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ThAI experimental research on hydrogen risk and source term related safety systems

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Frontiers in Energy 2021年第4期15卷 887-915页

作者： Sanjeev GUPTA martin FREITAG Gerhard POSS Becker Technologies Gmbh Rahmannstrasse 11Eschborn 65760Germany

In the defense-in-depth concept employed for the safety of nuclear installations,maintaining integrity of containment as the last barrier is of high importance to limit the release of radioactivity to the environment in case of a severe *** active and passive safety systems implemented in containments of light water reactors(LWRs)are designed to limit the consequences of such *** the performance and reliability of such systems under accident conditions is critical to the safety of nuclear *** the aftermath of the Fukushima accident,there has been focus on re-examining the existing safety systems to demonstrate their capabilities for a broader range of boundary conditions comprising both the early as well as the late phases of an *** addition to the performance testing of safety systems,their interaction with containment atmosphere needs detailed investigations to evaluate the effects of operation of safety systems on h2 risk and fission product(FP)behavior in containment,which may ultimately have an impact on the source term to the *** this context,an extensive containment safety related experimental research has been conducted in a thermalhydraulics,hydrogen,aerosols,and iodine test facility(ThAI,60 m3,single vessel)/(ThAI+,80 m3,two interconnected vessels).Related to the subject of this paper,experimental investigations covered performance testing of various safety and mitigation systems,i.e.,containment spray,passive autocatalytic recombiner(PAR),pressure suppression pool(water pools),and effects of their operation on h2 risk and in-containment FP *** experimental results have provided a better phenomenological understanding and database for validation and further improvement of a safety analysis tool based on computation fluid dynamic(CFD)and lumped parameter(LP)modeling *** paper summarizes the main insights obtained from the aforesaid ThAI experimental research covering safety systems

关键词： severe accident containment safety mitigation h2 risk source term

Combustion mechanism development and CFD simulation for the prediction of soot emission during flaring

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Frontiers of Chemical Science and Engineering 2016年第4期10卷 459-471页

作者： Anan Wang helen h. Lou Daniel Chen Anfeng Yu Wenyi Dang Xianchang Li Christopher martin Vijaya Damodara Ajit Patki Dan F. Smith Department of Chemical Engineering Lamar University Beaumont TX 77710 USA SINOPEC Safety Engineering Institute Qingdao 266000 China Department of Mechanical Engineering Lamar University Beaumont TX 77710 USA Department of Chemistry Lamar University Beaumont TX 77710 USA

Industrial Flares are important safety devices to bum off the unwanted gas during process startup, shutdown, or upset. however, flaring, especially the associated smoke, is a symbol of emissions from refineries, oil gas fields, and chemical processing plants. how to simultaneously achieve high combustion efficiency （CE） and low soot emission is an important issue. Soot emissions are influenced by many factors. Flare operators tend to over-steam or over-air to suppress smoke, which results in low CE. how to achieve optimal flare performance remains a question to the industry and the regulatory agencies. In this paper, regulations in the US regarding flaring were reviewed. In order to determine the optimal operating window for the flare, different combus- tion mechanisms related to soot emissions were summar- ized. A new combustion mechanism （Vsoot） for predicting soot emissions was developed and validated against experimental data. Computational fluid dynamic （CFD） models combined with Vsoot combustion mechanism were developed to simulate the flaring events. It was observed that simulation results agree well with experimental data.

关键词： flare soot emission combustion mechanism,CFD simulation

Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement

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World Journal of Gastroenterology 2010年第16期16卷 1986-1992页

作者： Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder hakan Alakus martin Kocher Stephan E Baldus Arnulf h hlscher Department of General Visceral and Cancer SurgeryCenter for Integrated OncologyUniversity Hospital of Cologne Department of Pathology University of Cologne Department of Radiation Oncology University of Cologne Department of Pathology University of Düsseldorf

AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal ***:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and *** hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were *** of the patients was analyzed according to intra-and extra-capsular ***:Five-year survival rate was 22.5% for the entire patient *** with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was *** therapy does not reduce the occurrence of extracapsular ***:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant *** a revised staging system for esophageal cancer,extracapsular LNI should be considered.

关键词： Esophageal cancer Neoadjuvant therapy Chemotherapy Radiotherapy Adenocarcinoma Squamous cell carcinoma Lymph node metastasis Extracapsular lymph node involvement Prognosis

A cop1 spa Mutant Deficient in COP1 and SPA Proteins Reveals Partial Co-Action of COP1 and SPA during Arabidopsis Post-Embryonic Development and Photomorphogenesis

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Molecular Plant 2015年第3期8卷 479-481页

作者： Natalia Ordonez-herrera Petra Fackendahl Xu Yu Sabine schaefer Csaba Koncz Ute hoecker Botanical Institute and Cluster of Excellence on Plant Sciences (CEPLAS) Biocenter University of Cologne Zülpicher Strasse 47b 50674 Cologne Germany Max Planck Institute for Plant Breeding Research Carl-von-Linné Weg 10 50829 Cologne Germany Institute of Plant Biology Biological Research Center of Hungarian Academy of Sciences Temesvari krt. 62 H-6726 Szeged Hungary

Dear Editor,The Arabidopsis CONSTITUTIVELY PhOTOMORPhOGENIC1/ SUPPRESSOR OF PhYA-105 （COP1/SPA） complex is a key repressor of light signaling that inhibits light responses in dark- ness. It acts as an E3 ubiquitin ligase, which ubiquitinates posi- tively acting light-signaling intermediates, mainly transcription factors, thereby targeting them for proteolytic degradation by the 26S proteasome. In the light, photoreceptors directly interact with the COP1/SPA complex, leading to its inactivation, which subsequently allows the target transcription factors to accumu- late and initiate vast reprogramming of gene expression （huang et al., 2014）.

