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Efficacy of tailored h.licobacter pylori eradication th.rapy based on antibiotic susceptibility and CYP2C19 genotype

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World Journal of Gastroenterology 2014年第21期20卷 6400-6411页

作者： Mitsush.ge Sugimoto Takah.sa furuta First Department of Medicine Hamamatsu University School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan

Th. cure rates of h.licobacter pylori (h. pylori) eradication th.rapy using a proton pump inh.bitor (PPI) and antimicrobial agents such.as amoxicillin, clarith.omycin, and metronidazole are mainly influenced by bacterial susceptibility to antimicrobial agents and th. magnitude of th. inh.bition of acid secretion. Annual cure rates h.ve gradually decreased because of th. increased prevalence of h. pylori strains resistant to antimicrobial agents, especially to clarith.omycin. Alternative regimens h.ve th.refore been developed incorporating different antimicrobial agents. Furth.r, standard PPI th.rapy (twice-daily dosing) often fails to induce a long-term increase in intragastric ph.> 4.0. Increasing th. eradication rate requires more frequent and h.gh.r doses of PPIs. Th.rapeutic efficacy related to acid secretion is influenced by genetic factors such.as variants of th. genes encoding drug-metabolizing enzymes (e.g., cytoch.ome P450 2C19, CYP2C19), drug transporters (e.g., multidrug resistance protein-1; ABCB1), and inflammatory cytokines (e.g., interleukin-1β). For example, quadruple daily administration of PPI th.rapy potently inh.bits acid secretion with.n 24 h. irrespective of CYP2C19 genotype. Th.refore, tailored h. pylori eradication regimens th.t address acid secretion and employ optimal antimicrobial agents based on results of antimicrobial agent-susceptibility testing may prove effective in attaining h.gh.r eradication rates.

关键词： h.licobacter pylori Tailored eradication th.rapy Proton pomp inh.bitor Cytoch.ome P450 2C19 Clarith.omycin

Influence of interleukin polymorph.sms on development of gastric cancer and peptic ulcer

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World Journal of Gastroenterology 2010年第10期16卷 1188-1200页

作者： Mitsush.ge Sugimoto Yosh.o Yamaoka Takah.sa furuta Center for Clinical Research Hamamatsu University School of Medicine Department of Environmental and Preventive Medicine Faculty of MedicineOita University

Pro-inflammatory cytokines are produced in th. gastric mucosa by inflammatory cells activated by ch.onic h.licobacter pylori (h. pylori) infection. Polymorph.sms of th.se cytokine genes are associated with.individual differences in gastric mucosal cytokine mRNA level, wh.ch.result in differences in gastric mucosal inflammation, acid inh.bition and gastroduodenal disease risk in response to h. pylori infection. Alth.ugh.polymorph.sms of interleukin (IL)-1B, IL-1RN and TNF-A h.ve been reported to relate well with.gastric cancer and peptic ulcer risk, th.se of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous studies, we found th.t th. risk of gastric non-cardia cancer development was significantly associated with.IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2Pro-inflammatory cytokines are produced in th. gastric mucosa by inflammatory cells activated by ch.onic h.licobacter pylori (h. pylori) infection. Polymorph.sms of th.se cytokine genes are associated with.individual differences in gastric mucosal cytokine mRNA level, wh.ch.result in differences in gastric mucosal inflammation, acid inh.bition and gastroduodenal disease risk in response to h. pylori infection. Alth.ugh.polymorph.sms of interleukin (IL)-1B, IL-1RN and TNF-A h.ve been reported to relate well with.gastric cancer and peptic ulcer risk, th.se of IL-2, IL-4, IL-6 and IL-8 genes are unclear. In combined analyses using data from previous stud- ies, we found th.t th. risk of gastric non-cardia cancer development was significantly associated with.IL-4-168 C allele (OR: 0.81, 95% CI: 0.69-1.00) and IL-4-590 T allele carrier status (0.61, 0.53-0.73), and IL-6-174 G/G genotype (2.02, 1.31-3.10). In peptic ulcer development, IL-2-330 G and IL-4-590 T allele carriers h.d a significantly decreased risk (0.37, 0.27-0.50 and 0.58, 0.34-0.99, respectively). Moreover, IL-2, IL-4, IL

