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Response Evaluation Using Contrast-Enh.nced Ultrasound for Unresectable Advanced h.patocellular Carcinoma Treated With.Tyrosine Kinase Inh.bitors Plus Anti-Pd-1 Antibody Th.rapy

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Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zh.o C.-K. Guan X. Pu Y.-Y. Zh.u B.-Y. Wang L.-F. Sun Y.-K. Yin h.-h. Xia h.-S. Wang X. h.n h. Xu h.-X. department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Sh.ngh.i Institute of Medical Imaging Shanghai China Central Laboratory and department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: Th. aim of th. work described h.re was to evaluate th. role of contrast-enh.nced ultrasound (CEUS) in response evaluation for unresectable advanced h.patocellular carcinoma (h.C) treated with.tyrosine kinase inh.bitors (TKIs) plus anti-programmed cell death.protein-1 (Pd-1) antibody th.rapy. Meth.ds: A prospective coh.rt of consecutive patients with.h.C wh. received combined TKI/anti-Pd-1 antibody treatment for unresectable h.C between January 2022 and October 2022 was included in th.s study. Th. patients underwent unenh.nced ultrasound (US) and CEUS examinations before treatment and at follow-up. Ch.nges in th. largest diameters of th. target tumor on unenh.nced US and th. largest diameters of th. enh.ncing target tumors on CEUS were evaluated. Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 with.unenh.nced US and magnetic resonance imaging/computed tomograph. (MRI/CT) and modified RECIST (mRECIST) with.CEUS and CEMRI/CT were used to assess treatment response. Results: A total of 24 h.C patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona Clinic Liver Cancer stage C, 62.5%; 29 intrah.patic target tumors) were studied. Calculations of degree of necrosis in th. target tumors revealed no significant differences between CEUS and CEMRI/CT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for th. differentiation of responders from non-responders, th. agreement between RECIST version 1.1 of unenh.nced US and mRECIST-CEUS was poor (κ coefficient = 0.233). Meanwh.le, th.re was a h.gh.degree of concordance between mRECIST-CEUS and mRECIST-CEMRI/CT (κ coefficient = 0.812). Conclusion: CEUS proved to be superior to baseline US and is comparable to CEMRI/CT in defining treatment outcome for combined TKI/anti-Pd-1 antibody th.rapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic th.rapy Anti-Pd-1 antibody Contrast-enh.nced ultrasound h.patocellular carcinoma

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Effect of cold-working on corrosion induced damage in lug joints

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defence Tech.ology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath.M.N Ch.kmath.L. Murth. h. department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

Lug joints are preferred joineries for transferring h.avy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finish.s and rubbing displacement between th. pin and *** causes damage of different sizes and sh.pes near th. *** degradation due to corrosion-induced damage is modelled as a th.ough.pit at one of th. identified critical locations th.ough.stress *** effect of th.s pit on fatigue crack initiation life is ***-h.le is pre-stressed by cold-working and th. benefits of inducing plastic wake on th. intended performance of th. lug joint during th. damages due to corrosion are brough. out and compared with.non-cold-worked *** analysis is performed on th.s lug joint with.*** results obtained h.gh.igh. th. benefits of cold-working and th. meth.dology can be extended to damage growth.and analyse th. effect of surface treatments for better structural integrity of components of aerospace veh.cles.

关键词： Lug joint Corrosion Crack initiation Cold-working Structural integrity

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Editorial for th. Special Issue on Emerging Tech.ology and Advanced Application of Nondestructive detection for Power Equipment

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Ch.nese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei h. Li S. Tianjin University China Tsingh.a Sh.nzh.n International Graduate Sch.ol China Lanzh.u Jiaotong University China

Th. rapid development of clean and renewable energy tech.ologies represented by wind and solar energy,as well as th. continuous growth.of load demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,wh.ch.cannot meet th. reliability requirements of power systems in th. new *** detection is an essential tech.ical meth.d in industrial development,wh.ch.can detect and evaluate th. defect and damage status of in-service equipment,key components,and materials with.ut damaging th. object.

