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sTCF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov D.bodrov A.bogomyagkov A.bondar I.boyko z.h.bu F.M.Cai h.Cai j.j.Cao Q.h.Cao X.Cao z.Cao Q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen j.F.Chen K.Chen L.L.Chen P.Chen s.L.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng j.Cheng s.Cheng T.G.Cheng j.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko j.M.Dias D.z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.s.Du Y.j.Du z.G.Du L.M.Duan D.Epifanov Y.L.Fan s.s.Fang z.j.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng j.L.Fu j.Gao Y.N.Gao P.s.Ge C.Q.Geng L.s.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl j.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo j.C.Guo j.Guo Y.P.Guo z.h.Guo A.Guskov K.L.han L.han M.han X.Q.hao j.b.he s.Q.he X.G.he Y.L.he z.b.he z.X.heng b.L.hou T.j.hou Y.R.hou C.Y.hu h.M.hu K.hu R.j.hu W.h.hu X.h.hu Y.C.hu j.hua G.s.huang j.s.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.j.huang Y.b.huang Y.s.huang N.hüsken V.Ivanov Q.P.ji j.j.jia s.jia z.K.jia h.b.jiang.j.jiang.s.z.jiang.j.b.jiao z.jiao h.j.jing X.L.Kang X.s.Kang b.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li F.Li G.Li G.Li h.b.Li h.Li h.N.Li h.j.Li h.L.Li j.M.Li j.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li s.Li T.Li W.j.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li z.j.Li h.Liang j.h.Liang Y.T.Liang G.R.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.s.Lin b.j.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.b.Liu j.Liu j.j.Liu j.b.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu s.b.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.G.Lu j.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.j.Luo T.Luo X.F.Luo Y.h.Luo h.j.Lyu X.R.Lyu j.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas s.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov s.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.j.Peng K.Peters s.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin X.s.Qin T.L.Qiu j.Rademacker C.F.Redmer h.Y.sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAs Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher school of Economy 11 Pokrovsky bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China jilin University Changch

The superτ-charm facility(sTCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** sTCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the standard *** sTCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the sTCF,describes conceptual designs of the sTCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity sTCF detector conceptual design

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Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： jiali Yang Yu Liu En-Yang Wang jinbo Pang shirong huang Thomas Gemming jinshun bi Alicja bachmatiuk hao jia shu-Xian hu Chongyun jiang hong Liu Gianaurelio Cuniberti Weijia zhou Mark h Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany state Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of jiangsu Province Soochow UniversitySuzhou 215006China school of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland school of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic state Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials science and Max bergmann Center of biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,Pts_(2),Ptse_(2),Pds_(2),and Pdse_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,Pdse_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of Pdse_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of Pdse_(2) is yet to be *** this study,the doping level of Pdse_(2) was correlated with the concentration of Lewis acids,for example,snCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after snCl_(4) soaking ***_(2) transistors were soaked in snCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of Pdse_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

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The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large b-cell lymphoma

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Genes & Diseases 2024年第1期11卷 80-83页

作者： zhouliang bian benhong Gu Guohai shi jiahui Guo Dong Li hanlin zengg bin jiang Daliu Min hengchuan su Yanjie zhang Department of Oncology Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 201900China shanghai Institute of Precision Medicine Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Urology Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China Department of Urology Fudan University Shanghai Cancer CenterShanghai200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Diffuse large b cell lymphoma(DLbCL)is one of the most prevalent lymphoid *** current standard of care can cure about two-thirds of DLbCL patients.1 Primary testicular diffuse large b-cell lymphoma(PT-DLbCL)is a rare but highly aggressive form of mature b-cell lymphoma that accounts for approximately 1%-9%of testicular *** from nodal DLbCL,PT-DLbCL has a markedly worse prognosis because of inferior response to the current treatment regimens and significant extranodal tropism.2 Three main questions remained unresolved in the field of PT-DLbCL research.

