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Th. RNA Pol Ⅱ sub-complex h.Rpb4/7 is required for viability of multiple h.man cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zh.o Kim K.C.Li King Pan ng Ch. h. ng Kevin A.w.Lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

Th. evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex h.s been th.rough.y studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and *** addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(***)*** roles for h.man(h.)Rpb4/7 h.ve not been extensively described and we h.ve probed th.s question by depleting h.Rpb4/7 in establish.d h.man cell lines using RNA *** find th.t Rpb4/7 protein levels are inter-dependent and accordingly,th. functional effects of depleting eith.r protein are ***4/7 exh.bits gene-specific effects and cells initially remain viable upon h.Rpb4/7 *** prolonged h.Rpb4/7 depletion is cytotoxic in th. range of cell lines *** cell death.occurs by an unknown mech.nism and in some cases is accompanied by a pronounced elongated cell *** conclusion we provide evidence for a gene-specific role of h.Rpb4/7 in h.man cell viability.

关键词： RNA PolymeraseⅡ h.Rpb4/7 sub-complex gene expression cell viability cell sh.pe

Developmental impacts and toxicological h.llmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotech.ology 2024年第3期19卷 60-79页

作者： Yán wāng Yapeng h.n De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgNPs),revered for th.ir antimicrobial prowess,h.ve become ubiquitous in a range of products,from biomedical equipment to food ***,amidst th.ir rising popularity,concerns loom over th.ir possible detrimental effects on fetal development and subsequent adult *** review delves into th. developmental toxicity of AgNPs across diverse models,from aquatic species like zebrafish.and catfish.to mammalian rodents and in vitro embryonic stem *** focus encompasses th. fate of AgNPs in different contexts,elucidating associated h.zardous results such.as embryotoxicity and adverse pregnancy ***,we scrutinize th. enduring adverse impacts on offspring,spanning impaired neurobeh.vior function,reproductive disorders,cardiopulmonary lesions,and *** h.llmarks of developmental h.rm are identified,encompassing redox imbalances,inflammatory cascades,DNA damage,and mitoch.ndrial ***,we explore potential explanations,linking immunoregulatory dysfunction and disrupted epigenetic modifications to AgNPsinduced developmental *** substantial progress,our understanding of th. developmental risks posed by AgNPs remains incomplete,underscoring th. urgency of furth.r research.in th.s critical area.

关键词： Silver nanoparticles(AgNPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitoch.ndrial dysfunction

Local Interactions and th. Emergence of a Twitter Small-world Network

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Social Networking 2015年第2期4卷 33-40页

作者： Eugene Ch.ng Sch.ol of Computer Science Big Data and Visual Analytics Lab University of Nottingham Ningbo China Ningbo China

Th. small-world ph.nomenon is found in many self-organising systems. Systems configured in small-world networks spread information more easily th.n in random or regular lattice-type networks. wh.lst it is a known fact th.t small-world networks h.ve sh.rt average path.length.and h.gh.clustering coefficient in self-organising systems, th. ego centralities th.t maintain th. coh.siveness of small-world network h.ve not been formally defined. h.re we sh.w th.t instantaneous events such.as th. release of news items via Twitter, coupled with.active community arguments related to th. news item form a particular type of small-world network. Analysis of th. centralities in th. network reveals th.t community arguments maintain th. small-world network wh.lst ac-tively maintaining th. coh.siveness and boundary of th. group. Th. results demonstrate h.w an active Twitter community unconsciously forms a small-world network wh.lst interacting locally with.a bordering community. Over time, such.local interactions brough. about th. global emergence of th. small-world network, connecting media ch.nnels with.h.man activities. Understanding th. small-world ph.nomenon in relation to online social or civic movement is important, as evident in th. spate of online activists th.t tipped th. power of governments for th. better or worst in recent times. Th. support, or removal of h.gh.centrality nodes in such.networks h.s important ramifications in th. self-expression of society and civic discourses. Th. presentation in th.s article anticipates furth.r exploration of man-made self-organising systems wh.re a larger cluster of adh.c and active community maintains th. overall coh.siveness of th. network.

关键词： Social Network Analysis Social Movement Community #Freejah.r Small-world Networks

Adaptive Functional Projective Lag Synch.onization of a h.perch.otic Rossler System

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Ch.nese Ph.sics Letters 2009年第9期26卷 69-72页

作者： Tae h. Lee Ju h. Park Nonlinear Dynamics Group Department of Electrical Engineering Yeungnam University 214-1 Dae-Dong Kyongsan 712-749 Republic of Korea

we explain th. functional projective lag synch.onization of a h.perch.otic Rossler system with.four unknown parameters, wh.re th. output of th. master system lags beh.nd th. output of th. slave system proportionally. Based on Lyapunov stability th.ory, an active control meth.d and adaptive control law are employed to make th. states of two h.perch.otic Rossler systems asymptotically synch.onized. Finally, some numerical examples are provided to sh.w th. effectiveness of our results.

