven southeast of the Changjiang Estuary by the WSC was detected while the Pbot21generated northeast of the Changjiang Estuary was not.

关键词： pressure-recording inverted echo sounder East China Sea bottom pressure wind stress curl

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Two new steroidal glucosides from Ophiopogon japonicus (L.f.) Ker-Gawl

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Chinese Chemical Letters 2008年第7期19卷 825-828页

作者： Ya Jiuan Xu Tun hai Xu Ling Zhu hao hong Feng Zhao Sheng Xu Xie Yun Shan Si Dong han Dong Ming Xu Academy of Traditional Chinese Medicine and Material Medica of Jilin Province Changchun 130021China School of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100102China School of Traditional Chinese Medicine Xinjiang University of Medicine Urumchi 830011 China

Two new steroidal glucosides, 26-O-β-D-glucopyranosyl （25S）-furost-5-ene-1β,3β,22α,26-tetraol l-O-β-D-xylopyranosyl- （1 → 3）-[α-h-rhamnopyranosyl-（1 → 2）]-[β-D-fueopyranoside and （25R） spirost-5-ene-3β,14α-diol-3-β-O-β-L-rhanmopyranosyl- （1 → 2）-[β-D-xylopyranosyl（1 → 4）]-[-β-D-glucopyranoside, were isolated from the Ophiopogon japonicus （L.f.） Ker-Gaw. Their structures were elucidated by spectroscopic methods.

关键词： Ophiopogon japonicus (L.f.) Ker-Gawl Steroidal glucosides Liliaceae

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纳米Fe_3O_4及Ni^(2+)掺杂Fe_3O_4的制备、表征及吸附Pb(Ⅱ)的特性（英文）

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无机化学学报 2013年第12期29卷 2615-2622页

作者：魏世勇杨小洪生物资源保护与利用湖北省重点实验室湖北民族学院化学与环境工程学院恩施445000

采用一种改进的共沉淀法制备了纳米磁铁矿(Fe3O4)及Ni2+掺杂磁铁矿(Ni x Fe3-x O4,x=0.1,0.3,0.6),用X-射线衍射(XRD)、扫描电镜(SEM)、氮气物理性吸附、酸碱滴定等手段对产物进行了表征,用平衡吸附法研究了4种样品对Pb(Ⅱ)离子的吸附... 详细信息

采用一种改进的共沉淀法制备了纳米磁铁矿(Fe3O4)及Ni2+掺杂磁铁矿(Ni x Fe3-x O4,x=0.1,0.3,0.6),用X-射线衍射(XRD)、扫描电镜(SEM)、氮气物理性吸附、酸碱滴定等手段对产物进行了表征,用平衡吸附法研究了4种样品对Pb(Ⅱ)离子的吸附容量及吸附模型。结果表明,Fe3O4和3种Ni x Fe3-x O4均为近似球形的单相晶质纳米颗粒;与Fe3O4比较,Ni x Fe3-x O4的颗粒尺寸变小、表面电荷零点和ph=5.0时的表面正电荷量降低;样品的孔体积、比表面积和表面分形度以及表面羟基含量都随产物中Ni2+掺杂量的增加而升高。4种样品对Pb(Ⅱ)的等温吸附数据均适合用Langmuir模型拟合(R2=0.9942～0.9858),其相关系数的大小表现为:Fe3O4>Ni0.1Fe2.9O4>Ni0.3Fe2.7O4=Ni0.6Fe2.4O4;Freundlich模型对样品等温吸附Pb(Ⅱ)的实验数据拟合度较低(R2=0.981 3～0.947 7),4种样品的Freundlich相关系数的大小关系与Langmuir相关系数相反。初始ph=5.0时,Fe3O4,Ni0.1Fe2.9O4,Ni0.3Fe2.7O4和Ni0.6Fe2.4O4对Pb(Ⅱ)的最大吸附容量分别为6.02,6.68,7.29和8.34 mg·g-1。可见,Ni x Fe3-x O4(尤其是Ni2+掺杂量较高的产物)对水环境中重金属Pb(Ⅱ)的去除能力明显高于Fe3O4。

关键词：纳米Fe3O4 Ni^2+掺杂表面性质吸附铅(Ⅱ)

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Intracytoplasmic sperm injection in cases with a history of in vitro fertilization failure

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Asian Journal of Andrology 2003年第1期5卷 69-72页

作者： hor>Zhi-Ling LI, hong LIN, Xin-Neng ZhANG, Wan-Fen XIAO Reproduction Center, First Affiliated hospital, Medical College, Shantou University, Shantou 515041, China Reproduction Center First Affiliated Hospital Medical College Shantou University Shantou 515041 China. lizhilin@***

Aim: To evaluate the effect of intracytoplasmic sperm injection (ICSI) in the management of cases with a history of conventional in vitro fertilization (IVF) failure. Methods: Two groups of patients, 19 with normal semen parameters and a history of IVF failure (metaphase Ⅱ oocytes: 0~30 %) and 28 with severe male factor infertility received ICSI technology during the same period. Ovarian stimulation was achieved by conventional procedure. Transvaginal ultrasound-guided oocyte collection was done 35~37 h after human chorionic gonadotrophin (hCG) injection. Only metaphase Ⅱ oocytes were selected for microinjection. Results: Fertilization was achieved with ICSI in all the patients. The fertilization rate (75.6 %±21.1 % vs. 73.9 %±19.2 %), cleavage rate (85.1 %±19.3 % vs. 82.7 %±22.1 %), clinical pregnancy rate per embryo transfer cycle (31.6 % vs. 28.6 %) and implantation rate per embryo (15.3 % vs. 14.4 %) did not differ significantly between the two groups. Conclusion: ICSI is a valuable method for couples with a history of IVF failure. These patients may have a similar ICSI result as in severe male infertility.

