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癫痫:从儿童至成年的医疗过渡——来自安大略省癫痫执行工作组的建议

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癫痫杂志 2018年第4期4卷 362-373页

作者： Danielle M.Andrade Anne S.bassett Eduard bercovici borlot F bui E Camfield P Clozza GQ Cohen E Gofine T Graves L Greenaway J guttman b guttman-Slater M Hassan A Henze M Kaufman M Lawless b Lee H Lindzon L Lomax Lb McAndrews MP Menna-Dack D Minassian bA Mulligan J Nabbout R Nejm T Secco M Sellers L Shapiro M Slegr M Smith R Szatmari P Tao L Vogt A Whiting S Carter Snead O 3rd 刘旭熊维希慕洁

从儿童到成人的医疗保健系统的转变对许多患有癫痫的年轻人及其家庭来说是一个挑战。最近,加拿大安大略省卫生部和长期医疗部门成立了一个过渡工作组(Transition working group,TWG),为安大略省癫痫患者的过渡提出建议。在此对这项工作... 详细信息

从儿童到成人的医疗保健系统的转变对许多患有癫痫的年轻人及其家庭来说是一个挑战。最近,加拿大安大略省卫生部和长期医疗部门成立了一个过渡工作组(Transition working group,TWG),为安大略省癫痫患者的过渡提出建议。在此对这项工作做出总结。TWG包括儿科和成人癫痫病专家、精神科医生和来自学术界和社区的家庭医生,从事儿童和成人癫痫项目的社区医师、护士和社会工作者,以及青少年内科医师、律师、职业治疗师、社区癫痫机构的代表、癫痫患者和患者父母。该小组主要解决3个领域的问题:(1)癫痫的诊断和管理;(2)癫痫患者心理健康和社会心理需求;(3)癫痫患者经济、社会和法律支持。目前虽然还没有对过渡方案的结果进行系统研究,但TWG能早期识别处于过渡失败风险的青少年,在实际过渡之前即应协调儿童和成人神经科医师以及其他专家。过渡期是重新思考诊断和重复诊断检测(特别是基因检测,现有技术较多年前可发现更多病因)的理想时期。在转至成人医疗系统后部分筛查应重复。文章提出的7个步骤可以促进过渡,从而有助于为青少年癫痫患者转出儿童保健系统提供持续且合理的医疗服务。

关键词：癫痫过渡青少年青年遗传学出院方案过渡准备问卷

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米托蒽醌对复发性视神经脊髓炎(Devic病)的疗效研究

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 1-1页

作者： Weinstock-guttman b. Ramanathan M. Lincoff N. 张磊 William C.baird Multiple Sclerosis Center Jacobs Neurological Institute 100 High St Buffalo NY 14203 United States Dr.

background:Neuromyelitis optica is a severe demyelinating disease that selectively involves the optic nerves and the spinal cord but usually spares the *** is considered to have a b-cell-induced *** hydrochloride, a synthetic anthracenedione approved for worsening relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, has been shown to primarily suppress the humoral ***:To evaluate the benefit of mitoxantrone treatment in patients with relapsing neuromyelitis ***:Prospective 2-year ***:Academic multiple sclerosis ***:Five patients(3 women and 2 men)with an age range of 20 to 51 years and an Expanded Disability Status Scale score of 2.5 to 6.5(mean± SD, 4.40± 1.88).Interventions:Monthly intravenous infusions of mitoxantrone hydrochloride, 12 mg/m2, for 6 months followed by 3 additional treatments every 3 *** Outcome Measures:Expanded Disability Status Scale score measured every 3 months and during relapses;findings on orbital, brain, and spinal cord magnetic resonance images performed at baseline and at 3, 6, 12, 18, and 24 months;and visual evoked potentials and results of ophthalmologic evaluations performed at baseline and ***:During the 2 years of treatment, 2 patients each had a relapse once within the initial 5 months of treatment(1 severe and 1 moderate).Improvement was seen clinically and on magnetic resonance images in 4 *** generally tolerated the treatment well, although 1 patient had a reversible decrease in cardiac ejection ***:Our results suggest a beneficial effect of mitoxantrone treatment for relapsing neuromyelitis optica.