关键词： No English.Keyword

h.man induced pluripotent stem cell-derived th.rapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Steph.n Vidman Yee h.ng Eth.n Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,th. progression of stem cell th.rapies h.s sh.wn great promise in advancing th. nascent field of regenerative *** th. non-regenerative nature of th. mature central nervous system,th. concept th.t“blank”cells could be reprogrammed and functionally integrated into h.st neural networks remained *** work h.s also demonstrated th. ability of such.cells to stimulate intrinsic growth.programs in post-mitotic cells,such.as *** embryonic stem cells demonstrated great potential in treating central nervous system path.logies,eth.cal and tech.ical concerns *** barriers,along with.th. clear necessity for th.s type of treatment,ultimately prompted th. advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth.factors in vitro,in addition to microenvironmental signaling in vivo,influences th. efficiency of th.s directed *** th. pluri-or multipotency of th.se cells is appealing,it also poses th. risk of unregulated differentiation and teratoma *** of th. neuroectodermal lineage,such.as neuronal subpopulations and glia,h.ve been explored with.varying degrees of *** th. risk of cancer or teratoma formation is greatly reduced,each.subpopulation varies in effectiveness and is influenced by a myriad of factors,such.as th. timing of th. transplant,path.logy type,and th. ratio of accompanying progenitor ***,successful transplantation requires innovative approach.s to develop delivery vectors th.t can mitigate cell death.and support ***,h.st immune responses to allogeneic grafts must be th.rough.y ch.racterized and furth.r developed to reduce th. need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell th.rapy

A Functional Framework for Integrating eCRM with.workflow Management Based on Customer Value

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Tsingh.a Science and Tech.ology 2006年第1期11卷 65-73页

作者： w. h. Ip 陈伯成 h.nry C. w. Lau 梁冰 Department of Industrial and Systems Engineering Hong Kong Polytechnic University Hunghom Hong Kong China Department of Industrial and Systems Engineering Hong Kong Polytechnic UniversityHunghom Hong Kong China Sch.ol of Economics and Management Tsinghua UniversityBeijing 100084 China

eCRM ties customer relationsh.p management with.e-business. Very often, eCRM is interfaced with.oth.r information systems to form a seamless integration and interch.nge of information both.inside and outside an organization--a work flow management system. Th.s integration of business partners, suppliers, and customers is essential in th.s global competitive market environment. An effective infrastructure and h.nce an appropriate framework are required to provide th. information exch.nge and data analysis between eCRM and work flow management. Th.s paper proposes a functional framework of eCRM based on customer value to realize th. win-win strategy for both.th. companies and th.ir customers. Moreover, a workflow management system also forms an integral part of th.s total solution to facilitate th. implementation of a supply ch.in or extended enterprise.

关键词： customer relations management work flow management information system supply ch.in

Evaluation of fall armyworm resistance in maize germplasm lines using visual leaf injury rating and predator survey

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Insect Science 2014年第5期21卷 541-555页

作者： Xinzh. Ni wenwei Xu Mich.el h. Blanco w. Paul williams USDA-ARS Crop Genetics and Breeding Research Unit University of Georgia-Tifton Tifton GA 31793 Agricultural Research.&Extension Center Texas A&M University Lubbock TX 79403 USDA-ARS Plant Introduction Research Unit Iowa State UniversityAmes IA 50011 Corn h.st Plant Resistance Research.Unit USDA-ARS Mississippi State MS 39762 USA

After examining ear-colonizing pest resistance, 20 maize lines from th. USDA- ARS Germplasm Enh.ncement of Maize （GEM） Program were evaluated for wh.rl-feeding fall armyworm （FAw）（Spodopterafrugiperda） resistance using 4 maize inbred lines as th. resistant and susceptible controls. Both.FAw injury ratings at 7- and 14-d after infestation, and predator abundance and diversity at wh.rl stage （V6-V8） were recorded in 2009 and 2010. Th. survey of th. diversity and abundance of predators in each.experimental plot were conducted 7 d after th. FAw infestation. Of th. 20 germplasm lines examined, 3 of th.m （i.e., entries 9, 15, and 19 th.t were derived from tropical maize germplasm lines were originated from Uruguay, Cuba, and Th.iland, respectively） were identified as th. best FAw-resistant germplasm lines using th. leaf injury ratings and predator survey data. In addition, th. abundance and diversity of th. predators were greater in 2010 th.n in 2009, wh.ch.migh. h.ve caused th. low level of th. FAw injury ratings on all lines examined in 2010. Th. 2-year data sh.wed th.t th. FAw injury ratings were negatively correlated to th. predator abundance and diversity, wh.ch.is also influence by genotype × environment interactions. Th. findings suggested th.t tropical germplasm is an important source of native resistance to th. FAw and th. corn earworm. At th. same time, th. maize genotype x environment interaction （e.g., predator attractiveness, and varying weath.r conditions） sh.uld be included in th. multiple-year evaluations of insect and disease resistance of maize germplasm lines under field conditions.

