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Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives

Neural Regeneration Research 2021年第12期16卷 2425-2426页

作者： gustavo de bem silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila Paulo Cesar Lock silveira Laboratory of Experimental Pathophysiology Graduate Program in Health SciencesUniversidade do Extremo Sul CatarinenseCriciúmaSCBrazil Programa de Pós Graduação em Farmacologia UFSCFlorianópolisSCBrazil

Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to disability due to gradual neuronal death in both the central nervous system and the peripheral nervous *** many of these diseases have unknown causes,sometimes these are due to medical conditions such as alcoholism,a tumor,or a stroke,or other causes which may include genetic mutations,toxins,chemicals,and viruses.

关键词： diseases degenerative treatment

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COVID-19 liver and gastroenterology findings:An in silico analysis of SARS-CoV-2 interactions with liver molecules

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World Journal of Hepatology 2022年第6期14卷 1131-1141页

作者： Gabrielle Caroline Peiter Cristiano de bem Torquato de Souza Lucca Miketen de Oliveira Luis gustavo Pagliarin Valentina Nunes Fontoura dos Anjos Filipe Antônio França da Silva Fabrício Freire de Melo Kádima Nayara Teixeira Universidade Federal do Paraná Campus ToledoToledo 85919-899ParanáBrazil Universidade Federal da Bahia Campus Anísio TeixeiraVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Coronavirus disease 19(COVID-19)has not only been shown to affect the respiratory system,but has also demonstrated variable clinical presentations including gastrointestinal tract *** addition,abnormalities in liver enzymes have been reported indicating hepatic *** is known that severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)might infect cells via the viral receptor angiotensin-converting enzyme 2(ACE2)which is expressed in several organs including the *** viral Spike glycoprotein binds to ACE2 and must be cleaved by Furin and Type 2 Serine Protease to enter the *** that,the Akt/mTOR signaling pathway is activated and several COVID-19 changes are *** To analyze liver and gastrointestinal symptoms and cell signaling pathways triggered by SARS-CoV-2 infection due to virus-liver interactions in *** In this in silico study,the three-dimensional structures of the Akt,mTORC1 and Furin(receptors)were selected from the Protein Data Bank(PDB)and the structures of inhibitors(ligands)MK-2206,CC-223 and Naphthofluorescein were selected from PubChem and ZINC *** files were downloaded as 2D structures and converted to optimized 3D structures using ViewerLite 4.2 *** Sketch®software was used to calculate prediction of the protonated form of inhibitors in a physiological environment(pH 7.4).AutoDock Tools(ADT)software was used to calculate and delimit the Grid box used in the molecular docking of each structure selected in the *** addition,protonated ligands were prepared for molecular docking using ADT *** docking was performed using ADT software tools connected to Vina *** of the amino acid residues involved in ligand interactions,as well as ligand twists,the atoms involved in interactions,bond type and strength of interactions were performed using PyMol^(■)and Discovery Studio^(■)(BIOVIA)*** Molecular docking analysis showed that the mTOR

关键词： Bioinformatics Cell signaling pathway COVID-19 Liver injury SARS-CoV-2

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Effect of microencapsulated watermelon(Citrullus lanatus)intake on plasma amino acids and glycemic response in healthy adults

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Food Bioscience 2022年第2期46卷 450-455页

作者： Mˆonica Volino-Souza gustavo Vieira Oliveira Rafael Vargas Anna Carolina Tavares Carlos Adam Conte-Junior Thiago da silveira Alvares Nutrition and Exercise Metabolism Research Group Multidisciplinary Center UFRJ-Maca´eFederal University of Rio de JaneiroMaca´eRio de JaneiroBrazil Postgraduate Program in Food Science Chemistry InstituteFederal University of Rio de JaneiroRJBrazil Nanotechnology Network Carlos Chagas Filho Research Support Foundation of the State of Rio de Janeiro(FAPERJ)Rio de JaneiroRJ20.020-000Brazil Food and Nutrition Institute Multidisciplinary Center UFRJ-Maca´eFederal University of Rio de JaneiroMaca´eBrazil

