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Geoscience Frontiers 2019年第1期10卷 285-297页

作者： Ravish Lal h.s.saini N.C.Pant s.A.I.Mujtaba Department of Geology University of Delhi Geological survey of India

The Indus River flows through Ladakh, one of the driest and coldest places on earth, in a tectonically active domain. Fluvial, glaciofluvial, lacustrine and debris dominated sequences represent the Late Quaternary sedimentary record along the river course. Karakoram Fault, a major crustal scaled feature reported to be active during the Quaternary, is associated with the Indus River drainage. Linkages between a major, active fault and deposits formed during the activity period of the fault are explored using heavy mineral deduced provenance and Optically stimulated Luminescence(OsL) *** deposits in a ~200 km long stretch of the Indus River have been examined for a ~80 ka period to decipher the climate linked aggradation history. Damming of the Indus River at ~79 ka and existence of the spituk Lake for >30 ka is demonstrated. Using geology of the provenance in relation to the mineralogical attributes of the Quaternary deposits, the major drainage reorganization when the connection of the Tangtse Valley to the Indus was blocked, is inferred at ~73 ka. It is supported by the geologicalgeomorphological evidence. The study demonstrates the application of provenance linked mineralogy in terrestrial aggradation in a tectonically active region.

关键词： Karakoram Fault Indus Drainage reorganization heavy minerals Aggradation

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI h.GhANDVAR E.JUMAEV s.KhATIR T.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

Nonplanar dust acoustic solitary and rogue waves in an ion beam plasma with superthermal electrons and ions

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Plasma science and Technology 2018年第7期20卷 64-71页

作者： nimardeep kaur kuldeep singh yashika ghai n s saini Guru Nanak Dev University Amritsar-143005India

The propagation characteristics of dust acoustic solitary and rogue waves are investigated in an unmagnetized ion beam plasma with electrons and ions following kappa-type distribution in nonplanar geometry. The reductive perturbation method （RPM） is employed to derive the cylindrical/spherical Korteweg-de Vries （KdV） equation, which is further transformed into standard KdV equation by neglecting the geometrical effects. Using new stretching coordinates, nonlinear schrrdinger equation （NLsE） has been derived from the standard KdV equation to study the different order rational solutions of dust acoustic rogue waves （DARWs）. The impact of various physical parameters on the characteristics of dust acoustic solitary waves （DAsWs） is elaborated specifically in nonplanar geometry. Further, the effects of ion beam and superthermality of electrons/ions on the characteristics of DARWs are studied. The results obtained in the present investigation may be useful in comprehending a variety of phenomena in Earth＇s magnetosphere polar cap region where the presence of positive ion beam has been detected and also in other regions of space/astrophysical environments where dust along with superthermal electrons and ions exists.

关键词： dust acoustic ion beam kappa distribution rogue waves

Dust acoustic shock waves in magnetized dusty plasma

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Plasma science and Technology 2018年第7期20卷 27-34页

作者： yashika ghai nimardeep kaur kuldeep singh n s saini Department of Physics Guru Nanak Dev UniversityAmritsar-143005India

We have presented a theoretical study of the dust acoustic （DA） shock structures in a magnetized, electron depleted dusty plasma in the presence of two temperature superthermal ions. By deriving a Korteweg-de Vries-Burgers equation and studying its shock solution, we aim to highlight the effects of magnetic field and obliqueness on various properties of the DA shock structures in the presence of kappa-distributed two temperature ion population. The present model is motivated by the observations of Geotail spacecraft in the Earth＇s magnetotail and it is seen that the different physical parameters such as superthermality of the cold and hot ions, the cold to hot ion temperature ratio, the magnetic field strength, obliqueness and the dust kinematic viscosity greatly influence the dynamics of the shock structures so formed. The results suggest that the variation of superthermalities of the cold and hot ions have contrasting effects on both positive and negative polarity shock structures. Moreover, it is noted that the presence of the ambient magnetic field affects the dispersive properties of the medium and tends to make the shock structures less wide and more abrupt. The findings of present investigation may be useful in understanding the dynamics of shock waves in dusty plasma environments containing two temperature ions where the electrons are significantly depleted.

关键词： dusty plasma KdV-Burgers superthermal distribution Earth's magnetotail

Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. surface plasmon resonance（sPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based sPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi Department of Veterinary sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MsCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MsC *** increasing number of pre-clinical studies suggest that delivering in vivo an MsC-conditioned medium(i.e.,the medium collected from MsC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

spectroscopic investigations on Dy^(3+) ions doped zinc lead alumino borate glasses for photonic device applications

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Journal of Rare Earths 2019年第1期37卷 52-59,M0004页

作者： Nisha Deopa shubham saini sumandeep Kaur Aman Prasad A.s.Rao Department of Applied Physics Delhi Technological University

This paper presents the structural, optical absorption, photoluminescence (PL) and decay spectral properties of Dy^(3+)ions doped zinc lead alumino borate (ZPAB) glasses to elucidate their possible usage in photonic devices such as w-LEDs and lasers. A broad hump shown by the XRD spectrum recorded for an un-doped ZPAB glass confirms its non-crystalline nature. The Judd-Ofelt (J-O) intensity parameter evaluated from the measured oscillator strengths of the absorption spectral features were used to estimate various radiative parameters and also to understand the nature of bonding between Dy^(3+)ions and oxygen ligands. Under 350 nm excitation, the as-prepared glasses are exhibiting two emission bands^4F_(9/2)→~6h_(15/2)(blue),and^4F_(9/2)→~6h_(13/2)(yellow) at 483 and 575 nm,respectively. From the PL spectra,the Y/B ratio values, CIE chromaticity color coordinates and color correlated temperature (CCT) were evaluated. The experimental lifetimes measured from the decay profiles are decreasing with increase in Dy^(3+)ions concentration in these glasses which may be attributed to the cross-relaxation and nonradiative multiphonon relaxation process. Decay profiles observed for higher concentration were well fitted to Inokuti-hirayama (I-h) model to understand the energy transfer process and subsequent decrease in experimental lifetimes. The higher values of radiative parameters, emission cross-sections,quantum efficiency, optical gain and gain band width suggest the suitability of 0.5 mol%of Dy^(3+) ions in these ZPAB glasses for the photonic device application.

关键词： Glasses J-O parameters Luminescence Inokuti-hirayama model Energy transfer Rare earths

miR-153 as biomarker for cancer-functional role as tumor suppressor

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BIOCELL 2022年第1期46卷 13-26页

作者： sALONI ThAKUR ADEsh K.saini JOYDEEP DAs VIPIN saini PARIN BALhARA JAGPREET s.NANDA REENA V.saini Faculty of Applied sciences and Biotechnology Shoolini UniversitySolan173229India Department of Biotechnology MMECMaharishi Markandeshwar(Deemed to be University)Mullana133207India Maharishi Markandeshwar University KumarhattiSolan173229India Department of Chemistry Physical SciencesMizoram UniversityAizawl796004India Department of Kinesiology California State UniversitySacramentoCA 95819USA Laboratory on the Mechanism and Regulation of Protein synthesis Eunice K.ShriverNational Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMD 20892USA

MicroRNA-153(miR-153),belongs toa dass of small non-coding *** is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the *** recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor *** review summarizes the connection between dysrgulation of miR-153 and various typas of cancer ***-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer *** addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.

关键词： Biomarker Cancer miR-153 Oncogenic Tumor suppressor