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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

DNA Dynamics Studied Using the homogeneous Balance method

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Chinese Physics Letters 2012年第8期29卷 9-11页

作者： e.m.e.Zayed A.h.Arnous mathematics Department Faculty of ScienceZagazig UniversityP.O.Box 44519ZagazigEgypt

We employ the homogeneous balance method to construct the traveling waves of the nonlinear vibrational dynamics modeling of *** new explicit forms of traveling waves are *** is shown that this method provides us with a powerful mathematical tool for solving nonlinear evolution equations in mathematical *** and weaknesses of the proposed method are discussed.

关键词： traveling nonlinear method

Seismic assessment of unanchored steel storage tanks by endurance time method

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earthquake engineering and engineering Vibration 2011年第4期10卷 591-603页

作者： m. Alembagheri h.e. estekanchi Department of Civil engineering Sharif University of Technology (SUT)

Liquid storage tanks are essential structures that are often located in residential and industrial areas; thus an assessment of their seismic performance is an important engineering issue. In this paper, the seismic response ofunanchored steel liquid storage tanks is investigated using the endurance time （eT） dynamic analysis procedure and compared to responses obtained for anchored tanks under actual ground motions and intensifying eT records. In most cases, the results from ground motions are properly obtained with negligible differences using eT records. It is observed that uplifting of the tank base, which is closely related to the tank aspect ratio, has the greatest significance in the responses of the tank and can be predicted with reasonable accuracy by using currently available eT records.

关键词： steel liquid storage tanks endurance time method seismic assessment intensifying dynamic excitation tank base uplifting

Landau damping in a dipolar Bose–Fermi mixture in the Bose–einstein condensation(BeC) limit

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Chinese Physics B 2016年第12期25卷 367-376页

作者： S m moniri h Yavari e Darsheshdar Department of Physics University of Isfahan

By using a mean-field approximation which describes the coupled oscillations of condensate and noncondensate atoms in the collisionless regime, Landau damping in a dilute dipolar Bose-Fermi mixture in the BeC limit where Fermi superfluid is treated as tightly bounded molecules, is investigated. In the case of a uniform quasi-two-dimensional （2D） case, the results for the Landau damping due to the Bose-Fermi interaction are obtained at low and high temperatures. It is shown that at low temperatures, the Landau damping rate is exponentially suppressed. By increasing the strength of dipolar interaction, and the energy of boson quasiparticles, Landau damping is suppressed over a broader temperature range.

关键词： Landau damping mixtures of Bose and Fermi superfluids dipole-dipole interaction

Oxidation Resistance of the Aluminide Coating Formed on Carbon Steels

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Journal of materials Science & Technology 1997年第5期13卷 383-388页

作者： Soliman, h.m. mohamed, K.e. Abd el-Azim, m.e. hammad, F.h. metallurgy Dept. Atomic Energy Authority Cairo Egypt

Low and medium carbon steels were aluminized by the pack aluminizing technique using halideactivated pure-Al and Fe-Al packs. The effect of mixture composition, aluminizing temperatureand time and C content of the steel substrate on the structure and thickness of the aluminidelayer, and on the oxidation resistance was investigated. The optimum oxidation resistance canbe achieved with a low carbon steel substrate when the intermetallic phases Fe3Al and FeAlform the surface of the aluminide layer. In this case, the Al concentration at the surface of thealuminide coating is at least ≥15 wt pct. Formation of high Al concentration phases (FeAl3 andFe2Al5) during aluminizing should be avoided as they tend to embrittle the aluminide layer andreduce its oxidation resistance.

关键词： OO Figure Oxidation Resistance of the Aluminide Coating Formed on Carbon Steels

Impurity effects on electrical conductivity of doped bilayer graphene in the presence of a bias voltage

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Chinese Physics B 2016年第7期25卷 316-323页

作者： e Lotfi h Rezania B Arghavaninia m Yarmohammadi Department of Physics Sanandaj Branch Islamic Azad University Department of Physics Razi University Department of Physics Kermanshah Branch Islamic Azad University Young researchers and elite Club Kermanshah Branch Islamic Azad University

We address the electrical conductivity of bilayer graphene as a function of temperature, impurity concentration, and scattering strength in the presence of a finite bias voltage at finite doping, beginning with a description of the tight-binding model using the linear response theory and Green＇s function approach. Our results show a linear behavior at high doping for the case of high bias voltage. The effects of electron doping on the electrical conductivity have been studied via changing the electronic chemical potential. We also discuss and analyze how the bias voltage affects the temperature behavior of the electrical conductivity. Finally, we study the behavior of the electrical conductivity as a function of the impurity concentration and scattering strength for different bias voltages and chemical potentials respectively. The electrical conductivity is found to be monotonically decreasing with impurity scattering strength due to the increased scattering among electrons at higher impurity scattering strength.

