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Simulation of optimal dose regimens of photoactivated curcumin for antimicrobial resistance pneumonia in CoVID-19 patients:A modeling approach

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Infectious Disease Modelling 2023年第3期8卷 783-793页

作者： Teerachat Saeheng Kesara na-Bangchang Centre of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma Chulabhorn International College99 Moo 18Phaholyothin RoadThammasat University(Rangsit Campus)KlongneungKlongluang DistrictPathumthani12121Thailand Drug Discovery and Development Centre Office of Advanced Science and Technology99 Moo 18Phaholyothin RoadThammasat University(Rangsit Campus)KlongneungKlongluangPathumthani12121Thailand

Background:Secondary antimicrobial resistance bacterial(AMR)pneumonia could lead to an increase in mortality in CoVID-19 patients,particularly of geriatric patients with underlying *** comedication of current medicines for AMR pneumonia with corticosteroids may lead to suboptimal treatment or toxicities due to drug-drug interactions(DDIs).objective:This study aimed to propose new promising dosage regimens of photoactivated curcumin when co-administered with corticosteroids for the treatment of antimicrobial resistance(AMR)pneumonia in CoVID-19 ***:A whole-body physiologically-based pharmacokinetic(PBPK)with the simplified lung compartments model was built and verified following standard model verification(absolute average-folding error or AAFEs).The pharmacokinetic properties of photo-activated were assumed to be similar to curcumin due to minor changes in physiochemical properties of compound by *** acceptable AAFEs values were within *** verified model was used to simulate new regimens for different formulations of photoactivated ***:The AAFEs was *** formulation(120 mg once-daily dose)or new intramuscular nano-formulation(100 mg with a release rate of 10/h given every 7 days)is suitable for outpatients with MRSA pneumonia to improve patient *** intravenous formulation(2000 mg twice-daily doses)is for hospitalized patients with both MRSA and VRSA ***:The PBPK models,in conjunction with MIC and applied physiological changes in CoVID-19 patients,is a potential tool to predict optimal dosage regimens of photo-activated curcumin for the treatment of co-infected AMR pneumonia in CoVID-19 *** formulation is appropriate for different patient conditions and pathogens.

关键词： PBPK MRSA VRSA Photoactivated-curcumin CoVID-19 Pneumonia Antimicrobial-resistance bacteria Pharmacokinetics

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Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst

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Chemical Research in Chinese Universities 2012年第2期28卷 225-229页

作者： XIE Xiao-na ZhANG Chun-li XUN Er-na WANG Jia-xin ZhANG hong WANG Lei WANG Zhi The First hospital of Jilin University Changchun 130021P.R.China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education College of Physical Education Jilin UniversityChangehun 130012P.R.China

The regioselective acylation of quercetin catalyzed by a novel thermophilic esterase（APE1547） from the archaeon Aeropyrum pernix K1 was successfully conducted in organic *** effects of acyl donor,substrate ratio,organic solvent,temperature,and water activity were *** the optimum conditions,a yield of 74% for its mono ester could be achieved in the reaction for about 6 *** the reaction time extending to about 30 h,the final conversion of quercetin was about 100% and three products were synthesized.

关键词： Quercetin Vinyl acetate APE1547 Acylation

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Electrolytes additives for Zn metal anodes:regulation mechanism and current perspectives

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Rare Metals 2024年第9期43卷 4162-4197页

作者： Yu-Zhe Zhang huai-Sheng Ao Qi Dong Sh.o-Jie Zhang Zhi-Guo hou na-na Wang Xue-Song Xie Jian Rong Zhong-Yu Li Sch.ol of Environmental Science and Engineering Changzhou UniversityChangzhou 213164China Sch.ol of Petrochemical Engineering Changzhou UniversityChangzhou 213164China hefei national Laboratory for Physical Science at Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsInnovation CampusUniversity of WollongongNorth WollongongNSW 2500Australia Department of Chemical and Materials Engineering University of AlbertaEdmonton AB T6G 1H9Canada

With distinct advantages such as high gravimetric and volumetric capacity(5855 mAh·cm^(-3)and 820mAh·g^(-1)),low redox potential(-0.762 V *** hydrogen electrode(ShE)),high abundance,low toxicity and intrinsic safety of Zn metal anode,Zn-ion batteries have become a potential alternative to Li-ion ***,several challenges still need to be addressed prior to the practical applications of Zn-ion batteries,such as dendrite growth during Zn plating/stripping and interfacial side reactions on the Zn *** issues can be addressed by introducing additives to regulate the components and structures of the *** this review,we systematically discussed the core issues of metallic Zn anodes and comprehensively summarized a novel perspective of the regulation mechanism of inhibiting dendrite growth.or interfacial side reactions in Zn anodes by introducing additives into aqueous ***,some discussions and prospects for aqueous Zn ion batteries(AZIBs)are presented for future research.

