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Primate torpor: Regulation of Stress-activated Protein kinases During Daily torpor in the Gray Mouse Lemur, Microcebus murinus

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Genomics, Proteomics & Bioinformatics 2015年第2期13卷 81-90页

作者： kyle k.Biggar Cheng-Wei Wu Shannon n.tessier Jing Zhang Fabien Pifferi Martine Perret kenneth B.Storey Institute of Biochemistry and Department of Biology Carleton University Biochemistry Department Schulich School of Medicine and Dentistry Western University Department of Biology Genetics Institute University of Florida Department of Surgery & Center for Engineering in Medicine Massachusetts General Hospital & Harvard Medical School Chemistry and Chemical Engineering Department Royal Military College of Canada UMR 7179 Centre national de la Recherche Scientifique Muse'um National d0Histoire Naturelle

Very few selected species of primates are known to be capable of entering torpor. this exciting discovery means that the ability to enter a natural state of dormancy is an ancestral trait among primates and, in phylogenetic terms, is very close to the human lineage. to explore the regulatory mechanisms that underlie primate torpor, we analyzed signal transduction cascades to discover those involved in coordinating tissue responses during torpor. the responses of mitogen-activated protein kinase（MAPk） family members to primate torpor were compared in six organs of control（aroused） versus torpid gray mouse lemurs, Microcebus murinus. the proteins examined include extracellular signal-regulated kinases（ERks）, c-jun nh2-terminal kinases（Jnks）, MAPk kinase（MEk）, and p38, in addition to stress-related proteins p53 and heat shock protein 27（hSP27）. the activation of specific MAPk signal transduction pathways may provide a mechanism to regulate the expression of torpor-responsive genes or the regulation of selected downstream cellular processes. In response to torpor, each MAPk subfamily responded differently during torpor and each showed organ-specific patterns of response. For example, skeletal muscle displayed elevated relative phosphorylation of ERk1/2 during torpor. Interestingly, adipose tissues showed the highest degree of MAPk activation. Brown adipose tissue displayed an activation of ERk1/2 and p38, whereas white adipose tissue showed activation of ERk1/2, p38, MEk, and Jnk during torpor. Importantly, both adipose tissues possess specialized functions that are critical for torpor, with brown adipose required for non-shivering thermogenesis and white adipose utilized as the primary source of lipid fuel for torpor. Overall, these data indicate crucial roles of MAPks in the regulation of primate organs during torpor.

关键词： Metabolic rate depression Signal transduction Mitogen activated protein kinase

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PLACEntAL tRAnSFER OF DICLOFEnAC In EARLY PREGnAnCY

PLACENTAL TRANSFER OF DICLOFENAC IN EARLY PREGNANCY

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海峡两岸三地药理学学术报告会

作者：楊鹤强 t.k.Lau S.S.n.Siu Dept.Obstetrics & Gynaecology The Chinese University of Hong Kong Dept.Obstetrics and Gynaecology Prince of wales HospitalShatinHong Kong SARChina

Aim non-steroidal anti-inflammatory drugs (nSAID) are commonly used during pregnancy for the treatment and prevention of obstetric complications. teratogenic effects of nSAIDs such as aspirin, indomethacin and diclofenac have been demonstrated in animals but evidence in man remains inconclusive. the apparent lack of teratogenic effect of nSAID in man could be due to poor placental transfer in the first trimester. this study aims to investigate the placental transfer of the newer nSAIDs such as diclofenac in the first trimester of human pregnancy.

关键词： Placental transfer diclofenac nSAID.

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Deep convolutional neural network models for weed detection in polyhouse grown bell peppers

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Artificial Intelligence in Agriculture 2022年第1期6卷 47-54页

作者： A.Subeesh S.Bhole k.Singh n.S.Chandel Y.A.Rajwade k.V.R.Rao S.P.kumar D.Jat ICAR-Central Institute of Agricultural Engineering(CIAE) BhopalMadhya PradeshIndia

Conventional weed management approaches are inefficient and non-suitable for integration with smart agricultural *** identification and classification of weeds can play a vital role in weed management contributing to better crop *** and smart spot-spraying system's efficiency relies on the accuracy of the computer vision based detectors for autonomous weed *** the present study,feasibility of deep learning based techniques(Alexnet,GoogLenet,InceptionV3,Xception)were evaluated in weed identification from RGB images of bell pepper *** models were trained with different values of epochs(10,20,30),batch sizes(16,32),and hyperparameters were tuned to get optimal *** overall accuracy of the selected models varied from 94.5 to 97.7%.Among the models,InceptionV3 exhibited superior performance at 30-epoch and 16-batch size with a 97.7%accuracy,98.5%precision,and 97.8%*** this Inception3 model,the type 1 error was obtained as 1.4%and type II error was 0.9%.the effectiveness of the deep learning model presents a clear path towards integrating them with image-based herbicide applicators for precise weed management.

