检索结果-南通市图书馆

Neuroinflammation as a therapeutic target in huntington's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hd) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

Glial response in the midcingulate cortex in huntington’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hd)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hd results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merighi department of Veterinary Sciences University of TurinGrugliascoTOItaly department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： h.hOSSEINI O.BALILAShAKI department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3d) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： point source cylindrical cavity porous medium wave-field transformation stress concentration O353.4

Effect of Wavelength on Metrological Characteristics of Non-holographic Fiber Specklegram Sensor

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Photonic Sensors 2015年第1期5卷 1-5页

作者： Victor h. aristizabal Alejandro hOYOS Edgar RUEdA Nelson d. GOMEZ Jorge A. GOMEZ Grupo de Sistemas en Operaciones y desarrollo Aplicado -SOdA- Universidad Cooperativa de Colombia Cll 50A#41-40 Medellin Colombia Grupo de Fisica Basica y Aplicada Politecnico Colombiano Jaime Isaza Cadavid Cra 48 #7-151 Medellin Colombia Grupo de Optica y Fotonica Instituto de Fisica Universidad de Antioquia Cll 70No. 52-21 Medellin Colombia Grupo de lnvestigacion en Automatica Electronica y Ciencias Computacionales-AE&CC- Instituto Tecnologico Metropolitano - lnstitucion Universitaria Cll 54A #30-01 Medellin Colombia

In this paper, we report some results about the effects of varying the wavelength in a structure of a non-holographic fiber specklegram sensor. In these arrangements, the speckle pattern produced by a multi-mode optical fiber is coupled to the asingle-mode optical fiber with lower numerical aperture, which produces a filtering effect that can be used as an optical transduction mechanism. The influence of the wavelength on the sensor performance is evaluated by changing the laser wavelength, and a strong effect on the linearity and reproducibility of its response is found. Lasers emitting at 1310nm, 1550nm, and 1625nm are used.

关键词： Optical sensing speckle sensor optical fiber sensor mechanical perturbation sensor

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge d.Miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Analytical modelling of end thermal coupling in a solid-state laser longitudinally bonded by a vertical-cavity top-emitting laser diode

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2009年第11期18卷 4912-4918页

作者：吴坚 h.d.Summers School of Physics Beijing University of Aeronautics and Astronautics School of Physics and Astronomy Cardiff University

The intrinsic features involving a circularly symmetric beam profile with low divergence, planar geometry as well as the increasingly enhanced power of vertical-cavity surface-emitting lasers （VCSELs） have made the VCSEL a promising pump source in direct end bonding to a solid-state laser medium to form the minimized, on-wafer integrated laser system. This scheme will generate a surface contact pump configuration and thus additional end thermal coupling to the laser medium through the joint interface of both materials, apart from pump beam heating. This paper analytically models temperature distributions in both VCSEL and the laser medium from the end thermal coupling regarding surface contact pump configuration using a top-emitting VCSEL as the pump source for the first time. The analytical solutions are derived by introducing relative temperature and mean temperature expressions. The results show that the end contact heating by the VCSEL could lead to considerable temperature variations associated with thermal phase shift and thermal lensing in the laser medium. however, if the central temperature of the interface is increased by less than 20 K, the end contact heating does not have a significant thermal influence on the laser medium. In this case, the thermal effect should be dominated by pump beam heating. This work provides useful analytical results for further analysis of hybrid thermal effects on those lasers pumped by a direct VCSEL bond.

关键词： solid-state laser end pump thermal coupling vertical-cavity surface-emitting laser

Relationship between the Vitória-Ecoporanga dyke Swarm and the Vitória Structural high,Brazil

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2016年第S1期90卷 145-150页

作者： Camilo I.Ordónez aristizabal Andre Luiz FERRARI NACAd/COPPE/UFRJ Centro de Tecnologia-Bloco h(anexo)Av.Athos da Silveira Ramos 149 Cidade UniversitáriaRio de Janeiro Universidade Federal Fluminense/LAGEMAR Departamento de Geologia Universidade Federal Fluminense Av.Gen.Milton Tavares de Souza s.n.

In Espírito Santo State,Brazil,between the municipalities of Vitória,Colatina and Ecoporanga,there is a mountainous region characterized by a shear zone which trends NNW-SSE and is filled by a diabase

关键词： ria-Ecoporanga dyke Swarm and the Vit Brazil ria Structural high

On some aspects of compressive properties and serrated flow in Mg-Y-Nd-Zr alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2013年第8期31卷 804-810页

作者： h.Azzeddine d.Bradai Faculty of Physics University of Sciences and Technology Houari BoumedieneBP32 El-Alia Bab Ezzouar 16111 Algiers Algeria

The deformation behavior of the Mg-Y-Nd-Zr （WE54） alloy at temperatures between 25 and 400 ℃ was investigated by uniaxial and plans strain compression tests at strain rate values of 10-2 and 10^-4 s^-1. The results showed that the flow stress had a strong dependency on the loading condition. Yield stress and peak stress decreased with increasing deformation temperature and with decrease in the strain rate for both deformation types. The serration flow behavior was observed markedly at high temperatures and under a strain rate of 10^-4S^-1. The serration amplitude for samples deformed by plans strain compression was larger than that by uni- axial compression. Serrated flow was attributed to the interaction of dislocations with precipitates at 300 ℃ and to dynamic discon- tinuous recrystallization effects at 400 ℃.

关键词： Mg-Y-Nd-Zr (WE54) alloy serrated flow dynamic precipitation hot deformation rare earths