关键词： bilayer graphene Green's function electrical conductivity

Fundamental solutions for axi-symmetric translational motionof a microstretch fluid

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Acta mechanica Sinica 2012年第3期28卷 605-611页

作者： h.h.Sherief m.S.Faltas e.A.Ashmawy Department of mathematics Faculty of ScienceAlexandria University

The fundamental solution for the axi-symmetric translational motion of a microstretch fluid due to a concen- trated point body force is obtained. A general formula for the drag force exerted by the fluid on an axi-symmetric rigid par- ticle translating in it is then deduced. As an application to the obtained drag formula, this paper has discussed the problem of creeping translational motion of a rigid sphere in a mi- crostretch fluid. The slip boundary condition on the surface of the spherical particle is applied. The drag force and the other physical quantities are obtained and represented graph- ically for various values of the micropolarity and slip param- eters.

关键词： Drag force Fundamental solution mi-crostretch fluid Slip condition

exact solution for the unsteady flow of a semi-infinite micropolar fluid

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Acta mechanica Sinica 2011年第3期27卷 354-359页

作者： h.h. Sherief m.S. Faltas e.A. Ashmawy Department of mathematics Faculty of ScienceAlexandria University

The unsteady motion of an incompressible micropolar fluid filling a half-space bounded by a horizontal infinite plate that started to move suddenly is considered. Laplace transform techniques are used. The solution in the Laplace transform domain is obtained by using a direct approach. The inverse Laplace transforms are obtained in an exact manner using the complex inversion formula of the transform together with contour integration techniques. The solution in the case of classical viscous fluids is recovered as a special case of this work when the micropolarity coecient is assumed to be zero. Numerical computations are carried out and represented graphically.

关键词： Unsteady motion . Laplace transform . microp-olar fluid

In vitro corrosion-fatigue behavior of biodegradable mg/hA composite in simulated body fluid

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Journal of magnesium and Alloys 2021年第6期9卷 2169-2184页

作者： e.Ghazizadeh A.h.Jabbari m.Sedighi School of mechanical engineering Iran University of Science and TechnologyNarmakTehranIran

magnesium and its composites as biodegradable materials offer especial capabilities to be used as bio-absorbable ***,their poor corrosion and fatigue properties in the physiological environment can restrict their *** this study,corrosion-fatigue tests have been performed on the extruded magnesium and magnesium/hydroxyapatite(mg/hA)composites in a high cycle *** produce the composites,pure magnesium was reinforced by 2.5 wt.%and 5 wt.%of hydroxyapatite submicron particles using an electromagneticmechanical stirring method and hot extrusion *** experimental density measurement exhibits that the porosity increases in the extruded samples with more hydroxyapatite *** investigate the corrosion and corrosion-fatigue behavior of the specimens,simulated body fluid(SBF)was used during in vitro *** results of the potentiodynamic polarization corrosion test show that the composite with 2.5 wt.%of hydroxyapatite(mg/2.5 wt.%hA)and the pure magnesium specimen exhibit the highest and the lowest corrosion resistance,*** the elemental mapping analysis of the corroded samples,this behavior could be due to the formation of strong phosphorus-calcium based layers on the composite *** results obtained from the mechanical tests indicate that mg/5 wt.%hA offered the highest tensile and compressive yield strengths,as well as the most promising high cycle fatigue *** the corrosionfatigue test,the simultaneous effects of fatigue and corrosion damages led to a similar corrosion-fatigue behavior in both *** fracture surfaces of the corrosion-fatigue samples suggest that the cracks are initiated in the corroded regions of the samples surface,which reduces the crack initiation step and subsequently decreases the fatigue *** comparison with the pure magnesium,both composites exhibit more promising corrosion and corrosion-fatigue behaviors with a significant fatigue life improvement in the ph

关键词： magnesium magnesium/hydroxyapatite composite Corrosion Biodegradation high cycle fatigue Corrosion-fatigue