关键词： lymphoma markedly prognosis

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.bai O.bakina I.balossino Y.ban h.-R.bao V.batozskaya K.begzsuren N.berger M.berlowski M.bertani D.bettoni F.bianchi E.bianco A.bortone I.boyko R.A.briere A.brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin j.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.s.Chen M.L.Chen s.j.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.b.Chen Y.Q.Chen z.j.Chen z.Y.Chen s.K.Choi X.Chu G.Cibinetto F.Cossio j.j.Cui h.L.Dai j.P.Dai A.Dbeyssi R.E.de boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori b.Fang s.s.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.h.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu j.L.Fu Y.W.Fu h.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia P.T.Ge z.W.Ge C.Geng E.M.Gersabeck b.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du z.h.Duan P.Egorov Y.h.Fan j.Fang jA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.b.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.han T.T.han X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou z.L.hou b.Y.hu h.M.hu j.F.hu T.hu Y.hu G.s.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain F.h\"olzken N.h\"usken N.in der Wiesche M.Irshad j.jackson s.janchiv j.h.jeong Q.ji Q.P.ji W.ji X.b.ji X.L.ji Y.Y.ji X.Q.jia z.K.jia D.jiang h.b.jiang P.C.jiang s.s.jiang T.j.jiang X.s.jiang Y.jiang j.b.jiao j.K.jiao z.jiao s.jin Y.jin M.Q.jing X.M.jing T.johansson s.Kabana N.Kalantar-Nayestanaki X.L.Kang X.s.Kang M.Kavatsyuk b.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn j.j.Lane P.Larin L.Lavezzi T.T.Lei z.h.Lei h.Leithoff M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.Li h.b.Li h.j.Li h.N.Li hui Li j.R.Li j.s.Li K.Li L.j.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Y.Li Y Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780 BochumGermany budker Institute of Nuclear Physics sb RAs(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GsI helmholtzcentre for heavy Ion Research Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the bEsIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(s)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the b^(−)→DK^(−)decay.

关键词： bEsIII D^(0)meson decays amplitude analysis CP-even fraction

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Determination of the number ofψ(3686)events taken at bEsⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.bai O.bakina I.balossino Y.ban h.-R.bao V.batozskaya K.begzsuren N.berger M.berlowski M.bertani D.bettoni F.bianchi E.bianco A.bortone I.boyko R.A.briere A.brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin j.F.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.s.Chen h.Y.Chen M.L.Chen s.j.Chen s.L.Chen s.M.Chen T.Chen X.R.Chen X.T.Chen Y.b.Chen Y.Q.Chen z.j.Chen z.Y.Chen s.K.Choi G.Cibinetto F.Cossio j.j.Cui h.L.Dai j.P.Dai A.Dbeyssi R.E.de boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori b.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du s.X.Du Y.Y.Duan z.h.Duan P.Egorov Y.h.Fan j.Fang j.Fang s.s.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.h.Feng Y.T.Feng M.Fritsch C.D.Fu j.L.Fu Y.W.Fu h.Gao X.b.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia L.Ge P.T.Ge z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl s.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.b.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.han T.T.han F.hanisch X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou z.L.hou b.Y.hu h.M.hu j.F.hu s.L.hu T.hu Y.hu G.s.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain F.hölzken N.hüsken N.in der Wiesche j.jackson s.janchiv j.h.jeong Q.ji Q.P.ji W.ji X.b.ji X.L.ji Y.Y.ji X.Q.jia z.K.jia D.jiang h.b.jiang P.C.jiang s.s.jiang T.j.jiang X.s.jiang Y.jiang j.b.jiao j.K.jiao z.jiao s.jin Y.jin M.Q.jing X.M.jing T.johansson s.Kabana N.Kalantar-Nayestanaki X.L.Kang X.s.Kang M.Kavatsyuk b.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn j.j.Lane P.Larin L.Lavezzi T.T.Lei z.h.Lei M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li D.M.Li F.Li G.Li h.b.Li h.j.Li h.N.Li hui Li j.R.Li j.s.Li Ke Li L.j.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li s.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.z.Li Xi Institute of high Energy Physics Beijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780BochumGermany budker Institute of Nuclear Physics sb RAs(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central south University Changsha 410083China China Center of Advanced science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GsI helmholtzcentre for heavy Ion Research Gmbh D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile jilin University Changchun 130012China joha

The number ofψ(3686)events collected by the bEsⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process hadronic events bEsⅢdetector

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structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan jinyi zhao sulin zhang Lu Liu Yumin zhang Wei Xu Maolin shao jingjing Peng shuai Xia Yan zhu Keke zhang Xianglei zhang Ruxue zhang jian Li Wenhao Dai zhen Ge shulei hu Changyue Yu jiang Wang Dakota Ma Mingyue zheng haitao Yang Gengfu Xiao zihe Rao Lu Lu Leike zhang Fang bai Yao zhao shibo jiang hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NhC/CAMs) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China shanghai Institute for Advanced Immunochemical studies and school of Life science and Technology ShanghaiTech UniversityShanghai 201210China state Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China school of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina school of Pharmaceutical science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several sARs-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including sARs-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTsL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTsL and *** X-ray crystal structures of human CTsL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTsL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against sARs-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against sARs-CoV-2 Xbb 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against hCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

