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MR扩散加权成像在预测经活检证实的乳腺导管原位癌分期中的价值

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国际医学放射学杂志 2023年第1期46卷 103页

作者： s.A.Lee Y.Lee h.s.ryu M.Jang W.K.Moon h.G.Moon 胡金玥

摘要术前准确预测活检证实的乳腺导管原位癌(DCIs)的分期,对于制定手术方案至关重要,但一直缺少采用MRI特征建立的预测模型。目的纳入活检证实的DCIs病人,建

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Concurrent generation and amplification of longitudinal and bending waves using defective phononic crystals

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 269-288页

作者： s.h.JO Department of Mechanical Robotics and Energy Engineering Dongguk University

Defective phononic crystals (PnCs) have enabled spatial localization and quantitative amplification of elastic wave energy. Most previous research has focused on applications such as narrow-bandpass filters, ultrasonic sensors, and piezoelectric energy harvesters, typically operating under the assumption of an external elastic wave incidence. Recently, a novel approach that uses defective PnCs as ultrasonic actuators to generate amplified waves has emerged. however, the existing studies are limited to the generation of either longitudinal or bending waves, with no research addressing the concurrent generation of both. hence, this paper proposes a straightforward methodology for the concurrent generation and amplification of both wave types utilizing defect modes at independent defect-band frequencies. Bimorph piezoelectric elements are attached to the defect, with each element connected to independent external voltage sources. By precisely adjusting the magnitude and temporal phase differences between the voltage sources, concurrently amplified wave generation is achieved. The paper highlights the advantages of the proposed analytical model. This model is both computationally timeefficient and accurate, in comparison with the COMsOL simulation results. For instance,in case studies, the analytical model reduces the computational time from one hour to mere seconds, while maintaining acceptable error rates of 1%in peak frequencies. This concurrent wave-generation methodology opens new avenues for applications in rotating machinery fault diagnosis, structural health monitoring, and medical imaging.

关键词： phononic crystal (PnC) defect concurrent generation piezoelectric ultrasonic actuator O328 O346

Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI h.GhANDVAR E.JUMAEV s.KhATIR T.CUONG-LE school of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for Engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： double curved beam finite element method functionally graded porous (FGP) material intermediate straight beam O313 vibration analysis

早期三阴性乳腺癌:与复发相关的影像及临床病理因素

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国际医学放射学杂志 2016年第2期 188-188页

作者： M.s.Bae h.G.Moon W.han D.Y.Noh h.s.ryu I.A.Park 曹祯 Department of Radiology Seoul National University Hospital

摘要目的确定早期三阴性乳腺癌病人与肿瘤复发相关的影像及临床病理因素。材料与方法本研究是由机构伦理委员会批准,免除病人知情同意。共评估了398例在2003年1月—2008年12月期间接受治疗的Ⅰ期或Ⅱ期三阴性乳腺癌病人（21;1岁,中位年... 详细信息

摘要目的确定早期三阴性乳腺癌病人与肿瘤复发相关的影像及临床病理因素。材料与方法本研究是由机构伦理委员会批准,免除病人知情同意。共评估了398例在2003年1月—2008年12月期间接受治疗的Ⅰ期或Ⅱ期三阴性乳腺癌病人（21;1岁,中位年龄48岁）,收集的数据包括术前乳腺MRI影像,乳腺X线密度,病人的年龄、症状、乳腺癌

关键词：三阴性乳腺癌病人临床病理因素致密型乳腺

术前MRI在经超声筛查发现的女性乳腺癌病人中的应用

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国际医学放射学杂志 2017年第3期 334-334页

作者： M.s.Bae s.h.Lee A.J.Chu s.U.shin h.s.ryu W.K.Moon 胡文笳 Department of Radiology Seoul National University College of Medicine and Seoul National University Hospital

