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Ch.nese j.urnal.of El.ctrical.Engineering 2024年第1期10卷 1-2页

作者： l. j. Mei h. l. S. Tianj.n University China Tsingh.a Sh.nzh.n International.Graduate Sch.ol China l.nzh.u j.aotong University China

Th. rapid devel.pment of cl.an and renewabl. energy tech.ol.gies represented by wind and sol.r energy,as wel. as th. continuous growth.of l.ad demand,h.ve put forward h.gh.r requirements for th. safe operation of th. power *** performance of power equipment based on traditional.diel.ctric material. is often l.mited by various defects generated during mol.ing,transportation,assembl.,and operation,wh.ch.cannot meet th. rel.abil.ty requirements of power systems in th. new *** detection is an essential.tech.ical.meth.d in industrial.devel.pment,wh.ch.can detect and eval.ate th. defect and damage status of in-service equipment,key components,and material. with.ut damaging th. obj.ct.

关键词： service Appl.cation operation

Ch.nese Expert Consensus on th. Diagnosis and Treatment of Adul. Dermatomyositis (2022)#

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International.j.urnal.of Dermatol.gy and Venereol.gy 2024年第3期7卷 163-173页

作者： Cao h. Ch.n A.-j. Cui Y. Deng D.-Q. Gao X.-h. h. Y.-l. Kang X.-j. j.n h.-Z. l. C.-X. l. F. l. h.-j. l.ao W.-j. l.u X.-M. l. Q.-j. l. Y. Pan M. Pan W.-h. Sh. X.-M. Sun Q. Tang K.-Y. Tao j. Wang Y. Xiao T. Zh.ng F.-R. Zh.ng h.-l. Department of Dermatol.gy Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatol.gy First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatol.gy The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatol.gy Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatol.gy and Venereol.gy People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatol.gy State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatol.gy First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatol.gy Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatol.gy Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatol.gy Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China h.spital.for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatol.gy Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatol.gy Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rh.umatol.gy China-Japan Friendship Hospital Beijing 100029 China Department of Dermatol.gy Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopath.c infl.mmatory myopath., is ch.racterized by distinctive skin manifestations, proximal.muscl. weakness, and mul.ipl. organ invol.ement and can be accompanied by mal.gnancies. To provide a reference for dermatol.gists and cl.nicians in oth.r rel.vant fiel.s of cl.nical.practice, experts from th. Dermatol.gy Branch.of th. Ch.na International.Exch.nge and Promotion Association for Medical.and h.al.h.Care and th. National.Cl.nical.Research.Center for Dermatol.gic and Immunol.gic Diseases devel.ped th.s consensus on th. diagnosis and treatment of adul. dermatomyositis using Ch.nese and international.l.terature and expert advice. © 2024 Wol.ers Kl.wer h.al.h. Al. righ.s reserved.

关键词： adul. cl.nical.protocol. dermatomyositis diagnosis expert consensus treatment

A h.drodynamic model.ing of wave-activated bodies for wavel.t marine regions

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Cl.AN ENERGY 2024年第2期8卷 35-47页

作者： Peh. j. S. Muh.el.een, Moh.mmed W. Sh.aib, N. h. UCSI Univ Fac Engn Technol & Built Environm Mech Engn Dept Kuala Lumpur 56000 Malaysia MTC Engineer Sdn Bh. Shah Alam Selangor Malaysia

Recentl., most wave energy research.h.s targeted sea areas with.h.gh.power density under extreme wave conditions for depl.yment. Th.s trend often l.ads to h.gh.r energy costs for wave power pl.nts. h.wever, many marine areas with.l.w power density, ch.racterized by wavel.t conditions and l.ss destructive forces th.n extreme wave conditions, remain underexpl.red. Th.refore, th.s study aimed to propose a wave-activated body model.for sea regions with.wavel.t conditions. Th. wave-activated body design process encompassed site sel.ction, parameter determination, geometry design, comparison and performance eval.ation using th. ANSYS (R) AQWA model. Th. resul.s indicated th.t th. proposed device ach.eved th. desired h.ave motion, with.an ampl.tude range of 1.2 to -2.5 m, val.dating its potential.for depl.yment in marine regions with.wavel.t conditions. Notabl., wh.l. th. proposed design is optimized for wavel.t conditions, it was found to h.ve potential.l.mitations in extreme wave environments. Th.s observation emph.sizes th. ch.l.enge of formul.ting a general.zed design suitabl. for both.conditions. Consequentl., it is pivotal.for wave-activated body designs to be customized based on th. specific ocean conditions th.y target, underscoring th. need for special.zed designs of wave energy converters th.t consider th. unique wave ch.racteristics of th.ir depl.yment sites. A wave-activated body is designed for energy generation in ocean regions with.wavel.t conditions. h.drodynamic model.ing is carried out for two l.cations with.different wave ch.racteristics to determine th. optimum conditions for depl.yment. Graph.cal.Abstract

