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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sheikh Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

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Ehlers-Danlos syndrome:prevalence and outcomes in gender affirming surgery-a single institution experience

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Plastic and Aesthetic Research 2022年第1期9卷 605-613页

作者： Alireza Najafian Isabel Cylinder Breanna Jedrzejewski Craig Sineath Zbigniew Sikora Leigh h.martin Daniel Dugi Geolani W.Dy Jens Urs Berli Division of Plastic Surgery Department of General SurgeryOregon Health&Science UniversityPortlandOR 97239USA Department of Urology Oregon Health&Science UniversityPortlandOR 97239USA

Aim:Patients with Ehlers-Danlos Syndrome(EDS)are considered to have an increased risk for wound healing *** may therefore be hesitant to offer elective surgeries,including gender-affirming surgeries(GAS),to EDS *** our center,we frequently encountered patients presenting for GAS evaluation with the co-existing diagnosis of *** study aims to establish the prevalence of EDS diagnosis in our GAS patients and compare their post-operative complications to patients without EDS ***:This is a single-institution retrospective case-control study on all patients who underwent GAS from *** include EDS diagnosis,demographics,operation,and complications(including minor wound healing issues).Results:Of 1363 patients presenting for GAS,36(2.6%)had EDS diagnoses and were matched with 108 control *** complications requiring surgical intervention in the OR occurred in 6 patients(4.2%),(2.8% EDS vs.5.4%controls;P=0.63),while 8.3% of EDS and 14% of controls required minor interventions(P=0.38).The rate of wound healing issues of any severity was 28% in EDS vs.47% in control groups(P=0.04).Conclusion:The prevalence of EDS diagnosis in our patient population is 132 times the highest reported prevalence in the general *** healing issues and the need for additional post-operative interventions in the group with EDS diagnosis were not significantly different from the control *** findings suggest that patients with a diagnosis of EDS undergoing GAS have comparable outcomes to patients without *** for post-operative complications should not be a barrier to offering GAS to patients presenting with an EDS diagnosis.

关键词： Ehlers-Danlos gender transgender gender affirmation surgery outcomes

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Fe_(3)O_(4)对黄铜矿在酸性硫酸铁溶液中铜溶解氧化还原反应的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1965-1975页

作者： Kolela J NYEMBWE Elvis FOSSO-KANKEU Frans WAANDERS martin MKANDAWIRE Didier K NYEMBWE Bhekie B MAMBA Water Pollution Monitoring and Remediation Initiatives Research Group School of Chemical and Minerals EngineeringFaculty of EngineeringNorth-West UniversityPotchefstroomSouth Africa Department of Mining Engineering College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa Department of Metallurgy Faculty of Engineering and Built EnvironmentUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa Department of Chemistry School of Science and TechnologyCape Breton UniversityCanada School of Mining Metallurgy and Chemical EngineeringFaculty of Engineering and the Built EnvironmentUniversity of JohannesburgJohannesburgSouth Africa Institute for Nanotechnology and Water Sustainability College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同ph值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(... 详细信息

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同ph值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(4))_(3)−h_(2)SO_(4)浸出剂中添加磁铁矿(Fe_(3)O_(4))对铜溶解速率的影响。结果表明,溶液ph值、电位和温度在溶解过程中起着关键作用。在ph 1.8、50℃和400 mV的条件下,Fe_(3)O_(4)−CuFeS_(2)混合体系中铜的回收率达到最大值(70%),而未添加Fe_(3)O_(4)时,CuFeS_(2)中铜的回收率较低(48%)。添加Fe_(3)O_(4)有助于维持较高的氧化还原值。添加Fe_(3)O_(4)还使活化能从79.04 kJ/mol降低到53.69 kJ/mol。这表明,当Fe_(3)O_(4)存在时,由于形成了更易溶解的中间体斑铜矿(Cu_(5)FeS_(4))和辉铜矿(Cu_(2)S),CuFeS_(2)更易被氧化。两种溶解过程都受到矿物表面的化学控制。此外,对浸出残渣的矿物学分析表明,当无Fe_(3)O_(4)存在时,作为表面钝化物的黄钾铁矾浓度较高。因此,添加Fe_(3)O_(4)减少了钝化层的形成,提升了铜的回收率。

关键词：黄铜矿溶解磁铁矿电偶钝化

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Manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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Molecular Plant 2024年第9期17卷 1458-1471页

