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Advances in Applied Mathematics and Mechanics 2024年第1期16卷 47-74页

作者： Adyllyson h.Nascimento Eugenio S.Rosa Department of Energy School of Mechanical EngineeringUniversity of CampinasCampinasBrazil

A computational code is developed for the numerical solution of onedimensional transient gas-liquid flows using drift-flux models,in isothermal and also with phase change *** these two-phase models,classical upwind schemes such as Roe-and Godunov-type schemes are generally difficult to derive and expensive to use,since there are no treatable analytic expressions for the Jacobian matrix,eigenvalues and eigenvectors of the system of *** the other hand,the highorder compact finite difference scheme becomes an attractive alternative on these occasions,as it does not make use of any wave propagation information from the system of *** present paper extends the localized artificial diffusivity method for high-order compact finite difference schemes to solve two-phase flows with *** numerical method has simple formulation,straightforward implementation,low computational cost and,most importantly,*** numerical methodology proposed is validated by solving several numerical examples given in the *** simulations are sixth-order accurate and it is shown that the proposed numerical method provides accurate approximations of shock waves and contact *** is an essential property for simulations of realistic mass transport problems relevant to operations in the petroleum industry。

关键词： Compressible two-phase flows drift-flux model localized artificial diffusivity highorder numerical methods

Nonlinear boundary control problem of hyperbolic systems

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Journal of Control and Decision 2024年第1期11卷 73-83页

作者： A.Bouhamed A.El Kabouss h.Bouzahir ISTI Lab Ibn Zohr UniversityENSAAgadirMorocco Faculty of sciences Moulay Ismail UniversityMeknesMorocco

The paper is devoted to the study of optimal control of a hyperbolic system,where the control enters the system through the *** hyperbolic system is the wave equation on a smooth and open domain,where the boundary condition involves the normal derivative at the boundary of z,the time derivative of z times a constant k,and a nonlinear term ***,z is the state and u is the control,satisfying some boundedness condition depending on *** functional cost consists of the energy and the difference between the solution of the system at final time,and a desired state in *** a closed convex set,we prove the existence of an optimal control that minimises the cost functional using a priori ***,using the differentiability of the cost functional with respect to the control,we establish the characterisation by deriving necessary conditions that an optimal control must satisfy.A numerical approach is successfully illustrated by simulations.

关键词： Non-linear system hyperbolic system boundary control optimal control controllability

Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

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Chinese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsinghua Shenzhen International Graduate School China Lanzhou Jiaotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the object.

关键词： service Application operation

Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey T.Zhu Ronnie h.Fang Liangfang Zhang Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of host-Microbe Systems and Therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

The continued development of clustered regularly interspaced short palindromic repeats(CRISPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and *** high demand for the in vivo delivery of CRISPR-based therapies,significant challenges *** include rapid degradation by enzymes,inefficient disease site targeting,and the risk of undesired off-target *** platforms,with their tailorable properties,have been engineered to efficiently package CRISPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprotein complexes,for in vivo *** them,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles have displayed exceptional *** review will discuss the development of these and other nanocarriers for in vivo CRISPR-based genome editing.

关键词： clustered regularly interspaced short palindromic repeats(CRISPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong S.W.Lee W.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the hCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

Connections Between Induction Generator Effect and Open-loop Modal Proximity to Cause Sub-synchronous Oscillations in Series-compensated Power System

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 963-973页

作者： Wenjuan Du Yang Wang h.F.Wang Tao Zhao Tim Littler College of Electrical Engineering Sichuan UniversityChengduChina School of Electrical Engineering the Queen’s University of BelfastBelfastUK IEEE

The induction generator effect(IGE)and the openloop modal proximity(OLMP)are two different reasons why subsynchronous oscillations(SSOs)in a series-compensated power system(SCPS)may *** IGE attributes the growing SSOs to negative resistance,while the OLMP explains the SSO mechanism from the standpoint of modal *** this paper,we investigate the connections between the IGE and the OLMP through equivalent RLC circuit and open-loop modal *** investigation is conducted for two types of seriescompensated power systems where either a synchronous generator or a DFIG is connected at the sending *** investigation reveals the conditions,in which the IGE and the OLMP may jointly cause the growing SSOs,i.e.,both the IGE and the OLMP can explain why the growing SSOs ***,the investigation indicates that the IGE and the OLMP may be totally irrelevant and lead to growing SSOs *** implies that it is possible that in a SCPS,the growing SSOs are only due to the IGE,and the OLMP is non-existent,and vice ***,when the growing SSOs occurs in a SCPS,examination based on both the IGE and the OLMP should be carefully conducted in order to find if the oscillatory instability is due to the IGE,or the OLMP,or both of them.

关键词： Induction generator effect open-loop modal proximity series compensation sub-synchronous oscillations

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

Biophotoelectrochemistry:An emerging frontier for channeling photoelectric effect into darkness zone of soils and sediments

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Pedosphere 2024年第1期34卷 5-8页

作者： Jie YE Shungui ZhOU Kenneth h.NEALSON Christopher RENSING Fujian Provincial Key Laboratory of Soil Environmental health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China Department of Earth Science University of Southern CaliforniaLos Angeles CA 90007USA

Solar energy captured by photosynthetic plants in the photic zone is recognized as the main driver for the formation of organic matter utilized by soil communities. however, the contribution of organic transformation to the linkage of solar energy and microbial metabolism of soils is reduced when the vadose zone is saturated. In contrast to the conventional biophotoelectrochemistry via photosynthesis with phytoplankton during the periodic saturation of soils, recent studies suggest that non-phototrophic microorganisms in soils and sediments are able to conduct light-dependent metabolism to sustain their functionality with photosensitizers under illumination. These interactions and processes utilize long-distance electron transfer networks to interconnect diverse electron transfer chains that channel photoexcited electrons into the opaque zone for soil communities. Such an emerging process not only allows for a better understanding of biogeochemical processes such as soil carbon sequestration and mitigation, but also shows great potential for environmental treatment such as the bioremediation of contaminated soils. Therefore, we suggest that biophotoelectrochemistry via photoelectric effect can have significant, heretofore unappreciated, theoretical and practical values.

关键词： soils soil metabolism

Multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

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Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： haifa A Alyousef Alvaro h Salas B M Alotaibi S A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(MSM)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** MSM first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order MSM approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the MSM,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(MSM)and he-MSM to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim h.Maleki Ahmad Reza Bahrami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy