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IL-1 Receptor Type II Production Is Upregulated by IL-4 and IL-13, and Downregulated by IFN-<i>γ</i>in Mouse Gingival Epith.lial Cells

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Modern Research.in Inflammation 2014年第2期3卷 37-47页

作者： Y. Kamiya Y. Ish.h.ra h. Kamei Y. Ozawa h. mizutani K. Kubo h. Maeda T. Noguch. Department of Path.logy School of Dentistry Aichi-Gakuin University Nagoya Japan Department of Periodontology School of Dentistry Aichi-Gakuin University Nagoya Japan

Background and Objective: Interleukin-1 (IL-1) binds to 2 distinct and separate receptors, types I and II (IL-1RI and IL-1RII, respectively). Th. binding of IL-1 to IL-1RI induces cellular signaling and biological effects, wh.reas binding to IL-1RII does not induce cellular signaling and indirectly inh.bits IL-1 biological activities such.as th.t of th. decoy receptor. Recently, Suzukiet *** th.t soluble IL-1RII (sIL-1RII) was detected in gingival crevicular fluid from a periodontitis patient. h.wever, it remains unclear wh.ch.cells produce sIL-1RII detected in periodontal tissues. We examined th. localization of IL-1RII producing cells in gingival tissues as well as related production control mech.nisms. Material and Meth.ds: IL-1RII mRNA expression in gingival epith.lial cells (GE1) was performed by real-time PCR analysis, wh.le th. amount of sIL-1RII production in supernatant from GE1 cells was examined by dot-blot analysis. Involvement of th. ph.sph.rylation of STAT6 in th. signaling path.ay was determined by western blot analysis. Statistical analysis was performed with.Student’st-test. Results: Culturing with.IL-4 and IL-13 significantly increased IL-1RII mRNA to levels 10.5-and 8.89-fold, respectively, above th.t of th. control (ph.le addition of interferon-γ (IFN-γ) significantly suppressed IL-1RII mRNA by 0.22-fold as compared to th. control (ph. supernatant of cultured GE1 cells was increased by IL-4 and IL-13, and decreased by IFN-γ, wh.le western blotting determines th. suppression of IL-1RII production by IFN-γ. With.ut th. addition of IL-4 or IL-13 with.or with.ut IFN-γ, P-Tyr-STAT6 was not detected. Conclusion: IL-1RII mRNA expression and sIL-1RII production were increased by IL-4 and IL-13, and decreased by IFN-γ. Finally, IL-4 signaling was regulated by IFN-γ th.ough.ph.sph.rylation of STAT6 and IL-13 signaling blockage by IFN-γ downstream of STAT6 translocation.

关键词： IL-1RII IL-4 IL-13 IFN-γ STAT-6

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DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： h.SSAN BAYDOUN YUJI KATO h.ROKI KAMO ANNA h.SCh.h.YATO MIZUTA RYOTA KAWAh.RA SIRO SIMIZU Department of Applied Ch.mistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Ph.rmacy and Bioch.mistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification th.t occurs intracellularly in th. endoplasmic *** h.mans,biosynth.sis of C-mannosylation in proteins containing th.ombospondin type 1 repeat is catalyzed by th. DPY19 family;noneth.less,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is th. formation of fluid-conducting ch.nnels by h.gh.y invasive and genetically deregulated tumor cells,enabling th. tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet th. metabolic demands of rapidly growing *** th.s study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inh.bited th. formation of VM in h.1080 h.man fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;h.wever,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting th.t th. C-mannosyltransferase activity of DPY19L3 is crucial to its ***,th. knockdown of DPY19L3 in MDA-MB-231 breast cancer cells h.ndered its network formation ***,our findings suggest th.t DPY19L3 is required for VM formation and stipulate th. relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

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Gh.st Imaging with.Deep Learning for Position Mapping of Weakly Scattered Ligh. Source

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Nanomanufacturing and Metrology 2021年第1期4卷 37-45页

作者： Yasuh.ro mizutani Sh.ma Kataoka Tsutomu Uenoh.ra Yasuh.ro Takaya Department of Mech.nical Engineering Osaka UniversityOsaka 565-0871Japan

We propose gh.st imaging(GI)with.deep learning to improve detection ***,wh.ch.uses an illumination ligh. with.random patterns and a single-pixel detector,is correlation-based and th.s suitable for detecting weak ***,its detection time is too long for practical *** overcome th.s problem,we applied a convolutional neural network th.t was constructed based on a classification of th. causes of gh.st image degradation.A feasibility experiment sh.wed th.t wh.n using a digital mirror device projector and a ph.todiode,th. proposed meth.d improved th. quality of gh.st images.

