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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Xenos peckii vision inspires an ultrathin digital camera

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Light(science & Applications) 2018年第1期7卷 272-278页

作者： Dongmin Keum Kyung-Won Jang Daniel s.jeon Charles s.h.hwang Elke K.Buschbeck Min h.Kim Ki-hun jeong Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea school of Computing Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Korea Department of Biological sciences University of CincinnatiCincinnatiOH 45221-0006USA

Increased demand for compact devices leads to rapid development of miniaturized digital ***,conventional camera modules contain multiple lenses along the optical axis to compensate for optical aberrations that introduce technical challenges in reducing the total thickness of the camera ***,we report an ultrathin digital camera inspired by the vision principle of Xenos peckii,an endoparasite of paper *** male Xenos peckii has an unusual visual system that exhibits distinct benefits for high resolution and high sensitivity,unlike the compound eyes found in most insects and some *** biologically inspired camera features a sandwiched configuration of concave microprisms,microlenses,and pinhole arrays on a flat image *** camera shows a field-of-view(FOV)of 68 degrees with a diameter of 3.4mm and a total track length of *** biologically inspired camera offers a new opportunity for developing ultrathin cameras in medical,industrial,and military fields.

关键词： camera sandwich digital

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： hasan M Isa Marwa J Abdulnabi Nawra s Naser Fatema N Lahmda Noor M AlAnsari Zahra h Isa Afaf M Mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Public health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using student’s t-test or the Mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Psented with more cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Psitive physical findings(P=0.002)than non-IgE-mediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 mo

关键词： Children Milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MsCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MsC *** increasing number of pre-clinical studies suggest that delivering in vivo an MsC-conditioned medium(i.e.,the medium collected from MsC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

s-Factor of the ^(3)h(α,γ)^(7)Li Reaction at Astrophysical Energies

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Chinese Physics Letters 2013年第10期30卷 59-62页

作者： h.sadeghi Department of Physics Faculty of ScienceArak UniversityArak 8349-8-38156Iran

The astrophysical s-factor forα-^(3)h radiative capture is calculated at astrophysical *** construct conserved two-and three-body electromagnetic currents,using minimal substitution in the explicit momentum dependence of the two-and three-nucleon *** realistic Argonne v_(18) two-nucleon and Urbana IX or Tucson–Melbourne three-nucleon interactions are considered for *** extrapolation of results for the astrophysical s-factor at zero energy,the energy in the order of 1 keV and less is found to be s(0)=0.107(0.112)keV·b,with(without)three-body interactions in satisfactory agreement with other theoretical results and experimental data.

关键词： calculation substitution momentum

Numerical tests of theoretical models describing ionization of h(1s) atom by linearly polarized flat pulse of laser radiation

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Chinese Physics B 2018年第9期27卷 254-261页

作者： Jarostaw h Bauer Min Deng Katedra Fizyki Teoretycznej Wydzial Fizyki i lnformatyki Stosowanej Uniwersytetu LddzkiegoUI.Pomorska 149/153PL-90-236 LddlPoland state Key Laboratory o fLow-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China

We derive the well-known Coulomb correction factor for the Gordon-Volkov wave function describing an outgoing electron in the process of ionization in an intense laser field. Although rigorous treatment would limit its use only to laser fields much lower than the so-called barrier-suppression field, it appears that in practice the correction factor may be used also close to and even above this critical value of the laser field. We compare predictions of several analytical expressions describing ionization rate of the hydrogen atom in its ground state in the strong linearly polarized laser field. We also compare ionization probabilities obtained by integrating these ionization rates over a temporal envelope of the laser pulse with predictions based on the exact numerical solution to the time-dependent schr ¨odinger equation.

关键词： laser fields ionization s-matrix Coulomb-Volkov wave function

Quantitative hazard assessment for Zonguldak Coal Basin underground mines

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International Journal of Mining science and Technology 2019年第3期29卷 453-467页

作者： h.h.Erdogan h.s.Duzgun A.s.selcuk-Kestel Directorate for strategy Development Ministry of Energy and Natural ResourcesAnkara 06520Turkey Department of Mining Engineering Colorado School of MinesIL 80401USA Institute of Applied Mathematics Middle East Technical UniversityAnkara 06531Turkey

Underground coal mining is one of the most dangerous occupations throughout the *** reasons behind an underground occupational accident are too complex to analyze mainly due to many uncertainties which may arise from geological,operational conditions of the mine or individual characteristics of *** study proposes implementing a quantitative methodology for the analysis and assessment of hazards associated with occupational *** application of the proposed approach is performed on the mines of Turkish hard Coal Enterprises(TTK).The accidents in TTK between the years 2000 and 2014 are firstly statistically analyzed with respect to the number,type and location of accidents,age,experience,education level and main duty of the casualties and also injuries resulting from such *** hazards are classified as individual,operational and locational hazards and quantified using contingency tables,conditional and total probability *** and upper boundaries of hazards are determined and event trees for each hazard class are *** hazard evaluation results show that Armutcuk,Karadon and Uzulmez mines have relatively high hazard levels while Amasra and Kozlu mines have relatively lower hazard values.

关键词： Underground coal mining Occupational accidents hazard assessment Contingency tables Zonguldak Coal Basin

Field-dependent resistive transitions in YBa_2Cu_3O_(7-δ) thin films:Influence of the pseudogap on vortex dynamics

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Chinese Physics B 2015年第1期24卷 467-473页

作者： s h Naqib R s Islam Department of Physics University of RajshahiRajshahi-6205 Bangladesh

The nature of resistive transition of high-quality crystalline thin films of YBa2Cu3O7-δhas been studied under magnetic fields（h） applied along the c direction over a wide range of doped holes, p, in the Cu O2 planes. The field- and temperature-dependent in-plane resistivity, ρab（T, h）, has been analyzed within the thermally assisted flux-flow（TAFF）formalism. The flux activation energy, U（T, h）, has been extracted from this analysis. The low-T part of the ρab（T, h）data can be described by an activation energy having the functional form of U（T, h） =（1- t）m（h-0/h）β, where t = T /Tc（reduced temperature）, and h0 is a field scale that primarily determines the magnitude of U（T, h）. The temperature exponent, m, shows a systematic variation with p, whereas the field exponent, β, is insensitive to the p values and is close to unity. The h0, on the other hand, changes rapidly as p is varied. U（T, h） is linked to the pinning potential and consequently on the superconducting condensation energy. since the normal state pseudogap directly affects superconducting condensation energy, a clear correspondence between h0 and the PG energy scale, ε g, is found. Possible implications of these results are discussed.

关键词： Y123 superconductors thermally assisted flux-flow model activation energy pseudogap