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Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting chen Banglong Fu Junjun Shen Uceu F.h.R.Suhuddin Björn Wiese Yuanding huang Min Wang Jorge F.dos Santos Jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology Group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute for Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical performances,a novel friction-based processing method,name as“constrained friction processing(CFP)”,was investigated.Via CFP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were produced.Compared to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process cycle.The compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear deformation.From the base material to the rod,the material experienced three stages,i.***.deformation by the tool,upward flow with additional tilt,followed by upward transportation.The microstructural evolution was revealed by“stop-action”technique.The microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DRX)as well as particle stimulated nucleation,while that within the rod is related to DRX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic deformation

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A wideband,high-resolution vector spectrum analyzer for integrated photonics

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Light(Science & Applications) 2024年第4期13卷 760-771页

作者： Yi-han Luo Baoqi Shi Wei Sun Ruiyang chen Sanli huang Zhongkai Wang Jinbao Long chen Shen Zhichao Ye hairun Guo Junqiu Liu International Quantum Academy 518048 ShenzhenChina. Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology518055 ShenzhenChina. Department of Optics and Optical Engineering University of Science and Technology of China230026 HefeiChina. hefei National Laboratory University of Science and Technology of China230088 HefeiChina. Qaleido Photonics 518048 ShenzhenChina. Key Laboratory of Specialty Fiber Optics and Optical Access Networks Shanghai University200444 ShanghaiChina

The analysis of optical spectra—emission or absorption—has been arguably the most powerful approach for discovering and understanding matter.The invention and development of many kinds of spectrometers have equipped us with versatile yet ultra-sensitive diagnostic tools for trace gas detection,isotope analysis,and resolving hyperfine structures of atoms and molecules.With proliferating data and information,urgent and demanding requirements have been placed today on spectrum analysis with ever-increasing spectral bandwidth and frequency resolution.These requirements are especially stringent for broadband laser sources that carry massive information and for dispersive devices used in information processing systems.In addition,spectrum analyzers are expected to probe the device’s phase response where extra information is encoded.here we demonstrate a novel vector spectrum analyzer(VSA)that is capable of characterizing passive devices and active laser sources in one setup.Such a dual-mode VSA can measure loss,phase response,and dispersion properties of passive devices.It also can coherently map a broadband laser spectrum into the RF domain.The VSA features a bandwidth of 55.1 Thz(1260–1640 nm),a frequency resolution of 471 khz,and a dynamic range of 56 dB.Meanwhile,our fiber-based VSA is compact and robust.It requires neither high-speed modulators and photodetectors nor any active feedback control.Finally,we employ our VSA for applications including characterization of integrated dispersive waveguides,mapping frequency comb spectra,and coherent light detection and ranging(LiDAR).Our VSA presents an innovative approach for device analysis and laser spectroscopy,and can play a critical role in future photonic systems and applications for sensing,communication,imaging,and quantum information processing.

关键词： spectrum resolution coherent

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The roles and mechanisms of SREBP1 in cancer development and drug response

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Genes & Diseases 2024年第4期11卷 258-269页

作者： Ying he Shasha Qi Lu chen Jinyu Zhu Linda Liang Xudong chen hao Zhang Lvjia Zhuo Shujuan Zhao Shuiping Liu Tian Xie School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhouZhejiang 311121China Laboratory of Cancer Genomics Division of Cellular and Molecular ResearchNational Cancer Centre SingaporeSingapore 169610Singapore

Cancer occurrence and development are closely related to increased lipid produc-tion and glucose consumption.Lipids are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition,signal transduction,and energy supply,which are vital for cancer cell rapid proliferation,invasion,and metastasis.Sterol regulatory element-binding transcription factor 1(SREBP1)is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis,lipid homeostasis,and fatty acid synthesis.In addition,SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases,particularly cancer.however,no review of sREBP1 in cancer biology has yet been published.herein,we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells,including SREBP1 modification,lipid metabolism and reprogramming,glucose and mitochondrial metabolism,immunity,and tumor microenvi-ronment,epithelial-mesenchymal transition,cell cycle,apoptosis,and ferroptosis.Addition-ally,we discussed the potential role of SREBP1 in cancer prognosis,drug response such as drug sensitivity to chemotherapy and radiotherapy,and the potential drugs targeting SREBP1 and its corresponding pathway,elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.