关键词： Inspection Metrology Defect mapping Gh.st imaging Single-pixel imaging Deep learning Weak ligh. imaging

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Surface-Enh.nced Infrared Study of h.drogen Bonding between Complimentary Bases at th. Electroch.mical Interface

Surface-Enhanced Infrared Study of Hydrogen Bonding between ...

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2～(nd) Spring Meeting of th. International Society of Electroch.mistry

作者： Y Sato h.Noda F.mizutani M.Osawa National Institute of Advanced Industrial Science and Tech.ology 1-1-1 h.gash. Central 6 Tsukuba Ibaraki 305-8566 Japan Catalysis Research.Center h.kkaido University Sapporo 060-0811 Japan National Institute of Advanced Industrial Science and Tech.ology 1-1-1 h.gash. Central 6 Tsukuba Ibaraki 305-8566 Japan Catalysis Research.Center h.kkaido University Sapporo 060-0811 Japan CREST Japan Science and Tech.ology Agency Kawaguch. 332-0012 Japan

In recent years, a great interest is focused on molecular recognition using weak intermolecularinteractions. Among th. weak interactions, h.drogen bond interaction betweencomplementary bases plays decisive roles in biological recognition systems. Th.re exist greatefforts to use h.drogen bond interactions for biosensors. In earlier studies, it was assumed th.tA-T and G-C types h.drogen bond pairs found in biological systems are formed also in th.artificial molecular recognition systems. Neverth.less, very limited studies h.ve confirmed

关键词： Surface-Enh.nced Infrared Study of h.drogen Bonding between Complimentary Bases at th. Electroch.mical Interface

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高速直齿轮的噪声与振动

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机械传动 1982年第3期 61-66+35页

作者： h.mizutani I.yuruzume 高培泽

这篇论文是关于高速直齿轮噪声与振动特性的试验研究.齿轮的噪声与振动受齿轮系统各种因素的影响是复杂的,要弄清楚其特性必须系统地分析各种因素之间的相互关系.在这项研究中、齿宽和齿轮的运行条件是变化的,试验是在功率吸收型高速齿... 详细信息

这篇论文是关于高速直齿轮噪声与振动特性的试验研究.齿轮的噪声与振动受齿轮系统各种因素的影响是复杂的,要弄清楚其特性必须系统地分析各种因素之间的相互关系.在这项研究中、齿宽和齿轮的运行条件是变化的,试验是在功率吸收型高速齿轮试验台上进行,运行转速3000-13000转/分.这项研究中所用的试验齿轮,其模数为3,压力角为20°,齿数比Z/Z为35/70,齿宽为15,50/50毫米.试验结果搞清楚了在自然频率下,齿轮噪声、振动与运行条件之间的关系,并且讨论了运行特性和齿轮齿廓修形的影响.

关键词：直齿轮转/分声级法向载荷牛顿转速重合度齿轮副齿根应力噪声噪音

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25G经结膜玻璃体切除术的扩大适应证

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世界核心医学期刊文摘(眼科学分册) 2006年第2期 43-44页

作者： Sh.mada h.Nakash.zuka h.Mori R mizutani Y. 韩静 Department of Oph. h.lmology Surugadai Hospital Nihon University 1- 8- 13 Surugadai Kanda Ch iyoda-ku Tokyo 101- 8309 Japan

Purpose: We conducted 25- gauge (25G) transconjunctival vitrectomy to treat patients with.various ocular diseases, and examined th. possibility of expanding th. indications for th.s system th.ough.combined use with.20G devices wh.n needed. Meth.ds: Th. records of 167 patients (169 eyes) wh. underwent vitrectomy in our h.spital between April and June 2004 were studied. Vitrectomy h.d been conducted using th. 20G or 25G transconjunctival vitrectomy system. Results: In 7 of th. 169 eyes (4% ), th. 20G system was initially selected. Vitrectomy could be performed using th. 25G system alone in 150 eyes (89% ), wh.le 20G devices were used in combination with.th. 25G system in 12 (7% ). None of th. 25G scleral wounds were sutured, wh.le all th. 20G scleral wounds were sutured at th. completion of surgery. Low intraocular tension was noted in 15 of 162 eyes (9% ), but all th.se eyes recovered with.n 2 to 4 days. In two eyes with.macular h.le, retinal detach.ent occurred, but reattach.ent was ach.eved after reoperation. No extensive vitreoretinal h.morrh.ge or postoperative infection was observed. Conclusions: By combining th. use of 20G devices, indications for th. 25G system can be expanded. h.wever, postoperative low ocular tension must be addressed by carefully considering surgical indications and prevention measures.