关键词： COP1 SPA 蛋白质拟南芥光形态建成胚胎发育突变体 26S蛋白酶体

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牦牛绒选择性漂白工艺的研究

纺织学报 2002年第1期23卷 7-9页

作者：阎克路宋心远 K.schaefer h.hoecker 东华大学上海200051 WoolResearch Institute

研究牦牛绒选择性漂白工艺中不同预处理条件对牦牛绒吸铁量的影响,提出最佳预处理工艺条件;研制新型清洗工艺,可较大程度降低漂白后纤维的损伤和改善手感。

关键词：牦牛绒选择性漂白工艺前处理吸铁量清洗工艺纤维损伤

Investigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders

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World Journal of Diabetes 2022年第6期13卷 434-441页

作者： Arjun Jain Kristof Bozovicar Vidhi Mehrotra Tomaz Bratkovic martin h Johnson Ira Jha ET-Traps Limited Cambridge CB30JEUnited Kingdom Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridge CB23DYUnited Kingdom Accelerate Cambridge Judge Business SchoolUniversity of CambridgeCambridge CB21AGUnited Kingdom Department of Pharmaceutical Biology Faculty of PharmacyUniversity of LjubljanaSlovenia 1000Slovenia

BACKGROUND Endothelin(ET)-traps are Fc-fusion proteins with a design based on the physiological receptors of *** work has shown that use of the selected ET-traps potently and significantly reduces different markers of diabetes pathology back to normal,non-disease *** To demonstrate the selected ET-traps potently and significantly bind to *** We performed phage display experiments to test different constructs of ET-traps,and conducted bio-layer interferometry binding assays to verify that the selected ET-traps bind specifically to ET-1 and display binding affinity in the double-digit picomolar range(an average of 73.8 rM,n=6).RESULTS These experiments have confirmed our choice of the final ET-traps and provided proof-of-concept for the potential use of constructs as effective biologics for diseases associated with pathologically elevated *** There is increased need for such therapeutics as they could help save millions of lives around the world.

关键词： Endothelin-1 Endothelin-traps Diabetes heart failure Chronic kidney disease Novel therapeutic

Near-Wall Flow in the Blade Cascades Representing Last Rotor Root Sections of Large Output Steam Turbines

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Journal of Thermal Science 2021年第1期30卷 220-230页

作者： ŠIMURDA David FÜRST Jiří hÁLA Jindřich LUXA martin BOBČÍK Marek NOVÁK Ondřej SYNÁČJaroslav Institute of Thermomechanics of the Czech Academy of Sciences Prague 18200Czech Republic Dpt.of Technical Mathematics Faculty of Mechanical EngineeringCTU in PraguePrague 12000Czech Republic Doosan Skoda Power Pilsen 30100Czech Republic

This paper investigates the flow past two variants of root section profile cascades for a last stage rotor considering three-dimensional flow structures in the near-wall *** were drawn based on RANS numerical simulations of both variants and on the experimental data obtained by the 3 D traversing in the exit flow field of one of the *** of 3 D structures at two different regimes and its influence on aerodynamic characteristics of the blade cascades was *** distributions of Mach number along the profiles were compared with 2 D optical measurements and its distortion due to the presence of the sidewall was *** interaction between main vortical structures was described and its influence on the loading of the blades,mechanical energy losses and exit flow angle was *** results showed that for a front loaded blade the vortical structures appeared earlier and at a larger extent than for an aft loaded ***,due to different Mach number distribution,contribution of end wall flow to the energy losses was lower in the case of the aft loaded *** influence of the near wall flow on the loading was found to be rather weak while the deviation of the exit flow angle appeared to be comparable for both of the variants.

关键词： turbine blade cascade secondary flow near wall flow supersonic flow CFD experiment

Recent Ventures in Interdisciplinary Arctic Research:The ARCPATh Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KING Noel KEENLYSIDE François COUNILLON Brynhildur DAVIÐSDÓTTIR Níels EINARSSON Sergey GULEV Ke FAN Torben KOENIGK James R.MCGOODWIN Marianne h.RASMUSSON Shuting YANG Institute of Arctic and Alpine Research(INSTAAR) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland Royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway Nansen Environmental and Remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATh(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the Nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATh made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, Norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATh was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATh served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic Research:The ARCPATh Project

多米尼加共和国高海拔新热带山地森林的林火与植被动态

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AMBIO－人类环境杂志 2008年第7期37卷 466-471页

作者： Ruth E.Sherman Patrick h.martin Timothy J.Fahey Steve D. Degloria 梁虹康奈尔大学自然资源系康奈尔大学作物栽培与土壤学系

2005年3～4月,多米尼加共和国中央山脉幅员1000 km^2的热带山地森林曾发生严重火灾。林火范围涵盖了我们在1999年建立的永久植被样地网络,这一网络设立的目的是检测森林环境、植被与干扰的相互作用。我们采用快鸟(QuickBird)卫星影像和... 详细信息

2005年3～4月,多米尼加共和国中央山脉幅员1000 km^2的热带山地森林曾发生严重火灾。林火范围涵盖了我们在1999年建立的永久植被样地网络,这一网络设立的目的是检测森林环境、植被与干扰的相互作用。我们采用快鸟(QuickBird)卫星影像和野外调查绘制了景观区域内的林火程度和等级图示。96%的松林发生火灾,但在沿大部分群落交错区边界的松林-云林中被迅速扑灭。地形因素和林火等级对群落交错区的林火特征无显著影响。该结果验证了我们之前的假设,即林火是构成这一山区松林和云林之间不连续边界的主要因素。植被结构和组成对景观内林火特征与蔓延的调节具有直接作用。

关键词：林火特征植被动态山地森林多米尼加共和国热带高海拔不连续边界