Watermelon is an L-citrulline-rich fruit that has been used as a supplement to increase L-arginine in plasma,which in turn plays a critical role in the synthesis of nitric oxide,a molecule that regulates vascular *** rind,similar to its pulp,presents a high L-citrulline content,yet a lower concentration of sugar,which would be more convenient for individuals who need to refrain from excessive sugar ingestion(i.e.,diabetics and obese individuals).Further,ingestion of watermelon rind can be a sustainable alternative to increase plasma L-arginine,given that rind of fruits is commonly ***,we evaluated the effect of ingestion of a product derived from watermelon rind and pulp(microencapsulation in spray drier)on plasma amino acids(L-citrulline,L-arginine and L-ornithine),glucose,and *** participants(28.36±5.70 years)were enrolled in a single blind,cross-over and randomized *** ingested microencapsulated watermelon rind and pulp(containing 4 g of L-citrulline)plasma amino acids,glucose,and insulin were evaluated before and 30,60,90 and 120 min after *** was observed that both microencapsulated watermelon rind and pulp increased L-citrulline through 120 min and microencapsulated watermelon rind significantly increased L-arginine at 30 *** addition,microencapsulated watermelon rind and pulp similarly increased plasma glucose and insulin *** conclusion,these findings suggest that both microencapsulated watermelon rind and pulp are effective to increase plasma L-citrulline and microencapsulated watermelon rind effectively increases plasma *** addition,rind and pulp promote similar changes on plasma glucose and insulin.

关键词： L-citrulline Watermelon rind Microencapsulation Glucose Plasma amino acids

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Impact of hormonal modulation at proestrus on ovarian responses and uterine gene expression of suckled anestrous beef cows

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Journal of Animal Science and Biotechnology 2018年第1期9卷 77-90页

作者： Manoel Francisco de Sá Filho Angela Maria Gonella-Diaza Mariana Sponchiado Marcio Ferreira Mendanha Guilherme Pugliesi Roney dos Santos Ramos Sónia Cristina da Silva Andrade gustavo Gasparin Luiz Lehmann Coutinho Marcelo demarchi Goissis Fernando silveira Mesquita Pietro Sampaio Baruselli Mario Binelli departamento de Reproducao Animal FMVZ USP Sao Paulo SP Brazil departamento de Genetica e Biologia Evolutiva IB-USP- Sao Paulo SP Brazil Laboratorio de Biotecnologia Animal ESALQ USP Av Padua Dias Piracicaba SP 11 Brazil Universidade Federal do Pampa Uruguaiana RS Brazil Universidade de Sao Paulo Faculdade de Medicina Veterinriae Zootecnia Departamento de Reprodcao Animal Avenida Duque de Caxias Norte 225 Pirassununga SP Zip Code 13635900 Brazil

Background： This study evaluated the impact of hormonal modulation at the onset of proestrus on ovarian response and uterine gene expression of beef ***： A total of 172 anestrous beef cows were assigned to one of four groups according to the treatment with estradiol cypionate（ECP） and/or equine chorionic gonadotropin（eCG） [CON（n = 43）, ECP（n = 43）, eCG（n = 44）and ECP ＋ eCG（n = 42）].Results： ECP-treated cows（ECP and ECP ＋ eCG groups） presented greater occurrence of estrus（44.6% vs. 65.4%; P = 0.01） and pregnancy per AI [47.1% vs. 33.3%; P = 0.07], but similar progesterone（P4） concentration at subsequent diestrus than cows not treated with ECP（CON and eCG groups）. Nonetheless, eCG-treated cows（eCG and ECP ＋ eCG groups） presented larger follicle at timed AI（12.6 ± 0.3 vs. 13.5 ± 0.3 mm; P = 0.03）, greater ovulation rate（96.5%vs. 82.6%; P = 0.008） and greater P4 concentration at d 6（3.9 ± 0.2 vs. 4.8 ± 0.2 ng/mL; P = 0.001） than cows not treated with eCG（CON and ECP groups）. Next, cows with a new corpus luteum 6 d after TAI were submitted to uterine biopsy procedure. Uterine fragments [CON（n = 6）, ECP（n = 6）] were analyzed by RNA-Seq and a total of 135 transcripts were differentially expressed between groups（73 genes up-regulated by ECP treatment）. Subsequently,uterine samples were analyzed by q PCR（genes associated with cell proliferation）. ECP treatment induced greater abundance of PTCH2（P = 0.07） and COL4 A1（P = 0.02）, whereas suppressed EGFR（P = 0.09） expression. Conversely, eCG treatment increased abundance of HB-EGF（P = 0.06）, ESR2（P = 0.09）, and ITGB3（P = 0.05）, whereas it reduced transcription of ESR1（P = 0.05）. Collectively, supplementation with ECP or eCG at the onset of proestrous of anestrous beef cows influenced ovarian responses, global and specific endometrial gene ***： Proestrus estradiol regulate the endometrial transcriptome, particularly stimulating proliferative activity in the endometrium.