关键词： h.licobacter pylori Cytokines Genetic polymorph.sm Stomach.neoplasms Peptic ulcer

Experimental study on SC RF cavities by using Ch.na large grain niobium for ILC

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Ch.nese Ph.sics C 2008年第2期32卷 151-155页

作者：宗占国高杰 K. Saito 徐庆金 F. furuta Y. J. Sh.m T. Saeki h. Inoue 翟纪元葛明骐谷俊刘立强张亮 Institute of h.gh.Energy Ph.sics Chinese Academy of Sciences Beijing 100049 China Tech.ical Institute of Ph.sics and Ch.mistry Chinese Academy of Sciences Beijing 100080 China Institute of Particle and Nuclear Studies High Energy Accelerator Research Organization (KEK) 1-1 Oho Tsukuba Ibavaki-305-0801 Japan Department of Ph.sics Pusan National University Korea Graduate University of Ch.nese Academy of Sciences Beijing 100049 China

Large grain niobium h.s th. potential of simplifying th. production sequence and consequently reducing th. cost of th. superconducting RF cavities for ILC. To investigate th. feasibility of fabrication and th. possibility to ach.eve h.gh.gradient by large grain cavities, two 1.3 Gh. cavities were made of Ch.na large grain niobium and a series of vertical tests were carried out following several different surfaces treatment procedures. Two cavities h.ve both.reach.d th. h.gh.gradient of more th.n 43 MV/m repeatedly and th. maximum accelerating field of 47.9 MV/m h.s been ach.eved by Ch.na large grain niobium. Th.s paper introduces th. features of th. fabrication and surface treatments on th. large grain cavities and presents th. preliminary results of th. research.

关键词： ILC superconducting RF cavity large grain niobium

Novel Porph.rinoids—Synth.sis and Optoelectronic Functions

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Novel Porphyrinoids—Synthesis and Optoelectronic Functions

Effect of dietary supplementation with.sugar cane extract on meat quality and oxidative stability in finish.ng pigs

大环化学和超分子化学的新发展——当前学科交叉的一个重要桥梁——中国化学会全国第十五届大环化学暨第七届超分子化学学术讨论会

作者：解永树 furuta h. h.ll J.P. Ariga K. Key Laboratory for Advanced Materials and Institute of Fine Ch.micals East China University of Science & Technology Department of Applied Ch.mistry Kyushu University. National Institute for Materials Science Japan.

*** Porph.rinoids,with.th. macrocyclic structures similar to th.se of porph.rins,h.ve received extensive interest in th. areas of anion sensing,luminescent materials and electron transfer supramolecular ***,we report ... 详细信息

关键词： porph.rin fullerene supramolecular assembly electron transfer anion recognition

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Animal Nutrition 2017年第3期3卷 295-299页

作者： Yangch.n Xia Yansen Li Xiangxing Sh.n Massami Mizu Toma furuta Ch.nmei Li College of Animal Science and Tech.ology Nanjing Agricultural University Product Development Division Mitsui Sugar Co.Ltd.

Th. aim of th. present study was to investigate th. effect of dietary supplementation with.sugar cane extract(SCE) on meat quality and oxidative stability of Longissimus dorsi muscle in finish.ng *** barrows(Duroc × Landrace × Jiaxing Black), with.an average initial body weigh. of 62.1 ± 5.0 kg,were randomly allotted to 1 of 3 diets with.6 replicates per treatment for 42 days. Th. diets comprised a normal diet and th. normal diets supplemented with.5 and 25 g/kg SCE. Th. results sh.wed th.t SCE supplementation did not affect final body weigh. of finish.ng pigs. Dietary SCE supplementation significantly increased(P h.(24 h.,and tended to reduce(P h.ar force, drip loss, myofiber cross sectional area and lactate deh.drogenase activity at 5 and 25 g/kg, respectively. Meanwh.le, dietary SCE treatments significantly decreased(P h.de content and total superoxide dismutase activity in Longissimus dorsi muscle, and tended to reduce(P h.de content in serum. Altogeth.r, th.se data indicate th.t SCE is an effective feed additive to improve pork meat quality, and th. underlying mech.nism may be partly due to th. improved oxidative stability induced by dietary SCE supplementation.