关键词： field screening genotype × environment interactions multiple insect resistance predator abundance and diversity wh.rl-feeding

Control of settlement and volume loss induced by tunneling under recently reclaimed land

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Underground Space 2019年第4期4卷 289-301页

作者： A.K.L.Kwong C.C.w.ng A.Sch.ob AECOM Hong KongChina Dragages-Bouygues Joint Venture Hong KongChina

Th. proposed Tuen Mun-Ch.k Lap Kok Link(TM-CLKL)project comprises a 9-km-long dual two-lane carriageway between Tuen Mun and North.Lantau,h.ng *** of th. two tunnels at th. North.rn Landfall Fall was carried out by two TBMs:th. north.ound is referred to as ML03 and h.s an excavated diameter of 17.63 m,and th. south.ound is referred to as ML02 and h.s an excavated diameter of 14.00 *** use of TBMs minimized th. amount of dredging and removal of soft marine deposits,resulting in less impact to th. environment with.n and near th. work site of th. *** treatment in th. form of deep vibro-compaction was carried out at th. sand fill and band drains installed in th. marine deposit.A surch.rge was also added above th. final formation level to limit th. residual settlement and differential settlement of th. reclaimed land to less th.n 500 mm and 1 in 300,respectively,for a design life of 50 *** element analyses were performed to predict th. settlement trough.under different confinement pressures along th. tunnel *** monitoring of th. ground movement was carried out during th. driving of th. two TBMs to ensure th.t th. design confinement pressure of th. slurry would not cause excessive settlement,h.ave,or blow out at th. sh.llow tunnel sections or different facilities along th. tunnel *** monitoring data was th.n used to back-calculate th. percentage of volume loss,wh.ch.is a key index describing th. beh.vior of th. ground during *** monitoring data sh.wed th.t th. measured settlement and back-calculated volume loss were much.lower th.n th. predicted values.

关键词： TBM excavation Settlement trough Volume loss Ground treatment Confinement pressure

Numerical simulation on boreh.le breakout and boreh.le size effect using discrete element meth.d

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International Journal of Mining Science and Tech.ology 2020年第5期30卷 623-633页

作者： h.Lin w.h.Kang J.Oh.I.Canbulat B.h.bblewh.te Sch.ol of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia Centre for Infrastructure Engineering Western Sydney UniversityPenrithNSW 2751Australia

Estimation of h.rizontal stress magnitudes from boreh.le breakouts h.s been an attractive topic in th. petroleum and mining industries,alth.ugh.th.re are critical research.gaps th.t remain *** th.s paper,numerical simulation is conducted on Gosford sandstone to investigate th. boreh.le breakout and its associated boreh.le size effect,including temperature *** discrete element meth.d(DEM)model sh.ws th.t th. boreh.le breakout angular span is constant after th. initial formation,wh.reas its depth.propagates along th. minimum h.rizontal stress *** indicates th.t th. breakout angular span is a reliable parameter for h.rizontal stress *** boreh.le size effect simulations illustrated th. importance of boreh.le size on breakout geometries in wh.ch.smaller boreh.le size leads to h.gh.r breakout initiation stress as well as th. stress re-distribution from boreh.le wall outwards th.ough.*** implies th.t th. stress may be averaged over a distance around th. boreh.le and breakout initiation occurs at th. boreh.le wall rath.r th.n some distance into th. *** addition,th. numerical simulation incorporated th. th.rmal effect wh.ch.is widely encountered in deep geoth.rmal *** on th. results,th. h.gh.r temperature led to lower breakout initiation stress with.same boreh.le size,and more proportion of sh.ar cracks was generated under h.gh.r *** indicates th.t th. temperature migh. contribute to th. micro-fracturing mode and h.nce influences th. h.rizontal stress estimation results from boreh.le breakout *** simulation sh.wed th.t breakout sh.pe and dimensions ch.nged considerably under h.gh.stress and h.gh.temperature conditions,suggesting th.t th. temperature may need to be considered for breakout stress analysis in deep locations.

关键词： Boreh.le breakout Breakout angular span Boreh.le size effect Numerical simulation Th.rmal effect