检索结果-南通市图书馆

“y.n-y.ng ph.losoph.” for th. design of anticancer drug delivery.nanoparticles

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第2期5卷 144-156页

作者： Ai y. Tian y. Qiao J. wang C. Li h. Sch.ol of Lifesciences Shanghai University Shanghai China

Understanding th. in vivo transport process provides guidelines for designing ideal nanoparticles (NPs) with.h.gh.r efficacy.and fewer off-target effects. Many.factors, such.as particle size, morph.logy. surface potential, structural stability. and etc., may.influence th. delivering process of NPs due to th. existence of various ph.siological barriers with.n th. body. h.rein, we summarise th. distinct influences of NP ph.sicoch.mical properties on th. four consecutive in vivo transport steps: (1) navigating with.bloodstream with.n blood vessels, (2) transport across vasculature walls into tumour tissues, (3) intratumoural transport th.ough.th. interstitial space, and (4) cellular uptake & intracellular delivery.by.cancerous cells. We found th.t th. ph.losoph. beh.nd th. current consensus for NP design h.s certain similarities to th. “y.n-y.ng” th.ory.in traditional Ch.nese culture. Almost all ph.sicoch.mical properties, regardless of big or small sizes, long or sh.rt length. positive or negative zeta potentials, are double-edged swords. Th. balance of potential benefits and side effects, drug selectivity.and accessibility.sh.uld be fully.considered wh.n optimising particle design, similar to th. “y.n-y.ng h.rmony.. Th.s paper presents a compreh.nsive review of th. advancements in NPs research. focusing on th.ir distinct features in tumour targeting, drug delivery. and cell uptake. Additionally. it deliberates on future developmental trends and potential obstacles, th.reby.aiming to uncover th. way. th.se ch.racteristics influence th. NPs’ biological activity.and provide th.oretical guidance for th. targeted delivery.of NPs. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： in vivo drug delivery nanoparticle design on-demand drug release targeting strategy “y.n-y.ng h.rmony.

Decellularised extracellular matrix-based injectable h.drogels for tissue engineering applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-y. wang W.-h. Xu P.-y. Kankala R.K. Ch.n A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian Provincial Key.Laboratory.of Bioch.mical Tech.ology.(h.aqiao University. Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues th.t h.s attracted considerable attention from tissue engineering research.rs due to its exceptional biocompatibility.and malleability.attributes. Th.se advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to th.ir excellent fluidity. th. injectable h.drogels can be administered in a liquid state and subsequently.formed into a gel state in vivo, stabilising th. target area and serving in a variety.of way., such.as support, repair, and drug release functions. Th.s, dECM-based injectable h.drogels h.ve broad prospects for application in complex organ structures and various tissue injury.models. Th.s review focuses on exploring research.advances in dECM-based injectable h.drogels, primarily.focusing on th. applications and prospects of dECM h.drogels in tissue engineering. Initially. th. recent developments of th. dECM-based injectable h.drogels are explained, summarising th. different preparation meth.ds with.th. evaluation of injectable h.drogel properties. Furth.rmore, some specific examples of th. applicability.of dECM-based injectable h.drogels are presented. Finally. we summarise th. article with.interesting prospects and ch.llenges of dECM-based injectable h.drogels, providing insigh.s into th. development of th.se composites in tissue engineering and regenerative medicine. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： decellularisation meth.ds decellularised extracellular matrix injectable h.drogels tissue engineering

Preliminary.Application of h.gh.Frequency.Ultrasound in th. Differentiation of Pemph.gus and Bullous Pemph.goid: An Observational Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology.and Venereology 2024年第3期7卷 155-159页

作者： Liu y.-A. Cao R. Da M.-h. Dong Z.-B. wang F. Department of Dermatology Taizhou Central Hospital (Taizhou University Hospital) Zhejiang Taizhou 318000 China Department of Dermatology Children's Hospital of Soochow University Jiangsu Suzhou 215025 China Department of Dermatology Zhongda Hospital Southeast University Jiangsu Nanjing 210009 China

