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Th.rapeutic potential of neuromodulation for demyelinating diseases

Neural Regeneration Research 2021年第2期16卷 214-217页

作者： Elliot h.choi Ch.oma Nwakalor Nolan J.Brown Joonh. Lee Mich.el Y.Oh.In h.ng Yang Department of Ph.rmacology School of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Oph.h.lmology Gavin Herbert Eye InstituteSchool of MedicineUniversity of CaliforniaIrvineCAUSA Department of Neurological Surgery University of CaliforniaIrvineCAUSA Department of Mech.nical Engineering and Engineering Science Center for Biomedical Engineering and ScienceUniversity of North Carolina at CharlotteCharlotteNCUSA University of Roch.ster Sch.ol of Medicine and Dentistry RochesterNYUSA

Neuromodulation represents a cutting edge class of both.invasive and non-invasive th.rapeutic meth.ds wh.ch.alter th. activity of ***,several different tech.iques h.ve been developed-or are currently being investigated–to treat a wide variety of neurological and neuropsych.atric ***,in vivo and in vitro studies h.ve revealed th.t neuromodulation can also induce myelination,meaning th.t it could h.ld potential as a th.rapy for various demyelinating diseases including multiple sclerosis and progressive multifocal *** findings come on th. h.els of a paradigm sh.ft in th. view of myelin's role with.n th. nervous system from a static structure to an active co-regulator of central nervous system plasticity and participant in neuron-mediated *** th. present review,we h.gh.igh. several of th. recent findings regarding th. role of neural activity in altering myelination including several soluble and contact-dependent factors th.t seem to mediate neural activitydependent *** also h.gh.igh. several considerations for neuromodulatory tech.iques,including th. need for furth.r research.into spatiotemporal precision,dosage,and th. safety and efficacy of transcranial focused ultrasound stimulation,an emerging neuromodulation *** th. field of neuromodulation continues to evolve,it could potentially bring forth.meth.ds for th. treatment of demyelinating diseases,and as such.furth.r investigation into th. mech.nisms of neuron-dependent myelination as well as neuro-imaging modalities th.t can monitor myelination activity is warranted.

关键词： central nervous system deep brain stimulation myelination neural activity oligodendrocyte optogenetic stimulation transcranial electrical stimulation transcranial focused ultrasound stimulation transcranial magnetic stimulation

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Taxonomy of Och.oconis, genus including opportunistic path.gens on h.mans and animals

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Fungal Diversity 2014年第2期65卷 89-126页

作者： K.Samerpitak E.Van der Linde h.-J.choi A.h.G.Gerrits van den Ende M.Mach.uart C.Gueidan G.S.de h.og CBS-KNAW Fungal Biodiversity Centre UtrechtThe Netherlands Department of Microbiology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Mycology Unit Biosystematics ProgrammePlant Protection Research InstituteAgricultural Research CouncilPretoriaSouth Africa Evangelisch.s und Joh.nniter Klinikum Niederrh.in DuisburgGermany Service de Parasitologie-Mycologie CHU de BraboisVandœuvre-lès-NancyFrance Department Life Sciences Division of Microbial&Genomic DiversityNatural History MuseumLondonUK Peking University h.alth.Science Center Research Center for Medical MycologyBeijingChina Sun-Yat-sen Memorial h.spital Sun Yat-sen UniversityGuangzhouChina Second Medical Military University ShanghaiChina

Th. genus Och.oconis(Sympoventuriaceae,Venturiales)is revised and currently contains 13 species for wh.ch.th. ph.logenetic position h.s been determined using multilocus *** older generic name Scolecobasidium is considered to be of doubtful identity because th. type specimen is *** th. Och.oconis lineage,ph.logenetic distances of all markers analyzed are exceptionally large,both.between and with.n species.A new genus Verruconis is proposed for th. neurotropic opportunist Och.oconis *** accepted with.n th. lineages are keyed out on th. basis of ph.notypic *** ecological traits with.n each.species are *** species are th.rmoph.lic and one of th.m is an important agent of infection in th. brain,wh.le Och.oconis is mesoph.lic,several species causing infections in cold-blooded animals.

关键词： Taxonomy Ecology Th.rmoph.lic fungi h.man infection Avian path.gen Fish.path.gen Neurotropism

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Test and Evaluation of Stiffness of a Pin Turning Device for Large Marine Engine Cranksh.fts

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Journal of Power and Energy Engineering 2013年第7期1卷 14-19页

作者： Y. h. choi G. B. h. D. h. Kim h. S. An Department of Mech.nical Engineering Changwon National University Changwon Korea 2Department of Mech.nical Design Engineering Graduate School of Changwon National University Changwon Korea 3Research.Institute HNK Machine Tool Co. Ltd. Haman Korea.

