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IMMUNOCYTOCHEMICAL STUDY OF ENTEROCHROMAFFIN CELLS IN CARCINOMAS OF THE LARGE INTESTINE

Chinese Journal of Cancer Research 1991年第2期3卷 48-52页

作者：陈培辉 gustavo baretton Udo Lhrs Department of Pathology Zhejiang Medical University Hangzhou Institute of Pathology Medical University of Lubeck Germany Institute of Pathology Medical University of Lubeck Germanyn a series of 130 cases of adenocarcinomas of the large intestine enterochromaffin (EC) cells were detected in 54 cases (41.3%) by limmunocytochemistry with anti-chromogranin monoclonal antibody. Among the 54 cases 30 were found positive for serotonin 14 for somatostatin 11 for glucagon 5 for pancreatic polypeptide and only one for gastrin. The cases with EC cell (++) or polypeptide positive cells exhibited higher grade of differentiation earlier stage of tumor extension and higher survival rate than those without EC cells. A significant difference of the EC cell population pattern among different histological grades of the tumors and non-neoplastic mucosa was found. The proportion of hormone especially polypeptied positive cells was the highest in the mucosa and lowest in the moderately or poorly-differentiated carcinomas. The incidence methodology and clinicopathological significance of EC cells found in the tumors are discussed.

In a series of 130 cases of adenocarcinomas of the large intestine, enterochromaffin (EC) cells were detected in 54 cases (41.3%) by limmunocytochemistry with anti-chromogranin monoclonal antibody. Among the 54 cases, 30 were found positive for serotonin, 14 for somatostatin, 11 for glucagon, 5 for pancreatic polypeptide, and only one for gastrin. The cases with EC cell (++) or polypeptide positive cells exhibited higher grade of differentiation, earlier stage of tumor extension and higher survival rate than those without EC cells. A significant difference of the EC cell population pattern among different histological grades of the tumors and non-neoplastic mucosa was found. The proportion of hormone, especially polypeptied positive cells was the highest in the mucosa and lowest in the moderately or poorly-differentiated carcinomas. The incidence, methodology and clinicopathological significance of EC cells found in the tumors are discussed.

关键词： EC IMMUNOCYTOCHEMICAL STUDY OF ENTEROCHROMAFFIN CELLS IN CARCINOMAS OF THE LARGE INTESTINE than

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Level of education and mortality after radical prostatectomy

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Asian Journal of Andrology 2017年第2期19卷 173-177页

作者： Michael Froehner Rainer Koch Stefan Propping Dorothea Liebeheim Matthias Hfibler gustavo B baretton Oliver W Hakenberg Manfred P Wirth Department of Urology University Hospital 'Carl Gustav Carus' Technische Universit~t Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Medical Statistics and Biometry University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Anesthesiology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Pathology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Urology University of Rostock Ernst-Heydemann-Strasse 6 D-18055 Rostock Germany

Estimating the risk of competing mortality is of importance in men with early prostate cancer to choose the most appropriate way of management and to avoid over- or under-treatment. In this study, we investigated the impact of the level of education in this context. The study sample consisted of 2630 patients with complete data on level of education （college, university degree, master craftsmen, comparable profession, or others）, histopathological tumor stage （organ confined or extracapsular）, lymph node status （negative or positive）, and prostatectomy specimen Gleason score （〈7, 7, or 8-10） who underwent radical prostatectomy between 1992 and 2007. Overall, prostate cancer-specific, competing, and second cancer-related mortalities were study endpoints. Cox proportional hazard models for competing risks were used to study combined effects of the variables on these endpoints. A higher level of education was independently associated with decreased overall mortality after radical prostatectomy （hazard ratio [HR]： 0.75, 95% confidence interval [95% CI]： 0.62-0.91, P = 0.0037）. The mortality difference was attributable to decreased second cancer mortality （HR： 0.59, 95% Ch 0.40-0.85, P = 0.0052） and noncancer mortality （HR： 0.73, 95% Ch 0.55-0.98, P = 0.0345） but not to differences in prostate cancer-specific mortality （HR： 1.16, 95% Ch 0.79-1.69, P = 0.4536 in the full model）. In conclusion, the level of education might serve as an independent prognostic parameter supplementary to age, comorbidity, and smoking status to estimate the risk of competing mortality and to choose optimal treatment for men with early prostate cancer who are candidates for radical prostatectomy.

关键词： comorbidity competing risk analysis level of education life expectancy mortality proportional hazards model prostate cancer radical prostatectomy smoking socioeconomic status

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Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

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World Journal of Gastroenterology 2008年第7期14卷 1060-1066页

作者： Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker gustavo B baretton Daniela E Aust Institute for Pathology University of TechnologyFetscherstr. 74D-01307 DresdenGermany Department of General Visceral and Transplantation SurgeryUniversity Medical Center of GttingenRobert-Koch-Str. 40D-37075 GttingenGermany

AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment ***: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading ***: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor ***: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.

