检索结果-南通市图书馆

Dynamic RNA methylation modifications and their regulatory role in mammalian development and diseases

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第10期67卷 2084-2104页

作者： Wenlan yang Yongliang Zhao Yungui yang State Key Laboratory of Reproductive Regulation&Breeding of Grassland Livestock Inner Mongolia Key Laboratory for Molecular Regulation of the CellSchool of Life SciencesInner Mongolia UniversityHohhot 010020China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Among over 170 different types of chemical modifications on RNA nucleobases identified so far,RNA methylation is the major type of epitranscriptomic modifications existing on almost all types of RNAs,and has been demonstrated to participate in the entire process of RNA metabolism,including transcription,pre-mRNA alternative splicing and maturation,mRNA nucleus export,mRNA degradation and stabilization,mRNA *** to the development of high-throughput detection technologies and the identification of both dynamic regulators and recognition proteins,mechanisms of RNA methylation modification in regulating the normal development of the organism as well as various disease occurrence and developmental abnormalities upon RNA methylation dysregulation have become increasingly ***,we particularly focus on three types of RNA methylations:N^(6)-methylcytosine(m^(6)A),5-methylcytosine(m^(5)C),and N^(7)-methyladenosine(m^(7)G).We summarize the elements related to their dynamic installment and removal,specific binding proteins,and the development of high-throughput detection ***,for a comprehensive understanding of their biological significance,we also overview the latest knowledge on the underlying mechanisms and key roles of these three mRNA methylation modifications in gametogenesis,embryonic development,immune system development,as well as disease and tumor progression.

关键词： RNA methylation(m^(6)A m5C and m7G) detection techniques RNA metabolism gametogenesis embryogenesis immune system development tumorigenesis

Input-to-State Stability for Impulsive Switched Singular Systems with Mismatched Disturbances

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第3期37卷 924-946页

作者： yang Anqing MA Shuping School of Information Engineering Shandong Management UniversityJinan 250357China School of Mathematics Shandong UniversityJinan 250100China

This work investigates the input-to-state stability(ISS)problem for impulsive switched singular systems(ISSSs)with mismatched *** this paper,‘disturbance’is a general concept that includes model uncertainty,unknown system dynamic,external disturbance,*** modified uncertainty and disturbance estimator(UDE)-based control method is presented for singular systems and ISSSs,a virtual control is introduced to offset the effects of mismatched *** the basis of a discontinuous multiple Lyapunov functional and admissible edge-dependent average dwell time(AED-ADT)method,several sufficient conditions in terms of linear matrix inequalities(LMIs)are obtained to ensure that the closed-loop systems are regular,impulse-free and ***,two examples are given to demonstrate the effectiveness of the proposed results.

关键词： Impulsive switched singular systems input-to-state stability UDE-based control

Group control for procedural rules:parameterized complexity and consecutive domains

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第3期18卷 133-141页

作者： Yongjie yang Dinko DIMITROV Chair of Economic Theory Saarland UniversitySaarbrücken 66123Germany

We consider GROUP CONTROL BY ADDING INDIVIDUALS(GCAI)in the setting of group identification for two procedural rules-the consensus-start-respecting rule and the liberal-start-respecting *** is known that GCAI for both rules are NP-hard,but whether they are fixed-parameter tractable with respect to the number of distinguished individuals remained *** resolve both open problems in the *** addition,we strengthen the NP-hardness of GCAI by showing that,with respect to the natural parameter the number of added individuals,GCAI for both rules are W[2]-***,the W[2]-hardness for the liberal-startrespecting rule holds even when restricted to a very special case where the qualifications of individuals satisfy the so-called consecutive ones ***,for the consensus-startrespecting rule,the problem becomes polynomial-time solvable in this special *** also study a dual restriction where the disqualifications of individuals fulfill the consecutive ones property,and show that under this restriction GCAI for both rules turn out to be polynomial-time *** reductions for showing W[2]-hardness also imply several algorithmic lowerbounds.

关键词： group control by adding individuals group identification parameterized complexity consecutive ones property FPT W-hard

Protein acetylation sites with complex-valued polynomial model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第3期18卷 217-226页

作者： Wenzheng BAO Bin yang School of Information Engineering Xuzhou University of TechnologyXuzhou 221018China School of Information Science and Engineering Zaozhuang UniversityZaozhuang 277160China

Protein acetylation refers to a process of adding acetyl groups(Ch3CO-)to lysine residues on protein *** one of the most commonly used protein post-translational modifications,lysine acetylation plays an important role in different *** our study,we developed a humanspecific method which uses a cascade classifier of complexvalued polynomial model(CVPM),combined with sequence and structural feature descriptors to solve the problem of imbalance between positive and negative *** gene expression programming and differential evolution are utilized to search the optimal CVPM *** also made a systematic and comprehensive analysis of the acetylation data and the prediction *** performances of our proposed method are 79.15%in Sp,78.17%in Sn,78.66%in ACC 78.76%in F1,and 0.5733 in MCC,which performs better than other state-of-the-art methods.

