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Antipyretic Action of Isatin and Its Analogues in Mice and Rats

Neuroscience & Medicine 2011年第1期2卷 1-5页

作者： gyula telegdy Agnes Adamik Vivette Glover 不详

The effects of isatin (2,3-dioxo-indole) and isatin analogues (5-methylisatin, 6-hydroxyisatin, 7-ethylisatin, N-acety- lisatin) were tested on prostaglandin E2 (PGE2)-induced fever in mice and rats. Two modes of administration were tested. Isatin or an analogue was injected simultaneously with PGE2 and the development of fever was tested, or the test compound was given 30 min following PGE2 administration and the effects on the already existing fever were measured, in mice and in rats. Isatin in a dose of 3.12 mg/kg ip was found to block the development of PGE2-induced fever in mice, while in a dose of 12.5 mg/kg ip it attenuated the existing fever. In rats isatin in a dose of 12.5 mg/kg ip blocked fever initiation, and at 25.0 mg/kg ip attenuated existing PGE2-induced fever. In mice, 5-methylisatin in a dose of 0.21 mg/kg ip blocked the initiation of fever, and at 6.72 mg/kg ip attenuated the existing fever. In rats in a dose of 3.36 mg/kg ip it blocked the development of fever, and at 13.44 mg/kg ip attenuated existing PGE2-induced fever. In mice 5,6-dimetylisatin in a dose of 0.02 mg/kg ip both blocked fever initiation and attenuated the existing fever in mice, in rats in a dose of 0.42 mg/kg ip it blocked the initiation of fever, and at 0.21 mg/kg ip attenuated the existing PGE2-induced fever. In mice 6-hydroxyisatin in a dose of 5.2 mg/kg blocked the development of fever, and at 10.4 mg/kg attenuated the existing fever. In rats in a dose of 10.40 mg/kg ip it blocked fever development and also attenuated the existing fever. In mice, 7-ethylisatin in a dose of 0.02 mg/kg ip both blocked fever initiation and also attenuated the existing fever. In rats, a dose of 0.11 mg/kg both blocked fever initiation and also attenuated the existing fever. In mice, N-acethylisatin in the dose of 0.005 mg/kg blocked fever initiation, while at 1.024 mg/kg it attenuated existing fever, in rats, in a dose of 0.096 mg/kg it blocked fever initiation, and at 0.384 mg/kg attenuated the

关键词： Isatins Antipyretic Action

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Exploring Biocomplexity in Cancer: A Comprehensive Review

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Open Journal of Biophysics 2024年第2期14卷 154-238页

作者： Andras Szasz gyula Peter Szigeti Department of Biotechnics Hungarian University of Agriculture and Life Sciences G&#246d&#246ll&#337 Hungary John von Neumann Faculty of Informatics O&#769buda University Budapest Hungary

Living objects have complex internal and external interactions. The complexity is regulated and controlled by homeostasis, which is the balance of multiple opposing influences. The environmental effects finally guide the self-organized structure. The living systems are open, dynamic structures performing random, stationary, stochastic, self-organizing processes. The self-organizing procedure is defined by the spatial-temporal fractal structure, which is self-similar both in space and time. The system’s complexity appears in its energetics, which tries the most efficient use of the available energies;for that, it organizes various well-connected networks. The controller of environmental relations is the Darwinian selection on a long-time scale. The energetics optimize the healthy processes tuned to the highest efficacy and minimal loss (minimalization of the entropy production). The organism is built up by morphogenetic rules and develops various networks from the genetic level to the organism. The networks have intensive crosstalk and form a balance in the Nash equilibrium, which is the homeostatic state in healthy conditions. Homeostasis may be described as a Nash equilibrium, which ensures energy distribution in a “democratic” way regarding the functions of the parts in the complete system. Cancer radically changes the network system in the organism. Cancer is a network disease. Deviation from healthy networking appears at every level, from genetic (molecular) to cells, tissues, organs, and organisms. The strong proliferation of malignant tissue is the origin of most of the life-threatening processes. The weak side of cancer development is the change of complex information networking in the system, being vulnerable to immune attacks. Cancer cells are masters of adaptation and evade immune surveillance. This hiding process can be broken by electromagnetic nonionizing radiation, for which the malignant structure has no adaptation strategy. Our objective is to review

关键词： Complexity Networks Small-World Genetic Mutations Self-Organizing Self-Symmetry Energetic Balance Entropy Nash Equilibrium Games Evolution Cancer Therapy

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Proton irradiation-induced cracking and microstructural defects in UN and (U,Zr)N composite fuels

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Journal of Materiomics 2024年第4期10卷 906-918页