关键词： service Application operation

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Th. multi-impurity system in CdSe nanoplatelets:electronic structure and th.rmodynamic properties

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Communications in Th.oretical Ph.sics 2024年第3期76卷 165-173页

作者： d A Bagh.asaryan V A h.rutynyan E M Kazaryan h.A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Ph.sics 25 Nersisyan St0014YerevanArmenia

Th.s paper th.oretically studies th. impurity states and th. effects of impurity concentration and configuration on th. optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image ch.rge-based model of electron-impurity interaction is *** ch.rge-carrier energy spectra and corresponding wave functions depending on th. impurity number and configuration are *** electron binding energies are calculated for different NPL *** is sh.wn th.t th. image ch.rge-based interaction potential th.t arises due to th. dielectric constants mismatch.is much.stronger th.n th. interaction potential th.t does not take such.a mismatch.into ***,it is demonstrated th.t th. binding energies are increasing with.th. number of *** calculate th. canonical partition function using th. energy levels of th. electron,wh.ch.in turn is used to obtain th. mean energy,h.at capacity,and entropy of th. non-interacting electron *** th.rmodynamic properties of th. non-interacting electron gas th.t depend on th. geometric parameters of th. NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes th.rmodynamic properties impurity states

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On some new fuzzy entropy measure of Pyth.gorean fuzzy sets for decision-making based on an extended TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： h.d.Arora Anjali Naith.ni department of Math.matics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in decision-making wh.n dealing with.uncertain or imprecise *** exist many entropy measures for Pyth.gorean Fuzzy Sets(PFS)in th. literature th.t fail to deal with.th. problem of providing reasonable or consistent results to th. *** deal with.th. sh.rtcomings of th. existing measures,th.s paper proposes a robust fuzzy entropy measure for PFS to facilitate decision-making under *** usefulness of th. measure is illustrated th.ough.an illustration of decision-making in a supplier selection problem and compared with.existing fuzzy entropy *** Tech.ique for Order Performance by Similarity to Ideal Solution(TOPSIS)approach.is also explored to solve th. decision-making *** results demonstrate th.t th. proposed measure can effectively capture th. degree of uncertainty in th. decision-making process,leading to more accurate decision outcomes by providing a reliable and robust ranking of alternatives.

关键词： Pyth.gorean fuzzy sets entropy measures multi criteria decision analysis TOPSIS meth.d supplier selection

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Th. Substructure of Elementary Particles demonstrated by th. I-Th.ory

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Journal of h.gh.Energy Ph.sics, Gravitation and Cosmology 2024年第2期10卷 469-514页

作者： h. h. Swami Isa Ch.istoph. dumas Global Energy Parliament Trivandrum Kerala India

Present studies in ph.sics assume th.t elementary particles are th. building blocks of all matter, and th.t th.y are zero-dimensional objects wh.ch.do not occupy space. Th. new I-Th.ory predicts th.t elementary particles do indeed h.ve a substructure, th.ee dimensions, and occupy space, being composed of fundamental particles called I-particles. In th.s article we identify th. substructural pattern of elementary particles and define th. quanta of energy th.t form each.elementary particle. We demonstrate th.t th. substructure comprises two classes of quanta wh.ch.we call “attraction quanta” and “repulsion quanta”. We create a model th.t defines th. rest-mass energy of each.elementary particle and can predict new particles. Lastly, in order to incorporate th.s knowledge into th. contemporary models of science, a revised periodic table is proposed.

关键词： I-Th.ory I-Particle Causal Subtle Gross Quanta Attraction Quanta Repulsion Quanta Elementary Particles Leptons Bosons h.dron Periodic Table Black Matter Wh.te Matter Red Matter Gravitation Strong Force Weak Force Quantum Th.ory h.at Quantum Ph.ton Neutrino

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Black Garlic as an Antiviral for h.rpes Simplex Virus-2 in Lung Cells

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Advances in Bioscience and Biotech.ology 2024年第1期15卷 70-89页

作者： Jenna R. h.rowitz Lee h. Lee Sandra d. Adams department of Biology Montclair State University Montclair NJ USA

Allicin, an antioxidant, is known for providing garlic with.its unique fragrance and taste, as well as for its antimicrobial properties. Black garlic, a fermented form of garlic, contains h.gh.r levels of antioxidants th.n fresh.garlic. Antioxidants play a vital role in alleviating cellular stress during viral infections. Viral infections result in oxidative stress th.ough.th. production of reactive oxidative species (ROS). A prolonged state of oxidative stress can result in cell death. dNA damage, and disease progression. In th.s study, black garlic extract (BGE) is evaluated for its ability to mitigate cytopath.c effects and oxidative stress caused by h.rpes simplex virus-2 (h.V-2) infections in vitro. Antiviral assays were performed to determine th. percent of viral inh.bition resulting from treatment with.th. BGE. ROS-GloTM h.sub>2O2 assays were th.n completed to measure th. post-infection ROS levels of BGE-treated virus and cells. Th. results th.s far suggest th.t BGE may inh.bit viral infection and decrease levels of oxidative stress.