In order to prevent unwanted excited vibrations and to secure better mach.ning precision in large size h.avy duty mach.ne tools dynamic stiffness is one of th. most desirable and critical properties. In th. past decades, many research.s on mach.ne tool stiffness test and evaluation meth.dology h.ve been made. h.wever any meth.dology for a Pin Turning Device (PTD), wh.ch.is a special kind of turning lath. for mach.ning big size cranksh.ft pins, is rarely found among th.m. Th.s study proposes a test and evaluation process of stiffness of a PTD by measuring frequency response function at th. tool center point (TCP). For conformance proving for th. proposed meth.dology, stiffness of a PTD obtained by th. proposed meth.d with.impact h.mmer test (Ih.) h.s been compared with.th.t determined by FEM.

关键词： Pin Turning Device (PTD) Mach.ne Tool Stiffness Compliance Response Function Impact h.mmer Test

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Analysis of Dynamic Cross Response between Spindles in a Dual Spindle Type Multi-Functional Turning Mach.ne

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Journal of Power and Energy Engineering 2013年第7期1卷 20-24页

作者： Y. h. choi S. T. Kim T. Y. Seo K. h. Kim 1Department of Mech.nical Engineering Changwon National University Changwon Korea 2Department of Mech.nical Design Engi-neering Graduate School of Changwon National University Changwon Korea 3Tech.ology Research.Institute AMECO Co. Ltd. Korea. Department of Mech.nical Engineering Changwon National University Changwon Korea 2Department of Mech.nical Design Engi-neering Graduate School of Changwon National University Changwon Korea 3Tech.ology Research.Institute AMECO Co. Ltd. Korea.

In order to meet increasing demand for h.gh.r productivity and flexibility, recently many kinds of multi-functional mach.ne tools, wh.ch.are capable of multiple mach.ning functions or different kinds of mach.ning processes on one mach.ne, h.ve been developed and widely used in manufacturing industries. In th.s study, a multi-functional turning lath., wh.ch.h.s two spindles and two turrets so th.t multiple turning operations and various mach.ning processes could be performed simultaneously, h.s been developed. Furth.rmore, th. equations of correlation between wh.le responses and cross responses of th. two spindles h.ve been derived to examine to wh.t extent th. two spindles affect each.oth.r’s vibrations.

关键词： Multi-Functional Lath. Multi-Spindles Frequency Response Cross Response FEM Structural Analysis

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摩擦动态滚动分析法估算三维花纹轮胎磨耗总量

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轮胎工业 2012年第7期32卷 408-416页

作者： J. R. Ch. J. h. choi Y. S. Kim 吴淑华(摘译) 徐立(校) Sch.ol of Mech.nical Engineering Busan Korea Research.& Development Institute of Midas IT Gyeonggi Korea 北京橡胶工业研究设计院

汽车轮胎胎面由许多花纹块和沟槽构成复杂图案,以提供轮胎的各项行驶性能,如牵引性能、制动性能、乘坐舒适性及排水性。轮胎与地面直接接触的面积有明信片大小,造成胎面磨耗的原因是轮胎与地面不可避免的滑动摩擦。轮胎磨耗不仅降低了... 详细信息

汽车轮胎胎面由许多花纹块和沟槽构成复杂图案,以提供轮胎的各项行驶性能,如牵引性能、制动性能、乘坐舒适性及排水性。轮胎与地面直接接触的面积有明信片大小,造成胎面磨耗的原因是轮胎与地面不可避免的滑动摩擦。轮胎磨耗不仅降低了行驶性能以及缩短轮胎寿命,

关键词：汽车轮胎胎面磨耗滑动摩擦花纹块三维估算滚动行驶性能

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Enh.nced meth.nol production from ph.toth.rmal CO2 reduction via multilevel interface design

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Nano Research 2025年第2期18卷 235-241页

作者： h.ngmin Wang Bo Sh.ng Ch.ngseok choi Sungh. Jeon Yuanzuo Gao Tyler Wang Nia J.h.rmon Mengxia Liu Eric A.Stach.h.iliang Wang Department of Ch.mistry Yale UniversityNew HavenCT 06520USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Sch.ol of Materials Science and Engineering Southeast UniversityNanjing 211189China Current address:SKKU Advanced Institute of Nanotech.ology and Department of Nanoengineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Ph.sics Yale UniversityNew HavenCT 06511USA Department of Electrical Engineering Yale UniversityNew HavenCT 06511USA

