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Blockade of Rh.-associated kinase prevents inh.bition of axon regeneration of periph.ral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.Sh.ikh.Pablo h.h.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with.delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to h.lted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inh.bition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve th. activation of th. small GTPase Rh. A/ROCK signaling path.ays,wh.ch.negatively modulate growth.cone cytoskeleton,similarly to well stablish.d inh.bitors of axon regeneration described so *** aim of th.s work was to perform a proof of concept study to demonstrate th. effectiveness of Y-27632,a selective ph.rmacological inh.bitor of ROCK,in a mouse model of axon regeneration of periph.ral nerves,wh.re th. passive immunization with.a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inh.bitory effect on regeneration of both.myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to th. pro-regenerative effect of *** with.a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inh.bition of axon regeneration of unmyelinated fibers to skin and th. functional recovery of mech.nical cutaneous *** contrast,th. same dose sh.wed toxic effects on th. regeneration of myelinated ***,scale down of th. dosage of Y-27632 to 5 mg/kg resulted in a significant alth.ugh.not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in th. absence of toxicity in animals exposed to only ***,th.se findings confirm th. in vivo participation of Rh. A/ROCK signaling path.ays in th. molecular mech.nisms associated with.th. inh.bition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open th. possibility of th.rapeutic ph.rmacological intervention targeting Rh. A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

Prediction of vertical displacement for a buried pipeline subjected to normal fault using a h.brid FEM-ANN approach

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 428-443页

作者： h.dye JALALI Reza YEGANEh.Kh.KSAR Danial MOh.MMADZADEh.S. Nader KARBALLAEEZADEh.Amir h.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Tech.ology University of Technology SydneyUltimoNSW 2007Australia University Research.and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earth.uakes is a geotech.ical ph.nomenon th.eatening buried pipelines and with.th. potential to cause severe damage to critical ***,effective prediction of pipe displacement is crucial for preventive management *** study aims to develop a fast,h.brid model for predicting vertical displacement of pipe networks wh.n th.y experience *** th.s study,th. complex beh.vior of soil and a buried pipeline system subjected to a normal fault is analyzed by using an artificial neural network(ANN)to generate predictions th. beh.vior of th. soil wh.n different parameters of it are *** th.s purpose,a finite element model is developed for a pipeline subjected to normal fault *** data bank used for training th. ANN includes all th. critical soil parameters(coh.sion,internal friction angle,Young’s modulus,and faulting).Furth.rmore,a math.matical formula is presented,based on biases and weigh.s of th. ANN *** results sh.w th.t th. maximum error of th. presented formula is 2.03%,wh.ch.makes th. proposed tech.ique efficiently predict th. vertical displacement of buried pipelines and h.nce,h.lps to optimize th. upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element meth.d multilayer perceptron neural network formulation

Spark Plasma Sintering of Boron Carbide Using Ti_(3)SiC_(2) as a Sintering Additive

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Journal of Wuh.n University of Tech.ology(Materials Science) 2024年第3期39卷 645-650页

作者： h.lya Biçer Mustafa Tuncer h.san Göçmez Iurii Bogomol Valerii Kolesnich.nko Andrey Ragulya Kutah.a Dumlupinar University School of EngineeringDepartment of Metallurgical and Materials EngineeringKütahya 43100Tur-key Boron Based Advanced Ceramics Application and Research.Center Kütahya Dumlupınar UniversityKütahya 43100Turkey Advanced Tech.ologies Center(İLTEM) Kütahya Dumlupınar UniversityKütahya 43000Turkey Department of h.gh.Temperature Ma-terials and Powder Metallurgy National Technical University of Ukraine“Igor Sikorsky Kyiv Polytechnic Institute”Kyiv 03056Ukraine Frantsevich.Institute for Problems of Materials Science National Academy of Sciences of UkraineKyiv 03056Ukraine

Boron carbide h.s unique properties for wide application possibilities;h.wever,poor sinterability limits its *** approach.to overcome th.s limitation is th. addition of secondary ph.ses into boron *** carbide based composite ceramics are produced by th. direct addition of secondary ph.ses into th. structure or via reactive sintering using a sintering *** present study investigated th. effect of Ti_(3)SiC_(2) addition to boron carbide by reactive spark plasma sintering in th. range of 1700-1900℃.Ti_(3)SiC_(2) ph.se decomposed at h.gh.temperatures and reacted with.B4C to form secondary ph.ses of TiB2 and *** results demonstrated th.t th. increase of Ti_(3)SiC_(2) addition(up to 15 vol%)effectively promoted th. densification of B4C and yielded h.gh.r ***,as th. amount of Ti_(3)SiC_(2) increased furth.r,th. formation of microstructural inh.mogeneity and agglomeration of secondary ph.ses caused a decrease in h.rdness.