关键词： Sugar cane extract Feed additive Meat quality Oxidative stability Finish.ng pigs

Novel alternative transplantation th.rapy for orth.topic liver transplantation in liver failure:A systematic review

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World Journal of Transplantation 2020年第3期10卷 64-78页

作者： Tomoaki furuta Kinji Furuya Yun-Wen Zh.ng Tatsuya Oda Department of Gastrointestinal and h.pato-Biliary-Pancreatic Surgery Faculty of MedicineUniversity of TsukubaTsukuba-shi 305-8575IbarakiJapan Institute of Regenerative Medicine and Affiliated h.spital of Jiangsu University Zhenjiang 212001Jiangsu ProvinceChina Department of Regenerative Medicine School of MedicineYokohama City UniversityYokohama 236-0004Japan Center for Stem Cell Biology and Regenerative Medicine The Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan

BACKGROUND Orth.topic liver transplantation(OLT)is th. only treatment for end-stage liver failure;h.wever,graft sh.rtage impedes its ***,studies investigating alternative th.rapies are ***,no study h.s compreh.nsively analyzed th.se th.rapies from different *** To summarize th. current status of alternative transplantation th.rapies for OLT and to support future *** A systematic literature search.was performed using PubMed,Coch.ane Library and EMBASE for articles publish.d between January 2010 and 2018,using th. following MeSh.terms:[(liver transplantation)AND cell]OR[(liver transplantation)AND differentiation]OR[(liver transplantation)AND organoid]OR[(liver transplantation)AND xenotransplantation].Various types of studies describing th.rapies to replace OLT were retrieved for full-text *** th.m,we selected articles including in vivo *** A total of 89 studies were *** are th.ee principle forms of treatment for liver failure:Xeno-organ transplantation,scaffold-based transplantation,and cell ***-organ transplantation was covered in 14 articles,scaffold-based transplantation was discussed in 22 articles,and cell transplantation was discussed in 53 *** types of alternative th.rapies were discussed:Organ liver,25 articles;adult h.patocytes,31 articles;fetal h.patocytes,th.ee articles;mesench.mal stem cells(MSCs),25 articles;embryonic stem cells,one article;and induced pluripotent stem cells,th.ee articles and oth.r *** applications were discussed in 12 studies:Cell transplantation using h.patocytes in four studies,five studies using umbilical cord-derived MSCs,th.ee studies using bone marrow-derived MSCs,and two studies using h.matopoietic stem *** Th. clinical applications are present only for cell ***-based transplantation is a compreh.nsive treatment combining organ and cell transplantati

关键词： Cell transplantation Liver transplantation Organ transplantation Xenotransplantation Tissue engineering Scaffold

Ch.racteristics of non-erosive gastroesoph.geal reflux disease refractory to proton pump inh.bitor th.rapy

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World Journal of Gastroenterology 2011年第14期17卷 1858-1865页

作者： Mitsush.ge Sugimoto Masafumi Nish.no Ch.se Kodaira Mih.ko Yamade Takah.ro Uotani Mutsuh.ro Ikuma Kazuo Umemura Takah.sa furuta Center for Clinical Research Hamamatsu University School of MedicineShizuoka Hamamatsu 431-3192Japan First Department of Medicine Hamamatsu University School of MedicineShizuoka Hamamatsu 431-3192Japan Department of Ph.rmacology Hamamatsu University School of MedicineShizuoka Hamamatsu 431-3192Japan

AIM:To investigate wh.th.r potent acid inh.bition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METh.DS:We treated 10 Japanese patients with.NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesoph.geal reflux disease questionnaire frequency scale for th. symptoms of GERD (FSSG); and underwent 24 h.ph.monitoring on day 14. RESULTS:With.increased dosages and frequency of administration of RPZ,median intragastric ph.significantly increased,and FSSG scores significantly decreased. With.RPZ 10 mg qid,potent acid inh.bition was attained th.ough.ut 24 h. h.wever,five subjects were refractory to RPZ 10 mg qid,alth.ugh.th. median intragastric ph.in th.se subjects (6.6,range:6.2-7.1) was similar to th.t in th. remaining five responsive subjects (6.5,range:5.3-7.3). With.baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,wh.reas th.re was no significant decrease in th. resistant group. CONCLUSION:NERD patients wh.se FSSG score fails to decrease by > 30% after treatment with.RPZ 10 mg od for 14 d are refractory to h.gh.r dosage.

关键词： Non-erosive reflux disease Rabeprazole CYP2C19

Circulating immunocompetent cell profiles during oral cyclosporin th.rapy for immunoglobulin-resistant Kawasaki disease

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World Journal of Pediatrics 2021年第6期17卷 671-673页

作者： Seigo Okada Yuji Oh.ish.Takash. furuta Yasuo Suzuki Akiko Kawakami-Miyake Ch.e Matsuguma Takako Waniish. h.roki Yasudo Sh.nji h.segawa Department of Pediatrics Yamaguchi University Graduate School of Medicine1-1-1 MinamikogushiUbeYamaguchi 755-8505Japan

Alth.ugh.th. standard treatment for Kawasaki disease(KD)is intravenous immunoglobulin(IVIG)combined with.oral aspirin,18%of 1st IVIG is refractory[1].Recently,th. efficacy of immunomodulatory drugs for IVIG-resistant KD,such.as prednisolone,infliximab(IFX),and cyclosporine(CsA),h.s been reported[2-5].h.wever,optimal immunomodulatory th.rapy for IVIG-resistant KD h.s not yet been establish.d.

关键词： immuno drugs immunoglobulin

Maintenance time of sedative effects after an intravenous infusion of diazepam: A guide for endoscopy using diazepam

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World Journal of Gastroenterology 2008年第33期14卷 5197-5203页

作者： Mitsush.ge Sugimoto Takah.sa furuta Akiko Nakamura Naoh.to Sh.rai Mutsuh.ro Ikuma Sh.ngen Misaka Sh.nya Uch.da h.rosh. Watanabe Kyoich. Oh.sh. Takash. Ish.zaki Akira h.sh.da First Department of Medicine Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Center for Clinical Research Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Gastroenterology Enshu General Hospital1-1-1 Tyuou Naka-ku Hamamatsu 430-0929 Japan Department of Ph.rmacoki-netics and Ph.rmacodynamics School of Pharmaceutics Sciences University of Shizuoka52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Department of Clinical Ph.rmacology and Th.rapeutics Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Clinical Ph.rmacology and Th.rapeutics Oita University1-1 Idaigaoka Hazama Yufu 879-5593 Japan

AIM: To examine wh.th.r th. sedative effects assessed by psych.motor tests would depend on th. cytoch.ome P450 (CYP ) 2C19 genotypes after an infusion regimen of diazepam commonly used forgastrointestinal endoscopy in Japan. METh.DS: Fifteen h.alth. Japanese volunteers consisting of th.ee different CYP2C19 genotype groups underwent a critical ? icker fusion test, an eye movement analysis and a postural sway test as a test for ph.sical sedative effects, and a visual analog scale (VAS) symptom assessment meth.d as a test for mental sedative effects during th. 336 h.period after th. intravenous infusion of diazepam (5 mg). RESULTS: Th. ph.sical sedative effects assessed by th. critical flicker test continued for 1 h.(t values of 5 min, 30 min and 60 min later: 4.35, 5.00 and 3.19, respectively) and th.se by th. moving radial area of a postural sway test continued for 3 h.(t values of 5 h. 30 h. 60 min and 3 h.later: -4.05, -3.42, -2.17 and -2.58, respectively), wh.ch.ch.nged significantly compared with.th. baseline level before infusion (P h. oth.r h.nd, th. mental sedative effects by th. VAS meth.d improved with.n 1 h. Th. CYP2C19 genotype-dependent differences in th. postinfusion sedative effects were not observed in any of th. four psych.motor function tests. CONCLUSION: With.th. psych.motor tests, th. objective sedative effects of diazepam continued for 1 h.to 3 h.irrespective of CYP2C19 genotype status and th. subjective sedative symptoms improved with.n 1 h. Up to 3 h.of clinical care appears to be required after th. infusion of diazepam, alth.ugh.patients feel subjectively improved.

关键词： Diazepam Sedation cytoch.ome P450(CYP) 2C19 Endoscopy Complication Critical flicker fusion test Eye movement analysis Postural sway test Visual analog scale