关键词： Cattle eCG Endometrium Estradiol Transcriptome

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In silico evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment

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World Journal of Biological Chemistry 2023年第4期14卷 72-83页

作者： Luis gustavo Pagliarin Lucca Miketen de Oliveira Valentina Nunes Fontoura dos Anjos Cristiano de bem Torquato de Souza Gabrielle Caroline Peiter Cinthia Façanha Wendel Anderson Dillmann Groto Fabrício Freire de Melo Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Instituto Multidisciplinar em Saúde-Campus Anísio Teixeira Universidade Federal da BahiaVitória da Conquista 45.029-094BahiaBrazil

BACKGROUND Coronavirus disease 2019(COVID-19)has demonstrated several clinical manifestations which include not only respiratory system issues but also liver,kidney,and other organ *** of these abnormalities is coagulopathies,including thrombosis and disseminated intravascular *** of this,the administration of low molecular weight heparin is required for patients that need to be *** addition,Remdesivir is an antiviral that was used against Middle East Acute Respiratory Syndrome,Ebola,Acute Respiratory Syndrome,and other diseases,showing satisfactory results on ***,there is evidence suggesting that this medication can provide a better prognosis for patients with *** To investigate in silico the interaction between Remdesivir and clotting factors,pursuing a possibility of using it as *** In this in silico study,the 3D structures of angiotensin-converting enzyme 2(ACE2),Factor I(fibrinogen),Factor II(prothrombin),Factor III(thromboplastin),Factor V(proaccelerin),Factor VII(proconvertin),Factor VIII(antihemophilic factor A),Factor IX(antihemophilic factor B),Factor X(Stuart-Prower factor),and Factor XI(precursor of thromboplastin(these structures are technically called receptors)were selected from the Protein Data *** structures of the antivirals Remdesivir and Osetalmivir(these structures are called ligands)were selected from the PubChem database,while the structure of Atazanavir was selected from the ZINC *** software AutoDock Tools(ADT)was used to prepare the receptors for molecular ***,peptides,water molecules,and other ones were removed from each ligand,and then,hydrogen atoms were added to the *** grid box was delimited and calculated using the same software ADT.A physiological environment with pH 7.4 is needed to make the ligands interact with the receptors,and still the software Marvin sketch®(ChemAxon®)was used to forecast the protonation *** perform m

关键词： Clotting factors Coagulating blood cascade COVID-19 treatment Remdesivir SARS-CoV-2

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Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar(Panthera onca) populations

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Journal of Genetics and Genomics 2022年第1期49卷 77-80页

作者： gustavo P.Lorenzana Henrique V.Figueirò Jeremy Johnson Elinor Karlsson Ronaldo G.Morato Dênis A.Sana Laury Cullen Joares A.May Jr. Edsel A.Moraes Jr. Daniel L.Z.Kantek Leandro silveira William J.Murphy Oliver A.Ryder Eduardo Eizirik Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Christopher B.Kaelin Gregory S.Barsh HudsonAlpha Institute for BiotechnologyHuntsvilleAL 35806USA Vertebrate Genome Biology Broad InstituteCambridgeMA 02142USA CENAP/ICMBio AtibaiaSP 12952Brazil PPG Biologia Animal Instituto de Bioci^enciasUFRGSPorto AlegreRS 90650Brazil Instituto de Pesquisas Ecol ogicas Teodoro SampaioSP 19280Brazil UniSul TubarãoSC 88704Brazil Instituto Prò-CarnivorosAtibaiaSP 12945Brazil Instituto Biotr opicos DiamantinaMG39100Brazil Estacão Ecologica de Taiamã ICMBioCaceresMT 78200Brazil Instituto Onca-pintada-Jaguar Conservation Fund MineirosGO 75830Brazil Texas A&M University College StationTX 77843USA San Diego Zoo Institute for Conservation Research San DiegoCA 92027USA Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Instituto Pr o-Carni¬vorosAtibaiaSP 12945Brazil Centro Regional del Bajio INECOLP atzcuaroMIC61600Mexico Smithsonian Conservation Biology Institute WashingtonDC20008USA

Whole-genome sequences provide massive amounts of data that can illuminate many aspects of a species’biology and evolutionary history,as well as valuable information for conservation *** is particularly important for large carnivores,whose large area requirements and typical low densities make them prone to undergo rapid genetic erosion(*** of runs of homozygosity,Diez del Molino et al.,2018;Leroy et al.,2018)in the face of habitat loss and human *** such species is the jaguar(Pan-thera onca),the largest extant felid in the Americas,whose range has already declined by>50%and some of whose remaining popu-lations have been severely impacted by human-induced habitat frag-mentation(de La Torre et al.,2018).

关键词： Whole habitat erosion

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