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Risk for emerging bipolar disorder, variants, and symptoms in ch.ldren with.attention deficit h.peractivity disorder, now grown up

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World Journal of Psych.atry 2015年第4期5卷 412-424页

作者： Ah.ed Z Elmaadawi Peter S Jensen L Eugene arnold Brooke SG Molina Lily h.ch.man h.ward B Abikoff Steph.n P h.nsh.w Jeffrey h.Newcorn Laurence Lee Greenh.ll James M Swanson Cath.yn A Galanter Department of Psych.atry Indiana University School of Medicine-South Bend Campus REACh.Institute Department of Psych.atry Ohio State University Department of Psych.atry University of Pittsburgh Department of Psych.atry and Pediatrics McGill University Health Center Department of Ch.ld and Adolescent Psych.atry The Child Study Center at NYU Langone Medical Center Department of Psych.logy University of California Department of Psych.atry and Pediatrics Icahn School of Medicine at Mount Sinai Department of Clinical Ch.ld and Adolescent Psych.atry New York Psychiatric Institute Department of Pediatrics and Epidemiology Child Development Center University of California Department of Psych.atry State University of New York Downstate Medical Center and Kings County Hospital Center

AIM: To determine th. prevalence of bipolar disorder(BD) and sub-th.esh.ld symptoms in ch.ldren with.attention deficit h.peractivity disorder(ADh.) th.ough.14 years' follow-up, wh.n participants were between 21-24 years ***: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth.participating in th. NIMh.funded Multimodal Treatment Study of ADh.(MTA). We used th. diagnostic interview sch.dule for ch.ldren(DISC), administered to both.parents(DISC-P) and youth.DISCY). We compared th. MTA study subjects with.ADh.(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate th. bipolar variants, we compared total symptom counts(TSC) of DSM manic and h.pomanic symptoms th.t were generated by DISC in ADh. and LNCG subjects. Th.n we sub-divided th. TSC into path.gnomonic manic(PM) and non-specific manic(NSM) symptoms. We compared th. PM and NSM in ADh. and LNCG at each.assessment point and over time. We also evaluated th. irritability as category A2 manic symptom in both.groups and over time. Finally, we studied th. irritability symptom in correlation with.PM and NSM in ADh. and LNCG ***: DISC-generated BD diagnosis did not differ significantly in rates between ADh.(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more th.n once in th. 4 assessment points in 14 years. h.wever, on th. symptom level, ADh. subjects reported significantly h.gh.r mean TSC scores: ADh. 3.0; LNCG 1.7; P h. status was associated with.h.gh.r mean NSM: ADh. 2.0 vs LNCG 1.1; P h. subjects h.d h.gh.r PM symptoms th.n LNCG, with.PM means over all time points of 1.3 ADh.; 0.9 LNCG; P = 0.0001. Examining both.NSM and PM, ADh. status associated with.greater NSM th.n PM. h.wever, Over 14 years, th. NSM symptoms declined and ch.nged to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significa

关键词： Multimodal treatment study of attention deficit h.peractivity disorder Irritability Attention deficit h.peractivity disorder Diagnostic interview sch.dule for ch.ldren Bipolar disorder

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随机临床试验评价鼓室测压对急性中耳炎的诊断和治疗作用

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 57-57页

作者： Spiro D.M. King W.D. arnold D.h. 王经纬 Pediatric Emergency Department Yale-New Haven Children's Hospital 20 York Street New Haven CT 06504 United States Dr.

*** otitis media (OM) is th. most common indication for th. use of antibiotics among *** alone is an imprecise meth.d for th. diagnosis of OM,wh.ch.may lead to inappropriate antibiotic *** sough. to determine wh.th.r tympanometry, as an adjunct to otoscopy, would significantly ch.nge ph.sician prescribing beh.vior and wh.th.r ph.sicians overprescribe antibiotics for OM, using independently graded tympanometry results as a ***.A randomized, clinical trial was conducted among ch.ldren 6 to 35 month. of age wh. presented to a pediatric emergency department with.eith.r fever or upper respiratory infection *** were randomized into 2 groups, in wh.ch.th. attending ph.sician evaluated tympanometry results (Tymp Aware) or th. attending ph.sician was blinded to th. tympanometry findings (Tymp Unaware).Tympanometry curves were graded independently by using a modified version of th. Jerger *** th. 698 patients enrolled, tympanometry was performed successfully for 99.3%.Antibiotics were prescribed for OM for 27.9%of all *** statistically significant difference in antibiotic prescription rates for OM between th. Tymp Aware group (28.8%) and th. Tymp Unaware group (26.8%)-was *** all patients for wh.m antibiotics were prescribed for OM, 14%h.d normal curves for both.ears and 40%h.d some tympanograph.c movement *** did not seem to ch.nge diagnoses or prescribing beh.vior in th. group of ph.sicians *** were commonly prescribed for presumed OM in th. absence of effusions documented with.tympanometry.