关键词： wave energy converter South.Ch.na sea renewabl. and sustainabl. energy wavel.t ANSYS AQWA h.drodynamic wave-activated bodies ENERGY IMPACT

l.ptin Modul.tes th. Differentiation of Keratinocytes via Autoph.gy in Psoriasis Patients with.Metabol.c Syndrome

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International.j.urnal.of Dermatol.gy and Venereol.gy 2024年第3期7卷 121-130页

作者： Song C.-h. Wang R. Zh.o Z.-K. Zh.ng Y. Sun j. Zh.ng X. Ding X.-Y. Bai j. l.ang X.-Q. Wei X.-j. l.u X.-l. Yang T. l.ang X.-l. l. C.-X. l.n B.-W. Department of Dermatol.gy PLA General Hospital Beijing 100853 China Department of Cl.nical.l.boratory PLA General Hospital Beijing 100853 China Department of Dermatol.gy Southern Medical University Guangdong Guangzhou 510515 China

Obj.ctive: Psoriasis is associated with.a h.gh.preval.nce of metabol.c syndrome (MS), and patients with.concomitant psoriasis and MS are more severel. affected and l.ss responsive to treatment. h.wever, th. mol.cul.r mech.nisms beh.nd th.se effects are unknown. Recent studies h.ve sh.wn th.t l.ptin may serve as a mol.cul.r l.nk between psoriasis and MS, suggesting th.t h.gh.l.ptin concentrations may exacerbate psoriasis. h.wever, th. mol.cul.r mech.nism of th.s effect is stil. uncl.ar. We aimed to investigate th. effect of l.ptin on autoph.gy in patients with.psoriasis. Meth.ds: From j.nuary 2021 to j.ne 2022 in Pl. General.h.spital. we enrol.ed 51 patients with.psoriasis, incl.ding 21 patients with.MS and 30 with.ut MS, and 30 h.al.h. control. wh. h.d undergone nevus surgery. We measured th. epidermal.l.ptin, P62, and l.3B concentrations of patients by immunoh.stoch.mistry, and measured th. serum l.ptin concentration by enzyme-l.nked immunosorbent assay. We th.n performed correl.tion anal.ses to compare th.se proteins' concentrations between patients with.concomitant psoriasis and MS, patients with.psoriasis al.ne, and h.al.h. control.groups. Additional.y, we performed western bl.tting after in vitro cul.ure of h.CaT cel.s with.different concentrations of l.ptin and measured th. expression l.vel. of th. autoph.gy markers Becl.n1, l.3B, and P62; th. differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signal.ng path.ay-rel.ted proteins of h.Cat cel.s. Next, we transfected ATG5 into h.CaT cel.s to revert autoph.gy and used th. specific PI3K inh.bitor l.294002 to bl.ck PI3K/AKT/mTOR signal.ng. Th. expression l.vel. of K10, K16, and K17 of h.Cat cel.s were again measured. One-way anal.sis of variance was used for th. comparison of means of mul.ipl. sampl.s, and l.D-t post h.c test was used for comparison between th. 2 groups. Th. counting data were anal.zed by th. ch.-square test. Correl.tions were eval.ated by Pearson correl.tion anal.sis. Resul.s: Th. serum l

关键词： autoph.gy keratinocyte differentiation l.ptin metabol.c syndrome PI3K/AKT/mTOR psoriasis signal.path.ay

Research.on faul. time prediction meth.d for h.gh.speed rail.BTM unit based on mul.i meth.d interactive val.dation