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bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu zou Ran Liu Mei huang Yu-Rui jiao jie Wei Yangzi jiang Wen-zhen he Min huang Yi-Li Xu Ling Liu Yu-Chen sun Mi Yang Qi Guo Yan huang Tian su Ye Xiao Wei-shan Wang Chao zeng Guang-hua Lei Xiang-hang Luo Chang-jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and health statistics Xiangya School of Public HealthCentral South UniversityChangshaChina hunan Key Laboratory of joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related bone and joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina school of biomedical sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

skeletal stem/progenitor cell(ssPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of ssPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers ssPC senescence and impairs fracture *** injection of human rGCA in young mice induced ssPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate ssPC ***,GCA binds to the plexin-b2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in ssPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger ssPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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science bulletin 2024年第4期69卷 449-457页

作者： LhAAsO Collaboration zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China school of Astronomy and space science Nanjing UniversityNanjing 210023China University of science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UhE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive Ob association(Cygnus Ob2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UhEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium star cluster

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Evidence for particle acceleration approaching PeV energies in the W51 complex

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science bulletin 2024年第18期69卷 2833-2841页

作者： LhAAsO Collaboration zhen Cao F.Aharonian Axikegu Y.X.bai Y.W.bao D.bastieri X.j.bi Y.j.bi W.bian A.V.bukevich Q.Cao W.Y.Cao zhe Cao j.Chang j.F.Chang A.M.Chen E.s.Chen h.X.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.h.Chen s.Chen s.h.Chen s.z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui s.W.Cui X.h.Cui Y.D.Cui b.z.Dai h.L.Dai z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.h.Fan Y.z.Fan j.Fang j.h.Fang K.Fang C.F.Feng h.Feng L.Feng s.h.Feng X.T.Feng Y.Feng Y.L.Feng s.Gabici b.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.s.Geng G.Giacinti G.h.Gong Q.b.Gou M.h.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.han M.hasan h.h.he h.N.he j.Y.he Y.he Y.K.hor b.W.hou C.hou X.hou h.b.hu Q.hu s.C.hu D.h.huang T.Q.huang W.j.huang X.T.huang X.Y.huang Y.huang X.L.ji h.Y.jia K.jia K.jiang X.W.jiang z.j.jiang M.jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov b.b.Li C.M.Li Cheng Li Cong Li D.Li F.Li h.b.Li h.C.Li jian Li jie Li K.Li s.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.z.Li zhe Li zhuo Li E.W.Liang Y.F.Liang s.j.Lin b.Liu C.Liu D.Liu D.b.Liu h.Liu h.D.Liu j.Liu j.L.Liu M.Y.Liu R.Y.Liu s.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo h.K.Lv b.Q.Ma L.L.Ma X.h.Ma j.R.Mao z.Min W.Mitthumsiri h.j.Mu Y.C.Nan A.Neronov L.j.Ou P.Pattarakijwanich z.Y.Pei j.C.Qi M.Y.Qi b.Q.Qiao j.j.Qin A.Raza D.Ruffolo A.sáiz M.saeed D.semikoz L.shao O.shchegolev X.D.sheng F.W.shu h.C.song Yu.V.stenkin V.stepanov Y.su D.X.sun Q.N.sun X.N.sun z.b.sun j.Takata P.h.T.Tam Q.W.Tang R.Tang z.b.Tang W.W.Tian C.Wang C.b.Wang G.W.Wang h.G.Wang h.h.Wang j.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.h.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang z.h.Wang z.X.Wang zhen Wang zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen C.Y.Wu h.R.Wu Q.W.Wu s.Wu X.F.Wu Y.s.Wu s.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.h.Yan j.z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang R.z.Yang W.X.Yang Y.h.Yao z.G.Yao L.Q.Yin N.Yin X.h.You z.Y.You Y.h.Yu Q.Yuan h.Yue h.D.zeng T.X.zeng W.zeng M.zha b.b.zhang F.zhang h.zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany school of Physical science and Technology&school of Information science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and space science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of sciences Moscow 117312Russia hebei Normal University Shijiazhuang 050024China University of science and Technology of China Hefei 230026China state Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(zhuhai)&school of Physics(Guangzhou)&sino-French Institute of Nuclear Engineering and Technology(zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(sNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large high Altitude Air shower Observatory(LhAAsO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LhAAsO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of sNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51b could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UhE c-ray Cosmic rays sNR W51C star clusters

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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCs Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li zhong-Yu Yu jiamin Wang zhaoyang Liu Chao jiang zhen-Feng Chen Xiaoyu Wu Ming-Xing Li hong Yang zhao-Xi Wang jonathan L.sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 sijing Community health service Center of songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-hDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-hDCL is green and absorbs light e... 详细信息

stable neutral Fe(IV)complex(Fe-hDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(h upon photoirradiation).Fe-hDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-hDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-hDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-hDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-hDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-hDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-hDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

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