摘要目的明确经超声筛查的女性乳腺癌病人术前MRI的额外病灶的检出率,并确定可能从术前MRI中受益的亚组。材料与方法本回顾性研究获机构伦理委员会批准,无需知情同意。收集2007—2013年期间经超声筛查发现并行术前MRI检查的女性乳腺癌病... 详细信息

摘要目的明确经超声筛查的女性乳腺癌病人术前MRI的额外病灶的检出率,并确定可能从术前MRI中受益的亚组。材料与方法本回顾性研究获机构伦理委员会批准,无需知情同意。收集2007—2013年期间经超声筛查发现并行术前MRI检查的女性乳腺癌病人374例（其中浸润性乳腺癌321例）,年龄30;4岁,中位年龄48岁。计算病灶检出率和活检的阳性预测值。使用多因素Logistic回归分析明确这些临床病理特征与MRI检出额外病灶的相关性。结果 374

关键词： MRI 病灶超声筛查术前乳腺癌乳腺肿瘤病人女性

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOssEINI O.BALILAshAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： cylindrical cavity O353.4 point source porous medium stress concentration wave-field transformation

Multi-Objective optimization for stable and efficient cargo transportation of partial space elevator

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Defence Technology(防务技术) 2025年第2期44卷 17-29页

作者： Gefei shi Zheng h.Zhu school of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China shenzhen Key Laboratory of Intelligent Microsatellite Constellation Shenzhen 518107China Department of Mechanical Engineering York University4700 Keele StreetTorontoCanada

This paper proposed a new libration decoupling analytical speed function(LD-AsF)in lieu of the classic analytical speed function to control the climber's speed along a partial space elevator to improve libration stability in cargo *** LD-AsF is further optimized for payload transportation efficiency by a novel coordinate game theory to balance competing control objectives among payload transport speed,stable end body's libration,and overall control input via model predictive *** transfer period is divided into several sections to reduce computational *** validity and efficacy of the proposed LD-AsF and coordinate game-based model predictive control are demonstrated by computer *** results reveal that the optimized LD-AsF results in higher transportation speed,stable end body's libration,lower thrust fuel consumption,and more flexible optimization space than the classic analytical speed function.

关键词： Partial space elevator stable transportation Libration decoupling analytical speed function Coordinate game Model predictive control Pareto optimization

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Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

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World Journal of Gastroenterology 2025年第6期31卷 44-61页

作者： han-Ning Xuan Yuan hyun sung Kim Gye Ryeol Park Jae Eun ryu Ji Eun Kim In Young Kang hye Young Kim seung Min Lee Ju hee Oh Eileen L Yoon Dae Won Jun Department of Internal Medicine Hanyang University School of MedicineSeoul 04763South Korea Department of Pathology Hanyang University School of MedicineSeoul 04763South Korea Department of Translational Medicine Graduate School of Biomedical Science and EngineeringHanyang UniversitySeoul 04763South Korea Department of Obstetrics and Gynecology Institute of Women’s Medical Life ScienceYonsei Cancer CenterSeverance HospitalYonsei University College of MedicineSeoul 04763South Korea Department of Internal Medicine Sanggye Paik HospitalInje University College of MedicineSeoul 01757South Korea

BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver *** study aims to specifically investigate the role of MLKL’s adenosine triphosphate(ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease *** focusing on this mechanism,we seek to identify potential therapeutic targets that can modulate MLKL activity,offering new strategies for the prevention and treatment of liver-related *** To investigate the possibility of using the ATP-binding pocket-associated,necro-ptosis-independent MLKL pathway as a target for liver *** Cell death following necroptosis stimuli was evaluated using cell proliferation assays,flow cytometry,and electron microscopy in various *** human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate ***,alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver *** While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells,it did reduce the necroptosis-led expression of CXCL2,ICAM,and ***,MLKL ATP pocket inhibitor diminishes the expression of CXCL2,ICAM,and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid *** MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models,MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease *** MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.

关键词： RAW 264.7 cell Cell death Necroptosis Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease