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Pediatric dysphagia overview:best practice recommendation study by multidisciplinary experts

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World Journal of Pediatrics 2022年第11期18卷 715-724页

作者： Ebru Umay Sibel Eyigor Esra Giray Evrim Karadag Saygi Bulent Karadag Nihal Durmus Kocaaslan Deniz Yuksel Arzu Meltem Demir Engin Tutar Canan Tikiz Eda Gurcay Zeliha Unlu Pelin Celik Ece Unlu Akyuz guven Mengu Serkan Bengisu Sibel Alicura Necati Unver Nida Yekteusaklari Cuma Uz Merve Cikili Uytuni Fatih Bagcier Elif Tarihci Mazlum Serdar Akaltun Iclal Ayranci Sucakli Damla Cankurtaran Zeynep Aykin Resa Aydin Fatma Nazli Department of Physical Medicine and Rehabilitation Ankara University of Health Sciences TurkeyAnkara Diskapi Yildirim Beyazit Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Ege UniversityIzmirTurkey Department of Physical Medicine and Rehabilitation Fatih Sultan Mehmet Training and Research HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Marmara UniversityIstanbulTurkey Department of Pediatric Pulmonology Marmara UniversityIstanbulTurkey Department of Plastic Reconstructive and Aesthetic SurgeryMarmara UniversityIstanbulTurkey Department of Pediatric Neurology University of Health SciencesAnkara Dr Sami Ulus MaternityChildren's Health and Diseases Training and Research HospitalAnkaraTurkey Department of Pediatric Gastroenterology Ankara City HospitalAnkaraTurkey Department of Pediatric Gastroenterology Marmara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Celal Bayar UniversityManisaTurkey University of Health Sciences Turkey Gaziler Physical Medicine and Rehabilitation Training and Research HospitalAnkaraTurkey Department of Developmental Pediatric Ankara City HospitalAnkaraTurkey Department of Western Languages and Literatures Ankara Haci Bayram Veli UniversityEnglish Language and Literature DivisionAnkaraTurkey Department of Speech and Language Therapy Uskudar UniversityIstanbulTurkey Department of Otolaryngology Head and Neck SurgeryUniversity of Health SciencesAnkara Diskapi Yildirim Beyazit Training and Research HospitalAnkaraTurkey Department of Otolaryngology Head and Neck SurgeryMarmara UniversityIstanbulTurkey Department of Child and Adolescent Psychiatry Ankara UniversityAnkaraTurkey Department of Physical Medicine and Rehabilitation Istanbul Basaksehir Cam and Sakura City HospitalIstanbulTurkey Department of Physical Medicine and Rehabilitation Istanbul UniversityIstanbulTurkey Department of Physical Medicine and Rehabilitation Gaziantep UniversityGazian

Background Currently,there is no comprehensive and multidisciplinary recommendation study covering all aspects of pediatric dysphagia(PD).This study aimed to generate PD management recommendations with methods that can be used in clinical practice to fill this gap in our country and in the world,from the perspective of experienced multidisciplinary *** This recommendation paper was generated by a multidisciplinary team,using the seven-step process and a three-round modified Delphi survey via ***,ten open-ended questions were created,and then detailed recommendations including management,diagnosis,treatment,and follow-up were created with the answers from these *** recommendation item was voted on by the experts as overall consensus(strong recommendation),approaching consensus(weak recommendation)and divergent consensus(not recommended).Results In the 1st Delphi round,a questionnaire of 414 items was prepared based on the experts’responses to ten open-ended *** the 2nd Delphi round,59.2%of these items were accepted as *** the 3rd Delphi round,62.6%of 246 items were accepted for inclusion in the *** final version recommendations consisted of 154 *** This study includes comprehensive and detailed answers for every problem that could be posed in clinical practice for the management of PD,and recommendations are for all pediatric patients with both oropharyngeal and esophageal dysphagia.

