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新型完全生物可吸收封堵器经导管封堵膜周部室间隔缺损:一项多中心前瞻性随机对照研究（英文）

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Science Bulletin 2023年第10期 1051-1059页

作者：王首正李泽夫王云兵赵天力莫绪明范太兵李建华尤涛邓润迪欧阳文斌王伟伟张闯年 Gianfranco Butera Ziyad m.Hijazi 逄坤静朱达蒋世良张戈军胡晓鹏谢涌泉张凤文房芳孙静平李萍陈娟骆志玲潘湘斌 Department of Structural Heart Disease Fuwai Hospital & National Center for Cardiovascular Disease Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical Sciences & Peking Union Medical College National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine National Clinical Research Center for Cardiovascular Diseases National Engineering Research Center for Biomaterials Sichuan University Department of Cardiovascular Surgery The Second Xiangya Hospital Central South University Department of Cardiovascular Surgery Children's Hospital of Nanjing Medical University Department of Cardiovascular Surgery Fuwai Central China Cardiovascular Hospital Department of Cardiovascular Surgery The Children's Hospital Zhejiang University School of Medicine Department of Cardiovascular Surgery Gansu Province Hospital Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Science & Peking Union Medical College Department of Pediatric and Adult Congenital Heart Disease Evelina London Children's Hospital Guy's and St Thomas' NHS Foundation Trust Department of Pediatrics Sidra Heart Center Sidra Medical & Research Center Department of Echocardiography Fuwai Hospital & National Center for Cardiovascular Disease Chinese Academy of Medical Sciences & Peking Union Medical College National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine National Clinical Research Center for Cardiovascular Diseases Department of Structural Heart Disease Fuwai Yunnan Cardiovascular Hospital Cardiology Department The Clinic Cleveland Foundation Cardiology Department Fuwai Hospital & National Center for Cardiovascular Disease Chinese Academy of Medical Sciences & Peking Union Medical College National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine National Clinical Research Center for Cardiovascular Diseases Department of Cardiovascular Surgery Hefei High-Tech Cardiovascular Hospital De

生物可吸收封堵器的应用有望降低传统金属封堵器并发症的风险.之前研制的生物可吸收封堵器存在不完全降解的局限性并导致新的并发症,因此目前尚未有相关产品获批上市.本研究使用了一种新型完全可吸收封堵器,旨在探索完全可吸收封堵器治...

生物可吸收封堵器的应用有望降低传统金属封堵器并发症的风险.之前研制的生物可吸收封堵器存在不完全降解的局限性并导致新的并发症,因此目前尚未有相关产品获批上市.本研究使用了一种新型完全可吸收封堵器,旨在探索完全可吸收封堵器治疗室间隔缺损的疗效和安全性.从2019年4月到2020年1月,本研究在七个医学中心入组125名膜周部室间隔缺损患者,经筛查后108名患者被纳入研究并随机分为植入生物可吸收封堵器实验组和金属封堵器组.所有受试者均成功植入封堵器并完成24个月的随访.生物可吸收封堵器组患者经胸超声心动图显示高亮回声在24个月内逐渐消失,说明可吸收封堵器在体内实现完全降解.对比金属封堵器,实验组器械相关心律失常发生率(5.56%vs.14.81%,P=0.112)和持续传导阻滞发生率(0/54 vs.6/54,P=0.036)显著降低.本研究提示新型完全可吸收封堵器可以在单纯超声引导下实现成功植入,同时降低术后永久性心律失常的发生率.

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表皮松解性大疱病表皮真皮连接处发生鳞癌的危险增大

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 48-48页

作者： mallipeddi R. Keane F.m. mc Grath J.A. R.A.J. Eady 张宪旗 guy's King's/St Thomas'Sch. of med. St John's Institute of Dermatology St Thomas'Hospital London SE1 7EH United Kingdom

Non-Herlitz junctional epidermolysis bullosa (JEB) is an autosomal recessive genodermatosis characterized by skin fragility and blistering. It is usually caused by mutations in the genes encoding the basement membrane proteins laminin 5 or type XVII collagen. Clinically, impairedwound healing and chronic erosions cause major morbidity in affected patients. Previously it was thought that these individuals, unlike patients with dystrophic EB, did not have an increased risk of developing skin cancer. However, we describe three patients with non-Herlitz JEB (aged 42, 56 and 75 years) who developed cutaneous squamous cell carcinomas (SCCs). The tumours were well-differentiated in two cases, but one patient had multiple primary SCCs that were either well-or moderately differentiated. most cases of SCC in non-Herlitz JEB described have occurred in those with laminin 5 defects and on the lower limbs. These clinicopathological observations have important implications for the management of patients with this mechanobullous disorder as well as providing further insight into the biology of skin cancer associated with chronic inflammation and scarring.

关键词：表皮松解大疱鳞癌 Laminin 多发型临床病理学营养不良性基因突变于非

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吸入性99Tcm-甲氧异睛的清除与多药耐药蛋白1在人肺组织中的表达相关?

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国际医学放射学杂志 2016年第6期 684-684页

作者： H.K.mohan T.Routledge P.Cane L.Livieratos J.R.Ballinger A.m.Peters 孙劼 Departments of Nuclear medicine Guy's and St Thomas' Hospital

摘要目的检测吸入性99Tcm-甲氧异睛肺清除率同支气管肺多药耐药蛋白1（mRP1）、渗透性糖蛋白（P-gp）免疫组化表达的相关性,同时评估吸入性99Tcm-甲氧异睛清除率测

关键词：吸入性甲氧多药耐药 Tc~m 蛋白

微白蛋白尿对预测Ⅱ型糖尿病患者发生冠心病的价值

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Oncology and Translational medicine 1995年第2期12卷 18-18页

作者： m.mattock,D.Barnes,GC Viberti,H.Keen,A.Fitzgerald,D.Burt,B.Sandhu,P.G.Jackson,李仁立 U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. U.m.D.S.guy's and St Thomas Hospitals and Lewisham Hospital London U.K. 同济医科大学附属同济医院

微白蛋白尿可预测Ⅱ型糖尿病患者的早期死亡率,这一前瞻性研究目的是观察微白蛋白尿能否预示冠心病的发病率和死亡率。微白蛋白尿是指整夜尿蛋白排泄率为20～200μg/min。冠心病发病率是根据静息心电图和询问有关病史,而冠心病死亡率应... 详细信息

微白蛋白尿可预测Ⅱ型糖尿病患者的早期死亡率,这一前瞻性研究目的是观察微白蛋白尿能否预示冠心病的发病率和死亡率。微白蛋白尿是指整夜尿蛋白排泄率为20～200μg/min。冠心病发病率是根据静息心电图和询问有关病史,而冠心病死亡率应有死亡证明和临床病情记录。1985年～1987年调查了144名欧洲Ⅱ型糖尿病患者,平均年龄56岁,平均随访7.5年。在随访中34名患者死亡,其中65％死于心血管疾病,这些患者中48％有微白蛋白尿,与之相比,尿白蛋白正常者为15％,P<0.001。在存活者多因素回归分析中,微白蛋白尿有意义地

关键词：微白蛋白尿冠心病冠状动脉病 Ⅱ型糖尿病二型糖尿病患者