关键词：视神经脊髓炎 Devic 复发性米托蒽醌

The role of Epstein-barr virus in multiple sclerosis:from molecular pathophysiology to in vivo imaging

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Neural Regeneration Research 2019年第3期14卷 373-386页

作者： Yi Guan Dejan Jakimovski Murali Ramanathan bianca Weinstock-guttman Robert Zivadinov buffalo Neuroimaging Analysis Center Department of Neurology Jacobs School of Medicine and Biomedical Sciences University at BuffaloState University of New York Jacobs Comprehensive MS Treatment and Research Center Department of Neurology Jacobs School of Medicine and Biomedical SciencesUniversity at Buffalo State University of New York Department of Pharmaceutical Sciences State University of New York Center for biomedical Imaging at Clinical Translational Science Institute University at Buffalo State University of New York

Multiple sclerosis(MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-barr virus(EbV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EbV infection, increases the risk of developing MS. EbV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging b-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. One potential effect of these therapies is the depletion of memory b-cells, the primary reservoir site where EbV latency occurs. In addition, EbV potentially interacts with both genetic and other environmental factors to increase susceptibility and disease severity of MS. This review examines the role of EbV in MS pathophysiology and summarizes the recent clinical and radiological findings, with a focus on b-cells and in vivo imaging. Addressing the potential link between EbV and MS allows the better understanding of MS pathogenesis and helps to identify additional disease biomarkers that may be responsive to b-cell depleting intervention.

关键词： Epstein-barr virus multiple sclerosis meningeal inflammation magnetic resonance imaging leptomeningeal contrast enhancement mononucleosis human endogeneous retrovirus-W b-cells

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biology / 1st ed.

利用MR静脉成像显示多发硬化病人与对照健康人颅外静脉系统的特点

1999年

作者： burton S. guttman contributing author Johns W. H

来源：畅想之星图书光盘版（南... 评论

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国际医学放射学杂志 2011年第2期 184-185页

作者： R.Zivadinov A.Lopez-Soriano b.Weinstock-guttman C.V.Schirda K.Dolic 唐光健 Department of Neurology School of Medicine and Biomedical SciencesBuffalo Neuroimaging Analysis CenterState University of New York

目的利用MR静脉成像研究多发硬化(MS)病人与健康对照组(HC)个体间颅外静脉系统的不同。材料与方法此项前瞻性研究经当地机构审查委员会批准,符合

关键词：多发硬化静脉系统静脉成像 MR 病人

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质量工作的十个基本点

中国认证认可 2008年第2期 47-57页

作者：达菲（Grace L．Duffy）巴拉夫斯基（PAUL E．bORAWSKI）福斯特（S．TOM FOSTER JR）格特曼（HOWARD M．guttman）黑尔（LYNNE b．HARE）欧克斯（DUKE OKES）佩恩（GRAEME C．PAYNE）鲁尼（JAMES J．ROONEY）韦斯特（JOHN E．“JACK” WEST）韦斯科特（RUSS WESTCOTT）李伟（译）佛罗里达州塔瓦雷斯市管理与绩效部主任美国质量学会（ASQ）执行董事兼首席战略执行官杨百翰大学质量与供应链管理教授格特曼发展战略公司负责人新泽西州东汉诺威市卡夫食品开发研究院应用统计指导主任 ASQ的特别会员 GK咨询公司董事长田纳西州肯农维利市美国船级社公众部风险与可靠性高级工程师 ASQ特别会员康涅狄格州老塞布卢克城R．T．韦斯科特合伙有限公司董事长不详

“没有人逼你学习……也没有人逼你活着。”这句话出自戴明（*** Deming）的《转危为安》一书，它提醒我们每天都应该在工作和生活中努力地吸收知识、强化专业。

关键词：质量工作知识生活质量管理