作者： martin William Battle Scott Fraser Ewing Cathryn Dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow Matthew Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

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A Comparison of hydrothermal Aging, SO₂ and Propene Poisoning Effects on Nh₃-SCR over Cu-ZSM-5 and Cu-SAPO-34 Catalysts

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Journal of Materials Science and Chemical Engineering 2024年第5期12卷 10-28页

作者： Kouadio Brou Albert Koffi Konan martin Zran Van Eric-Simon horo Kone Unité de Formation et de Recherche des Sciences et de Technologies (UFR ST) Universit&#233 Alassane Ouattara Bouak&#233 C&#244te d&#8217Ivoire Unité de Formation et de Recherche Environnement (UFR E) Universit&#233 Jean Lorougnon Gu&#233d&#233 Daloa C&#244te d&#8217Ivoire Unité de Formation et de Recherche des Sciences des Structures de la Mati&#232re et de Technologie (UFR SSMT) Abidjan C&#244te d&#8217Ivoire

This study was aimed to investigate the effects of hydrothermal aging, propene and SO2 poisoning on the ammonia-selective catalytic reduction (Nh3-SCR) performance of both Cu-SAPO-34 and Cu-ZSM-5. The catalytic activities of fresh, aged and poisoned samples were tested in ammonia-selective catalytic reduction (Nh3-SCR) of NOx conditions. The XRD, TG and N2-desorption results showed that the structures of the Cu-SAPO-34 and Cu-ZSM-5 remained intact after 750˚C hydrothermally aged, SO2 and propene poisoned. After hydrothermal aging at 750˚C for 12 h, the NO reduction performance of Cu-ZSM-5 was significantly reduced at lower temperatures, while that of Cu-SAPO-34 was less affected. Moreover, Cu-SAPO-34 catalyst showed high NO conversion with SO2 or propene compared to Cu-ZSM-5. however, Cu-ZSM-5 showed a larger drop in catalytic activity with SO2 or propene compared to Cu-SAPO-34 catalyst. The h2-TPR results showed that Cu2 ions could be reduced to Cu and Cu0 for Cu-ZSM-5, while no significant transformation of copper species was observed for Cu-SAPO-34. Meanwhile, the UV-vis DRS results showed that CuO species were formed in Cu-ZSM-5, while little changes were observed for the Cu-SAPO-34. Cu-SAPO-34 showed high sulfur and hydrocarbon poison resistance compared to Cu-ZSM-5. In summary, Cu-SAPO-34 with small-pore zeolite showed higher hydrothermal stability and better hydrocarbon and sulfur poison resistant than Cu-ZSM-5 with medium-pore.

关键词： hydrothermal Aging Propene and SO2Poisoning Ammonia-Selective Catalytic Reduction(Nh3-SCR) Cu-SAPO-34 Cu-ZSM-5

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Effective Utilization of Government-Provided CTI by Small Businesses within the Defense Industrial Base

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Journal of Information Security 2024年第2期15卷 196-217页

作者： Josiah Dykstra Lawrence A. Gordon martin P. Loeb Benjamin Wall Lei Zhou National Security Agency Fort Meade MD USA Robert h. Smith School of Business University of Maryland College Park MD USA

There are two broad objectives of the research reported in this paper. First, we assess whether government-provided cyber threat intelligence (CTI) is helpful in preventing, or responding to, cyber-attacks among small businesses within the U.S. Defense Industrial Base (DIB). Second, we identify ways of improving the effectiveness of government-provided CTI to small businesses within the DIB. Based on a questionnaire-based survey, our findings suggest that government-provided CTI helps businesses within the DIB in preventing, or responding to, cyber-attacks providing a firm is familiar with the CTI. Unfortunately, a large percentage of small firms are not familiar with the government-provided CTI feeds and consequently are not utilizing the CTI. This latter situation is largely due to financial constraints confronting small businesses that prevent firms from having the wherewithal necessary to effectively utilize the government-provided CTI. however, we found a significant positive association between a firm’s familiarity with the government-provided CTI and whether a firm is being periodically reviewed by the Defense Counterintelligence and Security Agency (DCSA) or is compliant with the Cybersecurity Maturity Model Certification (CMMC) program. The findings from our study also show that the participating firms believe that external cyber threats are more likely to be the cause of a future cybersecurity breach than internal cybersecurity threats. Finally, our study found that the portion of the IT budget that small businesses within the DIB spend on cybersecurity-related activities is dependent on the perception that a firm would be the target of an external cyber-attack.