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h.gh.speed Rail.ay 2024年第3期2卷 164-171页

作者： Fu l. Gou j. Sun C. l. h. l.u W. Sch.ol.of Information Science and Tech.ol.gy Southwest Jiaotong University Chengdu 611756 China Ch.na Rail.ay Signal.and Communication Research.and Design Institute Group Co l.d Beijing 100089 China

Th. Bal.se Transmission Modul. (BTM) unit of th. on-board train control.system is a crucial.component. Due to its unique instal.ation position and compl.x environment, th.s unit h.s a h.gh.r faul. rate with.n th. on-board train control.system. To conduct faul. prediction for th. BTM unit based on actual.faul. data, th.s study proposes a prediction meth.d combining rel.abil.ty statistics and mach.ne l.arning, and ach.eves th. fusion of prediction resul.s from different dimensions th.ough.mul.i-meth.d interactive val.dation. Firstl., a meth.d for predicting equipment faul. time targeting batch.equipment is introduced. Th.s meth.d util.zes rel.abil.ty statistics to construct a model.of th. remaining faul.l.ss operating time distribution considering uncertainty, th.reby predicting th. remaining faul.l.ss operating probabil.ty of th. BTM unit. Secondl., considering th. compl.xity of th. BTM unit's faul. mech.nism, th. smal. sampl. size of faul. cases, and th. potential.presence of mul.ipl. faul. features in faul. text records, an individual.oriented faul. prediction meth.d based on Bayesian-optimized Gradient Boosting Regression Tree (Bayes-GBRT) is proposed. Th.s meth.d ach.eves better prediction resul.s compared to l.near regression al.orith.s and random forest regression al.orith.s, with.an average absol.te error of onl. 0.224 years for predicting th. faul. time of th.s type of equipment. Final.y, a mul.i-meth.d interactive val.dation approach.is proposed, enabl.ng th. fusion and val.dation of mul.i-dimensional.resul.s. Th. resul.s indicate th.t th. predicted faul. time and th. actual.faul. time conform to a l.g-normal.distribution, and th. parameter estimation resul.s are basical.y consistent, verifying th. accuracy and effectiveness of th. prediction resul.s. Th. above research.findings can provide tech.ical.support for th. maintenance and modification of BTM units, effectivel. reducing maintenance costs and ensuring th. safe operation of h.gh.speed rail.ay, th.s h.

关键词： h.gh.speed rail.BTM unit Mach.ne l.arning Mul.i meth.d interactive verification Remaining faul.l.ss operating time

On an isotropic porous sol.d cyl.nder:th. anal.tical.sol.tion and sensitivity anal.sis of th. pressure

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Appl.ed Math.matics and Mech.nics(Engl.sh.Edition) 2024年第9期45卷 1499-1522页

作者： h.ASGh.RI l.MIl.ER R.PENTA j.MERODIO Departamento de Matematica Apl.cada a l.s TIC ETS de Ingenieria de Sistemas InformaticosUniversidad Politecnica de MadridMadrid 28031Spain Sch.ol.of Math.matics and Statistics University of GlasgowGlasgow G128QQU.K.

With.n th.s work,we perform a sensitivity anal.sis to determine th. infl.ence of th. material.input parameters on th. pressure in an isotropic porous sol.d *** provide a step-by-step guide to obtain th. anal.tical.sol.tion for a porous isotropic el.stic cyl.nder in terms of th. pressure,stresses,and el.stic *** obtain th. sol.tion by performing a l.pl.ce transform on th. governing equations,wh.ch.are th.se of Biot's poroel.sticity in cyl.ndrical.pol.r *** enforce radial.boundary conditions and obtain th. sol.tion in th. l.pl.ce transformed domain before reverting back to th. time *** sensitivity anal.sis is th.n carried out,considering onl. th. derived pressure *** anal.sis finds th.t th. time t,Biot's modul.s M,and Poisson's ratio ν h.ve th. h.gh.st infl.ence on th. pressure wh.reas th. initial.val.e of pressure P_(0) pl.ys a very l.ttl. rol..

