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Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： sofie Ingdam halkjaer Bobby Lo Frederik cold Alice hojer christensen savanne holster Julia Konig Robert Jan Brummer Olga c Aroniadis Perttu Lahtinen Tom holvoet Lise Lotte Gluud Andreas Munk Petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark copenhagen IBD center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions Research centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BAcKGROUND Irritable bowel syndrome(IBs)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBs,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched cochrane central,MEDLINE,EMBAsE and Web of science up to 24 October 2022 for randomised controlled trials(RcTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBs symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(RR)and corresponding 95%cI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%cI for continuous *** cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight RcTs(484 participants)were included in the *** resulted in no significant benefit in IBs symptoms three months after treatment compared to placebo(RR 1.19,95%cI:0.68-2.10).Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group(RR 1.17,95%cI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(RR 0.42,95%cI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBs patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%cI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis systematic review

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母体妊娠期糖尿病与子代高血压有关

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中华高血压杂志(中英文) 2020年第2期 198-198页

作者： Lu J Zhang s Li W Leng J Wang L Liu h Li W Zhang c Qi L Tuomilehto J chen J Yang X Yu Z hu G 陈云叶鹏

已有一些研究评估了母体妊娠期糖尿病(gestational diabetes mellitus,GDM)与儿童高血压风险的关系,但结果不都一致。本研究调查母体GDM与子代儿童早期高血压风险之间的关系。方法:在1 156个的母子配对的研究人群中进行研究(根据子代的... 详细信息

已有一些研究评估了母体妊娠期糖尿病(gestational diabetes mellitus,GDM)与儿童高血压风险的关系,但结果不都一致。本研究调查母体GDM与子代儿童早期高血压风险之间的关系。方法:在1 156个的母子配对的研究人群中进行研究(根据子代的年龄和性别配对578个患有GDM的母亲和578个未患有GDM的母亲)。根据世界卫生组织的诊断标准来诊断GDM。使用标准化方法测量儿童身高、体质量和血压。根据国家高血压教育计划项目

关键词：妊娠期糖尿病 GDM 高血压

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跳动视觉搜索训练:一种治疗同侧偏盲的方法

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世界核心医学期刊文摘(眼科学分册) 2005年第2期 2-3页

作者： Pambakian A.L.M.,Mannan s.K. ,hodgson T.L. ,Kennard c. ,杨建刚 Depart ment of sensory Motor systems Div. of Neurosci. and Psychol. Med. Imperial coll ege school of Medicine London United Kingdom

Objectives: We describe a novel rehabilitation tool for patients with homonymo us hemianopia based on a visual search (vs) paradigm that is portable, inexpensi ve, and easy to deploy. We hypothesised that by training patients to improve the efficiency of eye movements made in their blind field their disability would be alleviated. Methods: Twenty nine patients with homonymous visual field defects (hvFD) without neglect practised vs paradigms in 20 daily sessions over one mont h. search fields comprising randomly positioned target and distracter elements, differing by a single feature, were displayed for three seconds on a dedicated t elevision monitor in the patients'homes. Improvements were assessed by examinin g response time (RT), error rates in vs, perimetric visual fields (vFs) and visu al search fields (vsFs), before and after treatment. Functional improvements wer e measured using objective visual tasks which represented activities of daily li ving (ADL) and a subjective questionnaire. Results: As a group the patients had significantly shorter mean RT in vs after training (P strated a variety of mechanisms to account for this . Improvements were confined to the training period and maint ained at follow up. Three patients had significantly longer RT after training. T hey had high initial error rates which improved with training. Patients performe d ADL tasks significantly faster after training and reported significant subject ive improvements. There was no concomitant enlargement of the vF, but there was a small but significant enlargement of the vsF. conclusion: Patients can improve vs with practice. This usually involves shorter RTs, but occasionally a longer RT in a complex speed- accuracy trade-off. These changes translate to improved overall visual functi on, assessed objectively and subjectively, suggesting that they represent robust training effects. The underlying mechanism may involve the adoption of compensa tory eye movement strate

关键词：同侧偏盲视觉搜索

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中元古代具有高的cr同位素分异特征和高的大气氧浓度

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矿物岩石地球化学通报 2018年第6期37卷 1180-1180页

作者： D.E.canfield s.c.Zhang A.B.Frank X.M.Wang h.J.Wang J.su Y.T.Ye R.Frei 袁超

大气氧对生命大爆发具有重要意义。然而。前人通过cr同位素研究表明,中元古代时期具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物大爆发。cr同位素是揭示大气氧化历史的一个非常有用的办法。由于cr^3+物相发... 详细信息

大气氧对生命大爆发具有重要意义。然而。前人通过cr同位素研究表明,中元古代时期具有非常低的大气氧浓度(当今氧水平的0.1%),并不足以使得中元古代真核生物大爆发。cr同位素是揭示大气氧化历史的一个非常有用的办法。由于cr^3+物相发生大陆氧化性风化作用,cr同位素会发生分馏,重的53cr同位素会倾向于进入氧化的镉酸盐中(cr^4+),从而使得残留相(cr^3+)中亏损重cr同位素。