关键词： Cancer Drug Lipid metabolism reprogramming Resistance SREBP1

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Anchoring heterometallic cluster on P-doped carbon nitride for efficient photocatalytic nitrogen fixation in water and air ambient

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Chinese Chemical Letters 2024年第4期35卷 176-180页

作者： Chao-Long chen Rong chen La-Sheng Long Lan-Sun Zheng Xiang-Jian Kong Collaborative Innovation Center of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Light-driven nitrogen fixation to produce ammonia is a green and economical technology of nitrogen reduction but is still quite challenging, especially in an air atmosphere without any sacrificial reagents.herein, we demonstrate efficient photocatalytic nitrogen fixation using water and air directly by loading lanthanide–transition metal(4f–3d) cluster NdCo_(3) on two-dimensional P-doped graphitic carbon nitrides(PCN) material surface. Benefiting from the increase in the number of nitrogen vacancies(NVs) and highly matched band gap structure and excellent hole trapping ability of clusters, the NdCo_(3)/PCN photocatalyst exhibits efficient nitrogen reduction activity with 371(in air) and 825 μmol h^(-1)g^(-1)(in pure nitrogen)without any sacrificial reagents. The introduction of potassium sulfate inhibits hydrogen production and promotes nitrogen reduction activation. This work suggests that anchoring precisely structured clusters on 2D materials may enhance photocatalytic nitrogen reduction under normal temperature and pressure.

关键词： Photocatalytic Nitrogen fixation 4f-3d Cluster Air atmosphere

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A new 4-Ti-added polyoxometalate

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Tungsten 2024年第2期6卷 465-471页

作者： hai-Lou Li chen Lian Guo-Yu Yang MOE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

A new inorganic–organic hybrid 4-Ti-added polyoxometalate:[h_(2)N(Ch_(3))_(2)]_(2)Na_(3)h_(5)[{Ti(C_(2)O_(4))(h_(2)O)}_(2){Ti(C_(2)O_(4))}_(2)(B-β-SbW_(9)O_(33))_(2)]·22h_(2)O(1)has been successfully made and further characterized by infrared spectroscopy,thermogravimetric analysis,powder X-ray diff raction and single-crystal X-ray diff raction.The polyoxoanion of 1 exhibits a Krebs-type structure that is constructed from two[B-β-SbW_(9)O_(33)]^(9)−fragments fused together by a belt of four additional Ti atoms decorated by oxalate ligands.Furthermore,1 as a heterogeneous catalyst exhibits high activity for Knoevenagel condensation under mild reaction conditions.

关键词： Polyoxometalate Ti-added POM Krebs-type structure Knoevenagel condensation

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Di-and tri-methylation of histone h3K36 play distinct roles in DNA double-strand break repair

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Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa chen Meng-Jie Zhao Yu-Min Li Ao-hui Liu Ru-Xin Wang Yu-Chao Mei Xuefeng chen hai-Ning Du hubei Key Laboratory of Cell homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China hubei Key Laboratory of Cell homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

histone h3 Lys36(h3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different h3K36 methylation forms impact repair pathways is unclear.here,we unveil the distinct roles of h3K36 dimethylation(h3K36me2)and h3K36 trimethylation(h3K36me3)in DSB repair via non-homologous end joining(NhEJ)or homologous recombination(hR).Yeast cells lacking h3K36me2 or h3K36me3 exhibit reduced NhEJ or hR efficiency.y Ku70 and Rfa1 bind h3K36me2-or h3K36me3-modified peptides and chromatin,respectively.Disrupting these interactions impairs y Ku70 and Rfa1 recruitment to damaged h3K36me2-or h3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair efficiency.Conversely,h3K36me2-enriched intergenic regions and h3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB stress.Importantly,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with h3K36me2 and h3K36me3 in a conserved manner.These findings provide valuable insights into how h3K36me2 and h3K36me3 regulate distinct DSB repair pathways,highlighting h3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone h3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

