检索结果-南通市图书馆

A Model for the Formation of Ring Mitochondria in Retinal Pigment Epithelium

在线全文

学校读者我要写书评

暂无评论

眼科学报 1995年第1期11卷 9-15页

作者： h·liang S·G·Crewther School of Optometry University of N.S.W. Kensington Australia.

Purpose:To investigate the mechanism and sequence of formation of ring-shaped mitochondria in retinal pigment epithelial ce3lls of a chick model of gyrate ***:Electron microscopic analysis of the ultrastructure of retinal pigment epithelial(RPE)mitochondria was carried out in chicks injected intravitreally with formoguanamine regularly(every4days)over the first 2weeksor4weeks *** is a triazine drug which induces hyperor-nithinemic symptoms in the chick eye similar to those seen in human gyrate ***:A large population of irregularly shaped mitochondria was observed in the RPE of both peripheral and central *** showed extensive morpholog-ical *** 2wk,the mitochondria appeared enlarged and abnormal in shape with vacuolisation,partial loss of their double membrane and reduced mitochon-drial *** 4wk,the mitochondria had assumed a rounder,almost circular profile,many with central holes,so-called ring ***:The appearance of ring-shaped mitochondria has been previously as-cribed to the section of cupshaped three-dimensional *** present evi-dence that ring-shaped mitochondrial profiles arise through at least two different mechanisms of membrane breakdown and intraorganelle *** nature of the three dimensional structures of these abnormal mit.

关键词：视网膜色素上皮层环状线粒体扫描电镜形态学

Biomass-derived carbon doping to enhance the current carrying capacity and flux pinning of an isotopic Mg^(11)B_(2)superconductor

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第7期10卷 1868-1877页

作者： M.Shahbazi Y.hao D.Patel h.liang Y.Yamauchi M.S.A.hossain QUT Centre for Materials Science and School of Chemistry and Physics Queensland University of Technology(QUT)BrisbaneQLD 4001Australia School of Mechanical and Mining Engineering Faculty of EngineeringArchitecture and Information Technology(EAIT)The University of QueenslandBrisbaneQLD 4072Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandBrisbaneQLD 4072Australia JST-ERATO Yamauchi Materials Space-Tectonics Project and International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki 305-0044Japan

Low activation isotopic boron(11B)based magnesium diboride(Mg^(11)B_(2))superconductors doped with biomass-derived activated carbon were synthesized using11B and magnesium powder via solid-state *** effect of carbon doping on the lattice structure and superconducting properties of Mg^(11)B_(2)bulks were evaluated using X-ray powder diffraction,high resolution transmission electron microscopy,scanning electron microscopy and magnetization *** refinement of structural parameters indicates successful substitution of carbon in Mg^(11)B_(2)*** critical current density(Jc)of carbon doped Mg^(11)B_(2)synthesized at 650℃was enhanced more than two times compared with the pure Mg^(11)B_(2)*** improvement was observed for the Mg^(11)B_(2)bulks heat-treated at 800℃.This enhancement is due to successful substitution of biomass-derived carbon with high surface area into Mg^(11)B_(2)*** flux pinning mechanism of pure and doped Mg^(11)B_(2)bulks were investigated using the Dew-hughes *** study provides information regarding enhancement of the Jc of low activation Mg^(11)B_(2)superconductors suitable for next-generation fusion magnets.

关键词： Magnesium diboride Critical current Flux pinning mechanism Fusion reactor applications

[^(18)F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第1期12卷 308-315页

作者： Tuo Shao Zhen Chen Jian Rong Vasily Belov Jiahui Chen Andre Jeyarajan Xiaoyun Deng hualong Fu Qingzhen Yu Steve h.Rwema Wenyu Lin Mikhail Papisov Lee Josephson Raymond T.Chung Steven h.liang Division of Nuclear Medicine and Molecular Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonmA 02114USA Liver Center and Gastrointestinal Division Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonA 02114USA Shriners hospitals for Children-Boston Boston BostonMA 02114USA