关键词： protein acetylation complex-valued polynomial model machine learning

Comprehensive Assessment of STGSA Generated Skeletal Mechanism for the Application in Flame-Wall Interaction and Flame-Flow Interaction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第5期33卷 1946-1960页

作者： YU Chunkan yang Bin Institute of Technical Thermodynamics Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Center for Combustion Energy Tsinghua UniversityBeijing 100084China

In this study,we conduct a thorough evaluation of the STGSA-generated skeletal mechanism for C_(2)h_4/*** STGSA-reduced mechanisms are taken into account,incorporating basic combustion models such as the homogeneous reactor model,one-dimensional flat premixed flame,and non-premixed counterflow ***,these models are applied to more complex combustion systems,considering factors like flame-flow interaction and flame-wall *** considerations take into account additional physical parameters and processes such as mixing frequency and *** results indicate that the skeletal mechanism adeptly captures the behavior of these complex combustion ***,it is suggested to incorporate strain rate considerations in generating the skeletal mechanism,especially when the combustion system operates under high turbulent intensity.

关键词： Species-Targeted Global Sensitivity Analysis(STGSA) mechanism reduction Partially Stirred Reactor(PaSR) spark ignition head-on Quenching(hoQ)

Sparse Reconstructive Evidential Clustering for Multi-View Data

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu Gong yang You School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

An improved initial rotor position estimation method using high-frequency pulsating voltage injection for PMSM

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 19-29页

作者： yang Jiang Ming Cheng School of Electrical Engineering Southeast UniversityNanjing 210096China

high frequency pulsating voltage injection method is a good candidate for detecting the initial rotor position of permanent magnet synchronous ***,traditional methods require a large number of filters,which leads to the deterioration of system stability and dynamic *** order to solve these problems,a new signal demodulation method is proposed in this *** proposed new method can directly obtain the amplitude of high-frequency current,thus eliminating the use of filters,improving system stability and dynamic performance and saving the work of adjusting filter *** addition,a new magnetic polarity detection method is proposed,which is robust to current measurement ***,experiments verify the effectiveness of the method.

关键词： Initial position detection Signal demodulation algorithm Magnetic polarity detection Filter elimination

Theoretical study on the synergistic mechanism of Fe–Mn in sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第10期93卷 284-290页

作者： yang You Mingliang Yuan School of Mineral Processing and Bioengineering Central South UniversityChangsha410083China

This article conducts first-principles calculations to initially explore the construction of two configurations,NaFeO_(2)(NFO)and NaMnO_(2)(NMO),and studies the mixing enthalpies under different Fe–Mn *** results indicate that NaFe3/8Mn5/8O_(2)(NFMO)exhibits the most thermodynamically stable *** calculations on the mixing enthalpies and volume changes during the sodium extraction process for NFO,NMO,and NFMO configurations are presented,along with the partial density of states(PDOS)and Bader charges of transition metals(TM)and *** calculations reveal the synergistic mechanism of Fe and *** and Mn can engage in more complex electron exchanges during sodium extraction,optimizing the internal electron density distribution and overall charge balance,thereby stabilizing the crystal structure and reducing the migration of Fe^(3+)to the sodium layers during deep sodium *** interaction between Fe’s 3d electrons and Mn’s 3d electrons through the shared oxygen atoms’2p orbitals occurs in the Fe–Mn–O *** interaction can lead to a rebalancing of the electron density around Mn³⁺atoms,mitigating the asymmetric electron density distribution caused by the d4 configuration of the lone Mn³⁺and suppressing the Jahn-Teller effect of Mn^(3+).Moreover,the synergistic effects between Fe and Mn can provide a more balanced charge distribution,reducing extreme changes to the charge state of oxygen atoms and decreasing the irreversible oxygen release caused by anionic redox reactions during deep sodium extraction,thereby enhancing the material’s *** in-depth study of the interaction mechanism at the microscopic level when co-doping Fe and Mn offers valuable insights for the rational design and development of high-performance cathode materials.

关键词： First-principles calculations Sodium-ionbatteries Layered oxides NaFe_(3/8)Mn_(3/8)O_(2)

Recent advances in phenazine-linked porous catalysts toward photo/electrocatalytic applications and mechanism

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第10期9卷 1518-1549页

作者： yang Liu Yu Zhang Zhao-Di yang Liqiang Jing heilongjiang Provincial Key Laboratory of CO2 Resource Utilization and Energy Catalytic Materials School of Material Science and Chemical EngineeringHarbin University of Science and Technology Institute of Process Engineering Chinese Academy of Sciences Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Heilongjiang University

In recent years, porous organic catalysts have been developed and become research hotspots in photo/electrocatalysis due to their inherent pores, high specific surface area, chemical and thermal stability, and diverse functional building blocks. Phenazine-linked organic catalysts,exhibited excellent conjugation, electrical conductivity, chemical, and thermal stability, could bring in N atoms with specific numbers and positions to regulate electron levels, anchor metals, and absorb near-infrared light, which expands solar energy utilization. These advantages of the phenazine-linked catalysts attracted our group and numerous researchers to conduct experimental and computational work on photo/electrocatalytic applications and mechanisms. This review summarizes the recent significant research progress, synthesis methods, photo/electrocatalytic performance, and applications of relative phenazine-linked catalysts. Furthermore, the photo/electrocatalytic mechanism was systematized and summarized by combining experiments and density functional theory calculations simultaneously.

关键词： Phenazine-linked porous catalysts Photo/electrocatalytic applications Catalytic mechanism