关键词： p53 Ki67 Neoadjuvant treatment Rectal cancer Thymidylate synthase

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Entanglement,Identical Particles and the Uncertainty Principle

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Communications in Theoretical Physics 2016年第8期65卷 201-206页

作者： gustavo Rigolin Departamento de Fisica Universidade Federal de Sao Carlos 13565-905 Sao Carlos SP Brazil

A new uncertainty relation(UR) is obtained for a system of N identical pure entangled particles if we use symmetrized observables when deriving the inequality. This new expression can be written in a form where we identify a term which explicitly shows the quantum correlations among the particles that constitute the system. For the particular cases of two and three particles, making use of the Schwarz inequality, we obtain new lower bounds for the UR that are different from the standard one.

关键词： quantum mechanics uncertainty relations identical and entangled particles

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A Modern Approach to the Solution and Analysis of the Simha-Somcynsky Model for the Description of Pressure-Volume-Temperature Properties of Polymer Fluids

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Chinese Journal of Polymer Science 2015年第4期33卷 523-523,524-539页

作者： gustavo A.Carri Department of Polymer Science College of Polymer Science and Polymer EngineeringThe University of Akron

We revisit the Simha-Somcynsky model of polymer fluids with the purpose of developing novel theoretical and computational approaches to simplify and speed up its solution as well as the fitting of experimental data, and decrease its level of mathematical complexity. We report a novel method that allows us to solve one of the two equations of the model exactly, thus putting the level of mathematical difficulty on a par with the one of other models for polymer fluids. Moreover, we describe a computational algorithm capable of fitting all five parameters of the model in an unbiased way. The results obtained reproduce literature results and fit experimental pressure-volume-temperature and solubility parameter data for three polymers very accurately. Moreover, the new techniques allow for the investigation of the model at very low temperatures. Unexpectedly, the model predicts behaviors that could be interpreted as a glass transition, as routinely observed in dilatometry and differential scanning calorimetry, and a glass phase. We compared the predicted and experimental Tg＇s for cis poly（1,4-butadiene） and found an excellent quantitative agreement.

关键词： Simha-Somcynsky model PVT properties Polymer fluids.

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Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

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Asian Journal of Andrology 2013年第3期15卷 368-374页

作者： gustavo F Gonzales High Altitude Research Institute and Department of Biological and Physiological Sciences Faculty of Sciences and Philosophy Universidad Peruana Cayetano Heredia Lima 31 Peru

Populations living at high altitudes （HAs）, particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis （16 g dl-1〈haemoglobin （Hb）≤21 gdl-1） and others with excessive erythrocytosis （EE）（Hb〉21 g dl-1）. Elevated haemoglobin values （EE） are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate （DH EAS） to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase （17beta-HSD） activity. Lower 17beta-HSD activity via A4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the A5-pathway. Currently, there are various situations in which people live （human biodiversity） with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.

关键词： chronic mountain sickness DHEA haemoglobin high altitudes men oestradiol women

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Modularity and specialization in bat-fly interaction networks are remarkably consistent across patches within urbanized landscapes and spatial scales

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Current Zoology 2021年第4期67卷 403-410页

作者： gustavo Lima Urbieta gustavo Graciolli Jeferson Vizentin-Bugoimi Programa de Pós-Graduação em Ciencias Biológicas Departamento de Sistematica e EcologiaUniversidade Federal da ParaibaCidade Jardim Universitários/nCastelo BrancoJoão Pessoa 58051-900Brazil Programa de Pós-Graduação em Biologia Animal Laboratorio de SistematicaEcologia e Evoluqao(LSEE)Instituto de BiocienciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo Grande 79090-900Brazil Department of Natural Resources and Environmental Sciences University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Patterns of specialization and the structure of interactions between bats and ectoparasitic flies have been studied mostly on non-urban environments and at local ***,how anthropogenic disturbances influence species interactions and network structure in this system remain poorly ***,we investigated patterns of interaction between Phyllostomidae bats and ectoparasitic Streblidae flies,and variations in network specialization and structure across Cerrado patches within urbanized landscapes in Brazil and between local and regional *** found high similarity in the richness and composition of bat and fly species across communities,associated with low turnover of interactions between *** high specialization of bat-streblid interactions resulted in little connected and modular networks,with the emergence of modules containing subsets of species that interact exclusively or primarily with each *** similarities in species and interaction composition and network structure across communities and scales suggest that bat-fly interactions within Cerrado patches are little affected by the degree of human modification in the surrounding *** remarkable consistency is likely promoted by specific behaviors,the tolerance of Phyllostomidae bats to surrounding urbanized landscapes as well as by the specificity of the streblid-bat interactions shaped over evolutionary time.

