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对比增强心脏多层CT右心室脂肪自动量化技术在致心律失常性右室心肌病中的应用

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国际医学放射学杂志 2015年第4期 379-379页

作者： h.cochet A.Deni Y.Komatsu A.S.Jadidi T.A.Ali F.Sacher 李鹏 Department of Cardiovascular Imaging H?pital Cardiologique Haut LévêqueCHU/Université de Bordeaux Avenue Magellan 33604 Pessac France

摘要目的评价多层CT右心室游离壁脂肪自动量化方法,并评估其对致心律失常性右室心肌病(ARVC)的诊断价值。材料与方法本研究经机构伦理委员会批准,所有病人均

关键词：致心律失常性右室心肌病右心室脂肪对比增强心脏 CT

CT关节成像研究肩袖损伤,影像采集前行外展外旋(ABER)位检查的必要性

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国际医学放射学杂志 2010年第4期 399-399页

作者： h.cochet S.Couderc E.Pelé N.Amoretti M.h.Moreau-Durieux O.hauger 赵芳 Unité d'imagerie thoracique et cardiovasculaire Hopital cardiologique du Haut-LévêqueCHU BordeauxPessacFrance

目的评价CT关节成像之前行外展外旋(ABER)位检查对于肩袖损伤评价的影响。方法对27例临床怀疑有肩袖损伤的病人,先行肩关节正中位CT关节成像,在下一次正中位CT影像采

关键词：肩袖损伤外旋 ABER 外展关节运动器官影像采集 CT

9.4T MR在活鼠体内的血管成像及速率测量:冠状动脉血流速度储备率评价

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国际医学放射学杂志 2010年第2期 181-181页

作者： h.cochet M.Montaudon F.Laurent G.Calmettes J.M.Franconi S.Miraux 金涵弢 Unit of Thoracic and Cardiovascular Imaging Hpital Cardiologique du Haut-LévêqueCHU Bordeauxavenue Magellan33604 PessacFrance

目的本研究旨在证明冠状动脉MR血管成像技术在活鼠中应用的可行性,并评估9.4T场强中,动态MR血管成像在冠状动脉血流测量中的应用。材料与方法本研究完全遵照欧

关键词：冠状动脉实验鼠 MR 血管成像血流速度储备

Pathogenicity and amino acid sequences of hemagglutinin cleavage site and neuraminidase stalk of differently passaged h9N2-avian influenza virus in broilers

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Advances in Bioscience and Biotechnology 2011年第4期2卷 198-206页

作者： houssam A. Shaib Nelly cochet Thierry Ribeiro Afif M. Abdel Nour Georges Nemer Maya F. Saade Elie K. Barbour Department of Animal and Veterinary Sciences Faculty of Agricultural and Food Sciences American University of Beirut (AUB) P.O. Box 11-0236 Beirut Lebanon

Low pathogenic Avian Influenza (AI) virus has the ability to evolve to high pathogenic viruses resulting in significant economic losses in the poultry sector. This study aims at assessing the impact of h9N2 viral passaging in broilers and its relatedness to pathogenicity and amino acid (a.a) sequences of the hemagglutinin (hA) cleavage site and neuraminidase (NA) stalk. The original h9N2 AI virus (P0) was used to challenge ten-21 days old broilers. Individual recovery of h9N2 virus from homogenates of trachea, lungs and airsacs was attempted in 9 days old chicken embryos, as a conclusion of the first passage (P1). Tracheal isolates of h9N2 were passaged for a second (P2) and a third (P3) time in broilers, followed by a similar embryonic recovery procedure. The a.a. sequence of a part of hA1 cleavage site and Neuraminidase stalk were compared among the differently passaged viruses;an assessement of the relatedness of the determined a.a. sequences to the pathogenicity in broilers, based on frequency of mortality, morbidity signs, gross and microscopic lesions at 3 days post challenge with the P1, P2, and P3-h9N2, is concluded. An increase in certain morbidity signs and specific lesions was observed in P2- and P3-h9N2 challenged broilers compared to birds challenged with P1-h9N2. A conserved R-S-S-R amino acid sequence at the hA1 cleavage site was observed in the differently passaged h9N2, associated with a variability in the NA stalk-a.a sequences. The passaging of the low pathogenic h9N2 virus in broilers leads to a trend of increase in pathogenicity, manifested in higher frequency of morbidity signs, and of specific gross and microscopic lesions of the examined organs. This passaging was associated with a conserved a.a. sequence of the hemaglutinin cleavage site and a variability in the sequence of the neuraminidase stalk. A detailed study of the potential of the detected variability in the neuraminidase stalk of h9N2 in induction of a higher pathogenicity in broile