关键词： cr^3+ 中元古代同位素氧浓度大气特征和分异生命大爆发

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草类木素的氨化反应 Ⅱ.反应动力学和产物结构分析

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中国造纸学报 2001年第2期16卷 101-104页

作者：林鹿 c.L.chen J.s.Gratzl 詹怀宇华南理工大学制浆造纸工程国家重点实验室广州510641 DepartmentofWoodandPaperscience NorthCarolinaStateUniversityUSA

木素的氨化反应可分为两个阶段 ,反应遵循准一级 (pseudo firstorder)方程 :ln[(N∞ -Nt) /N∞]=-kt;动力学研究表明 ,在 10 0℃条件下约有 2 .3%的N在刚达到预定温度的时间内结合进入麦草工业木素 (PTL) ,但预定温度为 130℃时 ,约有 3... 详细信息

木素的氨化反应可分为两个阶段 ,反应遵循准一级 (pseudo firstorder)方程 :ln[(N∞ -Nt) /N∞]=-kt;动力学研究表明 ,在 10 0℃条件下约有 2 .3%的N在刚达到预定温度的时间内结合进入麦草工业木素 (PTL) ,但预定温度为 130℃时 ,约有 3 .7%的N在同样时间内结合进入PTL分子。1h 13c2D NMRhMQc谱图可见木素分子的碎裂化现象十分明显。

关键词：草类木素氨化反应反应动力学产物结构

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Ethanol inhibits the motility of rabbit sphincter of Oddi in vitro

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World Journal of Gastroenterology 2004年第23期10卷 3470-3474页

作者： Réka sári Attila Pálv lgyi Zoltán Rakonczay Jr Tamás Takács János Lonovics László czakó Péter hegyi Zoltán szilvássy First Department of Medicine Faculty of MedicineUniversity of Szeged H-6720Koranyi fasor 10Hungary Department of Pharmacology Medical University of Debrecen H-4032Nagyerdei krt98Hungary

AIM:The rote of the sphincter of Oddi(sO)in ethanol (ETOh)-induced pancreatitis is *** aim was to characterise the effect of E-I-Oh on basal and stimulated sO motility. METhODs:sOs removed from white rabbits were placed in an organ bath(Krebs solution,ph7.4,37℃).The effects of 2 mL/L,4 mL/L,6 mL/L and 8 mL/L of ETOh on the contractile responses of the sphincter were determined. sOs were stimulated with either 0.1 μmol/L carbachol,1 μmol/L erythromycin or 0.1 μmol/L cholecystokinin(ccK). REsULTs:ETOh at a dose of 4 mL/L significantly decreased the baseline contractile amplitude from 11.98±0.05 mN to 11.19±0.07 ***,no significant changes in the contractile frequency were ***(0.6%) significantly decreased both the baseline amplitude and the frequency compared to the control group(10.50±0.01 mN, 12.13±0.10 mN and 3.53±0.13 c/min,5.5±0.13 cycles(c)/min, respectively).Moreover,0.8% of ETOh resulted in complete relaxation of the ***(0.1 μmol/L)or erythromycin (1 μmol/L)stimulated the baseline amplitudes(by 82% and 75%,respectively)and the contractile frequencies (by 150% and 106%,respectively).In the carbachol or erythromydn-stimulated groups 2-6 mL/L of E-IOh significantly inhibited both the amplitude and the ***, a 4-5 min administration of 6 mL/L ETOh suddenly and completely relaxed the ***(0.1 μmol/L)stimulated the baseline amplitude from 12.37±0.05 mN to 27.40±1.82 mN within 1.60±0.24 *** this peak,the amplitude decreased to 17.17±0.22 mN and remained constant during the *** frequency peaked at 12.8±0.2 c/min, after which the constant frequency was 9.43±0.24 c/min throughout the rest of the *** at a dose of 4 mL/L significantly decreased the amplitude from 16.13±0.23 mN to 14.93±0.19 ***,no significant changes in the contractile frequency were *** at a dose of 6 mL/L inhibited both the amplitudes and the frequencies in the ccK-stimulated group,while 8 mL/L of E

关键词： Animals carbachol central Nervous system Depressants cholecystokinin cholinergic Agonists Erythromycin Ethanol Gastrointestinal Agents Gastrointestinal Motility In vitro Male Rabbits Research support, Non-U.s. Gov't sphincter of Oddi

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L-DOPs治疗自身免疫性自主神经病变患者的难治性直立性低血压

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 48-48页

作者： Gibbons c.h. vernino s.A. Kaufmann h. Freeman R. 陈海 Autonomic and Peripheral Nerve Laboratory Department of Neurology Beth Israel Deaconess Medical Center 1 Deaconess Road Boston MA 02215 United States.Dr

The authors report a 46-year-old woman with antibodies to the nicotinic acetylcholine receptor (NiAchR) of the autonomic ganglia. she presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading. Addition of L-threo-3,4-dihidroxyphenylserine (L-DOPs) substantially improved blood pressure and orthostatic tolerance. L-DOPs may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies.