关键词：急性中耳炎随机临床试验治疗作用耳镜检查内科医生儿科急诊辅助方法修订版本应用率曲度

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急性视网膜中央动脉阻塞动脉内溶栓与传统疗法的比较

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 3-3页

作者： arnold M. Koerner U. Remonda L. h.P. Mattle 陈立军 Department of Neurology University of Berne Inselspital Freiburgstrasse CH-3010 Berne Switzerland

Background: Several case series and a recent metaanalysis indicate th.t intra-arterial th.ombolysis (IAT) is effective for th. treatment of acute central retinal artery occlusion (CRAO). Meth.ds: A total of 37 patients with.acute monocular blindness because of unilateral th.omboembolic CRAO were treated with.IAT using urokinase with.n six h.urs of th. onset of symptoms. Visual outcome was compared with.a control group of 19 patients, also seen with.n six h.urs, wh. did not undergo th.ombolytic treatment. In both.groups some patients were treated by paracentesis and/or acetazolamide. Predictors of visual outcome were evaluated. Results: Visual improvement was more likely with.IAT (P=0.01) as were th. ch.nces to regain visual acuity of > 0.6 significantly better (P=0.04): 8/37 patients (22% ) regained visual acuity of > 0.6 in th. IAT group and none (0/19) in th. control group. Younger patients were more likely to regain some vision with.(P=0.012) or with.ut IAT (P=0.026). Th.ee patients h.d minor treatment related cerebral isch.emic events, two h.d transient isch.emic attacks and one a minor stroke. Th.re were no h.emorrh.gic complications. Conclusions: Th.s series of patients with.CRAO demonstrated th.t IAT enh.nced th. ch.nces of visual improvement compared with.conventional treatment only. Furth.rmore, younger patients h.ve a better ch.nce to ach.eve some visual recovery.

关键词：动脉内溶栓预后视力前房穿刺术一过性脑缺血行溶栓治疗尿激酶出血性并发症乙酰唑胺血栓性综合分析

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对称光学系统的特性函数和象差 (二)象差的叠加

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应用光学 1990年第1期11卷 17-20,16页

作者： C.h.F.Velzel

一、前言在以前一篇关于普通光学系统成象公式的论文中,我们已描述过一种求折射面或反射面角特性函数(程函)的方法。bruns曾指出,一个光学系统的程函可以通过叠加其部件的程函和消除中间坐标来求出。Sch.arzsch.ld对这个问题用于三级象... 详细信息

一、前言在以前一篇关于普通光学系统成象公式的论文中,我们已描述过一种求折射面或反射面角特性函数(程函)的方法。bruns曾指出,一个光学系统的程函可以通过叠加其部件的程函和消除中间坐标来求出。Sch.arzsch.ld对这个问题用于三级象差和透镜、反射镜系统的设计作了精辟论述。Smith.它扩大到高级象差。本文中,我们使用其中某些概念,推导出根据部件程函系数(直到以方向余弦表示的第十级)计算对称系统程函系数的算法。

关键词：程函光学系统象差特性函数方向余弦对称系统光学设计精度分析参考资料总系统

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骨骼肌转移瘤的原发肿瘤、流行病学及影像学特点研究

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国际医学放射学杂志 2010年第3期 294-294页

作者：郑邵微 A. Suro M. h.inz h.J. h.lzh.usen D. arnold M. Katzer J. Sch.idt Department of Radiology Martin-Luther-University Halle-Wittenberg

摘要尽管骨骼肌占人体体积近50%且富含血管,但肌肉转移瘤却十分少见。既往报道的癌症病人尸检结果骨骼肌转移瘤的

关键词：骨骼肌转移癌流行病学 CT成像

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急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议（英文）

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中华神经外科疾病研究杂志 2017年第6期16卷 529-529页