关键词： h9N2 Avian Influenza Pathogenicity Passaging Broilers Amino Acid Sequences hemagglutinin (hA) Neuraminidase (NA) Stalk

心脏MRI评估盐诱导高血压性心脏病活小鼠的综合表型

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国际医学放射学杂志 2013年第2期 193-194页

作者： h. cochet W. Lefranois M. Montaudon F. Laurent L. Pourtau S. Miraux 李宁 Departement d'Imagerie Cardiovasculaire Hopital Cardiologique Haut Lévêque CHU Bordeaux 33604 Pessac France

目的使用心脏MRI分析高盐饮食(hSD)在活小鼠左心室(LV)质量、收缩功能和冠状动脉储备中的作用。方法 30只C57BL/6母鼠喂养1个月,包括15只对照组和15只hSD组。3个月后,采用三维(3D)高时间分辨率锰-增强MRI黑血序列评估LV容积、射血分数... 详细信息

目的使用心脏MRI分析高盐饮食(hSD)在活小鼠左心室(LV)质量、收缩功能和冠状动脉储备中的作用。方法 30只C57BL/6母鼠喂养1个月,包括15只对照组和15只hSD组。3个月后,采用三维(3D)高时间分辨率锰-增强MRI黑血序列评估LV容积、射血分数和质量,采用动态MR血管成像在静息期及腺苷诱导的充血期评估冠状动脉血流速度储备(CFVR)。切除心脏对LV湿质量及组织学的微血管重构进行评估。结果 hSD组全部心脏组织学研究均发现微血管重构,而对照组未发现一例。就心脏质量、LV容积和射血分数而言,hSD组和对照组之间没有区别。与对照组相比,由于hSD组的体质量较低[(22.3±0.9)g∶(24.0±1.4)g,PhSD组具有较低的CFVR[(1.73±0.11)∶(1.94±0.12),PhSD与冠状动脉储备的早期损害存在相关性,早于心脏显著肥大的发生。要点①采用MRI评估小鼠高血压性心脏病的活体表型是可行的。②小鼠hSD与冠状动脉储备的早期损害有关。③小鼠高盐饮食引起冠状动脉储备的改变早于心室肥厚的发生。

关键词： MRI 心脏小鼠高血压冠状动脉储备

急性心肌梗死再灌注病人心脏MR增强成像评价持续性微血管阻塞对预后的价值

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国际医学放射学杂志 2009年第6期 593-593页

作者： A.A.cochet L.Lorgis A.Lalande M.Zeller J.C.Beer P.M.Walker 钟小梅 Unité d’IRM et CNRS UMR 5158 CHU H?pital d’EnfantsBoulevard du Maréchal de Lattre de Tassigny21034 DijonFrance

本研究目的是评价心脏磁共振(cardiac magnetresonance,CMR)评估微血管阻塞(microvascular obstructioMO)和持续性微血管阻塞(persistent microvascular obstructioPMO)在急性心肌梗死病人中的预后价值。184例首发急性心肌梗死病人成功

关键词：病人 PMO 心肌梗死微血管 MR 持续性预后

眼干燥症的角膜神经及角膜知觉的形态学研究:一项初步研究

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 27-27页

作者： hocl B.M. rnek N. Zilelio■lu G. Elhan A.h. 王海燕 Burcu sitesi no: 16/31 451 sok CkurambarAnkara 06520 Turkey

PURPOSE: To evaluate the corneal sensitivity and nerve morphology in dry eyes. Methods: A total of 32 eyes of 16 patients (10 Sjgren’s syndrome and six non-Sjgren’s syndrome) and 19 eyes of 10 age-matched controls were studied. Sensitivity of the central cornea was measured by the cochet-Bonnet aesthesiometer. The morphology of corneal nerves was studied by in vivo confocal microscopy (ConfoScan 2.0, Fortune Technologies Srl, Vigonza (PD), Italy). Sub-basal epithelial nerve plexus, subepithelial nerve plexus, and stromal nerves were localized and evaluated for the number of nerves, thickness, reflectivity, and tortuosity for each frame. Results: The mean corneal sensitivity of dry eye patients (5.6mm/grs/S) was found significantly lower than that of the control (5.0mm/grs/S)-group (Phough the subepithelial nerves were thicker in dry eyes (mean: 6.38±1.18 μm) than control eyes (mean: 5.72±1.27 μm), this difference was not significant (P >0.05). Conclusion: Decreased corneal sensitivity is not associated with morphological changes of corneal nerves in dry eyes.

关键词：角膜神经形态学研究眼干燥症 Sjogren综合征角膜知觉步研究活体共聚焦显微镜角膜敏感性形态学表现测量器

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