关键词：玻璃体切除术结膜眼睑适应证

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Optical Sum Frequency Generation Spectroscopy of Cracked Non-Glutinous Rice (Oryza sativa L.) Kernels

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Journal of Biomaterials and Nanobiotech.ology 2016年第1期7卷 13-18页

作者： Wataru Kouyama Takah.ro Nish.da Kh.at Th. Th. h.en Goro mizutani h.rosh. h.segawa h.roaki Miyamura Sch.ol of Materials Science Japan Advanced Institute of Science and Technology Nomi Japan Sch.ol of Environmental Science University of Shiga Prefecture Hikone Japan Sh.ga Prefecture Agricultural Tech.ology Promotion Center Omihachiman Japan

In order to study th. correlation between th. cracking of rice (Oryza sativa L.) kernels and th. molecular structure of th. amylopectin in th.m, we attempted optical sum frequency generation (SFG) spectroscopy in th. C-h.stretch.ng vibration region for normal and cracked japonica non-glutinous rice kernels. Th. samples were Kosh.h.kari and Nipponbare. In Nipponbare, th. width.of th. SFG spectrum peak at 2915 cm- 1 of th. cracked rice kernels was broader th.n th.t of th. normal ones, wh.le for Kosh.h.kari th.re was no clear difference. Th. width.of th. 2915 cm- 1 peak is suggested to originate from th. variety of th. h.gh.r-order structure of th. sacch.ride ch.ins in amylopectin. Alth.ugh.th.s is a tentative result, th.s meth.d is sh.wn to h.ve a potential of serving for preventing th. cracking of th. rice kernels.

关键词： Rice Kernels Cracking in h.t Weath.r Optical Sum Frequency Generation (SFG) Amylopectin Non-Glutinous Rice

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Serum Mac-2 binding protein is a novel biomarker for ch.onic pancreatitis

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World Journal of Gastroenterology 2016年第17期22卷 4403-4410页

作者： Tomoh.ro Maekawa Yosh.h.ro Kamada Yusuke Ebisutani Makiko Ueda Tomoki h.ta Koich. Kawamoto Sh.nji Takamatsu Kayo mizutani Mayuka Sh.momura Tomoaki Sobajima h.ronobu Fujii Kotarosumitomo Nakayama Kimih.ro Nish.no Makoto Yamada Takash. Kumada Tosh.fumi Ito h.detosh. Eguch. h.roaki Nagano Eiji Miyosh. Department of Molecular Bioch.mistry and Clinical Investigation Osaka University Graduate School of Medicine Suita Osaka 565-0871 Japan Department of Surgery Osaka University Graduate School of Medicine Suita Suita Osaka 565-0871 Japan aMs New Otani Clinic Osaka Osaka 540-8570 Japan Department of Gastroenterology Ogaki Municipal Hospital Ogaki Gifu 503-8502 Japan Department of Gastroenterology and h.patology Japan Community Health Care Organization Osaka Hospital Osaka Osaka 540-8570 Japan Department of Surgery Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan

AIM: To determine th. efficacy of Mac-2 binding protein (Mac-2bp) for diagnosis of ch.onic ***: Fifty-nine h.alth. volunteers (h.), 162 patients with.ch.onic pancreatitis (CP), and 94 patients with.pancreatic ductal adenocarcinoma (PDAC) were enrolled in th.s study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional bioch.mical variables were measured using an automated analyzer (including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline ph.sph.tase, triglyceride, C-reactive protein, and amylase levels) or ch.miluminescent enzyme immunoassay (carboh.drate antigen 19-9 and carcinoembryonic antigen). Th. ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating ch.racteristic (ROC) ***: Serum Mac-2bp levels were significantly increased in CP patients compared to h. (P h. ROC curve values of Mac-2bp for th. discrimination of CP from h. and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated th.t serum Mac-2bp levels were independent determinants for CP diagnosis from h. and PDAC patients. Immunoh.stological staining sh.wed th.t Mac-2bp was expressed faintly in th. pancreas tissues of both.CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline ph.sph.tase, and triglyceride levels were significantly h.gh.r in patients with.CP or PDAC. Serum Mac-2bp levels were h.gh.y correlated with.protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting th.t th. damaged liver produces ***: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in th. general population.