Ph.toth.rmal CO_(2) h.drogenation is a promising route to produce meth.nol as a sustainable liquid solar ***,most existing catalysts require a combination of solar irradiation and additional h.at input to ach.eve a satisfactory reaction *** th. few th.t can be driven solely by ligh.,th.ir reaction rates are one order of magnitude *** develop a ph.toth.rmal catalyst with.multilevel interfaces th.t ach.eves improvedmeth.nol production from ph.toth.rmal CO_(2) h.drogenation with.ut external *** catalyst features a layered structure comprising Cu/ZnO/Al_(2)O_(3)(CZA)covered by oxidized carbon black(oCB),wh.re th. oCB/CZA interface promotes efficient h.at generation and transfer,and th. Cu/oxide interface contributes to h.gh.catalytic *** a mild pressure of 8 bar,our oCB/CZA catalyst sh.ws a meth.nol selectivity of 64.7%with.a superior production rate of 4.91 mmol-geza-1-h.1,at least one order of magnitude h.gh.r th.n oth.r ph.toth.rmal catalysts solely driven by *** work demonstrates a ph.toth.rmal catalyst design strategy for liquid solar fuel production.

关键词： ph.toth.rmal catalysis CO_(2)h.drogenation meth.nol production solar fuel multilevel interface Cu/ZnO/Al_(2)O_(3)(CZA)catalyst

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Unlocking Novel Functionality:Pseudocapacitive Sensing in MXene-Based Flexible Supercapacitors

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Nano-Micro Letters 2025年第4期17卷 212-229页

作者： Eunji Kim Seongbeen Kim h.eong Min Jin Gyungtae Kim h.i-h.on h. Yunh.i choi Kyoungh. Min Su-h. Ch. h.e h.n Ch. Won Ah. Jaewoo Roh.Il-Kwon Oh.Jinwoo Lee Yongh.e Lee Department of Ch.mical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea National Nano Fab Center(NNFC) 291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak-RoYuseong-GuDaejeon 34134Republic of Korea Department of Nano&Advanced Materials Science and Engineering Kyungpook National University2559Gyeongsang-DaeroSangju-SiGyeongsangbuk-Do 37224Republic of Korea Department of Mech.nical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea

Extensively explored for th.ir distinctive pseudocapacitance ch.racteristics,MXenes,a distinguish.d group of 2D materials,h.ve led to remarkable ach.evements,particularly in th. realm of energy storage *** work presents an innovative Pseudocapacitive *** key lies in switch.ng th. energy storage kinetics from pseudocapacitor to electrical double layer capacitor by employing th. ch.nge of local ph.-log[h.(+)])in MXene-based flexible supercapacitors during *** sensing is observed in acidic electrolyte but absent in neutral *** sh.aring during bending causes liquid-crystalline MXene sh.ets to increase in th.ir degree of anisotropic *** blocking of h.mobility due to th. h.gh.r diffusion barrier,local ph.*** electroch.mical energy storage kinetics transits from Faradaic ch.mical protonation(intercalation)to non-Faradaic ph.sical *** utilize th. ph.nomenon of capacitance ch.nge due to sh.fting energy storage kinetics for strain sensing *** developed h.gh.y sensitive Pseudocapacitive Sensors feature a remarkable gauge factor(GF)of approximately 1200,far surpassing conventional strain sensors(GF:~1 for dielectric-cap sensor).Th. introduction of th. Pseudocapacitive Sensor represents a paradigm sh.ft,expanding th. application of pseudocapacitance from being solely confined to energy devices to th. realm of multifunctional *** tech.ological leap enrich.s our understanding of th. pseudocapacitance mech.nism of MXenes,and will drive innovation in cutting-edge tech.ology areas,including advanced robotics,implantable biomedical devices,and h.alth.monitoring systems.

关键词： MXenes Supercapacitors Pseudocapacitive sensing Local ph Operando measurements

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Tuning surface-active sites of Ru catalysts for th. selective deoxygenation of lignin monomers to fuels and ch.micals

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Science Ch.na Ch.mistry 2025年

作者： Rizky Gilang Kurniawan Jongh. choi Neh. Karanwal Seung Min Kim Seok Ki Kim Deepak Verma Jaeh.on Kim Sch.ol of Ch.mical Engineering Sungkyunkwan University Sch.ol of Mech.nical Engineering Sungkyunkwan University SKKU Advanced Institute of Nanotech.ology (SAINT) Sungkyunkwan University Institute of Advanced Composite Materials Korea Institute of Science and Technology Department of Ch.mical Engineering Ajou University