关键词： Bell pepper Computer vision Convolutional neural networks Deep learning Weed identification

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End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients

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World Journal of Gastroenterology 2018年第41期24卷 4691-4697页

作者： tarek Sawas Fateh Bazerbachi Samir haffar Won k Cho Michael J Levy John A Martin Bret t Petersen Mark D topazian Vinay Chandrasekhara Barham k Abu Dayyeh Division of Gastroenterology and hepatology Mayo Clinic Department of Gastroenterology Digestive Center for Diagnosis and Treatment Division of Gastroenterology and hepatology Georgetown University Medstar Washington Hospital Center

AIM to determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). MEthODS We performed a retrospective cohort study using the nationwide Inpatient Sample (nIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CkD), and control. the primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression *** there were 492175 discharges that underwent ERCP during the 3 years. the ESRD and CkD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP ted with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP nger hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP nd higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP nCLUSIOn ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes.

关键词： End-stage renal disease nationwide Inpatient Sample Endoscopic retrograde cholangiopancreatography

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形变双奇核^(178)Ir转动带能级的旋称反转

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高能物理与核物理 2000年第12期24卷 1123-1130页

作者：张玉虎 t.hayakawa M.Oshima Y.toh J.katakura Y.hatsukawa M.Matsuda n.Shinohara t.Ishii h.kusakari M.Sugawara t.komatsubara 中国科学院近代物理研究所兰州730000 Japan Atomic Energy Research Institute Chiba University Chiba Institute of technology Institute of Physics and tandem Accelerator Center

利用１５２Ｓｍ（３１Ｐ，５ｎγ）１７８Ｉｒ反应产生并研究了双奇核１７８Ｉｒ的高自旋态．实验中进行了１７８Ｉｒ核的在束 γ测量，包括γ射线的激发函数测量、Ｘ－γ和γ－γ符合测量．首次建立了双奇核１７８Ｉｒ基于πｈ９／２... 详细信息

利用１５２Ｓｍ（３１Ｐ，５ｎγ）１７８Ｉｒ反应产生并研究了双奇核１７８Ｉｒ的高自旋态．实验中进行了１７８Ｉｒ核的在束 γ测量，包括γ射线的激发函数测量、Ｘ－γ和γ－γ符合测量．首次建立了双奇核１７８Ｉｒ基于πｈ９／２νｉ１３／２和πｈ１１／２νｉ１３／２准粒子组态上的转动带能级纲图．发现在低自旋区，两个转动带能级均出现旋称反转．对此核区半退耦带的旋称反转作了简要的分析和讨论．

关键词：在束γ谱学形变双奇核转动带旋称反转

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Large deformation plasticity From basic relations to finite deformation

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Acta Mechanica Sinica 2020年第2期36卷 472-492页

作者： Otto t.Bruhns Institute of Mechanics Ruhr-University Bochum44780 BochumGermany

the theory of plasticity as a special field of continuum mechanics deals with the irreversible,***,deformation of *** the action of given loads or deformations,the state of the stresses and strains or the strain rates in these bodies is *** this way,it complements the theory of elasticity for the reversible behavior of *** practice,it has been observed that many materials behave elastically up to a certain load(yield point),beyond that load,however,increasingly plastic or *** combination of these two material properties is known as *** classical elastoplastic material behavior is assumed to be time-independent or *** contrast,we call a time-or rate-dependent behavior visco-elastoplastic and visco-plastic—if the elastic part of the deformation is *** plasticity theory,because of the given loads the states of the state variables stress,strain and temperature as well as their changes are *** this purpose,the observed phenomena are introduced and put into mathematical *** constitutive relations describing the specific material behavior are finally embedded in the fundamental relations of continuum theory and ***,the theory of plasticity was introduced in order to better estimate the strength of *** analysis based purely on elastic codes is not in a position to do this,and can occasionally even lead to incorrect *** the other hand,the entire field of forming techniques requires a theory for the description of plastic *** from the classical description of plastic behavior with small deformations,the present review is intended to provide an insight into the state of the art when taking into account finite deformations.

关键词： Finite deformation Elasto-plasticity Constitutive relations thermodynamics history of plasticity

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traumatic Diaphragmatic hernia in Children: A Case Report

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Surgical Science 2024年第3期15卷 111-117页

作者： Lucienne Irène Patricia Ondima Rhodia hélène Bosseba Missengue nuptia Erica Akobande Cardinale Princilia Okiemy niendet Jean-Claude Mieret Caryne Mboutol-Mandavo Department of Pediatric Surgery Marien Ngouabi University Brazzaville Congo Department of Paediatric Surgery Hospital and University Centre (HUC) Brazzaville Congo