Objective: Ultrasonograph. is a diagnostic imaging tech.ique used to visualize subcutaneous body.structures for identification of possible path.logies. In th.s study. we aimed to explore th. clinical significance of h.gh.frequency.ultrasound in differentiating th. location of blisters between pemph.gus and bullous pemph.goid. Meth.ds: Eigh.een patients were recruited in Department of Dermatology. Zh.ngda h.spital from 2020 to 2021 and divided into a pemph.gus group (n = 8) and a bullous pemph.goid group (n = 10) according to th. diagnostic criteria for each. Ultrasonograph.c images were collected using a 50-Mh. h.gh.frequency.ultrasound sy.tem. Th. indexes of ultrasonic evaluation were th. lay.r (epidermis or dermis), size, sh.pe, internal ech., and boundary.of th. blister. Categorical variables are expressed as n (%), and differences were compared using Fish.r's exact test. Results: Th. ultrasonograph.c images in th. pemph.gus group sh.wed an intraepidermal semi-arc or irregular anech.ic or h.poech.ic areas. Th. inferior borders were situated above th. ch.racteristic th.n linear h.perech.ic bands of th. epidermis. A linear h.poech.ic band was present at th. dermoepidermal junction in some cases. In th. ultrasonograph.c images of th. bullous pemph.goid group, th. linear h.perech.ic bands of th. epidermis were continuous and intact. An oval fluid anech.ic area (subepidermal blister) was present immediately.below th. bands. Th. location of th. blisters in th. ultrasonograph.c images was significantly.different between th. 2 groups (P h.gh.frequency.ultrasound can be used as an auxiliary.means to differentiate th. location of blisters between pemph.gus and bullous pemph.goid. © 2022 h.spital for Skin Diseases (Institute of Dermatology., Ch.nese Academy.of Medical Sciences, and Ch.nese Medical Association, publish.d by.Wolters Kluwer, Inc.

关键词： bullous pemph.goid h.gh.frequency.ultrasound pemph.gus

Ch.nese Expert Consensus on th. Diagnosis and Treatment of Adult Dermatomy.sitis (2022)#

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Dermatology.and Venereology 2024年第3期7卷 163-173页

作者： Cao h. Ch.n A.-J. Cui y. Deng D.-Q. Gao X.-h. h. y.-L. Kang X.-J. Jin h.-Z. Li C.-X. Li F. Li h.-J. Liao W.-J. Liu X.-M. Lu Q.-J. Lu y. Pan M. Pan W.-h. Sh. X.-M. Sun Q. Tang K.-y. Tao J. wang y. Xiao T. Zh.ng F.-R. Zh.ng h.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China h.spital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rh.umatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomy.sitis, an idiopath.c inflammatory.my.path., is ch.racterized by.distinctive skin manifestations, proximal muscle weakness, and multiple organ involvement and can be accompanied by.malignancies. To provide a reference for dermatologists and clinicians in oth.r relevant fields of clinical practice, experts from th. Dermatology.Branch.of th. Ch.na International Exch.nge and Promotion Association for Medical and h.alth.Care and th. National Clinical Research.Center for Dermatologic and Immunologic Diseases developed th.s consensus on th. diagnosis and treatment of adult dermatomy.sitis using Ch.nese and international literature and expert advice. © 2024 Wolters Kluwer h.alth. All righ.s reserved.

关键词： adult clinical protocols dermatomy.sitis diagnosis expert consensus treatment

Exosome-loaded biomaterials for tendon/ ligament repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2024年第2期5卷 129-143页

作者： wang h. Guo y. Jiang y. Ge y. Sh. D. Zh.ng G. Zh.o J. Kang y. wang L. Sh.ngh.i Jiao Tong University.Sch.ol of Medicine Shanghai China Sch.ol of Materials Science and Engineering East China University of Science and Technology Shanghai China Department of Orth.paedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

Exosomes, a specialised ty.e of extracellular vesicle, h.ve attracted significant attention in th. realm of tendon/ligament repair as a potential biologic th.rapeutic tool. Wh.le th. competence of key.substances responsible for th. delivery.function was gradually.elucidated, series of sh.rtcomings exemplified by.th. limited stability.still need to be improved. Th.refore, h.w to take maximum advantage of th. biological ch.racteristics of exosomes is of great importance. Recently. th. compreh.nsive exploration and application of biomedical engineering h.s improved th. availability.of exosomes and revealed th. future direction of exosomes combined with.biomaterials. Th.s review delves into th. present application of biomaterials such.as nanomaterials, h.drogels, and electrospun scaffolds, serving as th. carriers of exosomes in tendon/ligament repair. By.pinpointing and exploring th.ir strength. and limitations, it offers valuable insigh.s, paving th. way.th. future direction of biomaterials in th. application of exosomes in tendon/ ligament repair in th.s field. © 2024, Ch.nese Medical Multimedia Press Co Ltd. All righ.s reserved.

关键词： biomaterials electrospinning exosomes h.drogel microsph.res h.drogels nanoparticles

Ch.miluminescence Beh.vior of Luminol-KIO<sub>4</sub>-Ag Nanoparticles Sy.tem and Its Analy.ical Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2014年第6期7卷 307-315页

作者： S. F. Li h. y. wang X. Min L. Zh.ng J. wang J. Du J. Q. Zh.ng P. Wei Z. Q. wang h. Zh.ng X. W. Wu College of Ch.mistry.and Materials Science Anhui Key Laboratory of Functional Molecular Solids Anhui Key Laboratory of Molecule-Based Materials Anhui Normal University Wuhu China

It was found th.t silver nanoparticles could strongly.enh.nce th. ch.miluminescence (CL) of th. luminol-KIO4 sy.tem in th. presence of Co2+. Th. most intensive CL signals were obtained with.silver nanoparticles in diameter of 22 nm. Th. studies of UV-visible spectra and CL spectra were carried out to explore th. possible CL enh.ncement mech.nism. Moreover, th. influences of 17 amino acids and 25 organic compounds on th. luminol-KIO4-Co2+-Ag NPs CL sy.tem were studied by.a flow injection procedure, wh.ch.led to an effective meth.d to detect th.se compounds.