Monoacylglycerol lipase(MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol(2-AG) into the proinflammatory eicosanoid precursor arachidonic acid(AA). MAGL and other endogenous cannabinoid(EC) degrading enzymes are involved in the fibrogenic signaling pathways that induce hepatic stellate cell(hSC) activation and ECM accumulation during chronic liver disease. Our group recently developed an;F-labeled MAGL inhibitor([18F]MAGL-4-11)for PET imaging and demonstrated highly specific binding in vitro and in vivo. In this study, we determined [18F]MAGL-4-11 PET enabled imaging MAGL levels in the bile duct ligation(BDL) and carbon tetrachloride(CCl_(4)) models of liver cirrhosis;we also assessed the hepatic gene expression of the enzymes involved with EC system including MAGL, NAPE-PLD, FAAh and DAGL that as a function of disease severity in these models;[18F]MAGL-4-11 autoradiography was performed to assess tracer binding in frozen liver sections both in animal and human. [18F]MAGL-4-11 demonstrated reduced PET signals in early stages of fibrosis and further significantly decreased with disease progression compared with control mice. We confirmed MAGL and FAAh expression decreases with fibrosisseverity, while its levels in normal liver tissue are high;in contrast, the EC synthetic enzymes NAPE-PLD and DAGL are enhanced in these different fibrosis models. In vitro autoradiography further supported that[18F]MAGL-4-11 bound specifically to MAGL in both animal and human fibrotic liver tissues. Our PET ligand [18F]MAGL-4-11 shows excellent sensitivity and specificity for MAGL visualization in vivo and accurately reflects the histological stages of liver fibrosis in preclinical models and human liver tissues.

关键词： [18F]MAGL-4-11 PET imaging Liver fibrosis MAGL

Tramacol- induced Physical Dependence and Its Effects on Behavioral Sensitization to Mthamphetamine in Mice

在线全文

学校读者我要写书评

暂无评论

中国药理通讯 2004年第2期21卷 13-14页

作者： J.-h.liang K.Wang h.-LSun NationalInstituteonDrugDependence PekingUniversityBeijing100083

AIM:Tramado is a centrally acting,synthetic analgesic with opioid agonist properties and effects on monoaminergie transmission,It is the unique non-controlled analgesic for the treatment of moderately severe acute or chronic *** recent years,however,some epidmiological data indicate that tramadol possess relatively high poly-drug abuse potential.

关键词：促进感受性感光度大鼠药理实验细菌诱导纳洛酮

基于公共领域理论的传统医药知识及相关资源保护

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科技管理研究 2017年第4期37卷 160-165页

作者：魏晋才方志耕 Matthew h.liang 南京航空航天大学经济与管理学院江苏南京211106 温州医科大学浙江温州325034 哈佛大学公共卫生学院美国波士顿ma02115

以知识产权法的公共领域理论为视角,讨论公共领域知识的特征、权益主体、利益原则,结合国际知识产权制度框架下传统医药知识的公共领域属性和法律地位,对传统医药知识及相关资源保护的策略进行了分析。思考和梳理我国传统医学知识及相... 详细信息

以知识产权法的公共领域理论为视角,讨论公共领域知识的特征、权益主体、利益原则,结合国际知识产权制度框架下传统医药知识的公共领域属性和法律地位,对传统医药知识及相关资源保护的策略进行了分析。思考和梳理我国传统医学知识及相关资源保护的制度架构与缺陷。提出在经济和文化全球化的背景下,政府需要采取相关措施,努力争取我国传统医药和相关资源在国际知识产权体系中的法律地位和知识权益,实现中医传统知识与现代科学及国际医药知识体系的对接,促进传统医药知识的保护与发展。

关键词：知识产权保护传统医学遗传资源

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第2期11卷 373-393页

作者： Lingling Zhang Kuan hu Tuo Shao Lu hou Shaojuan Zhang Weijian Ye Lee Josephson Jeffrey h.Meyer Ming-Rong Zhang Neil Vasdev Jinghao Wang hao Xu Lu Wang Steven h.liang Center of Cyclotron and PET Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI CenterThe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Neurology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Department of Radiopharmaceuticals Development National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyChiba 263-8555Japan Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital&Department of RadiologyHarvard Medical SchoolBostonMA 02114USA Azrieli Centre for Neuro-Radiochemistry Brain Health Imaging CentreCentre for Addiction and Mental Health&Department of PsychiatryUniversity of TorontoToronto ON M5T 1R8Canada Department of Pharmacy the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

