检索结果-南通市图书馆

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

引用

neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl lászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes C.heinzel Antal nógrádi Andreas h.Teuschl-Woller David hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGCs). however, the use of tnGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGCs and compared the various features of these improved silk^(+) tnGCs with the tubes without holes(silk^(–) tnGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

引用

nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(h_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOh)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),h-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Musculoskeletal disorders in nursing staff

引用

World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios n Gkougkoulias nikolaos Stefanou Elena Manuela Samaila Maria Tsekoura Marianna Vlychou Charalampos Matzaroglou Zoe h Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders nursing staff Predisposing factors Ergonomics Prevention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

引用

neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

nonlinear stability of advanced sandwich cylindrical shells comprising porous functionally graded material and carbon nanotube reinforced composite layers under elevated temperature

引用

Applied Mathematics and Mechanics(English Edition) 2021年第9期42卷 1327-1348页

作者： h.V.TUnG l.T.n.TRAnG Faculty of Civil Engineering Hanoi Architectural UniversityHa Noi 10000Viet Nam Faculty of Civil Engineering University of Transport TechnologyHa Noi 10000Viet Nam

The nonlinear stability of sandwich cylindrical shells comprising porous functionally graded material(FGM) and carbon nanotube reinforced composite(CnTRC)layers subjected to uniform temperature rise is investigated. Two sandwich models corresponding to CnTRC and FGM face sheets are proposed. Carbon nanotubes(CnTs) in the CnTRC layer are embedded into a matrix according to functionally graded distributions. The effects of porosity in the FGM and the temperature dependence of properties of all constituent materials are considered. The effective properties of the porous FGM and CnTRC are determined by using the modified and extended versions of a linear mixture rule, respectively. The basic equations governing the stability problem of thin sandwich cylindrical shells are established within the framework of the Donnell shell theory including the von K’arm’an-Donnell nonlinearity. These equations are solved by using the multi-term analytical solutions and the Galerkin method for simply supported *** critical buckling temperatures and postbuckling paths are determined through an iteration procedure. The study reveals that the sandwich shell model with a CnTRC core layer and relatively thin porous FGM face sheets can have the best capacity of thermal load carrying. In addition, unlike the cases of mechanical loads, porosities have beneficial effects on the nonlinear stability of sandwich shells under the thermal load. It is suggested that an appropriate combination of advantages of FGM and CnTRC can result in optimal efficiency for advanced sandwich structures.

关键词： carbon nanotube reinforced composite(CnTRC) porous functionally graded material(FGM) thermal instability cylindrical shell advanced sandwich model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of cold-working on corrosion induced damage in lug joints

引用

Defence Technology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.n Chikmath l. Murthy h. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

lug joints are preferred joineries for transferring heavy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finishes and rubbing displacement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is modelled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended performance of the lug joint during the damages due to corrosion are brought out and compared with non-cold-worked *** analysis is performed on this lug joint with *** results obtained highlight the benefits of cold-working and the methodology can be extended to damage growth and analyse the effect of surface treatments for better structural integrity of components of aerospace vehicles.

关键词： lug joint Corrosion Crack initiation Cold-working Structural integrity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

引用

neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis h.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GlAST EAAT-2/GlT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Opportunities and challenges of biodegradable Zn-based alloys

引用

Journal of Materials Science & Technology 2020年第11期42卷 136-138页

作者： h.F.li Z.Z.Shi l.n.Wang Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China

Following the footsteps of biodegradable Mg-based and Fe-based alloys,biodegradable Zn-based alloy is a newcomer and rising star in the family of biodegradable metals and *** combined superior mechanical properties,appropriate degradation rates,excellent biocompatibility of biodegradable Zn-based alloys have brought worldwide research interest on the design,development and clinical translation of Zn-based *** present perspective has summarized opportunities and challenges in the development of biodegradable Zn-based alloys.

关键词： Biodegradable Zn-based alloys Clinical applications Mechanical properties Degradation behavior Biocompatibility Corrosion fatigue Bio-tribocorrosion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

nUMERICAl SIMUlATIOn STUDY On DEFORMATIOn UnIFORMITY OF EQUAl CROSS SECTIOn lATERAl EXTRUSIOn

引用

Acta Metallurgica Sinica(English letters) 2004年第1期17卷 61-63页

作者： Z.l.Chang J.l.Song n.h.hao Department of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 China

Equal cross section lateral extrusion (ECSlE) is an effective method realizing pure shear deformation. The influence of friction factor on the deformation uniformity of ECSlE was investigated with rigid plastic finite element method. The result shows that the non-uniform deformation in extrusion is caused mainly by the friction between workpiece and die. The higher the friction factor is, the more uneven plastic deformation resulted in extruded workpiece. The relation curve of deformation uniformity vs. friction factor was drawn based on the analysis result. The curve can be used as a basis of ECSlE process design.

关键词： equal cross section lateral extrusion strain finite element method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A COMPUTATIOnAl APPROACh FOR OPTIMAl COnTROl SYSTEMS GOVERnED BY PARABOlIC VARIATIOnAl InEQUAlITIES

引用

Journal of Computational Mathematics 2003年第6期21卷 815-824页

作者： n.h.Sweilam l.F.Abd-Elal Department of Mathematics Faculty of Science Cairo University Giza-EgyptDepartment of Mathematics Faculty of Science Cairo University Giza-Egypt

Iterative techniques for solving optimal control systems governed by parabolic varia-tional inequalities are presented. The techniques we use are based on linear finite elements method to approximate the state equations and nonlinear conjugate gradient methods to solve the discrete optimal control problem. Convergence results and numerical experiments are presented.

关键词： Parabolic variational inequalities finite elements method nonlinear conjugate gradient methods.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：