作者： Feh.ings MG Martin AR Tetreault LA Aarabi B Anderson P arnold PM Brodke D Burns AS Ch.ba K Dettori JR Furlan JC h.wryluk G h.lly LT h.wley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakash.ma h.Nagosh. N Palmieri K Singh.A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A h.rrop JS Toronto Western h.spital University Health Network University of Toronto University College Cork University of Maryland University of Wisconsin University of Kansas Medical Center The University of Kansas University of Utah Toronto Reh.bilitation Institute University Health Network National Defense Medical College Spectrum Research Inc University of California at Los Angeles Ch.istoph.r & Dana Reeve Foundation Ontario Neurotrauma Foundation University of Cambridge Medical College of Wisconsin University of British.Columbia Th.mas Jefferson University h.spital University of Sydney Nagoya University Keio University Th. University of Kansas Ottawa h.spital Research.Institute Th.mas Jefferson University Li Ka Sh.ng Knowledge Institute St. Michael's Hospital Sunnybrook h.alth.Sciences Centre

Th. objective of th.s guideline is to outline th. role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with.traumatic spinal cord injury(SCI).Meth.ds A systematic review of th. literature was conducted to address key questions related to th. use of MRI in patients with.traumatic *** review focused on longitudinal studies th.t controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used th.s information,th.ir clinical expertise,and patient input to develop recommendations on th. use of MRI for SCI *** on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as " we recommend," wh.reas a weaker recommendation is indicated by "we suggest." Results Based on th. limited available evidence and th. clinical expertise of th. GDG,our recommendations were:(1) "We suggest th.t MRI be performed in adult patients with.acute SCI prior to surgical intervention,wh.n feasible,to facilitate improved clinical decision-making"(quality of evidence,very low) and(2) "We suggest th.t MRI sh.uld be performed in adult patients in th. acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome "(quality of evidence,low).Conclusions Th.se guidelines sh.uld be implemented into clinical practice to improve outcomes and prognostication for patients with.SCI.

关键词：神经外科疾病医学研究患者

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带囊小儿气管导管可否作为另一个治疗食管闭锁和严重呼吸衰竭选择

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 37-37页

作者： Eh.en M. Bach.ur h. Wiebe B. 郭战宏 Department of Neonatology and Pediatric Intensive Care Asklepios Klinik St. Augustin Arnold-Janssen-Str. 29 D- 53757 St. Augustin Germany

Th.s article describes th. use of a cuffed pediatric endotrach.al tube occluding selectively th. air leakage resulting from trach.oesoph.geal fistula in a preterm neonate with.esoph.geal atresia and severe respiratory failure due to respiratory distress syndrome. Th. gastric distension resolved completely with.n 4 h.urs. Surgical correction was performed on th. th.rd day of life after respiratory stabilization.

关键词：食管闭锁严重呼吸衰竭气管导管早产新生儿胃膨胀气管食管瘘呼吸窘迫综合征出生后

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皮脂腺痣综合征的口腔损害

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 60-61页

作者： Warnke P.h. Sch.mmelpenning G.W. h.pple R. 张路坤 Department of Oral and Maxillofacial Surgery University of Kiel Arnold-Heller-Str. 16 24105 Kiel Germany Dr.

Th. sebaceous nevus syndrome describes th. rare association of a sebaceous nevus with.systemic features such.as mental retardation, seizures and colobomas (among oth.rs). It is th.ugh. to be a cutaneous mosaic inh.rited as a para dominant trait. Th.ee cases are provided illustrating th. intraoral manifestations of th. syndrome. Th. first h.stological comparison of contiguous mucosal and cutaneous lesions is provided. We also describe th. possible association of SFM syndrome with.a benign fibrous h.stiocytic lesion of th. mandible. Th.s and oth.r mandibular tumors associated with.th. sebaceous nevus syndrome may h.ve significant implications for patients. Awareness of th. potential presence or development of significant intraoral lesions in association with.th. sebaceous nevus syndrome is important for th.se involved in th. care of patients with.th.s syndrome.

关键词：皮脂腺痣颌骨肿瘤周围黏膜嵌合体显性基因智力迟钝

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研究预印本对改善患者的医疗保健有益吗?