作者： Elina Charatsidou Maria Giamouridou Andrea Fazi gyula Nagy Diogo Ribeiro Costa Sarmad Naim Katea Mikael Jolkkonen Gunnar Westin Mattias Thuvander Daniel Primetzhofer Pär Olsson KTH Royal Institute of Technology StockholmSweden Chalmers University of Technology GothenburgSweden Uppsala University UppsalaSweden Westinghouse Electric Sweden AB VästeråsSweden Höganäs Sweden AB HöganäsSweden

Proton irradiation with a primary ion energy of 2 MeV was used to simulate radiation damage in UN and(U,Zr)N fuel *** pellets,nominally at room temperature,were irradiated to peak levels of 0.1,1,10 dpa and 100.0 dpa resulting in a peak hydrogen concentration of at most 90 at.%.Microstructure and mechanical properties of the samples were investigated and compared before and after *** irradiation induced an increase in hardness,whereas a decrease in Young’s modulus was observed for both *** characterization revealed irradiation-induced cracking,initiated in the bulk of the material,where the peak damage was deposited,propagating towards the ***,transmission electron microscopy was used to study irradiation *** loops and fringes were identified and observed to increase in density with increasing dose *** high density of irradiation defects and hydrogen implanted are proposed as the main cause of swelling and consequent sample cracking,leading simultaneously to increased hardening and a decrease in Young's modulus.

关键词： Proton irradiation Uranium nitride Spark plasma sintering Irradiation induced cracking Simulated burn-up structure Composite nuclear fuels

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Almost sure, L1-and L2-growth behavior of supercritical multi-type continuous state and continuous time branching processes with immigration

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Science China Mathematics 2020年第10期63卷 2089-2116页

作者： Mátyás Barczy Sandra Palau gyula Pap MTA-SZTE Analysis and Stochastics Research Group Bolyai InstituteUniversity of SzegedSzeged H-6720Hungary Department of Statistics and Probability Instituto de Investigaciones en Matemáticas Aplicadas y en SistemasUniversidad Nacional Autònoma de MéxicoCiudad de México 04510México Bolyai Institute University of SzegedSzeged H-6720Hungary

Under a first order moment condition on the immigration mechanism,we show that an appropriately scaled supercritical and irreducible multi-type continuous state and continuous time branching process with immigration(CBI process)converges almost *** an x log(x)moment condition on the branching mechanism does not hold,then the limit is *** this x log(x)moment condition holds,then we prove L1 convergence as *** projection of the limit on any left non-Perron eigenvector of the branching mean matrix is ***,in addition,a suitable extra power moment condition on the branching mechanism holds,then we provide the correct scaling for the projection of a CBI process on certain left non-Perron eigenvectors of the branching mean matrix in order to have almost sure and L1 ***,under a second order moment condition on the branching and immigration mechanisms,we prove L2 convergence of an appropriately scaled process and the above-mentioned projections as well.A representation of the limits is also provided under the same moment conditions.

关键词： multi-type continuous state and continuous time branching processes with immigration almost sure L1-and L2-growth behaviour

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中国特色社会主义与欧洲社会主义的复兴

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世界社会主义研究 2024年第2期9卷 54-56页

作者：蒂尔默·久洛秦振燕中国社会科学院马克思主义研究院

当今世界正面临着多重风险与挑战。资本主义制度深陷危机，匈牙利也深受其害。欧盟正在失去竞争力，欧洲的安全结构已经崩溃，冷战思维挥之不去，人类正面临世界大战的威胁。资本主义无法解决人类面临的各种问题，人们正在寻找新的行之... 详细信息

当今世界正面临着多重风险与挑战。资本主义制度深陷危机，匈牙利也深受其害。欧盟正在失去竞争力，欧洲的安全结构已经崩溃，冷战思维挥之不去，人类正面临世界大战的威胁。资本主义无法解决人类面临的各种问题，人们正在寻找新的行之有效的解决方案。套用马克思主义的表述，可以这样说：现在革命形势还没有到来，但是革命形势是可以到来的!我们不知道什么时候会发生，但我们知道，我们应该知道，这是可能发生的。

关键词：中国特色社会主义欧洲社会主义马克思主义

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Polysorb^R(an absorbable lactomer) staples, a safe closure technique for distal pancreatic resection

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World Journal of Gastroenterology 2014年第45期20卷 17185-17189页

作者： gyula Farkas László Leindler János Márton Gyorgy Lázár gyula Farkas Department of Surgery Faculty of Medicine University of Szeged H-6701 SzegedHungary