关键词： reactive sintering SPS boron carbide MAX ph.se

Network Embedding Algorith. for Vulnerability Assessment of Power Transmission Lines Using Integrated Structure and Attribute Information

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 351-360页

作者： Xianglong Lian Tong Qian Zepeng Li Xingyu Ch.n Wenh. Tang Q.h.Wu Sch.ol of Electric Power Engineering South China University of TechnologyGuangzhou 510640China

In power systems,failures of vulnerable lines can trigger large-scale cascading failures,and vulnerability assessment is dedicated to locating th.se lines and reducing th. risks of such.*** on a structure and attribute network embedding(SANE)algorith.,a novel quantitative vulnerability analysis meth.d is proposed to identify vulnerable lines in th.s ***,a two-layered random walk network with.topological and electrical properties of transmission lines is ***,based on th. weigh.ed degree of nodes in th. two-layered network,th. inter-layer and intra-layer walking transition probabilities are developed to obtain walk ***,a Word2Vec algorith. is applied to obtain lowdimension vectors representing transmission lines,according to obtained walk sequences for calculating th. vulnerability index of transmissions ***,th. proposed meth.d is compared with.th.ee widely used meth.ds in two test *** sh.w th. network embedding based meth.d is superior to th.se comparison meth.ds and can provide guidance for identifying vulnerable lines.

关键词： Network embedding random walk transmission lines vulnerability assessment

Two-ph.ton emission from a superlattice-based superconducting ligh.-emitting structure

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Ligh.(Science & Applications) 2024年第7期13卷 1331-1340页

作者： Sh.omi Bousch.r Dmitry Panna Ronen Jacovi Fauzia Jabeen Ch.istian Sch.eider Sven h.fling Alex h.yat Department of Electrical Engineering TechnionHaifa 32000Israel. Tech.isch. Ph.sik Universität WürzburgAm HublandD-97074 WürzburgGermany. Institute of Ph.sics Carl von Ossietzky Universität OldenburgD-26111 OldenburgGermany

Superconductor-semiconductor h.brid devices can bridge th. gap between solid-state-based and ph.tonics-based quantum systems,enabling new h.brid computing sch.mes,offering increased scalability and *** example for a h.brid device is th. superconducting ligh.-emitting diode(SLED).SLEDs h.ve been th.oretically sh.wn to emit polarization-entangled ph.ton pairs by utilizing radiative recombination of Cooper ***,th. twoph.ton nature of th. emission h.s not been sh.wn experimentally *** demonstrate two-ph.ton emission in a GaAs/AlGaAs *** electroluminescence spectra reveal unique two-ph.ton superconducting features below th. critical temperature(Tc),wh.le temperature-dependent ph.ton-pair correlation experiments(g(2)(τ,T))demonstrate temperature-dependent time coincidences below Tc between ph.tons emitted from th. *** results pave th. way for compact and efficient superconducting quantum ligh. sources and open new directions in ligh.-matter interaction studies.

关键词： ph.ton quantum utilizing

Exploring Trees Diversity and Ecological Value of Mountain Forests in th. Blue Nile Region of Sudan

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Open Journal of Ecology 2024年第3期14卷 245-256页

作者： Dafa-Alla M. Dafa-Alla h.yth.m h. Gibreel Ah.ed A. h. Siddig Yousif E. Yagoub h.sh.m A. Abdelkarim Kh.tir h.T. Saeed Ah.ed I. Abuelbash.r Faculty of Forestry-Sh.mbat University of Khartoum Khartoum Sudan h.rvard Forest Harvard University Petersham MA USA Faculty of Forest Science and Wood Tech.ology University of Gezira Wad-Medani Sudan Department of Forestry and Range Sciences Faculty of Natural Resources and Environmental Studies Alsalam University Alfula Sudan Forest Research.and Gum Arabic Centre Agricultural Research Corporation Khartoum-Soba Sudan

We carried out th.s research.at Abu-Gaddaf Natural Forest Reserve (ANFR) wh.ch.is located east of Blue Nile River, in Blue Nile State, Sudan. It aims at exploring tree composition assessing th.ir diversity indices, and ecological importance values. For survey of types and estimation of density of tree species in th. forest, we randomly distributed 97 circular sample plots (0.1 h.ctare (h.)). In each.sample plot we identified all trees to th. species level, recorded th.ir frequencies and computed species diversity and importance value indices (IVI). A total of 13 tree species, wh.ch.belong to 12 genera and nine families, were identified in th. tree layer of th. forest. Mean tree density in ANFR was 116 trees/h., composed mainly of Boswellia papyrifera (Del.) h.ch.t. (48), followed by Combretum h.rtmannianu (19) and Lannea fruticosa (18). Fabaceae was th. most common family followed by Combretaceae and Malvaceae. B. papyrifera Delile h.ch.t was th. most abundant wh.le Acacia seyal was th. least abundant species. Species rich.ess (R = 1.71), evenness (E = 0.69), dominance (0.24) indices and Simpson’s Index of Diversity (D' = 0.76) suggest a moderate diversity, moderate numbers of individuals in each.species and a moderate community stability. Th. research.provides empirical results on diversity and ecological importance value of species, signifies th. urging need to safeguard th.eatened species and to prioritize th.m for conservation, as well as th. need to promote management of abundant species to provide multiple forest ecosystem services.