关键词：直立性低血压患者 L-DOPs

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Е.А.Барбашин之一条定理的改进和推广

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东北人民大学自然科学学报 1957年第2期 25-33页

作者：王柔懷陈铭俊

其中(x~1,x~2,…,x~n)是点p∈G的局部坐标,(X~1,X~2,…,X~n)是属于c~r类(1≤r≤s)的逆变向量.用f(p,t)表示在t=0时经过点p的方程组(1)的轨道. 定义.设F是G关于(1)之闭的不变子集合,称F为渐近稳定,若

关键词：邻域含于引理 cr 紧致集定理截痕局部坐标紧致性渐近稳定紧致子集

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帕金森病“关”期间的步态僵硬和颞叶分辨阈值的关系研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 48-48页

作者： Lee M.-s. Kim h.-s. Lyoo c.-h. 邓剑平 Department of Neurology Youngdong Severance Hospital 146-92Dogok-dong Kangnam-gu Seoul South Korea Dr.

Objective: To investigate the relationship between temporal discrimination thr eshold (TDT) and “off" period gait freezing(OGF) in patients with fluctuating P arkinson disease (PD).Methods: TDT values were measured at the dorsum of the toe s in 11 control subjects and 22 patients with PD with a wearing off phenomenon ( 16 patients with OGF and 6 patients without OGF). Results: During the L-dopa “ off" period, TDT values increased abnormally in both patient groups but were sig nificantly higher in patients with OGF than in those without OGF. A positive cor relation was found between the severity of OGF and TDT values measured by differ ent point stimulation. In patients with OGF, a single dose of L-dopa treatment normalized TDTvalues and ameliorated OGF. conclusions: Dopa-responsive abnormal discriminative sensory processing may be a possible cause of “off" period gait freezing observed in patients with fluctuating Parkinson disease.

关键词：帕金森病步态僵硬分辨阈左旋多巴 stimulation abnormal 背侧不稳定性 fluctuating 感觉异常

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Microbial communities biostimulated by ethanol during uranium （vI） bioremediation in contaminated sediment as shown by stable isotope probing

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Frontiers of Environmental science & Engineering 2015年第3期9卷 453-464页

作者： Mary Beth LEIGh Wei-Min WU Erick cARDENAs Ondrej UhLIK sue cARROLL Terry GENTRY Terence L. MARsh Jizhong ZhOU Philip JARDINE craig s. cRIDDLE James M. TIEDJE center for Microbial Ecology Michigan State University East Lansing MI 48824 USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK 99775 USA Department of civil and Environmental Engineering Center for Sustainable Development & Global Competitiveness Codiga Resource Recovery Center Stanford University Stanford CA 94305-4020 USA Department of Biochemistry and Microbiology Institute of Chemical Technology Prague Technicka 3 166 28 Prague Czech Republic Environmental sciences Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA Department of crop and soil sciences Texas A&M University College Station TX 77843 USA

stable isotope probing （sIP） was used to identify microbes stimulated by ethanol addition in microcosms containing two sediments collected from the bioremediation test zone at the Us Department of Energy Oak Ridge site, TN, UsA. One sample was highly bioreduced with ethanol while another was less reduced. Microcosms with the respective sediments were amended with ^13c labeled ethanol and incubated for 7 days for sIP. Ethanol was rapidly converted to acetate within 24h accompanied with the reduction of nitrate and sulfate. The accumulation of acetate persisted beyond the 7 d period. Aqueous U did not decline in the microcosm with the reduced sediment due to desorption of U but continuously declined in the less reduced sample. Microbial growth and concomitant 13c-DNA production was detected when ethanol was exhausted and abundant acetate had accumulated in both microcosms. This coincided with U（vI） reduction in the less reduced sample. I3c originating from ethanol was ultimately utilized for growth, either directly or indirectly, by the dominant microbial community members within 7 days of incubation. The microbial community was comprised predominantly of known denitrifiers, sulfate-reducing bacteria and iron （Ⅲ） reducing bacteria including Desulfovibrio, sphingomonas, Ferribacterium, Rhodanobacter, Geothrix, Thiobacillus and others, including the known U（vI）-redueing bacteria Acidovorax, Anaeromyxobacter, Desulfovibrio, Geobac- ter and Desulfosporosinus. The findings suggest that ethanol biostimulates the U（vI）-reducing microbial com- munity by first serving as an electron donor for nitrate, sulfate, iron （Ih） and U（vI） reduction, and acetate which then functions as electron donor for U（vI） reduction and carbon source for microbial growth.

关键词： stable isotope probing (s/P) ethanol acetate uranium reduction sediment bioremediation

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