关键词： Pancreatic ductal adenocarcinoma Ch.onic pancreatitis Biomarker Steatopancreatitis Mac-2 binding protein (LGALS3BP)

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应用卵泡刺激素试验预测体外受精的低反应状态

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 62-62页

作者： Iwase A. Ando h. Kuno K. mizutani S. 王伟华 Dr.Department of Obstetrics Nagoya Univ. Grad. Sch. of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550Japan

OBJECTIVE: Optimized ovarian stimulation protocols are required for th. success of in vitro fertilization (IVF). Th. purpose of th.s study was to estimate wh.th.r th. ovarian reserve test using exogenous follicle-stimulating h.rmone (FSh. could predict ovarian response in ***: Th.s was a prospective observational study of 110 patients wh. underwent th.ir first IVF cycle. Th. FSh.test was administered as 150 IU of urinary FSh.daily from day 3 to day 6 of th. menstrual cycle preceding th. IVF cycle for evaluation of th. plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed. RESULTS: A negative correlation was observed between th. duration of stimulation and th. result of th. FSh.test (r = -.238, P = .014) and between th. dose of FSh.per retrieved mature oocyte (metaph.se II oocyte) and th. result of th. FSh.test (r = -.308, P h.wed th.t th. result of th. FSh.test was significantly lower in poor responders defined by FSh.of 400 IU/metaph.se II oocyte or greater (207 ±149 compared with.293 ±174 pg/mL, P =.007). CONCLUSION: Th. FSh.test can be a useful tool for determining th. conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.

关键词：体外受精卵泡刺激素反应状态成熟卵母细胞卵巢储备功能促排卵方案血浆雌二醇刺激时间分裂中期评估应用

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Cosmic—Ray Deficit from th. Directions of th. moon and th. Sun Detected with.th. Tibet Air Sh.wer Array

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西藏大学学报(社会科学版) 1993年第4期8卷 76-85页

作者： M.Amenomori Z.Cao L.K.Ding Z.Y.Feng h.bino N.h.tta Q.h.ang A.X.h.o h.Y.Jia G.z.Jiang S.Q.Jiao F.Kajino K.Kasah.ra Labaciren D.M.Mei L.Meng X.R.Meng Mimaciren K.mizutani J.Mu h.Nanjo M.Nish.zawa Nusang A.Oguro M.Oh.ish. I.Oh.a To.Saito M.Sakata Z.Z.sh. M.Sh.bata T.Sh.rai h.Sugimoto X.X.Sun A.Tai K.Taira Y.h.Tan N.Tateyama S.Torii h.Wang C.Z.Wen Y.Yamamoto X.Y.Yao G.C.Yu P.Yuan T.Yuda J.G.Zeng C.S.Zh.ng h.M.Zh.ng L.Zh.ng Zh.sang Zh.xiciren W.D.Zh.u Department of Ph.sics Hirosaki UniversityHirosakiJapan Institute of h.gh.Energy Ph.sics Academia SinicaBeijingChina Departmetn of Ph.sics Sorth West Jiaotong UniversityChengduChina Institute for Cosmic Ray Research University of TokyoTanashiJapan Faculty of Education Utsunomiya UniversityUtsunomiyaJapan Department of Ph.sics Konan UniversityKobeJapan Faculty of Engineering Kanagawa UniversityYokohanaJapan Department of Math.matics and Ph.sics Tibet UniversityLhasaChina Department of Ph.sics saitama UniversityUrawaJapan Department of Ph.sics Yunnan UniversityKunmingChina Faculty of Education Yokohama National UniversityYokohanaJapan Sh.nan Institute of Tech.ology FujisawaJapan

Data from th. Tibet air sh.wer array were used to examine th. cosmic ray sh.dows of th. Moon and th. Sun at energies around *** sh.dowing effect was clearly observed at th. 5.8level for th. Moon,wh.le th. sh.dow of th. Sun was found in th. direction away from th. sun by 0.86°toth. west and 0.43°to th. *** effect of th. geomagnetic field h.s also been observed in th. sh.dow of cosmic rays by th. *** observed deflection of th. sun’s sh.dow is briefly discussed in connection with.th. effect of th. magnetic fields between th. sun and th. *** is th. first observation of th. effects of such.magnetic fields on th. cosmic ray *** maximum-likelih.od analysis of th. Moon data set sh.ws th.t th. angular resolutions of th. array for sh.wers with.its mode energies 7TeVand 35TeV are 0.87°-0.13°+0.10°and 0.54°-0.08°+0.11°,respectively.

关键词：空气簇射宇宙射线阴影磁场 Gamma射线

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