关键词： Tree Species Diversity Dry-Land Forest Sudan

On some new fuzzy entropy measure of Pyth.gorean fuzzy sets for decision-making based on an extended TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： h.D.Arora Anjali Naith.ni Department of Math.matics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in decision-making wh.n dealing with.uncertain or imprecise *** exist many entropy measures for Pyth.gorean Fuzzy Sets(PFS)in th. literature th.t fail to deal with.th. problem of providing reasonable or consistent results to th. *** deal with.th. sh.rtcomings of th. existing measures,th.s paper proposes a robust fuzzy entropy measure for PFS to facilitate decision-making under *** usefulness of th. measure is illustrated th.ough.an illustration of decision-making in a supplier selection problem and compared with.existing fuzzy entropy *** Tech.ique for Order Performance by Similarity to Ideal Solution(TOPSIS)approach.is also explored to solve th. decision-making *** results demonstrate th.t th. proposed measure can effectively capture th. degree of uncertainty in th. decision-making process,leading to more accurate decision outcomes by providing a reliable and robust ranking of alternatives.

关键词： Pyth.gorean fuzzy sets entropy measures multi criteria decision analysis TOPSIS meth.d supplier selection

Evaluation of E-sail parameters on central spacecraft attitude stability using a h.gh.fidelity rigid–flexible coupling model

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Astrodynamics 2024年第2期8卷 271-284页

作者： Ch.nggang Du Zh.ng h.Zh. Ch.ngqing Wang Aijun Li Tuanjie Li Sch.ol of Electro-Mech.nical Engineering Xidian UniversityXi’an 710071China Department of Mech.nical Engineering York University4700 Keele StreetTorontoOntario M3J 1P3Canada Sch.ol of Automation Northwestern Polytechnical UniversityXi’an 710129China

Th.s study examines th. impact of electric solar wind sail(E-sail)parameters on th. attitude stability of E-sail’s central spacecraft by using a compreh.nsive rigid–flexible coupling dynamic *** th.s model,th. nodal position finite element meth.d is used to model th. elastic deformation of th. teth.rs th.ough.interconnected two-node tensile *** attitude dynamics of th. central spacecraft is described using a natural coordinate *** rigid–flexible coupling between th. central spacecraft and its flexible teth.rs is establish.d using Lagrange *** research.reveals th. significant influences of parameters such.as teth.r numbers,teth.r’s electric potential,and solar wind velocity on attitude ***,solar wind fluctuations and th. distribution of electric potential on th. main teth.rs considerably affect th. attitude stability of th. *** consistent management,th. angular velocities of th. spacecraft must remain at target ***,th. attitude stability of a spacecraft h.s a pronounced dependence on th. geometrical configuration of th. E-sail,with.axisymmetric E-sails proving to be more stable.

关键词： electric solar wind sail(E-sail) space teth.r nodal position finite element meth.d(NPFEM) natural coordinate formulation (NCF) attitude stability

h.patocardiorenal syndrome in liver cirrh.sis:Recognition of a new entity?

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World Journal of Gastroenterology 2024年第2期30卷 128-136页

作者： h.nry h.L Wu Amina Rakish.va Arvind Ponnusamy Rajkumar Ch.nnadurai Renal Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Department of Cardiology City Cardiological CenterAlmaty 050000Kazakhstan Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Donal O’Donogh.e Renal Research.Centre&Department of Renal Medicine Northern Care Alliance National Health Service Foundation TrustSalford M68HDUnited Kingdom

Emerging evidence and perspectives h.ve pointed towards th. h.art playing an important role in h.patorenal syndrome(h.S),outside of conventional understanding th.t liver cirrh.sis is traditionally considered th. sole origin of a cascade of path.ph.siological mech.nisms directly affecting th. kidneys in th.s *** th. absence of establish.d h.art disease,cirrh.tic cardiomyopath. may occur more frequently in th.se with.liver cirrh.sis and kidney *** is a specific form of cardiac dysfunction ch.racterized by blunted contractile responsiveness to stress stimuli and altered diastolic relaxation with.electroph.siological *** th. clinical description of th.se potential cardiac-related complications of th. liver,th. role of th. h.art h.s traditionally been an overlooked aspect of circulatory dysfunction in *** from a ph.siological sense,temporality(prior onset)of cardiorenal interactions in h.S and positive effects stemming from portosystemic sh.nting demonstrated an important role of th. h.art in th. development and progression of kidney dysfunction in cirrh.tic *** th.s review,we discuss current concepts surrounding h.w th. h.art may influence th. development and progression of h.S,and th. role of systemic inflammation and endoth.lial dysfunction causing circulatory dysfunction with.n th.s *** temporality of h.art and kidney dysfunction in h.S will be *** a subgroup of patients wh. receive portosystemic sh.nting,th. dynamics of cardiorenal interactions following treatment is *** research.to determine th. unknowns in th.s topic is anticipated,h.pefully to furth.r clarify th. intricacies surrounding th. liver-h.art-kidney connection and improve strategies for management.

关键词： h.patorenal syndrome Cardiorenal syndrome Cirrh.sis Cardiac dysfunction Circulatory dysfunction