关键词： Diagnosis Dysphagia Pediatric Recommendation Rehabilitation

辛伐他汀改善高胆固醇血症患者的内皮功能并增加纤维蛋白溶解

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心血管病学进展 2006年第5期27卷 673-674页

作者： guven G S Atalar E Yavuz B 李永梅（摘译）刘剑（校）不详重庆医科大学附属第一医院

Therapeutic Trials of Nigella sativa

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Journal of Pharmacy and Pharmacology 2019年第11期7卷 564-577页

作者： Aysenur Koc Nazan guven S1d1ka Buyukhelvac1gil Ozturk1 Burcak Deniz Dedeoglu Hale Feyza Buyukhelvacigil Ramazan Buyukhelvac1gil Beril Koparal Zade Vital■ Natural Supplements Istanbul 34775 Turkey Zade Vital■ Natural Supplements 2800 Lively Blvd Elk Grove Village IL 60007 Illinois USA

Nigella sativa (NS)(Ranunculaceae family) is generally utilized as a therapeutic plant all over the world. The seeds of the plant have a long history of use in different frameworks of medicines and food. N. sativa seeds reveal a broad spectrum of pharmacological activities including immunopotentiation and antihistaminic, antiseptic, antiallergic, anti-hypertensive, anti-inflammatory, and antimicrobial activities. It is known as a source of thymoquinone (TQ), thymohydroquinone, dithymoquinone, p-cymene, carvacrol, 4-terpineol, t-anethol, sesquiterpene longifolene, nigellicimine and nigellicimine-N-oxide,α-pinene and thymol etc. Additionally, this is uncovered that the majority of therapeutic properties of this plant are due to the presence of thymoquinone which is a major bioactive component of the essential oil. The incalculable medicinal properties and therapeutic uses of N. sativa prove its importance as a valuable medicinal plant. The aim of this review is to summarize some important pharmacological studies and phytochemical investigations on N. sativa and isolated principles which can be investigated further to get novel molecules in the search of novel herbal drugs.

关键词： Nigella sativa medicinal plant phytoconstituent pharmacological activity

结构破坏样综合征的3个新病例:其中1例伴膀胱外翻

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世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 43-44页

作者： Ilkehan H. Coban Y.K. guven M.A. Ceylaner S. 肖莉 Dept.of Plast.and Reconstr.Surg.Kahramanmaras Sutcu Imam University KahramanmarasTurkey

作者报道了3例互不相关的土耳其人的结构破坏样综合征病例。所有患者都有肢体附属物,其中2例附属有泌尿生殖器结构。更有趣的是。

关键词：膀胱外翻新病例泌尿生殖器土耳其人概率分布

艾哈迈德·阿德南·萨伊贡艺术中心,伊兹密尔,土耳其

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世界建筑 2010年第7期 26-31页

作者： Tevfik Tozkoparan Emre Ulas Macit Olcer Cavit Arikan Meric Batmaz Aylin Saracoglu Goknur Murat Ozyilmaz Sevgi Kayhan Ebru Soydas Izmir Branch Archives Noyan Sancar Mehmet Yasa guven Incirlioglu 李璠托兹科帕兰建筑师事务所 Tozkoparan Architects & Arup Engineering Inc. Cemal Emden photos in Chamber of Architects

一座建筑的性能应当如何来衡量？除了通过统治当代建筑舆论的美学、技术以及经济价值来进行描述之外,我们还能够如何来阐释一座建筑,尤其是一座致力于庇护那些渴望展现自己的艺术家的建筑？有人会问成功的表演是如何实现的,表演者是如... 详细信息

一座建筑的性能应当如何来衡量？除了通过统治当代建筑舆论的美学、技术以及经济价值来进行描述之外,我们还能够如何来阐释一座建筑,尤其是一座致力于庇护那些渴望展现自己的艺术家的建筑？有人会问成功的表演是如何实现的,表演者是如何进行伪装的、又是如何展现自己的？根据海德格尔的理论,当我们看不到钉子的时候,铁锤的表现才是成功的;钉子本身的出现通常表明出现了问题。

关键词：艺术中心土耳其当代建筑经济价值海德格尔艺术家表演钉子

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卵巢交界性肿瘤复发和预后的影响因素

世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 46-46页

作者： Ayhan A. guvendag guven E. S. guven S. Kucukali T. 张丽娟(译) S. guven Department of Obstetrics and Gynecology. Division of Gynecologic Oncology Hacettepe UniverSity Faculty of Medicine M Esat B. Caddesi No: 69/20NCEBECI Ankara Turkey 不详