关键词： Electrolyte additives Zn metal anode Regulation mechanism Current perspectives AZIBs

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大麻二酚对转化生长因子β1诱导肝星状细胞活化和肝纤维化的作用

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中国组织工程研究 2025年第23期29卷 4965-4974页

作者：王联谢娜赵珮伶陈浩李芏酉王豫萍贵州医科大学附属医院临床检验中心贵州省贵阳市550003 贵州医科大学医学检验学院临床微生物学及免疫学教研室贵州省贵阳市550004

背景:大麻二酚具有抗炎、抗氧化等药理学作用,并且不具有精神活性,在肝脏疾病中的研究日渐增加,但其对肝星状细胞转化生长因子β1/Smad信号转导通路的作用尚未明确。目的:探讨大麻二酚对肝星状细胞中转化生长因子β1/Smad信号转导通路... 详细信息

背景:大麻二酚具有抗炎、抗氧化等药理学作用,并且不具有精神活性,在肝脏疾病中的研究日渐增加,但其对肝星状细胞转化生长因子β1/Smad信号转导通路的作用尚未明确。目的:探讨大麻二酚对肝星状细胞中转化生长因子β1/Smad信号转导通路的影响,研究其抗肝纤维化的可能机制。方法:(1)体外实验:选取大鼠肝星状细胞株(hSC-T6),分6组培养:对照组常规培养24 h,单纯药物组加入大麻二酚培养24 h,造模组加入转化生长因子β1培养24 h,造模+低剂量药物组、造模+高剂量药物组、造模+阳性对照组均加入转化生长因子β1培养24 h后分别加入1,5μmol/L大麻二酚或水飞蓟素培养24 h。培养结束后,检测各组细胞α-平滑肌肌动蛋白与Ⅰ型胶原mRna表达、白细胞介素1β与肿瘤坏死因子α水平及Ⅰ型胶原、转化生长因子β1/Smad信号转导通路蛋白表达。(2)动物体内实验:将C57BL/6J小鼠随机分为5组,每组8只:假手术组不造模,造模组、造模+低剂量药物组、造模+高剂量药物组、造模+阳性对照组通过胆管结扎法建立肝纤维化模型,造模3周后分别腹腔注射4,8 mg/kg大麻二酚或水飞蓟素,1次/d,连续给药7 d。给药结束后,检测各组小鼠肝功能、肝脏病理形态及α-平滑肌肌动蛋白、Ⅰ型胶原、转化生长因子β1/Smad信号转导通路相关蛋白表达。结果与结论:(1)体外实验:与对照组比较,造模组hSC-T6细胞α-平滑肌肌动蛋白与Ⅰ型胶原mRna表达、白细胞介素1β与肿瘤坏死因子α水平以及Ⅰ型胶原、转化生长因子β1、p-Smad2/3蛋白表达均升高(PhSC-T6细胞上述指标的变化,并且以造模+高剂量药物组改善作用更明显;(2)体内实验:与假手术组比较,模型组小鼠血清丙氨酸氨基转移酶、天门冬氨酸氨基转移酶活性升高(P<0.05),肝组织中炎性细胞浸润及胶原含量增加(P<0.05),转化生长因子β1/Smad信号转导通路被激活,α-平滑肌肌动蛋白、Ⅰ型胶原蛋白表达升高(P<0.05);两种剂量大麻二酚干预可减轻造模小鼠上述指标的变化,并且以造模+高剂量药物组效果更明显;(3)结果表明,大麻二酚通过抑制肝星状细胞转化生长因子β1/Smad信号传导通路的激活抑制肝纤维化。

关键词：大麻二酚肝星状细胞肝纤维化信号转导通路转化生长因子β1/Smad hSC-T6细胞

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Photosynthesis in Phytoplankton: Insights from the Newly Discovered Biological Inorganic Carbon Pumps

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Molecular Plant 2020年第7期13卷 949-951页

作者： na Sui Fang huang Lu-Ning Liu Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJinan 250014China Institute of Integrative Biology University of LiverpoolLiverpool L697ZBUK College of Marine Life Sciences and Frontiers Science Center for Deep Ocean Multispheres and Earth SystemOcean University of ChinaQingdao 266003China

Aquatic C02 assimilation results in storage in the oceans of〜24%of anth.opogenic C02(〜40 petagrams per annum)released into the atmosphere and makes significant contributions to the global carbon *** processes are executed predominantly in phytoplankton in the oceans(including cyanobacteria),which account for nearly 50%of global primary productivity(~50 gigatons per annum)(Field et al.,1998).