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Laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

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hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 217-220页

作者： Song-Feng Yu Wei-chen Zhang Jun Yu Department of hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early 1990s.It has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic

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OsbZIP53 Negatively Regulates Immunity Response by Involving in Reactive Oxygen Species and Salicylic Acid Metabolism in Rice

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Rice science 2024年第2期31卷 190-202,I0022-I0028页

作者： WU Lijuan hAN Cong WANG huimei hE Yuchang LIN hai WANG Lei chen chen E Zhiguo State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Agricultural College of Yangzhou UniversityYangzhou 225009China

The basic region/leucine zipper(bZIP)transcription factors play important roles in plant development and responses to abiotic and biotic stresses.OsbZIP53 regulates resistance to Magnaporthe oryzae in rice by analyzing APIP5-RNAi transgenic plants.To further investigate the biological functions of OsbZIP53,we generated osbzip53 mutants using CRISPR/Cas9 editing and also constructed OsbZIP53 over-expression transgenic plants.Comprehensive analysis of phenotypical,physiological,and transcriptional data showed that knocking-out OsbZIP53 not only improved disease resistance by inducing a hypersensitivity response in plants,but also regulated the immune response through the salicylic acid pathway.Specifically,disrupting OsbZIP53 increased h2O2 accumulation by promoting reactive oxygen species generation through up-regulation of several respiratory burst oxidase homologs(Osrboh genes)and weakened h2O2 degradation by directly targeting OsMYBS1.In addition,the growth of osbzip53 mutants was seriously impaired,while OsbZIP53 over-expression lines displayed a similar phenotype to the wild type,suggesting that OsbZIP53 has a balancing effect on rice immune response and growth.

关键词： OsbZIP53 hypersensitive response reactive oxygen species metabolism rice immunity salicylic acid transcription factor

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Surface engineering with ionic polymers on membranes for boron removal

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 61-69页

作者： Xiting Zhang chenyi Fang J Paul chen Sui Zhang Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117576Singapore Department of Civil and Environmental Engineering National University of SingaporeSingapore 119260Singapore College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

Removal of boric acid from seawater and wastewater using reverse osmosis membrane technologies is imperative and yet remains inadequately addressed by current commercial membranes.Existing research efforts performed post-modification of reverse osmosis membranes to enhance boron rejection,which is usually accompanied by substantial sacrifice in water permeability.This study delves into the surface engineering of low-pressure reverse osmosis membranes,aiming to elevate boron removal efficiency while maintaining optimal salt rejection and water permeability.Membranes were modified by the self-polymerization and co-deposition of dopamine and polystyrene sulfonate at varying ratios and concentrations.The surfaces became smoother and more hydrophilic after modification.The optimum membrane exhibited a water permeability of 9.2±0.1 L·m^(-2)·h^(-1)·bar^(-1),NaCl rejection of 95.8%±0.3%,and boron rejection of 49.7%±0.1%and 99.6%±0.3%at neutral and alkaline ph,respectively.The water permeability is reduced by less than 15%,while the boron rejection is 3.7 times higher compared to the blank membrane.This research provides a promising avenue for enhancing boron removal in reverse osmosis membranes and addressing water quality concerns in the desalination process.

关键词： membrane low-pressure reverse osmosis boron surface engineering

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A near-infrared fluorescent probe for visualizing transformation pathway of Cys/hcy and h2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi cheng Xiao Wang Jiao chen Zihan Zhang Jiadong Ou Mengyao She Fulin chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-Sh)substances including hydrogen sulfide(h_(2)S),cysteine(Cys),homocysteine(hcy)and glutathione(GSh)play crucial roles in living systems,and their variations are closely associated with various diseases.herein,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/hcy and h_(2)S with different fluorescent signals(green-red for Cys/hcy,red for h_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSh.Y-NBD was successfully applied to image exogenous/endogenous Cys/hcy and h_(2)S in various living cancer cells(heLa,A549,and hepG2)and in zebrafish.It not only visualized the transformation pathway of several thiols in hepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver injury.This work provides a promising tool for imaging Cys/hcy and h_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

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