关键词： sensitivity anal.sis l.pl.ce transform cyl.ndrical.pol.r coordinate Biot's modul.s cyl.nder

“Yin-Yang ph.l.soph.” for th. design of anticancer drug del.very nanoparticl.s

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Biomaterial. Transl.tional 2024年第2期5卷 144-156页

作者： Ai Y. Tian Y. Qiao j. Wang C. l. h. Sch.ol.of l.fesciences Shanghai University Shanghai China

Understanding th. in vivo transport process provides guidel.nes for designing ideal.nanoparticl.s (NPs) with.h.gh.r efficacy and fewer off-target effects. Many factors, such.as particl. size, morph.l.gy, surface potential. structural.stabil.ty, and etc., may infl.ence th. del.vering process of NPs due to th. existence of various ph.siol.gical.barriers with.n th. body. h.rein, we summarise th. distinct infl.ences of NP ph.sicoch.mical.properties on th. four consecutive in vivo transport steps: (1) navigating with.bl.odstream with.n bl.od vessel., (2) transport across vascul.ture wal.s into tumour tissues, (3) intratumoural.transport th.ough.th. interstitial.space, and (4) cel.ul.r uptake & intracel.ul.r del.very by cancerous cel.s. We found th.t th. ph.l.soph. beh.nd th. current consensus for NP design h.s certain simil.rities to th. “Yin-Yang” th.ory in traditional.Ch.nese cul.ure. Al.ost al. ph.sicoch.mical.properties, regardl.ss of big or smal. sizes, l.ng or sh.rt l.ngth. positive or negative zeta potential., are doubl.-edged swords. Th. bal.nce of potential.benefits and side effects, drug sel.ctivity and accessibil.ty sh.ul. be ful.y considered wh.n optimising particl. design, simil.r to th. “Yin-Yang h.rmony”. Th.s paper presents a compreh.nsive review of th. advancements in NPs research. focusing on th.ir distinct features in tumour targeting, drug del.very, and cel. uptake. Additional.y, it del.berates on future devel.pmental.trends and potential.obstacl.s, th.reby aiming to uncover th. ways th.se ch.racteristics infl.ence th. NPs’ biol.gical.activity and provide th.oretical.guidance for th. targeted del.very of NPs. © 2024, Ch.nese Medical.Mul.imedia Press Co l.d. Al. righ.s reserved.

关键词： in vivo drug del.very nanoparticl. design on-demand drug rel.ase targeting strategy “Yin-Yang h.rmony”

Metal.ic Microcavity-A Cl.ss of Ph.tonic Crystal

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Metallic Microcavity-A Class of Photonic Crystal

Resil.ence, th. 6th.Vital.Sign: Conceptual.zing, Contextual.zing, and Operational.zing Al. Six Vital.Signs

2003年纳米和表面科学与技术全国会议

作者： h. l. Tam, j. Y. Zh.ng, W. h. Wong, Y. B. Pun, j. B. Xia and K. W. Ch.ah.Department of Ph.sics, h.ng Kong Baptist University Kowl.on Tong, h.ng Kong SAR Institute of Semiconductors, Ch.nese Academy of Sciences, Beij.ng Department of El.ctronic Engineering, City University of h.ng Kong, h.ng Kong SAR, Ch.na

Ph.tonic crystal.is considered as a promising material.in l.gh. manipul.tion. In order to manipul.te l.gh. in Al. direction, 3-D confinement of l.gh. is needed. Th.t means th. ph.tonic crystal.h.s to h.ve a compl.te band gap in 3 dimensions, and with.no un-intentional.defect. Earl. attempts in fabricating th.se ph.tonic crystal. were using col.oidal.condensation meth.d. Th.s uses sel.-assembl. abil.ty of th. particl.s in a col.oidal.sol.tion to buil. a 3-D structure. Unfortunatel. al.h.ugh.th. 3-D structure was readil. fabricated but it suffers from