关键词： Government-Provided CTI Small Businesses Defense Industrial Base

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成岩过程中受时间变化控制的花岗质岩石成分的演化:以芬兰东部太古宙为例

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华北地质 1987年第4期 1-13页

作者： h.martin 韩光

芬兰东部发育的灰色片麻岩构成了太古宙绿岩带的基底。它们是由英云闪长岩、奥长花岗岩和花岗闪长岩(TTG)组成的,并且是在两个性质不同的岩浆期即2.86Ga(Kivijarvi片麻岩)和2.56Ga(Naavala)之间侵位的。根据量痕元素特征建立起来的岩石... 详细信息

芬兰东部发育的灰色片麻岩构成了太古宙绿岩带的基底。它们是由英云闪长岩、奥长花岗岩和花岗闪长岩(TTG)组成的,并且是在两个性质不同的岩浆期即2.86Ga(Kivijarvi片麻岩)和2.56Ga(Naavala)之间侵位的。根据量痕元素特征建立起来的岩石成因模式显示出,TTG岩石最终是通过地幔的包括有两个阶段的一种机制所获得的:(1)地幔的熔融形成一种拉斑玄武质地壳;(2)这些拉斑玄武质重熔并转换成石榴斜长角闪岩*再产生TTG岩石。

关键词：太古宙角闪岩太古代前寒武纪闪岩区域变质岩局部熔融花岗质岩石 TTG 宝石石榴石石榴子石玄武质正片麻岩花岗岩酸性岩洋壳大洋型地壳拉斑玄武岩拉斑玄武质岩石岩石成因角闪石链状硅酸盐矿物绿岩带芬兰北欧

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Is there more than one stickiness criterion?

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Friction 2023年第6期11卷 1027-1039页

作者： Anle WANG martin h.MüSER Department of Material Science and Engineering Saarland UniversitySaarbrücken66123Germany INM—Leibniz Institute for New Materials Saarbrücken66123Germany

Adhesion between an elastic body and a smooth,rigid substrate can lead to large tensile stresses between ***,most macroscopic objects are microscopically rough,which strongly suppresses adhesion.A fierce debate has unfolded recently as to whether local or global parameters determine the crossover between small and large ***,we report simulations revealing that the dependence of the pull-off force Fn on the surface energyγdoes not only have two regimes of high and low adhesion but up to four *** are related to contacts,which at the moment of rupture consist of(i)the last individual hertzian-shaped contact,in which is linear inγ,(ii)a last meso-scale,individual patches with super-linear scaling,(iii)many isolated contact patches with extremely strong scaling,and(iv)a dominating largest contact patch,for which the pull-off stress is no longer negligible compared to the maximum,microscopic pull-off ***(iii)can be seen as a transition *** is located near the point where the surface energy is half the elastic energy per unit area in conformal contact.A criterion for the transition between regimes(i)and(ii)appears difficult to grasp.

关键词： adhesion pull-off force rough contact stickiness

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hAL/S——用于航天飞机的编程系统

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导弹与航天运载技术 1988年第3期 36-49页

作者： h.martin 任新潮

hAL/S是为满足高可靠性和精确性能要求而设计的一种先进的实时高级编程语言。为了强调可靠性和降低维护费用,hAL/S的设计采用了严格的编译校检,模块化/结构化编程手段,以及全部做了注释的标准可读程序列表。目前,为NASA开发的hAL/S语言... 详细信息

hAL/S是为满足高可靠性和精确性能要求而设计的一种先进的实时高级编程语言。为了强调可靠性和降低维护费用,hAL/S的设计采用了严格的编译校检,模块化/结构化编程手段,以及全部做了注释的标准可读程序列表。目前,为NASA开发的hAL/S语言及其编译器已进入使用阶段。同时,大量的目标计算机也都有了相应的模块化代码发生器。近来,hAL/S正用来为航天飞机机载计算机编制程序,并且被NASA定为一种标准的飞行软件开发语言。本文是介绍该hAL/S编程系统,重点放在语言方面,但对编译器、执行系统、诊断系统及程序统计包等都做了些功能上的介绍。

关键词： hAL/S语言编译程序实时操作系统

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Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo Sánchez Tala Alakhras Barbara Schreier Michael Gekle Stefan hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

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