AIM:To investigate twenty-year experience evaluated the use of the PolysorbR(an absorbable lactomer)staples for distal pancreatic ***:The data on 150 patients[92 men,58women,mean age 52(24-72)years]who underwent distal pancreatectomy(DP)in the last 20 years were collected prospectively from an electronic *** diagnosis was confirmed by endoscopic retrograde cholangiopancreatography,sonography,computed tomography and/or magnetic resonance *** indications for DP were focal pancreatic necrosis,spontaneous pancreatic fistulas,abscesses,pseudocysts,segmental chronic obstructive pancreatitis in the tail,traumatic disruption,and benign(cystadenomas,insulinomas,or glucagonomas)or malignant *** distal resections were performed without splenectomy in 29 of the 150 patients(19%).In the event of splenectomy,the splenic artery and vein were individually ligated,the TA-55 Auto Suture stapler,loaded with Premium PolysorbR 55 staples(5.5mm),was placed across the gland,and the trigger was pulled,the action of which produced two staggered absorbable suture *** gland distal to the stapler wasthen amputated with a scalpel on the TA-55 stapler and the two rows of staples were left in the proximal pancreatic *** the distal resection,a drainage tube was inserted into the pancreatic ***:The average duration of the operation was150 min(range:90-210 min)and no transfusion was indicated during the *** DP in one patient a type B fistula was diagnosed,which was treated successfully by conservative treatment comprising of 12-d octreotide medication(3×0.1 mg/d)and jejunal *** incidence of postoperative pancreatic fistula was therefore0.6%.Another 2 patients suffered postoperative pancreatitis,which was also conservatively *** were performed in 2 patients on the first or second postoperative day,necessitated by bleeding from the retroperitoneal *** morbidity was 3.3%(5 patients),but no mortality

关键词： Distal pancreatic resection PolysorbR sta-ples Closure technique Long-term experience Pancre-atic fistula

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Gastroprotection induced by capsaicin in healthy human subjects

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World Journal of Gastroenterology 2005年第33期11卷 5180-5184页

作者： gyula Mózsik János Szolcsányi István Rácz First Department of Medicine Medical and Health Center University of Pécs Hungary Department of Pharmacology and Pharmacotherapy Medical and Health Center University of Pécs Hungary First Department of Medicine County Hospital of Gyōr Hungary

AIM： To evaluate the gastro-protective effect of capsaicin against the ethanol- and indomethacin （IND）-induced gastric mucosal damage in healthy human subjects. METHODS： The effects of small doses （1-8 μg/mL, 100 mL） of capsaicin on the gastric acid secretion basal acid output （BAO） and its electrolyte concentration, gastric transmucosal potential difference （GTPD）, ethanol- （5 mL 300 mL/L i.g.） and IND- （3×25 mg/d） induced gastric mucosal damage were tested in a randomized, prospective study of 84 healthy human subjects. The possible role of desensitization of capsaicin-sensitive afferents was tested by repeated exposures and during a prolonged treatment. RESULTS： Intragastric application of capsaicin decreased the BAO and enhanced “non-parietal” component, GTPD in a dose-dependent manner. The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible. Gastric microbleeding induced by IND was inhibited by co-administration with capsaicin, but was not influenced by two weeks pretreatment with a daily capsaicin dose of 3×400μg i.g. CONCLUSION： Capsaicin in low concentration range protects against gastric injuries induced by ethanol or IND, which is attributed to stimulation of the sensory nerve endings.

关键词： Capsaicin Ethanol Indomethacin Gastric transmucosal potential difference Gastric microbleeding Gastroprotection Healthy human subjects

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Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of Gastroenterology 2005年第9期11卷 1351-1355页

作者： Zsolt Barta Gabriella Mekkel István Csíp(o|") László Tóth Szabolcs Szakáll Gábor G.Szabó gyula Bakó gyula Szegedi Margit Zeher Third Department of Medicine Department of Pathology

AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

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Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease

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World Journal of Gastroenterology 2003年第10期9卷 2308-2312页

作者： Zsolt Barta István Csíp■ Gábor G.Szabó gyula Szegedi 3~(nd) Department of Medicine University of DebrecenMóricz Zs.Krt.22.4004 DebrecenHungary

AIM:To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease. METHODS:A cohort of patients with inflammatory bowel diseases (42 patients with Crohn's disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16 patients) from Debrecen,Hungary were enrolled in the study. The diagnosis was made using the formally accepted criteria. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), antiendomysium antibodies (EMA),antigliadin antibodies (AGA) and anti human tissue transglutaminase antibodies (tTGA) were investigated. RESULTS:The results showed that ASCA positivity occurred not only in Crohn's disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved. CONCLUSION:It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease.

关键词： Adult Antibodies, Antineutrophil Cytoplasmic Antibodies, Fungal Celiac Disease Cohort Studies Crohn Disease Female Gliadin Humans Immunoglobulin A Immunoglobulin G Male Middle Aged Saccharomyces cerevisiae Seroepidemiologic Studies

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Revision of the genus Inouenola László,Ronkay & Witt,2010(Lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry Research 2015年第2期26卷 457-467页

作者： gyula M.László Gábor Ronkay László Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press Ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola La′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

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