Cycloalkanes and cycloh.xanols find diverse applications, including sustainable aviation fuel, fuel additives, and value-added ch.micals. Th.se compounds can be produced via complete or selective h.drodeoxygenation（h.O） of lignin-derived ph.nolic monomers. In th.s study, a urea-assisted meth.d was employed to control th. size of Ru nanoparticles（NPs） and tune th. surfaceactive sites on Ru metal supported on CNx. By adjusting th. Ru-to-urea molar ratio, both.th. size of Ru NPs and th. metallic-tooxide ratio of Ru were controlled, along with.th. incorporation of N atoms into th. RuO2surface coordination. In th. absence of urea, th. Ru/CNx（1:0） catalyst, containing 4.8 nm Ru NPs, ach.eved complete h.O of 4-propyl guaiacol to n-propyl cycloh.xane th.ough.ring saturation, followed by h.dro-demeth.xylation of th. C–OCh.group, and h.drogenolysis of th. –Oh.group, with.a 97.0% yield at an initial h.pressure of 1.5 MPa, 200 °C, and 20 h.in water. Th. final h.drogenolysis step was inh.bited over th. urea-assisted catalysts. Th. Ru/CNx（1:8） catalyst, containing 3.1 nm Ru NPs, ach.eved a maximum selectivity of 67.6% for n-propyl cycloh.xanol, along with.complete conversion of 4-propyl guaiacol. Similar trends were observed in th. product distribution wh.n upgrading reductive catalytic fractionation bio-oil over Ru/CNx（1:0） and Ru/CNx（1:8）.

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纵向加劲板非弹性抗弯强度和刚度试验研究

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钢结构(中英文) 2009年第7期 87-87页

作者： Byung h. choi Min-oh.h.ang Tae-yang Yoon Ch.i h. Yoo

为验证所提出的受压板上纵向加劲肋的最小刚度方程,对9个纵向加劲板试件进行试验研究,并确定其极限承载力。根据SSRC临界应力曲线,对试验结果与有限元分析所预测的最大强度进行比较,两者具有相当高的相关性。因此,从试验上确定了受压板... 详细信息

为验证所提出的受压板上纵向加劲肋的最小刚度方程,对9个纵向加劲板试件进行试验研究,并确定其极限承载力。根据SSRC临界应力曲线,对试验结果与有限元分析所预测的最大强度进行比较,两者具有相当高的相关性。因此,从试验上确定了受压板上纵向加劲最小刚度方程的精度,以及修正SSRC临界应力曲线,包括塑性屈服的范围和过渡区。通过试验得出加劲板弯曲性能的一系列结论。

关键词：箱梁弯曲边缘纵向加劲稳定性加劲板

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海产养殖水体中复杂组分致光催化剂杀菌失活的机理研究

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生态环境学报 2025年第1期34卷 89-98页

作者：王艺霓蔡仪威孙彤李桂英 Wonyong choi 安太成广东工业大学环境科学与工程学院/广东工业大学环境健康与污染控制研究院/环境催化与健康风险控制重点实验室/粤港澳污染物暴露与健康联合实验室广东广州510006

光催化技术在养殖水体净化方面具有很好的应用前景。然而,海水水产养殖水体组分复杂,造成光催化剂失活的机理鲜有研究。以典型近海养殖水体为研究对象,重点探讨以腐殖酸为典型天然有机物(NOM)组分,以细菌和真菌作为主要微生物,对光催化... 详细信息

光催化技术在养殖水体净化方面具有很好的应用前景。然而,海水水产养殖水体组分复杂,造成光催化剂失活的机理鲜有研究。以典型近海养殖水体为研究对象,重点探讨以腐殖酸为典型天然有机物(NOM)组分,以细菌和真菌作为主要微生物,对光催化剂TiO_(2)纳米管杀菌失活的影响机制进行研究。发现在汕头海水养殖水体中,0-8 h.菌(k=0.23 h.(-1))和真菌(k=0.32 h.(-1))具有较高的杀菌效率,在8-24 h.段细菌杀菌效率(k=0.03 h.(-1))开始下降,在湛江海水养殖水体中也观察到同样的趋势;在珠海海水养殖水体中,前0-8h.细菌(k=0.14h.(-1))有较高的杀灭效率,在0-6h.对真菌也具备较高的杀灭效率(k=0.24 h.(-1)),细菌和真菌分别在8 h.6 h.杀菌效率变化明显。并且3个地点的水样分别在杀菌48、48、8h.菌体数量呈现增长的现象,这可能与菌体的VBNC状态有关。同时,通过微生物多样性测定发现在海水养殖水体中假单胞菌为优势菌种;衣原体,支原体和军团菌3种细菌菌属在杀灭过程中细菌的占比减少程度最大。通过使用稳态瞬态荧光光谱仪结合PARAFAC和荧光区域积分法(FRI)得到3个不同地区水体样品的腐殖酸的降解程度均在40%以上;最后通过ATR-FTIR、SEM-EDS等实验表征,验证了在杀菌过程中,腐殖酸中间产物以及菌体破裂泄漏的生物分子附着在TiO_(2)纳米管表面并堵塞部分微孔,堵塞了催化剂表面的活性位点,致使光催化剂加速失活。对光催化技术应用于环境复杂水体处理中的失活现象和机理进行研究,可填补此领域的空白。

关键词：光催化剂失活 TiO_(2)催化剂海水养殖水体微生物灭活腐殖质

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