The 18 kDa translocator protein(TSPO),previously known as the peripheral benzodiazepine receptor,is predominately localized to the outer mitochondrial membrane in steroidogenic *** TSPO expression is relatively low under physiological conditions,but is upregulated in response to glial cell *** the primary index of neuroinflammation,TSPO is implicated in the pathogenesis and progression of numerous neuropsychiatric disorders and neurodegenerative diseases,including Alzheimer’s disease(AD),amyotrophic lateral sclerosis(ALS),Parkinson’s disease(PD),multiple sclerosis(MS),major depressive disorder(MDD)and obsessive compulsive disorder(OCD).In this context,numerous TSPO-targeted positron emission tomography(PET)tracers have been *** them,several radioligands have advanced to clinical research *** this review,we will overview the recent development of TSPO PET tracers,focusing on the radioligand design,radioisotope labeling,pharmacokinetics,and PET imaging ***,we will consider current limitations,as well as translational potential for future application of TSPO *** review aims to not only present the challenges in current TSPO PET imaging,but to also provide a new perspective on TSPO targeted PET tracer discovery *** these challenges will facilitate the translation of TSPO in clinical studies of neuroinflammation associated with central nervous system diseases.

关键词： TSPO Microglial activation Neuroinflammation Positron emission tomography(PET) CNS disorders

Cancer cell-secreted microRNA-214 facilitate tumor growth by inducing CD4+CD25+ regulatory T cells

在线全文

学校读者我要写书评

暂无评论

Cancer cell-secreted microRNA-214 facilitate tumor growth by...

遗传学与表观遗传学前沿暨第三届中国青年遗传学家论坛

作者：陈熹 h.liang J.Zhang K.Zen C-Y.Zhang Nanjing University

Regulatory T cell(Treg)expansion-mediated immune tolerance is generally associated with ***,the mechanism underlying the expansion of Treg by cancer cells remains incompletely *** we report that microRNAs secreted by cancer cells induce CD4+CD25+*** cells increase plasma miR-214 level in cancer patients and tumor-implanted *** vesicles(MVs)-containing miR-214 secreted from cancer cells entered into CD4+T cells,reduced the expression of phosphatase and tensin homolog(PTEN),leading to the polarization of CD4+T cells into Tregs in vitro and in ***,Tregs,whose numbers were increased due to circulating miR-214,facilitated the growth of implanted tumors in *** contrast,MV-delivered anti-miR-214 antisense oligonucleotides blocked the Treg induction by miR-214 secreted by implanted cancer cells and decreased tumor *** results provide the first evidence that cancer cell can actively secret miRNA to promote Treg expansion and therefore to facilitate cancer cell immune escape.

关键词： microRNA secreted microRNA regulatory T cell PTEN microvesicle immune evasion tumor

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

小麦花药培养单倍体的直接产生

麦类作物学报 1988年第1期 16-18页

作者： George h.liang

小麦单倍体已可从愈伤组织中再生出来,而愈伤组织既可通过马铃薯培养基(hu 等,1984;DeBuyser 等,1980;Schaeffer 等,1979)又可通过确定的化学培养基

关键词：单倍体植株一步法幼苗光照条件基因型平均数单步法计算方法遗传型平均指标小麦花药培养小麦单倍体

STCF conceptual design report (Volume 1): Physics & detector

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai J.J.Cao Q.h.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen h.Chen h.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen h.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.h.Guo A.Guskov K.L.han L.han M.han X.Q.hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.hou T.J.hou Y.R.hou C.Y.hu h.M.hu K.hu R.J.hu W.h.hu X.h.hu Y.C.hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia h.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao h.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.h.Li C.Li D.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.J.Li h.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.J.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.J.Li h.liang J.h.liang Y.T.liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.h.Luo h.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer h.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China hangzhou Institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of Technology Hefei 230601China helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China high Energy Physics Center Chung-Ang UniversitySeoul 06974Korea higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China hubei University of Automotive Technology Shiyan 442002China hunan Normal University Changsha 410081China hunan University of Science and Technology Xiangtan 411201China hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design