Introduction: traumatic diaphragmatic hernia is a rare condition in children complicating closed or penetrating trauma to the abdomen and thorax. We report the case of an 11-year-old girl with a traumatic diaphragmatic hernia. Case Presentation: An 11-year-old girl was seen in the paediatric surgery department for a thoracolumbar spine deformity and intermittent chest pain. these symptoms occurred after a domestic accident involving a fall from a low wall onto the thoracolumbar spine 5 months previously. the diagnosis was suggested by the presence of a left hemithoracic hydroaera and confirmed by a thoraco-abdominal Ct scan. Surgical exploration revealed a linear rupture of the entire left hemi-diaphragm with herniation of the stomach, small intestine, cecum, transverse colon and omentum. We performed a double-layer suture of the diaphragmatic rupture with a non-absorbable suture without edge rejuvenation after the reduction of the hernia. the outcome was favourable with normal postoperative radiographs at one year follow-up. Conclusion: traumatic diaphragmatic hernia, although uncommon and difficult to diagnose, is a condition that is relatively easy to manage surgically, even if it is discovered late. In all cases of trauma to the thoracolumbar spine, regular follow-up and repeat X-rays are necessary if pain persists.

关键词： hernia Diaphragm trauma Child Case Report

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新型酸性亮蓝染色剂对蚕丝的染色匀度试验(英文)

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蚕业科学 2009年第2期35卷 427-430页

作者： kADhAR A k M hARIRAJ G ROY S SOMAShEkAR t h 蚕丝技术研究中心蚕丝检验与测试室蚕丝中央委员会蚕丝技术研究中心印度bangalore560068

新型酸性亮蓝是目前纺织印染的流行染色剂。用不均匀性指数对染色匀度进行分级,研究了该染色剂不同色度对蚕丝染色匀度的影响。以该染色剂的14个色度对蚕丝进行染色,测定各色度染液处理蚕丝的反光值(用k/S值表示),结果发现该染色剂对蚕... 详细信息

新型酸性亮蓝是目前纺织印染的流行染色剂。用不均匀性指数对染色匀度进行分级,研究了该染色剂不同色度对蚕丝染色匀度的影响。以该染色剂的14个色度对蚕丝进行染色,测定各色度染液处理蚕丝的反光值(用k/S值表示),结果发现该染色剂对蚕丝染色的不均匀性指数在所有色度水平下并不是恒定的,染色均匀性在染色剂色度为1.5%时开始出现,其后随着色度增加染色匀度也越来越好,到染色剂色度为4%时染色匀度最好,之后染色匀度又变差。

关键词：染色剂新型酸性亮蓝蚕丝不均匀性指数反光值

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Protective effect of rhizome extracts of the herb, vacha (Acorus calamus) against oxidative damage: An in vivo and in vitro study

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Food Science and human Wellness 2016年第2期5卷 76-84页

作者： M.Devaki R.nirupama M.nirupama h.n.Yajurvedi Department of Zoology University of MysoreManasagangotriMysore 570006India Department of health technology and Informatics The Hong Kong Polytechnic UniversityHong Kong

the rhizome of Acorus calamus,an herb widely used in Indian system of medicine for many ailments including epilepsy,mental illness and rheumatism,was subjected to soxhlet extraction to elucidate antioxidant property of different solvent extracts using in vitro *** benzene extract was most potent in scavenging hydroxyl and superoxide radicals and in reducing 1,1-diphenyl-2-picryl hydrazyl and ferric reducing antioxidant *** addition the benzene extract prevented oxidative damage to DnA and *** was also effective in preventing stress-induced decrease in total plasma anti-oxidant activity as determined in vivo using rat model wherein stress was induced by exposing to restraint and forced *** minimum effective dose of the benzene extract was 5 mg/kg body weight(oral),and at this dose,its effect was similar to the same dose of a standard anti-oxidant,ascorbic *** study for the first time,clearly demonstrates a potent anti-oxidant activity of *** combining in vitro and in vivo ***,the therapeutic value of this herb maybe due to its anti-oxidant property.©2016 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Acorus calamus Antioxidant Forced swimming Radical scavenging DnA protection assay

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花生防病的技术策略与遗传修饰

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花生科技 1998年第2期27卷 39-40页

作者： h.t.Stalker A.k.Weisiager 蔡骥业

花生防病的技术策略与遗传修饰Ｈ．Ｔ．Ｓｔａｌｋｅｒ和Ａ．Ｋ．Ｗｅｉｓｉａｇｅｒ花生在南美和非洲至少出现了七个多样中心。在北美、南美、亚洲和非洲共搜集到１２０００份种质。栽培种内有两个形态上特殊的亚种（密枝、疏枝）分... 详细信息

花生防病的技术策略与遗传修饰Ｈ．Ｔ．Ｓｔａｌｋｅｒ和Ａ．Ｋ．Ｗｅｉｓｉａｇｅｒ花生在南美和非洲至少出现了七个多样中心。在北美、南美、亚洲和非洲共搜集到１２０００份种质。栽培种内有两个形态上特殊的亚种（密枝、疏枝）分别包括两个和四个植物变种。此外，通...

关键词：花生品种抗性作物育种遗传修饰

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