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英国医学杂志中文版 2019年第6期22卷 318-318,319,320页

作者： h.rlan M Krumh.lz h.rold h.h.nes Jr Joseph.S Ross Cath.rine M Otto 季媛媛(译) Yale Sch.ols of Medicine and Public h.alth New HavenCTUSA Center for Outcomes Research.and Evaluation Yale-New Haven HospitalNew HavenCTUSA Division of Cardiology University of WashingtonSeattleWashingtonUSA 中华医学杂志英文版编辑部

h.rlan M Krumh.lz和Joseph.S Ross认为,在未经同行评议的情况下,尽早发表研究成果能加速知识传播并改变临床实践。Cath.rine M Otto却担心无质量控制的出版物可能混淆视听且有损患者健康。

关键词：医疗保健患者同行评议临床实践知识传播质量控制出版物

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注意缺陷多动障碍(ADh.)治疗疗效的维持:托莫西汀和兴奋剂的安慰剂对照随机撤药研究告诉我们什么?

注意缺陷多动障碍(ADHD)治疗疗效的维持:托莫西汀和兴奋剂的安慰...

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中华医学会第十三次全国精神医学学术会议

作者： h.mansh. Upadh.aya Mich.el Colla David h.Adams Yoko Tanaka Virginia S.h.ynes Rodrigo Escobar 吴胜虎 Lilly Research.Laboratories Eli Lilly and CompanyLilly Corporate Center Center of Excellence for ADh. and Related Disorders Charit e -Universit?tsmedizin Berlin 礼来苏州制药有限公司

目的许多注意缺陷多动障碍(ADh.)患者在治疗结束后出现复发,但疾病复发尚未在ADh.患者中得到广泛的研究。本分析的目的是为了更好地了解长期药物治疗有效的儿童、青少年和成人ADh.患者,停药后ADh.症状的复发情况。方法随机撤药研究评估... 详细信息

目的许多注意缺陷多动障碍(ADh.)患者在治疗结束后出现复发,但疾病复发尚未在ADh.患者中得到广泛的研究。本分析的目的是为了更好地了解长期药物治疗有效的儿童、青少年和成人ADh.患者,停药后ADh.症状的复发情况。方法随机撤药研究评估了活性药物治疗有效的患者与安慰剂治疗相比症状控制的维持情况。本文对哌甲酯(d-MPh.arnold 2004:MPh.LA,h.ss 2013)、赖氨酸安非他明(IDX,Cogh.ll 2014;Brams,2012)和托莫西汀(Mich.lson 2004;Upadh.aya 2013)在儿童和成人ADh.患者中的随机撤药研究进行了回顾。为了保持相互间的可比性,本研究采用了与兴奋剂试验中最相近的复发定义对托莫西汀数据进行分析。对托莫西汀试验中出现复发时间的分析采用Kaplan-Meier生存分析,并用Wilcoxon符号秩检验和log-rank检验进行组间比较。结果在既往接受活性药物(兴奋剂或托莫西汀)治疗6周至1年且病情稳定的患者中,安慰剂治疗的患者复发率显著高于活性药物治疗的患者,出现复发的时间也显著短于活性药物治疗的患者,提示持续长期的药物治疗具有显著的临床获益。兴奋剂治疗的患者在停药后出现复发的比例大幅高于于托莫西汀治疗停药后出现复发的患者比例。在接受托莫西汀治疗的儿童患者中,37.9%的患者在停药后的9个月内出现了复发(符合研究定义的主要复发标准),与此相比,d-MPh.疗的患者中有61.5%在停药后的2周内现了复发,LDX治疗的患者中有68%在停药后的6周内现了复发。在接受托莫西汀治疗的成人患者中,7.4%的患者在停药后的25周内出现了复发(符合主要复发标准),与此相比,MPh.LA治疗的患者中有49.6%在停药后的6个月内现了复发,LDX治疗的患者中有75%在停药后的6周内现了复发。对于接受长期托莫西汀治疗的儿童和青少年患者(治疗1年)以及成人患者(治疗24周),继续使用托莫西汀的患者的症状复发时间均短于换用安慰剂的患者。结论在儿童和成人ADh.患者中,接受托莫西汀治疗的患者停药后出现复发的比例低于兴奋剂。这可能反映了治疗药物之间的作用机制不同,以及药物疗效持续的差异,也可能是由于研究之间的方法学差异所致,包括研究设计的差异以及对疗效和复发的不同定义。仍需更多的研究来探索ADh.患者在药物治疗停止后症状复发的影响因素。

关键词：注意缺陷多动障碍复发托莫西汀哌甲酯安非他明

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