. The purpose of this study was to evaluate the survival estimates and clinico-pathological variables in patients treated for borderline ovarian tumors. Methods. The patients treated for borderline ovarian tumors were evaluated retrospectively. Data were obtained from hospital records and special gynecologic oncology forms. Results. Overall, 100 patients were evaluated. The mean age at the time of diagnosis was 41.7 (range, 19- 84). Seventy one (71% ) patients underwent surgical staging including 49 (49% ) of them with comprehensive surgical staging, 22 (22% ) with fertility-sparing surgery. Only 30 (30% ) patients were unstaged. The histopathological diagnosis was serous, mucinous, and the other types of borderline ovarian tumor in 54 (54% ), 39 (39% ), and 7 (7% ) of the patients, respectively. Seventy patients had stage IA (70% ), 10 had st age IB (10% ), 9 had stage IC (9% ), 3 had stage IIIA (3% ), and 8 had stage IIIC (8% ) disease. The stage of only four patients in which disease confined to ovary was upgraded as stage IIIC following surgical staging procedure. The recurrence rate was found 3% (3). The overall disease-free survival rates of BOT in surgically staged (comprehensive, fertility-sparing surgery) and unstaged patients were 97.92% , 95.00% , and 96.30% , respectively. But, the overall tumor-free survival was significantly found to be decreased in cases of young age ( < 30 years old), performing fertility-sparing surgery and presence of micropapillary architecture or peritoneal implants. Overall survival rates of BOT in surgically staged (comprehensive, fertility-sparing surgery) and unstaged patients were 97.9% , and 100% and 100% , respectively. Conclusion. Low malignant potential ovarian tumors have excellent survival, and the patients can be treated safely by conservative surgery.

关键词：卵巢交界性肿瘤肿瘤复发率组织病理学诊断手术分期年轻患者无瘤生存率预后保守手术低度恶性潜能平均年龄

视神经萎缩和黄斑变性作为亚急性硬化性全脑炎的首发症状

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 28-28页

作者： Berker N. Batman C. guven A. 张自峰

To report a case of subacute sclerosing panencephalitis in which the initial c linical presentations were optic atrophy and macular degeneration. Observational case report. A 9 year old boy with visual loss attributable to optic atrophy and macular degeneration had a diagnostic examination. The visual acuity levels of both eyes were light perception at presentation. Fundus examination revealed bilateral optic atrophy and macular degenerative changes including retinal pigme nt epithelial atrophy, macular scarring, and epiretinal membrane formation. The antimeasles IgG titers were high both in serum and cerebrospinal fluid samples. Neurologic symptoms of myoclonus, ataxia, motor, and mental disabilities occurre d 4 months after the onset of first visual disturbances and 2 weeks after the pa tient applied to our clinic. Children with optic atrophy and macular degenerativ e lesions should be examined for sclerosing panencephalitis, even if the classic al neurologic symptoms of this disease are not present.

关键词：黄斑变性视神经萎缩视网膜色素上皮诊断性检查视网膜前膜瘢痕化智力障碍眼底检查共济失调全脑炎

卵巢皮质移植可作为更年期早期患者激素治疗的替代疗法

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 39-39页

作者： Kiran G. Kiran H. Coban Y.K. guven A.M. 李跃萍 Department of Obstetrics and Gynecology Kahramanmaras Sutcu Imam University Yoruk Selim Mah Hastane Cad. No:32 Kahramanmaras 46050 Turkey Dr.

Objective: To discuss the 18-month follow-up results of fresh ovarian cortical tissue transplant. Design: Case study. Setting: Academic medical center. Patient(s): A 46-year-old patient who was operated on for uterine fibroids, and who then received an ovarian tissue transplant in July 2003. Intervention(s): Serum hormone levels were measured at 3-month intervals. Main Outcome Measure(s): Follicular development evident by ultrasound examination; serum hormone levels (FSH, LH, E2). Result(s): Preoperative and 3rd-, 6th-, 9th-, 12th-, 15th-, and 18th-month hormone levels were, respectively, as follows: FSH: 9.06, 79.5, 13.7, 16.66, 51.91, 44.37, and 24.17 mIU/mL; LH: 5.91, 33.92, 8.78, 21.83, 38.31, 40.85, and 22.4 mIU/mL; E2: 166, 46, 48, 117, 31, 14.4, and 137.7 pg/mL. Folliculogenesis was confirmed by ultrasonography at the 6th, 9th, and 18th months during the follow-up period. Conclusion(s): Fresh ovarian autotransplantation may be a logical alternative for hormonal support for a specific patient group.

关键词：卵巢皮质卵巢组织移植血清激素水平子宫纤维瘤卵泡发育自体移植患者群病例研究超声检查