关键词： intracytoplasmic sperm injection in vitro fertilization male factor infertility fertilization failure

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高氧诱导大鼠肺泡Ⅱ型细胞内质网自噬与其功能的关系

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中国实验诊断学 2024年第3期28卷 348-353页

作者：刘嘉璐于恺华郭鸿姚莹鲍振星施华清李玉兰兰州大学第一临床医学院甘肃兰州730000 兰州大学第二临床医学院甘肃兰州730000 兰州大学第一医院麻醉科甘肃兰州730000

目的探讨不同时间高浓度氧对肺泡Ⅱ型细胞(AECII)内质网自噬与肺泡表面活性物质产生功能之间的关系。方法将大鼠RLE-6TN细胞分为对照组(C组,21%O2常规培养72 h)、高氧h1、h2、h3、h4组(95%O2分别培养12、24、48、72 h)。实时荧光定量PC... 详细信息

目的探讨不同时间高浓度氧对肺泡Ⅱ型细胞(AECII)内质网自噬与肺泡表面活性物质产生功能之间的关系。方法将大鼠RLE-6TN细胞分为对照组(C组,21%O2常规培养72 h)、高氧h1、h2、h3、h4组(95%O2分别培养12、24、48、72 h)。实时荧光定量PCR法检测内质网自噬受体ATL3、CCPG1、FAM134B、RTN3、SEC62的mRNA水平,Western blot法检测内质网自噬相关蛋白ATL3、CCPG1、FAM134B、RTN3、SEC62的水平,ELISA法检测各组二棕榈酰卵磷脂(DPPC)水平。结果与C组相比,h1组ATL3、SEC62的mRNA水平、CCPG1的蛋白水平、DPPC产量下降(Ph2组ATL3、CCPG1、FAM134B、RTN3、SEC62的mRNA水平、ATL3、CCPG1、FAM134B、RTN3、SEC62的蛋白水平差异无统计学意义(P均>0.05),DPPC产量增高(Ph3、h4组ATL3、CCPG1、FAM134B、RTN3、SEC62的mRNA水平、ATL3、CCPG1、FAM134B、RTN3、SEC62的蛋白水平、DPPC产量显著下降(P均h1组相比,h2组CCPG1、FAM134B的mRNA水平、ATL3、RTN3的蛋白水平、DPPC产量显著增高(Ph3组ATL3、SEC62的蛋白水平显著下降(Ph4组ATL3的mRNA水平、CCPG1的蛋白水平下降(Ph2组相比,h3组、h4组ATL3、CCPG1、FAM134B、RTN3的mRNA水平、ATL3、RTN3、SEC62的蛋白水平、DPPC产量显著下降(P均h4组SEC62的mRNA水平下降(Ph3组CCPG1、FAM134B的蛋白水平下降(Ph4组CCPG1、FAM134B的蛋白水平显著下降(Ph3组相比,h4组ATL3、RTN3、SEC62的蛋白水平显著下降(P0.05)。结论高氧12 h AECII内质网自噬水平、DPPC产量下降;高氧24 h AECII内质网自噬水平恢复到基础值,DPPC产量达到峰值,48 h后内质网自噬水平、DPPC产量再次下降,72 h后AECII内质网自噬水平、DPPC产量衰减仍保持较低水平,AECII内质网自噬与其功能密切相关。

关键词：高氧内质网自噬肺泡Ⅱ型上皮细胞二棕榈酰卵磷脂

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中国城乡成人居民谷类摄入与高血压

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中国食物与营养 2024年第5期30卷 12-19页

作者：李亚茹王楠葛智文丁冰杰王佳洪忠新首都医科大学附属北京友谊医院营养科北京100050

目的:探索中国城市和农村成年居民各类主食的摄入量与高血压关联。方法:依据中国健康与营养调查纵向队列研究,共纳入18岁及以上成人6701人。膳食信息采用连续3d24h回顾法收集。采用多元cox回归模型,分析各类主食摄入量与高血压发病风险... 详细信息

目的:探索中国城市和农村成年居民各类主食的摄入量与高血压关联。方法:依据中国健康与营养调查纵向队列研究,共纳入18岁及以上成人6701人。膳食信息采用连续3d24h回顾法收集。采用多元cox回归模型,分析各类主食摄入量与高血压发病风险的关系。结果:农村居民高血压发病率(38.57%)高于城市居民(27.09%)。城市居民多元cox回归分析显示,随着大米及制品摄入量增加,发生高血压的风险降低(P-趋势=0.009)。农村居民多元cox回归分析显示,随着面粉及制品摄入量增加,发生高血压的风险升高(P-趋势=0.0017)。与摄入量第1分位相比,第2~4分位水平发生高血压的风险比分别是1.201、1.422、1.534。结论:农村居民高血压发病率高于城市居民。城市居民大米及制品摄入量与高血压发生呈负相关,农村居民面粉及制品摄入量与高血压发生风险呈正相关。

关键词：谷类高血压城乡差异

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