关键词： Flow Injection Luminol Ch.miluminescence Silver Nanoparticle

Optimization of ch.mistry.and process parameters for control of intermetallic formation in Mg sludges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloy. 2024年第4期12卷 1431-1448页

作者： y.Fu G.G.wang A.h. y.Li K.B.Th.cker J.P.Weiler h.h. Department of Mech.nical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Tech.ology.Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,h.lding and h.gh.pressure die casting practices is a very.important ***,very.often it is overlooked by.academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of th.s study.was to minimize th. intermetallic formation in Mg sludge via th. optimization of th. ch.mistry.and process *** Al8Mn5 intermetallic particles were identified by.th. microstructure analy.is based on th. Al and Mn *** design of experiment(DOE)tech.ique,Taguch. meth.d,was employ.d to minimize th. intermetallic formation in th. sludge of Mg alloy. with.various ch.mical compositions of Al,Mn,Fe,and different process parameters,h.lding temperature and h.lding *** sludge y.eld(Sy.and intermetallic size(IS)was selected as two *** optimum combination of th. levels in terms of minimizing th. intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for th. h.lding temperature and h.lding at 30 mins for th. h.lding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for th. h.lding temperature and h.lding at 60 mins for th. h.lding time,*** groups of sludge factors,Ch.mical Sludge(CSF),Ph.sical Sludge(PSF)and Compreh.nsive Sludge Factors(and CPSF)were establish.d for prediction of sludge y.elds and intermetallic sizes in Al-containing Mg *** CPSF with.five independent variables including both.ch.mical elements and process parameters gave h.gh.accuracy.in prediction,as th. prediction of th. PSF with.only.th. two processing parameters of th. melt h.lding temperature and time sh.wed a relatively.large deviation from th. experimental *** Ch.mical Sludge Factor was primarily.designed for small ingot producers and die casters with.a limited melting and h.lding capacity.of wh.ch.process parameters could be fixed *** Ph.sical Sludge Factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguch. meth.d Sludge factor Ch.mical composition Process parameter

Electron kinetic effects in back-stimulated Raman scattering bursts driven by.broadband laser pulses

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.Liu L.Deng Q.wang X.Zh.ng F.Q.Meng y.P.wang y.Q.Gao h.B.Cai S.P.Zh. Graduate Sch.ol China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Ph.sics and Computational Math.matics Beijing 100094China Sch.ol of Nuclear Science and Tech.ology University of Science and Technology of ChinaHefei 230026China Sh.ngh.i Institute of Laser Plasma Shanghai 201800China h.DPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China Sch.ol of Ph.sics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using particle-in-cell *** bursts occur during th. nonlinear stage,causing reflectivity.spikes and generating large numbers of h.t ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate th. interference of th. broadband laser’s random intensity.*** th. simplified model,we isolate and ch.racterize th. spectrum of electron plasma *** spectrum ch.nges from a sideband structure to a turbulence-like structure during th. burst.A significant asy.metry.in th. spectrum is *** asy.metry.is amplified and transferred to electron ph.se space by.h.gh.intensity.broadband laser pulses,leading to violent vortex-merging and generation of h.t *** proportion of h.t electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate th.t kinetic effects profoundly.influence th. BSRS evolution driven by.broadband lasers.

关键词： scattering kinetic simplified

Editorial for Multiscale&Multifield Coupling in Geomech.nics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mech.nics and Geotech.ical Engineering 2024年第6期16卷 1919-1921页

作者： Min wang Pengzh. Pan Andrew h.C.Ch.n y.T.Feng T-3 Fluid Dy.amics and Solid Mech.nics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mech.nics Chinese Academy of SciencesWuhanChina Sch.ol of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

We are deligh.ed to serve as guest editors for th.s special issue in th. Journal of Rock Mech.nics and Geotech.ical *** purpose of th.s special issue is dedicated to gath.ring th. latest research.work on Multiscale&Multifield Coupling in Geomech.nics,wh.re we delve into th. intricate interplay.of various fields and scales th.t govern th. beh.vior of *** total,30 manuscripts from USA,Ch.na,UK,Germany.Canada,India and United Arab Emirates are selected to be included in th.s issue.

关键词： materials. gath.ring mech.nics