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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl james Ferguson Nicole Swiadek Xavier Monforte johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller David hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Decorating crystalline YFe_(2-x)Al_(x) on the Mg_(60)la_(10)Ni_(20)Cu_(10) amorphous alloy as “hydrogen pump” to realize fast de/hydrogenation

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journal of Materials Science & Technology 2024年第6期173卷 72-79页

作者： l.j.huang h.Wang l.Z.Ouyang M.Zhu h.j.l.n School of Materials Science and Engineering Key Laboratory of Advanced Energy Storage Materials of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510641China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China

Mg-based amorphous alloys are one of the potential hydrogen storage materials but suffer from sluggish dehydrogenation/hydrogenation(de/hydrogenation)*** this work,as a new strategy,a hydrogen pump is built on the surface of amorphous alloys to solve this *** milling crystalline YFe_(2-x)Al_(x) hydrogen storage alloy with Mg_(60)la_(10)Ni_(20)Cu_(10) amorphous alloy,fine crystalline particles were seeded on amorphous alloy powder to form a“strawberry”*** to the TEM observation,a metallurgical bonding boundary formed between the Mg-based amorphous matrix and the Y-Fe-Al crystalline *** microstructure and de/hydrogenation kinetics investigation,the“hydrogen pump”effect of the seeded crystalline alloy was confirmed,which makes it much easier for the hydrogen to dissociate on and diffuse through the surface of the Mg-based amorphous *** such effect,the h absorption rate of Mg_(60)la_(10)Ni_(20)Cu_(10) amorphous alloy became almost eight times faster and it absorbs ~2.8 wt.% in 1 h at 130℃ under 4.5 MPa-h_(2).Further,fast hydrogenation can even achieve at 70℃ and the low-temperature dehydrogenation kinetics of the amorphous hydride can be also greatly *** present work proves that surface modification is of great importance for obtaining Mg-based amorphous alloy with ideal hydrogen storage performance.

关键词： hydrogen storage Mg-based amorphous alloy hydrogen pump Composite structure

Effect of interlayer addition on microstructure and mechanical properties of NiTi/stainless steel joint by electron beam welding

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journal of Materials Science & Technology 2021年第2期61卷 16-24页

作者： h.Niu h.C.jiang M.j.Zhao l.j.Rong CAS Key laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of ScienceShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei230026China

NiTi/Stainless Steel(SS) sheets have been welded via a vacuum electron beam welding process, with three methods(offsetting electron beam to SS side without interlayer, adding Ni interlayer and adding Fe Ni interlayer), to promote mechanical properties of the Ni Ti/SS joints. The joints with different interlayers are all fractured in the weld zone near the Ni Ti side, which is attributed to the enrichment of intermetallic compounds including Fe2 Ti and Ni3 Ti. The fracture mechanisms of different joints are strongly dependent on the types of interlayers, and the joints without interlayer, adding Ni interlayer and adding Fe Ni interlayer exhibit cleavage fracture, intergranular fracture and mixed fracture composed of cleavage and tearing ridge, respectively. Compared with the brittle laves phase Fe2 Ti, Ni3 Ti phase can exhibit certain plasticity, block the crack propagation and change the direction of crack propagation. The composite structure of Ni3 Ti and Fe2 Ti will be formed when the Fe Ni alloy is taken as the interlayer, which provides the joint excellent mechanical properties, with rupture strength of 343 MPa.

关键词： NiTi Stainless steel Electron beam welding Interlayer Mechanical property

Properties of Co_2FeAl heusler Alloy Nano-particles Synthesized by Coprecipitation and Thermal Deoxidization Method

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journal of Materials Science & Technology 2013年第3期29卷 245-248页

作者： j.h.Du Y.l.Zuo Z.Wang j.h.Ma l.Xi Key laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou University

Co2FeAl nanoparticles were synthesized by reducing the coprecipitated precursor of COCl2·6h2O, Fe（NO3）3·9h2O and AI2（SO4）3·18h2O under h2 atmosphere with various annealing temperatures and durations. X-ray diffraction and transmission electron microscopy were used to characterize the crystal structure and microstructure of Co2FeAl particles, respectively. The investigation indicates that the crystal structure of CO2FeAI particles tends to be B2 structure, in which atoms are partially ordered. The saturation magnetization and hyperfine field of CO2FeAI particles, which were measured under a vibrating sample magnetometer and a 57Fe Mossbauer spectroscope, are consistent with those of the bulk sample and thin films. Furthermore, the higher annealing temperature and the longer annealing time, the better crystallinity of CO2FeAI and more ordered arrangement of atoms will be. It turned out that the coprecipitation thermal deoxidization method could be an easy and high efficient way to obtain the half-metallic CO2FeAI nanoparticles.

关键词： heusler alloy Coprecipitation Magnetic property

Electromagnetoelastic behaviors of functionally graded piezoelectric solid cylinder and sphere

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Acta Mechanica Sinica 2007年第1期23卷 55-63页

作者： h. l. Dai Y.M. Fu j.h. Yang Department of Engineering Mechanics Hunan University Changsha 410082 China

Analytical studies on electromagnetoelastic behaviors are presented for the functionally graded piezoelectric material （FGPM） solid cylinder and sphere placed in a uniform magnetic field and subjected to the external pressure and electric loading. When the mechanical, electric and magnetic properties of the material obey an identical power law in the radial direction, the exact displacements, stresses, electric potentials and perturbations of magnetic field vector in the FGPM solid cylinder and sphere are obtained by using the infinitesimal theory of electromagnetoelasticity. Numerical examples also show the significant influence of material inhomogeneity. It is interesting to note that selecting a specific value of inhomogeneity parameter β can optimize the electromagnetoelastic responses, which will be of particular importance in modern engineering designs.

关键词： Functionally graded piezoelectric material (FGPM) Electromagnetoelastic Solid cylinder Solid sphere Perturbation of magnetic field vector

EFFECT OF TESTING ENVIRONMENT ON FRACTURING BEhAVIOR OF Fe_3Si BASED AllOY

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Acta Metallurgica Sinica(English letters) 2003年第2期16卷 104-109页

作者： j.h.Peng G.l.Chen National Key laboratory for Nuclear Fuel&Materials China Nuclear Power InstituteChengdu 610041ChinaState Key Laboratory for Advanced Metal MaterialsUniversity of Science&Technology BeijingBeijing 100083China

The mechanical behavior of Fes Si based alloy with B2 structure was studied by tension and fracture toughness test in various testing media. The fracture strength σb of Fe3Si alloy decreased in the following order: oxygen, air and hydrogen respectively. The fracture toughness in different testing environment showed that KIC in oxygen is 11.5±0.3MPa·m1/2, and is 8.6±0.4MPa·ml/2 in distilled water. The reduction of fracture toughness is contributed to the environmental reaction of Si with water. Addition of Al element in Fe3Si is not beneficial to improve the intrinsic ductility of Fe-14Si-3Al alloy. The scattering phenomenon of fracture strength was found, and explained by fracture mechanics. It was found by means of SEM that the fracture mode changed from transgranular in oxygen to intergranular in hydrogen gas and distilled water.

关键词： Fe3Si intermetallic mechanical behavior environmental em- brittlement