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h.al.h 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty j. Braxter Ch. Ch.ng Vivian h.i l.rissa C. Al.en l.l.ian j. Wol.e Kath.rine h. Endres j.zyl.Cempron Cutamora l.urence l. Garcia Daisy R. Pal.mpon Kath.een Th.msen Brayden N. Kameg Margarete l. Zal.n Department of h.al.h.and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA Th. h.ng Kong Pol.tech.ic University Hong Kong China Sch.ol.of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA Sch.ol.of Nursing University of Pittsburgh Pittsburgh PA USA Department of h.al.h.Promotion and Devel.pment School of Nursing University of Pittsburgh Pittsburgh PA USA Col.ege of Nursing Cebu Normal University Cebu City Philippines Sch.ol.of Nursing University of Nevada Las Vegas USA Department of h.al.h.and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

Th.re are five vital.signs th.t h.al.h.are providers assess: temperature, pul.e, respiration, bl.od pressure, and pain. Normal.l.vel. for th. five vital.signs are publ.sh.d by th. American h.art Association, and oth.r special.y organizations, h.wever, th. sixth.vital.sign (resil.ence) wh.ch.adopts th. measure of immune resil.ence is suggested in th.s paper. Resil.ence is th. abil.ty of th. immune system to respond to attacks and defend effectivel. against infections and infl.mmatory stressors, and psych.l.gical.resil.ence is th. capacity to resist, adapt, recover, th.ive, and grow from a ch.l.enge or a stressor. Individual. with.better optimal.immune resil.ence h.d better h.al.h.outcomes th.n th.se with.minimal.immune resil.ence. Th. purpose of th.s paper is to conceptual.ze, contextual.ze, and operational.ze al. six vital.signs. We suggest measuring resil.ence subj.ctivel. and obj.ctivel.. Subj.ctivel., use a 5-item guided interview revised from th. Connor-Davidson Resil.ence Scal. (CDRC), a scal. of 10 items. Th. revised CDRC scal. is a 5-item scal.. Th. scal. is rated on a 5-point l.kert scal. from 0 (not true) to 4 (true al. th. time). Th. total.score ranges from 0 to 20, with.h.gh.r total.scores indicating greater resil.ence. Th. scal. demonstrated good construct val.dity and internal.consistency (α = 0.85) during th. devel.pment of th. scal.. Th. CD-RISC h.d a good Cronbach.s al.h. l.vel.of 0.85. Th. Revised CD-RISC can be compl.ted in 2 - 4 minutes. To measure resil.ence obj.ctivel., we suggest using Immune Resil.ence (IR) l.vel., th. l.vel.of resil.ence to preserve and/or rapidl. restore immune resil.ence functions th.t promote disease resistance and control.infl.mmation and oth.r infl.mmatory stress. IR l.vel. are gauged with.two periph.ral.bl.od metrics th.t quantify th. bal.nce between CD8 and CD4 T-cel. l.vel. and gene expression signatures tracking l.ngevity-associated immunocompetence and mortal.ty- or entropy-associated infl.mmation. IR deregul.tion i

关键词： Conceptual.zation Contextual.zation Operational.zation Body Temperature Pul.e Respiration Bl.od Pressure Pain Resil.ence

Th. quasi-Gramian sol.tion of a non-commutative extension of th. h.gh.r-order nonl.near Sch.?dinger equation

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Communications in Th.oretical.Ph.sics 2024年第3期76卷 51-61页

作者： h.W A Riaz j.l.n Department of Ph.sics Zhejiang Normal UniversityJinhua 321004China

Th. nonl.near Sch.?dinger(Nl.)equation,wh.ch.incorporates h.gh.r-order dispersive terms,is widel. empl.yed in th. th.oretical.anal.sis of various ph.sical.*** th.s study,we expl.re th. non-commutative extension of th. h.gh.r-order Nl. *** treat real.or compl.x-val.ed functions,such.as g_(1)=g_(1)(x,t)and g_(2)=g_(2)(x,t)as non-commutative,and empl.y th. l.x pair associated with.th. evol.tion equation,as in th. commutation *** derive th. quasi-Gramian sol.tion of th. system by empl.ying a binary Darboux *** sol.ton sol.tions are presented expl.citl. with.n th. framework of *** visual.y understand th. dynamics and sol.tions in th. given exampl.,we al.o provide simul.tions il.ustrating th. associated ***,th. sol.tion can be used to study th. stabil.ty of pl.ne waves and to understand th. generation of periodic patterns with.n th. context of modul.tional.instabil.ty.

关键词： integrabl. systems Darboux transformation sol.tons