关键词： oceans assimilation global

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Room temperature solution-phase synthesis of flower-like nanostructures of [Ni_3(BTC)_2·12h_2o] and their conversion to porous Nio

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Chinese Chemical Letters 2013年第8期24卷 663-667页

作者： Li-na Jin Qing Liu Wei-Yin Sun Coordination Chemistry Institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresNanjing University

hierarchical flower-like architectures of[Ni_3（BTC）_2·12h_2o]（BTC^3=benzene-1,3,5-tricarboxylate） were successfully prepared by a simple solution-phase method under mild conditions without any template or ***-pure porous Nio nanocrystals were obtained by annealing the Ni-BTC complex without significant alteration in *** product was characterized by X-ray diffraction techniques,field-emission scanning electron microscopy（FESEM）.transmission electron microscopy（TEM） and high-resolution TEM（hRTEM）.The catalytic effect of the Nio product was investigated on the thermal decomposition of ammonium perch.orate（AP） and it was found that the annealed Nio product has higher catalytic activity than the commercial Nio.

关键词： Nickel oxide nanostructures Metal-organic frameworks Mesoporous materials

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Assembly of Five Coordination Polymers Based on 5,11,17,23-Tetra-tert-butyl-25-（carboxymethoxy）- calix[4]arene Ligand

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Chemical Research in Chinese Universities 2017年第1期33卷 44-48页

作者： hE Yuanchun GUo Jiao XU na YU Yang College of Chemistry and Chemical Engineering Qufu Normal University Qufu 273165 P. R. China College of Chemistry and Chemical Engineering Xinxiang University Xinxiang 453003 P. R. China

Five coordination polymers, [Co（h3L）2（dib）]. 1.5h.o（1）, [Cu（h3L）2（dib）]（2）, [Co（h2L）（mtpy）].DMF（3）, [Ni（h3L）2（mtpy）（h.o）].3DMF.h.o（4）, and [Cd（h3L）2（pybim）]. 1.5h20（5）, have been successfully prepared from 5,11,17,23-tetra-tert-butyl-25-（carboxymethoxy）calix[4]arene, metal salts, and N-donor auxiliary ligands under hydrothermal conditions[dib=l,4-di（1h-imidazol-l-yl）butane, pybim=2-（2＇-pyridyl）benzimidazole, and mtpy=4＇-（4- methylphenyl）-2,2＇：6＇,2＂-terpyridine]. Structural analysis suggests that the metal ion first joins two organic carboxy- late ligands to form the independent units, which are fulther extended by the N-donor auxiliary ligand to give the final structure. Compounds 1 and 2 display 1D infinite chains bridged by a flexible bidentate dib ligand. Compounds 3-5, with multidentate chelate ligands, reveal discrete 0D units. Furthermore, in compounds 3 and 5, 1D supramolecular architectures are exhibited due to π-π interactions.

关键词： Calixarene Crystal structure Auxiliary ligand

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Deciphering the structural evolution and real active ingredients of iron oxides in photocatalytic Co_(2)hydrogenation

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Chinese Journal of Structural Chemistry 2024年第8期43卷 27-37页

作者： Mengjun Zh.o Yuh.o Guo na Li Tingjiang Yan Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu273165PR China College of Chemistry and Chemical Engineering Shaanxi University of Science and TechnologyXi'an710021PR China

Photocatalytic Co_(2)hydrogenation reactions can produce high-value-added chemicals for industry,solving the environmental problems caused by excessive Co_(2)*** oxides are commonly used in photocatalytic reactions due to their various structures and suitable band ***,the structural evolution and real active components during photocatalytic Co_(2)hydrogenation reaction are rarely ***,a variety of iron oxides including a-Fe_(2)o_(3),y-Fe_(2)o_(3),Fe_(3)o_(4)and Feo were derived from Prussian blue precursors to investigate the Co_(2)hydrogenation performance,structural evolution and active ***,the typical a-andγ-Fe_(2)o_(3)are converted to Fe_(3)o_(4)during the reaction,while Fe/Fe_(x)o_(y)remains structurally ***,it is confirmed that Fe_(3)o_(4)is the main active component for Co production and the formation of hydrocarbons(Ch_(4)and C_(2)-C_(4))are highly dependent on the Fe/Fe_(x)o_(y)*** optimal yields of Co,Ch_(4)and C_(2)-C_(4)hydrocarbons over the best catalyst(FeFe-550)can achieve 4 mmol g^(-1)h^(-1),350μmol g^(-1)h^(-1)and 150μmol g^(-1)h^(-1),respectively due to their suitable metal/oxide component *** work examines the structural evolution of different iron oxide catalysts in the photocatalytic Co_(2)hydrogenation reaction,identifies the active components as well as reveals the relationship between components and the products,and offers valuable insights into the efficient utilization of Co_(2).