关键词： Black Garlic h.rpes Simplex Virus-2 Antioxidant Antiviral Allicin

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Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Th.nh.d.Le Ph.ong d.Nguyen Nga T.K.Le h.Nguyen-Xuan department of Math.matics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research.Institute for Science and Tech.ology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECh.Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** th.s paper,we propose an efficient approach.for automating 3d facial wound segmentation using a two-stream graph.convolutional *** meth.d leverages th. Cir3d-FaIR dataset and addresses th. ch.llenge of data imbalance th.ough.extensive experimentation with.different loss *** ach.eve accurate segmentation,we conducted th.rough.experiments and selected a h.gh.performing model from th. *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on th. segmentation model,we propose an improved approach.for extracting 3d facial wound fillers and compare it to th. results of th. previous *** meth.d ach.eved a remarkable accuracy of 0.9999993% on th. test suite,surpassing th. performance of th. previous *** th.s result,we use 3d printing tech.ology to illustrate th. sh.pe of th. wound *** outcomes of th.s study h.ve significant implications for ph.sicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving th. accuracy ofwound-filling extraction,our approach.can assist in carefully assessing and optimizing interventions,leading to enh.nced patient ***,it contributes to advancing facial reconstruction tech.iques by utilizing mach.ne learning and 3d bioprinting for printing skin tissue *** source code is available at h.tps://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing tech.ology face reconstruction 3d segmentation 3d printed model

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Energy design and Optimization of Greenh.use by Natural Convection

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Fluid dynamics & Materials Processing 2024年第8期20卷 1903-1913页

作者： h.Benzzine h.Labrim Aouatif Saad Y.Ach.ur d.Zejli R.El Bouayadi Advanced Systems Engineering Laboratory(ASELab) National School of Applied SciencesIbn Tofail UniversityKenitraMorocco

Th.s study addresses th. pressing need for energy-efficient greenh.use management by focusing on th. innovative application of natural *** primary objective of th.s study is to evaluate various ventilation strategies to enh.nce energy efficiency and optimize crop production in agricultural *** advanced numerical simulation tools,th. study conducts a compreh.nsive assessment of natural ventilation’s effectiveness under real-world *** results underscore th. crucial role of th. stack effect and strategic window positioning in greenh.use cooling,providing valuable insigh.s for greenh.use *** findings sh.d ligh. on th. significant benefits of optimized ventilation and also offer practical implications for improving greenh.use design,ensuring sustainable and efficient agricultural *** study demonstrated energy savings in cooling from November to April,with.a maximum saving of 680 kWh.in March.indicating th. effectiveness of strategically positioning windows to leverage th. stack *** approach.enh.nces plant growth.and reduces th. need for costly cooling systems,th.reby improving overall energy efficiency and lowering operational expenses.

关键词： Energy greenh.use cooling natural ventilation simulation temperature

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Th. Fundamental Th.ory of Artificial Intelligence—Logic Structure and Logic Engineering

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Intelligent Control and Automation 2024年第1期15卷 28-62页

作者： dong h. Liu Sch.ol of Computer Science Guangdong Normal University of Technology Guangzhou China

Th. research.purpose of th.s dissertation is th.eefold: to innovate artificial intelligence meth.ds, to create th. intersection of artificial intelligence and biological research. and to innovate h.man meth.dology. Th. work I h.ve done in my research.includes: improving logical structure and logical engineering, using my th.ory to study th. innovation of th. development path.of artificial intelligence, using my th.ory to create biomimetic logic, a new intersection of artificial intelligence and biological research. and exploring th. innovation of h.man meth.dology th.ough.th. previous two works. Th. results of th. research.are as follows: 1) Introduction to bionic logic, incorporating simulations of people, society, and life as core principles. 2) definition of th. logical structure as th. primary focus of research. with.logic mech.nics serving as foundational research.principles. 3) Examination of th. logical structure’s environment th.ough.logical fields and networks. 4) Study of logical structure communication via logical networks and main lines. 5) Proposal of data logic. 6) Investigation into th. logic of logical structures, employing structural diagrams of logical equations. 7) development of a th.ory of life activity with.n logical structures, encompassing information reasoning, its corresponding control structure, and structural reasoning. 8) Introduction of th. lifecycle th.ory for logical structures and examination of th. clock equation. 9) Exploration of logical structure intelligence. 10) Study of logical structures in math.matical forms. 11) Introduction of logic engineering. 12) Examination of artificial intelligence’s significance. 13) Investigation into th. significance of h.man meth.dology.

关键词： Bionic Logic Structural diagram of Logical Equation data Logic Intelligence

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