关键词： Chiroptera ectoparasites host-parasite network neotropics Streblidae urbanization

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Function of seminal vesicles and their role on male fertility

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Asian Journal of Andrology 2001年第4期3卷 251-258页

作者： gustavo F.Gonzales Department of Physiological Sciences Faculty of Sciences and Philosophy and Instituto de Invertigaciones de la Altura Universidad Peruana Cayetano Heredia Lima Peru

The present review has been designed to update the recent developments on the function of seminal vesicles andtheir role on male fertility. It is indicated that the true corrected fructose level is a simple method for the assessment ofthe seminal vesicular function. Measurement of seminal fructose used universally as a marker of the seminal vesiclefunction is not an appropriate approach due to its inverse relationship with the sperm count. The true corrected fructosedefined as [log. motile sperm concentration] multiplied by [seminal fructose concentration] has been shown to be abetter marker of the seminal vesicle function. Seminal vesicular secretion is important for semen coagulation, sperm motility, and stability of sperm chromatinand suppression of the immune activity in the female reproductive tract. In conclusion, the function of seminal vesicle is important for fertility. Parameters as sperm motility, sperm chro-matin stability, and immuno-protection may be changed in case of its hypofunction. (Asian J Androl 2001 Dec; 3:251 -258)

关键词： seminal vesicles male fertility male infertility true corrected fructose

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Artificial neural network with a cross-validation approach to blast-induced ground vibration propagation modeling

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Underground Space 2021年第3期6卷 281-289页

作者： gustavo Paneiro Manuel Rafael DECivil/CERENA Tecnico LisboaULisboaPortugal Orica Mining Services Portugal Portugal

Given their technical and economic advantages,the application of explosive substances to rock mass excavation is widely ***,because of serious environmental restraints,there has been an increasing need to use complex tools to control environmental effects due to blast-induced ground *** the present study,an artificial neural network(ANN)with k-fold cross-validation was applied to a dataset containing 1114 observations that was obtained from published results;furthermore,quantitative and qualitative parameters were considered for ground vibration amplitude *** best ANN model obtained has a maximum coefficient of determination of 0.840 and a mean absolute error of 5.59 and it comprises 17 input parameters,12 neurons in a one-layer hidden layer,and a sigmoid transfer *** with the traditional models,the model obtained using the proposed methodology demonstrated better generalization ***,the proposed methodology offers an ANN model with higher prediction ability.

关键词： Rock blasting Excavation Ground vibrations Artificial neural network K-fold cross-validation Modeling

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Physicochemical properties of Li_(3)Ba_(2)La_(3)(MoO_(4))_(8):Eu,Tb red-emitting phosphor for solid state white lamps

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Journal of Rare Earths 2023年第9期41卷 1279-1287,I0001页

作者： Kora Lu Rojas Baldivia gustavo A.Hirata Center for Scientific Research and Higher Education of Ensenada Ensenada Baja California 22860Mexico Center for Nanoscience and Nanotechnology National Autonomous University of Mexico EnsenadaBaja Califomia 22860Mex

In this work,combustion synthesis was used for the first time to fabricate a phosphor material with red emission for applications in solid-state white-light *** synthesized a material with emission wavelength at λ_(em)=617 nm,excited under long UV-blue wavelength based on Eu^(3+),Tb^(3+)-activated molybdates Li_(3)Ba_(2)(La_(1-x-y)Eu_(x)Tb_(y))_(3)(MoO_(4))_(8) with 0 ≤ x ≤1 and 0 ≤ y ≤ 1.A series of powder samples were produced by the combustion method and post-annealed at 800℃ in *** crystalline phase formation was investigated by X-ray diffraction,which reveals the monoclinic C2/c(15) space *** is observed that crystalline structure and morphology are preserved when the host lattice is doped with Eu^(3+) or Tb^(3+) single ions and co-doped with both ions at different doping concentrations.A detailed characterization by scanning electron microscopy(SEM) and transmission electron microscopy(TEM)shows a similar morphology in all samples:rather large(1-7 μm) agglomerate particles with irregular shapes and surrounded by smaller nanoparticles of 50 nm in ***-visible absorption spectra confirm the presence of Eu^(3+) and Tb^(3+) *** luminescent properties of the obtained phosphors were studied in *** measurements indicate that the best emission intensity is for Eu^(3+):Tb^(3+)doping ratios of 80:0,90:0 and 20:*** the other hand,samples with 80:0,60:40,and 20:80 doping ratios show the highest intensity in a detailed photoluminescence analysis and they exhibit the highest quantum yield values.A complete and efficient energy transfer from the sensitizer Tb^(3+) to the activator Eu^(3+) is observed in all co-doped phosphors post-annealed at 800℃ for 4 ***,the Li_(3)Ba_(2)La_(3)(MaO_(4))_(8):Eu^(3+),Tb^(3+) materials fabricated by combustion synthesis are excellent phosphors for being applied as red-emitting component in solid-state white-light lamps due to an improved color rendering index(CRI) that can be obtained under lo

关键词： Molybdate Europium Terbium Luminescence Phosphor-converted LED Rare earths

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