关键词： Iron oxides Photocatalysis Co_(2)hydrogenation Structural evolution

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Potential Alzheimer’s disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles

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Bioactive Materials 2023年第6期24卷 497-506页

作者： Jaeh.on Kim hyeji Um na hee Kim Dokyoung Kim Department of Biomedical Science Graduate SchoolKyung Hee UniversitySeoul02447Republic of Korea Medical Research Center for Bioreaction to Reactive oxygen Species and Biomedical Science Institute Kyung Hee UniversitySeoul02447Republic of Korea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoul02447Republic of Korea Center for Converging humanities Kyung Hee UniversitySeoul02447Republic of Korea KhU-KIST Department of Converging Science and Tech.ology Kyung Hee UniversitySeoul02447Republic of Korea UC San Diego Materials Research Science and Engineering Center 9500 Gilman Drive La JollaCA92093USA

There has been a lot of basic and clinical research.on Alzheimer’s disease(AD)over the last 100 years,but its mechanisms and treatments have not been fully *** some controversies,the amyloid-beta hypothesis is one of the most widely accepted causes of *** this study,we disclose a new amyloid-beta plaque disaggregating agent and an AD brain-targeted delivery system using porous silicon nanoparticles(pSiNPs)as a therapeutic nano-platform to overcome *** hypothesized that the negatively charged sulfonic acid functional group could disaggregate plaques and construct a chemical *** a result of the in vitro assay of amyloid plaques and library screening,we confirmed that 6-amino-2-naphthalenesulfonic acid(Ana)showed the highest efficacy for plaque disaggregation as a hit *** confirm the targeted delivery of Ana to the AD brain,a nano-platform was created using porous silicon nanoparticles(pSiNPs)with Ana loaded into the pore of pSiNPs and biotin-polyethylene glycol(PEG)surface *** resulting nano-formulation,named Biotin-CaCl2-Ana-pSiNPs(BCAP),delivered a large amount of Ana to the AD brain and ameliorated memory impairment of the AD mouse model th.ough the disaggregation of amyloid plaques in the *** study presents a new bioactive small molecule for amyloid plaque disaggregation and its promising therapeutic nano-platform for AD brain-targeted delivery.

关键词： Alzheimer’s disease Plaques disaggregation nanotherapeutics Brain-targeted drug delivery Porous silicon nanoparticles

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Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver

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World Journal of Gastroenterology 2006年第12期12卷 1918-1923页

作者： Li-Juan Zhana Wei-Da Zheng Mei-na Shi Department of Gastroenterology Union Hospital of Fujian Medical University.Fuzhou 350001.Fujian Province.China

AIM： To study the effects of interleukin-10 （IL-10） on the expression of o-smooth muscle actin （α-SMA）, nuclear factor-κB（NF-κB） and Fas/Fas ligand （FasL） in hepatic stellate cells of experimental rats with hepatic fibrosis. METhoDS： Sixty clean SD rats were randomly divided into control group （group N）, liver fibrotic group （group C） and IL-10 treatment group （group I）. Control group received intraperitoneal injection of saline （2ml·kg^-1）, twice a week. Fibrotic group was injected intraperitoneally with 50% carbon tetrach.oride （CCh）（2 ml·kg^-1）, twice a week. IL-10 treatment group was given IL-10 at a dose of 4 pg·kg^-1 20 minutes before CCl4 administration from the third week. hepatic stellate cells （hSCs） were isolated from these rats at the seventh and eleventh weeks during the course of liver fibrosis, respectively. The expression of α-SMA and NF-κB in hSCs was measured by S-P immunohistochemistry. The expression of Fas and FasL mRna was measured by RT-PCR. Furthermore, liver tissues were harvested from three groups at the same time. RESULTS： The CCh- induced experimental rat hepatic fibrosis model was established successfully. The purity of extracted hepatic stellate cells was about 95% and the yield of hepatic stellate cells was 1.2-2.3×10^6/g liver tissue averagely. The positive expression of α-SMA and NF-κB was 36.5% and 28.5% respectively in group N. The positive levels of α-SMA and NF-κB were increased significantly in group C compared to group N （P〈0.01）. The positive signals decreased significantly （P〈0.05） in group I. In the 11^th week, the hSCs of group I became round with visible pyknotic nuclei. The expression of NF-κB in group C was significantly increased in a timedependentmanner （P〈0.01）, but there was no difference in the α-SMA expression （P〉0.05）. The mRna of Fas and FasL in group C was significantly increased in a timedependent manner compared to that in control group. After treated with IL-10, the expression level of Fas and FasL was h

关键词： Liver fibrosis hepatic stellate cell Znterleuldn-10 α-smooth muscle actin Nuclear factor-κB Rat

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